autocrine motility factor receptor, E3 ubiquitin protein ligase (AMFR) - coding DNA reference sequence

(used for variant description)

(last modified May 27, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_001144.5 in the AMFR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering AMFR transcript NM_001144.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                              ctcttccgcgccggcaggggcagcagcggga       c.-181

 .         .         .         .         .         .                g.5091
 gcagcgcggggcggagcggcgccagcagccaggagcggcccggcccggcccggcgcggcg       c.-121

 .         .         .         .         .         .                g.5151
 gcggcggcggcagcggcagcggcagcgacgccagagcccgtgggcgccgttcgcgaggcc       c.-61

 .         .         .         .         .         .                g.5211
 gccgcagaggcccggccgcagcgcagggaagcctgggggccagaggtcgccgctgccgcc       c.-1

          .         .         .         .         .         .       g.5271
 ATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCTC       c.60
 M  P  L  L  F  L  E  R  F  P  W  P  S  L  R  T  Y  T  G  L         p.20

          .         .         .         .         .         .       g.5331
 AGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAG       c.120
 S  G  L  A  L  L  G  T  I  I  S  A  Y  R  A  L  S  Q  P  E         p.40

          .         .         .         .         .         .       g.5391
 GCCGGCCCCGGCGAGCCGGACCAGCTAACGGCCTCGCTGCAGCCTGAGCCGCCGGCGCCC       c.180
 A  G  P  G  E  P  D  Q  L  T  A  S  L  Q  P  E  P  P  A  P         p.60

          .         .         .         .         .         .       g.5451
 GCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGAC       c.240
 A  R  P  S  A  G  G  P  R  A  R  D  V  A  Q  Y  L  L  S  D         p.80

          .      | 02  .         .         .         .         .    g.16239
 AGCCTCTTCGTGTGG | GTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAG    c.300
 S  L  F  V  W   | V  L  V  N  T  A  C  C  V  L  M  L  V  A  K      p.100

          .         .         .         .         | 03         .    g.20962
 CTCATCCAGTGTATTGTGTTTGGCCCTCTTCGAGTGAGTGAGAGACAG | CATCTCAAAGAC    c.360
 L  I  Q  C  I  V  F  G  P  L  R  V  S  E  R  Q   | H  L  K  D      p.120

          .         .         .         .         .         .       g.21022
 AAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCAG       c.420
 K  F  W  N  F  I  F  Y  K  F  I  F  I  F  G  V  L  N  V  Q         p.140

          .         .         .         .         .         .       g.21082
 ACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTG       c.480
 T  V  E  E  V  V  M  W  C  L  W  F  A  G  L  V  F  L  H  L         p.160

          .         .         .    | 04    .         .         .    g.22449
 ATGGTTCAGCTCTGCAAGGATCGATTTGAATAT | CTTTCCTTCTCGCCCACCACGCCGATG    c.540
 M  V  Q  L  C  K  D  R  F  E  Y   | L  S  F  S  P  T  T  P  M      p.180

          .         .         .         .         .         .       g.22509
 AGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACTG       c.600
 S  S  H  G  R  V  L  S  L  L  V  A  M  L  L  S  C  C  G  L         p.200

          .         .         .         .         .         .       g.22569
 GCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCT       c.660
 A  A  V  C  S  I  T  G  Y  T  H  G  M  H  T  L  A  F  M  A         p.220

        | 05 .         .         .         .        | 06.         . g.25510
 GCAGAG | TCTCTTCTTGTGACAGTGAGGACTGCTCATGTGATTTTACG | ATACGTAATTCAC c.720
 A  E   | S  L  L  V  T  V  R  T  A  H  V  I  L  R  |  Y  V  I  H   p.240

          .         .         .         .         .         .       g.25570
 CTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACACA       c.780
 L  W  D  L  N  H  E  G  T  W  E  G  K  G  T  Y  V  Y  Y  T         p.260

          .         .         .         .         .         .       g.25630
 GACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTG       c.840
 D  F  V  M  E  L  T  L  L  S  L  D  L  M  H  H  I  H  M  L         p.280

  | 07       .         .         .         .         .         .    g.27480
  | TTATTTGGCAACATCTGGTTATCCATGGCCAGCCTGGTCATCTTTATGCAGCTGCGTTAC    c.900
  | L  F  G  N  I  W  L  S  M  A  S  L  V  I  F  M  Q  L  R  Y      p.300

