ameloblastin (enamel matrix protein) (AMBN) - coding DNA reference sequence

(used for variant description)

(last modified October 18, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_016519.5 in the AMBN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering AMBN transcript NM_016519.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5041
                    gaagtacagagcaagtcccacgcacagtcctgaaaaaaatt       c.-61

 .         .         .         .         .         .                g.5101
 ttaatcttcttttcttagaactatcttggttggcatcatcaggccctgagagcacagtgc       c.-1

          .      | 02  .         .         .         .         .    g.6114
 ATGTCAGCATCTAAG | ATTCCACTTTTCAAAATGAAGGACCTGATACTGATCCTATGCCTC    c.60
 M  S  A  S  K   | I  P  L  F  K  M  K  D  L  I  L  I  L  C  L      p.20

          .         .     | 03   .         .         .         .    g.9777
 CTGGAAATGAGTTTTGCAGTGCCG | TTCTTTCCTCAGCAATCTGGAACACCGGGTATGGCT    c.120
 L  E  M  S  F  A  V  P   | F  F  P  Q  Q  S  G  T  P  G  M  A      p.40

          .      | 04  .         .         .         .         .    g.11143
 AGTTTGAGCCTTGAG | ACAATGAGACAGTTGGGAAGTCTGCAGAGATTAAACACACTTTCT    c.180
 S  L  S  L  E   | T  M  R  Q  L  G  S  L  Q  R  L  N  T  L  S      p.60

     | 05    .         .         .         .         .         .    g.12335
 CAG | TATTCTAGATACGGCTTTGGAAAATCATTTAATTCTTTGTGGATGCACGGTCTCCTC    c.240
 Q   | Y  S  R  Y  G  F  G  K  S  F  N  S  L  W  M  H  G  L  L      p.80

          .         .         .         .         .     | 06   .    g.14166
 CCACCACATTCCTCTCTTCCATGGATGAGGCCAAGAGAACATGAAACTCAACAG | TATGAA    c.300
 P  P  H  S  S  L  P  W  M  R  P  R  E  H  E  T  Q  Q   | Y  E      p.100

          .         .         .         .         .         .       g.14226
 TATTCTTTGCCTGTGCATCCCCCACCTCTCCCATCACAGCCATCCTTGAAGCCTCAACAG       c.360
 Y  S  L  P  V  H  P  P  P  L  P  S  Q  P  S  L  K  P  Q  Q         p.120

          .         .         .         .         .         .       g.14286
 CCAGGACTGAAACCTTTTCTCCAGTCTGCTGCTGCAACCACCAACCAGGCCACAGCACTG       c.420
 P  G  L  K  P  F  L  Q  S  A  A  A  T  T  N  Q  A  T  A  L         p.140

          .         .         .         .         .         .       g.14346
 AAAGAAGCACTTCAGCCTCCAATTCACCTGGGACATCTGCCCTTGCAGGAAGGAGAACTG       c.480
 K  E  A  L  Q  P  P  I  H  L  G  H  L  P  L  Q  E  G  E  L         p.160

          .         .         .         .         .  | 07      .    g.15375
 CCTCTGGTTCAGCAGCAGGTGGCACCATCAGATAAGCCACCAAAGCCTGAG | CTCCCAGGA    c.540
 P  L  V  Q  Q  Q  V  A  P  S  D  K  P  P  K  P  E   | L  P  G      p.180

          .         .         . | 08       .         .         .    g.15570
 GTAGATTTTGCTGATCCACAAGGTCCATCA | CTCCCAGGAATGGATTTTCCTGATCCACAA    c.600
 V  D  F  A  D  P  Q  G  P  S   | L  P  G  M  D  F  P  D  P  Q      p.200

           | 09        .         .         .         | 10         . g.16014
 GGTCCATCA | CTCCCAGGATTGGATTTTGCTGATCCACAAGGTTCAACA | ATTTTCCAAATA c.660
 G  P  S   | L  P  G  L  D  F  A  D  P  Q  G  S  T   | I  F  Q  I   p.220

          .         .         .         .         | 11         .    g.16170
 GCCCGTTTGATTTCTCACGGACCAATGCCACAAAATAAACAATCTCCA | CTTTATCCAGGA    c.720
 A  R  L  I  S  H  G  P  M  P  Q  N  K  Q  S  P   | L  Y  P  G      p.240

          .         .         .    | 12    .         .         .    g.16646
 ATGTTGTACGTGCCTTTTGGAGCAAATCAATTG | AATGCCCCTGCCAGACTTGGCATCATG    c.780
 M  L  Y  V  P  F  G  A  N  Q  L   | N  A  P  A  R  L  G  I  M      p.260

