anti-Mullerian hormone (AMH) - coding DNA reference sequence

(used for variant description)

(last modified October 14, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_000479.3 in the AMH gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012190.1, covering AMH transcript NM_000479.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5039
                      gcatgttgacacatcaggcccagctctatcactggggag       c.-181

 .         .         .         .         .         .                g.5099
 ggagataggctgccagggacagaaagggctctttgagaaggccactctgcctggagtggg       c.-121

 .         .         .         .         .         .                g.5159
 ggcgccgggcactgtcccccaaggtcgcggcagaggagataggggtctgtcctgcacaaa       c.-61

 .         .         .         .         .         .                g.5219
 caccccaccttccactcggctcacttaaggcaggcagcccagcccctggcagcacccacg       c.-1

          .         .         .         .         .         .       g.5279
 ATGCGGGACCTGCCTCTCACCAGCCTGGCCCTAGTGCTGTCTGCCCTGGGGGCTCTGCTG       c.60
 M  R  D  L  P  L  T  S  L  A  L  V  L  S  A  L  G  A  L  L         p.20

          .         .         .         .         .         .       g.5339
 GGGACTGAGGCCCTCAGAGCAGAGGAGCCAGCTGTGGGCACCAGTGGCCTCATCTTCCGA       c.120
 G  T  E  A  L  R  A  E  E  P  A  V  G  T  S  G  L  I  F  R         p.40

          .         .         .         .         .         .       g.5399
 GAAGACTTGGACTGGCCTCCAGGCAGCCCACAAGAGCCTCTGTGCCTGGTGGCACTGGGC       c.180
 E  D  L  D  W  P  P  G  S  P  Q  E  P  L  C  L  V  A  L  G         p.60

          .         .         .         .         .         .       g.5459
 GGGGACAGCAATGGCAGCAGCTCCCCCCTGCGGGTGGTGGGGGCTCTAAGCGCCTATGAG       c.240
 G  D  S  N  G  S  S  S  P  L  R  V  V  G  A  L  S  A  Y  E         p.80

          .         .         .         .         .         .       g.5519
 CAGGCCTTCCTGGGGGCCGTGCAGAGGGCCCGCTGGGGCCCCCGAGACCTGGCCACCTTC       c.300
 Q  A  F  L  G  A  V  Q  R  A  R  W  G  P  R  D  L  A  T  F         p.100

          .         .         .         .         .         .       g.5579
 GGGGTCTGCAACACCGGTGACAGGCAGGCTGCCTTGCCCTCTCTACGGCGGCTGGGGGCC       c.360
 G  V  C  N  T  G  D  R  Q  A  A  L  P  S  L  R  R  L  G  A         p.120

          .         .         .         .         .   | 02     .    g.6231
 TGGCTGCGGGACCCTGGGGGGCAGCGCCTGGTGGTCCTACACCTGGAGGAAG | TGACCTGG    c.420
 W  L  R  D  P  G  G  Q  R  L  V  V  L  H  L  E  E  V |   T  W      p.140

          .         .         .         .         .         .       g.6291
 GAGCCAACACCCTCGCTGAGGTTCCAGGAGCCCCCGCCTGGAGGAGCTGGCCCCCCAGAG       c.480
 E  P  T  P  S  L  R  F  Q  E  P  P  P  G  G  A  G  P  P  E         p.160

          .         .         .         .         .         .       g.6351
 CTGGCGCTGCTGGTGCTGTACCCTGGGCCTGGCCCTGAGGTCACTGTGACGAGGGCTGGG       c.540
 L  A  L  L  V  L  Y  P  G  P  G  P  E  V  T  V  T  R  A  G         p.180

          .      | 03  .         .         .         .         .    g.6583
 CTGCCGGGTGCCCAG | AGCCTCTGCCCCTCCCGAGACACCCGCTACCTGGTGTTAGCGGTG    c.600
 L  P  G  A  Q   | S  L  C  P  S  R  D  T  R  Y  L  V  L  A  V      p.200

          .         .         .         .         .         .       g.6643
 GACCGCCCTGCGGGGGCCTGGCGCGGCTCCGGGCTGGCCTTGACCCTGCAGCCCCGCGGA       c.660
 D  R  P  A  G  A  W  R  G  S  G  L  A  L  T  L  Q  P  R  G         p.220

      | 04   .         .         .         .         .         .    g.6791
 GAGG | ACTCCCGGCTGAGTACCGCCCGGCTGCAGGCACTGCTGTTCGGCGACGACCACCGC    c.720
 E  D |   S  R  L  S  T  A  R  L  Q  A  L  L  F  G  D  D  H  R      p.240

          .         .         .         .         .         .       g.6851
 TGCTTCACACGGATGACCCCGGCCCTGCTCCTGCTGCCGCGGTCCGAGCCCGCGCCGCTG       c.780
 C  F  T  R  M  T  P  A  L  L  L  L  P  R  S  E  P  A  P  L         p.260