          .         .         .         .         .         .       g.27540
 CTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGGA       c.960
 L  F  H  E  V  Q  R  R  I  R  R  H  K  N  Y  L  R  V  V  G         p.320

          .     | 08   .         .         .         .         .    g.28741
 AACATGGAGGCCAG | GTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGAC    c.1020
 N  M  E  A  R  |  F  A  V  A  T  P  E  E  L  A  V  N  N  D  D      p.340

          .         .         .         .         .         .       g.28801
 TGTGCCATCTGTTGGGACTCCATGCAGGCTGCGCGGAAACTGCCCTGTGGACATCTTTTC       c.1080
 C  A  I  C  W  D  S  M  Q  A  A  R  K  L  P  C  G  H  L  F         p.360

       | 09  .         .         .         .         .         .    g.41218
 CACAA | CTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAATG    c.1140
 H  N  |  S  C  L  R  S  W  L  E  Q  D  T  S  C  P  T  C  R  M      p.380

          .         .         .         .         .         .       g.41278
 TCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGAT       c.1200
 S  L  N  I  A  D  N  N  R  V  R  E  E  H  Q  G  E  N  L  D         p.400

          .         .         .         .         .         .       g.41338
 GAGAATTTGGTTCCTGTAGCAGCAGCCGAAGGGAGACCTCGCTTAAACCAACACAATCAC       c.1260
 E  N  L  V  P  V  A  A  A  E  G  R  P  R  L  N  Q  H  N  H         p.420

          .       | 10 .         .         .         .         .    g.44560
 TTCTTCCATTTCGATG | GGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGTG    c.1320
 F  F  H  F  D  G |   S  R  I  A  S  W  L  P  S  F  S  V  E  V      p.440

          .         .         .         .         .         .       g.44620
 ATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATG       c.1380
 M  H  T  T  N  I  L  G  I  T  Q  A  S  N  S  Q  L  N  A  M         p.460

  | 11       .         .         .         .         .         .    g.61271
  | GCTCATCAGATTCAAGAGATGTTTCCCCAGGTTCCATACCATCTGGTACTGCAGGACCTC    c.1440
  | A  H  Q  I  Q  E  M  F  P  Q  V  P  Y  H  L  V  L  Q  D  L      p.480

          .         .         .         .         .         .       g.61331
 CAGCTGACACGCTCAGTTGAAATAACAACAGACAATATTTTAGAAGGACGGATTCAAGTA       c.1500
 Q  L  T  R  S  V  E  I  T  T  D  N  I  L  E  G  R  I  Q  V         p.500

          .      | 12  .         .         .         .         .    g.63056
 CCTTTTCCTACACAG | CGGTCAGATAGCATCAGACCTGCATTGAACAGTCCTGTGGAAAGG    c.1560
 P  F  P  T  Q   | R  S  D  S  I  R  P  A  L  N  S  P  V  E  R      p.520

          .         .         .          | 13        .         .    g.66454
 CCAAGCAGTGACCAGGAAGAGGGAGAAACTTCTGCTCAG | ACCGAGCGTGTGCCACTGGAC    c.1620
 P  S  S  D  Q  E  E  G  E  T  S  A  Q   | T  E  R  V  P  L  D      p.540

          .         .         .         .         .         .       g.66514
 CTCAGTCCTCGCCTGGAGGAGACGCTGGACTTCGGCGAGGTGGAAGTGGAGCCCAGTGAG       c.1680
 L  S  P  R  L  E  E  T  L  D  F  G  E  V  E  V  E  P  S  E         p.560

          .         .         .         .         .         .       g.66574
 GTGGAAGACTTCGAGGCTCGTGGGAGCCGCTTCTCCAAGTCTGCTGATGAGAGACAGCGC       c.1740
 V  E  D  F  E  A  R  G  S  R  F  S  K  S  A  D  E  R  Q  R         p.580

          .         .         .         .     | 14   .         .    g.67498
 ATGCTGGTGCAGCGTAAGGACGAACTCCTCCAGCAAGCTCGCAA | ACGTTTCTTGAACAAA    c.1800
 M  L  V  Q  R  K  D  E  L  L  Q  Q  A  R  K  |  R  F  L  N  K      p.600

          .         .         .         .         .         .       g.67558
 AGTTCTGAAGATGATGCGGCCTCAGAGAGCTTCCTCCCCTCGGAAGGTGCGTCCTCTGAC       c.1860
 S  S  E  D  D  A  A  S  E  S  F  L  P  S  E  G  A  S  S  D         p.620