          .         | 13         .         .         .         .    g.18969
 AGTTCAGAAGAAGTGGCA | GGCGGGAGAGAAGACCCAATGGCCTATGGAGCCATGTTTCCA    c.840
 S  S  E  E  V  A   | G  G  R  E  D  P  M  A  Y  G  A  M  F  P      p.280

          .         .         .         .         .         .       g.19029
 GGATTTGGAGGCATGAGGCCCGGCTTTGAGGGAATGCCCCACAACCCAGCTATGGGCGGT       c.900
 G  F  G  G  M  R  P  G  F  E  G  M  P  H  N  P  A  M  G  G         p.300

          .         .         .         .         .         .       g.19089
 GACTTCACTCTGGAATTTGACTCCCCAGTGGCTGCCACCAAAGGCCCTGAGAACGAAGAA       c.960
 D  F  T  L  E  F  D  S  P  V  A  A  T  K  G  P  E  N  E  E         p.320

          .         .         .         .         .         .       g.19149
 GGAGGTGCACAAGGCTCCCCTATGCCGGAGGCCAACCCAGACAATCTAGAAAACCCAGCT       c.1020
 G  G  A  Q  G  S  P  M  P  E  A  N  P  D  N  L  E  N  P  A         p.340

          .         .         .         .         .         .       g.19209
 TTCCTTACAGAGCTAGAACCTGCTCCCCACGCAGGGCTCCTTGCTCTCCCTAAGGATGAC       c.1080
 F  L  T  E  L  E  P  A  P  H  A  G  L  L  A  L  P  K  D  D         p.360

          .         .         .         .         .         .       g.19269
 ATTCCCGGCCTGCCAAGGAGCCCTTCAGGGAAGATGAAGGGACTCCCCAGCGTCACCCCA       c.1140
 I  P  G  L  P  R  S  P  S  G  K  M  K  G  L  P  S  V  T  P         p.380

          .         .         .         .         .         .       g.19329
 GCAGCTGCTGACCCACTGATGACCCCTGAATTAGCTGATGTTTATAGGACCTACGATGCT       c.1200
 A  A  A  D  P  L  M  T  P  E  L  A  D  V  Y  R  T  Y  D  A         p.400

          .         .         .         .         .         .       g.19389
 GACATGACCACATCCGTGGATTTCCAGGAAGAAGCAACCATGGATACCACGATGGCCCCA       c.1260
 D  M  T  T  S  V  D  F  Q  E  E  A  T  M  D  T  T  M  A  P         p.420

          .         .         .         .         .         .       g.19449
 AACTCTCTGCAAACATCCATGCCAGGAAACAAAGCCCAGGAGCCCGAGATGATGCATGAC       c.1320
 N  S  L  Q  T  S  M  P  G  N  K  A  Q  E  P  E  M  M  H  D         p.440

          .         .                                               g.19473
 GCATGGCATTTCCAAGAGCCCTGA                                           c.1344
 A  W  H  F  Q  E  P  X                                             p.447

          .         .         .         .         .         .       g.19533
 cagctctaagatattagctactttctgtatgcacaagcttcccagctttgtccccacagt       c.*60

          .         .         .         .         .         .       g.19593
 gtacctttttgctaaaacacttattacccttctgcagcaaaggcattaaaagcgctaagc       c.*120

          .         .         .         .         .         .       g.19653
 atatattaataaatgcaagtggctagaaatagtgtaggtccccttcttgctttcaatatc       c.*180

          .         .         .         .         .         .       g.19713
 ttgttgaaataaaatgtgtcaattgtctctgtgatttagaaacactattaataacatcag       c.*240

          .         .         .         .         .         .       g.19773
 agcaaggttctaagggtctcagcatttgatcatcactttttcttagctgtcttaagcatt       c.*300

          .         .         .         .         .         .       g.19833
 atagaatttctcttaccagcatgacactattatattcaggaaacatggcactgctttttt       c.*360

          .         .         .         .         .         .       g.19893
 ctctaagcaaaggcaaatatcctcataattctaagctaattcatttaaactttattaaat       c.*420

          .         .         .         .         .         .       g.19953
 ggggattggtggaaaactcctgactggtattactgggtttggtataatttaatttaaaat       c.*480

          .         .         .         .         .         .       g.20013
 tctcatttatagagtattttatttaatctagtataaaaaatctagcctattttaaataaa       c.*540

          .                                                         g.20031
 gaatttttctcactgaaa                                                 c.*558

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ameloblastin (enamel matrix protein) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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