          .         .         .         .     | 05   .         .    g.7001
 CCTGCGCACGGCCAGCTGGACACCGTGCCCTTCCCGCCGCCCAG | GCCATCCGCGGAACTC    c.840
 P  A  H  G  Q  L  D  T  V  P  F  P  P  P  R  |  P  S  A  E  L      p.280

          .         .         .         .         .         .       g.7061
 GAGGAGTCGCCACCCAGCGCAGACCCCTTCCTGGAGACGCTCACGCGCCTGGTGCGGGCG       c.900
 E  E  S  P  P  S  A  D  P  F  L  E  T  L  T  R  L  V  R  A         p.300

          .         .         .         .         .         .       g.7121
 CTGCGGGTCCCCCCGGCCCGGGCCTCCGCGCCGCGCCTGGCCCTGGATCCGGACGCGCTG       c.960
 L  R  V  P  P  A  R  A  S  A  P  R  L  A  L  D  P  D  A  L         p.320

          .         .         .         .         .         .       g.7181
 GCCGGCTTCCCGCAGGGCCTAGTCAACCTGTCGGACCCCGCGGCGCTGGAGCGCCTACTC       c.1020
 A  G  F  P  Q  G  L  V  N  L  S  D  P  A  A  L  E  R  L  L         p.340

          .         .         .         .         .         .       g.7241
 GACGGCGAGGAGCCGCTGCTGCTGCTGCTGAGGCCCACTGCGGCCACCACCGGGGATCCT       c.1080
 D  G  E  E  P  L  L  L  L  L  R  P  T  A  A  T  T  G  D  P         p.360

          .         .         .         .         .         .       g.7301
 GCGCCCCTGCACGACCCCACGTCGGCGCCGTGGGCCACGGCCCTGGCGCGCCGCGTGGCT       c.1140
 A  P  L  H  D  P  T  S  A  P  W  A  T  A  L  A  R  R  V  A         p.380

          .         .         .         .         .         .       g.7361
 GCTGAACTGCAAGCGGCGGCTGCCGAGCTGCGAAGCCTCCCGGGTCTGCCTCCGGCCACA       c.1200
 A  E  L  Q  A  A  A  A  E  L  R  S  L  P  G  L  P  P  A  T         p.400

          .         .         .         .         .         .       g.7421
 GCCCCGCTGCTGGCGCGCCTGCTCGCGCTCTGCCCAGGTGGCCCCGGCGGCCTCGGCGAT       c.1260
 A  P  L  L  A  R  L  L  A  L  C  P  G  G  P  G  G  L  G  D         p.420

          .         .         .         .         .         .       g.7481
 CCCCTGCGAGCGCTGCTGCTCCTGAAGGCGCTGCAGGGCCTGCGCGTGGAGTGGCGCGGG       c.1320
 P  L  R  A  L  L  L  L  K  A  L  Q  G  L  R  V  E  W  R  G         p.440

          .         .         .         .         .         .       g.7541
 CGGGATCCGCGCGGGCCGGGTCGGGCACAGCGCAGCGCGGGGGCCACCGCCGCCGACGGG       c.1380
 R  D  P  R  G  P  G  R  A  Q  R  S  A  G  A  T  A  A  D  G         p.460

          .         .         .         .         .         .       g.7601
 CCGTGCGCGCTGCGCGAGCTCAGCGTAGACCTCCGCGCCGAGCGCTCCGTACTCATCCCC       c.1440
 P  C  A  L  R  E  L  S  V  D  L  R  A  E  R  S  V  L  I  P         p.480

          .         .         .         .         .         .       g.7661
 GAGACCTACCAGGCCAACAATTGCCAGGGCGTGTGCGGCTGGCCTCAGTCCGACCGCAAC       c.1500
 E  T  Y  Q  A  N  N  C  Q  G  V  C  G  W  P  Q  S  D  R  N         p.500

          .         .         .         .         .         .       g.7721
 CCGCGCTACGGCAACCACGTGGTGCTGCTGCTGAAGATGCAGGTCCGTGGGGCCGCCCTG       c.1560
 P  R  Y  G  N  H  V  V  L  L  L  K  M  Q  V  R  G  A  A  L         p.520

          .         .         .         .         .         .       g.7781
 GCGCGCCCACCCTGCTGCGTGCCCACCGCCTACGCGGGCAAGCTGCTCATCAGCCTGTCG       c.1620
 A  R  P  P  C  C  V  P  T  A  Y  A  G  K  L  L  I  S  L  S         p.540

          .         .         .         .         .         .       g.7841
 GAGGAGCGCATCAGCGCGCACCACGTGCCCAACATGGTGGCCACCGAGTGTGGCTGCCGG       c.1680
 E  E  R  I  S  A  H  H  V  P  N  M  V  A  T  E  C  G  C  R         p.560

                                                                    g.7844
 TGA                                                                c.1683
 X                                                                  p.560

          .         .         .         .         .         .       g.7904
 cccctgcgccgcgcggactcctgccccgagggtccggacgcgccccagctcgcgcccctt       c.*60

          .         .         .         .         .                 g.7960
 cccatatttattcggaccccaagcatcgccccaataaagaccagcaagcaaccggc           c.*116

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Anti-Mullerian hormone protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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