          .         .         .         .         .         .       g.67618
 CCCGTGACCCTGCGTCGAAGGATGCTGGCTGCCGCCGCGGAACGGAGGCTTCAGAAGCAG       c.1920
 P  V  T  L  R  R  R  M  L  A  A  A  A  E  R  R  L  Q  K  Q         p.640

          .                                                         g.67630
 CAGACCTCCTAG                                                       c.1932
 Q  T  S  X                                                         p.643

          .         .         .         .         .         .       g.67690
 cgctcccttgccttcctcagctgcctcctgcgccctgtgcccgactgactggaggaggcc       c.*60

          .         .         .         .         .         .       g.67750
 tgtcccaattctgcccgctccatggaaaagcgggcttgactgcattgccgctgtataaag       c.*120

          .         .         .         .         .         .       g.67810
 catgtggtcttatagtgtttggacagctgataaatttaatccttctttgtaatactttct       c.*180

          .         .         .         .         .         .       g.67870
 atgtgacatttctcttccccttagaaacactgcaaattttaactgtaggtatgatctctt       c.*240

          .         .         .         .         .         .       g.67930
 ctggtgttgactggactgcttggggtgggggacgatcaggaggaagtgagcagtcgcctg       c.*300

          .         .         .         .         .         .       g.67990
 cctgcagcaggcagcttctactcctgcctcatgcgtacgtcccacaaatgcaggtgtcct       c.*360

          .         .         .         .         .         .       g.68050
 gagcaccacacccagtgggaagagtgtgggggaggcgcacagtgtgagcccgcccccacg       c.*420

          .         .         .         .         .         .       g.68110
 tcgtggggtaacatctgttatcaaactgctgtcgttgttgtggaagcatgtagactgtgc       c.*480

          .         .         .         .         .         .       g.68170
 cagaggccagacccacgggctcatgcacccctgagccagcagggcatcttggaaaaggaa       c.*540

          .         .         .         .         .         .       g.68230
 ctcttggttcgatacctggagcagaggaggggaaagtccagggctatagggtgtgatgaa       c.*600

          .         .         .         .         .         .       g.68290
 gtcacccctttctgtcccactacatctgggactgactttccgagcctccagtccaaagcc       c.*660

          .         .         .         .         .         .       g.68350
 ggcttgatttccgtgaactctggtgctcctgcatctcatgagtgtgccccatgggtcccc       c.*720

          .         .         .         .         .         .       g.68410
 tcccctctcagcatttccttgtcccgtctggacctggggagtggttaggcagcaagcttt       c.*780

          .         .         .         .         .         .       g.68470
 ggtttatggttttcattcattggtgaagtaaattaggcagtgctaaagcctgtgggtttg       c.*840

          .         .         .         .         .         .       g.68530
 gtccttgaacaagatgtgggccttgcaagatgggagagtaaaccttgaagggctttatta       c.*900

          .         .         .         .         .         .       g.68590
 aagaaataaaaaagaacttttgtatcttttatcctgggagcactgcgttttcctagctgt       c.*960

          .         .         .         .         .         .       g.68650
 gttattcctggtttaattcagcagagaaggtaaggtgtgaacctacctgccttggagagg       c.*1020

          .         .         .         .         .         .       g.68710
 gcccaggtcccaaatctcttcaaattcttcacatgtttaactttaaggatttgaaccatg       c.*1080

          .         .         .         .         .         .       g.68770
 aagtcataggttacagacctcagttttatgccccattggattactttttttttttttttt       c.*1140

          .         .         .         .         .         .       g.68830
 tttttttttttttttactctttgaaagctttgttttgtggtagtccttttgggaagaatc       c.*1200

          .         .         .         .         .         .       g.68890
 cagtattatccacaattattggcaaagtttaaatgtattttacataacggaaagttttta       c.*1260

          .         .         .         .         .         .       g.68950
 gaatgttgaaaagtaattgaaaaaggtgataggtaaatttttaggcaaagataatttatt       c.*1320

          .         .         .         .         .         .       g.69010
 tcaataaatctttcaaaagccttaccttgaaatgctgttagtaaatttctgtgatttttt       c.*1380

          .         .         .         .         .         .       g.69070
 tttttaatttgttttgctgagagcatagctatttgtttttattgtaaaacaataataata       c.*1440

          .                                                         g.69087
 ataaaaagcaaactcta                                                  c.*1457

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Autocrine motility factor receptor, E3 ubiquitin protein ligase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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