adenosine monophosphate deaminase 1 (AMPD1) - coding DNA reference sequence

(used for variant description)

(last modified July 10, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000036.2 in the AMPD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008012.1, covering AMPD1 transcript NM_000036.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.4985
             acttagcagagaagaatcaaatttccgggggcaaagcaaaataataaa       c.-1

          .         .         .         .         .         .       g.5045
 ATGAATGTCAGGATATTTTATAGTGTCAGTCAGTCACCCCACAGTCTCCTCTCTCTTCTT       c.60
 M  N  V  R  I  F  Y  S  V  S  Q  S  P  H  S  L  L  S  L  L         p.20

          .         .         .         .         .         .       g.5105
 TTCTACTGTGCTATCCTAGAATCAAGGATTTCAGCAACAATGCCTCTGTTCAAACTCCCA       c.120
 F  Y  C  A  I  L  E  S  R  I  S  A  T  M  P  L  F  K  L  P         p.40

   | 02      .    | 03    .         .         .         .         . g.11861
 G | CTGAAGAGAAAC | AAATTGATGATGCAATGCGCAACTTTGCTGAAAAAGTGTTTGCCTCT c.180
 A |   E  E  K  Q |   I  D  D  A  M  R  N  F  A  E  K  V  F  A  S   p.60

          .         .         .         .         .         .       g.11921
 GAAGTCAAAGATGAAGGAGGTCGTCAGGAGATTTCCCCCTTTGATGTGGATGAGATCTGT       c.240
 E  V  K  D  E  G  G  R  Q  E  I  S  P  F  D  V  D  E  I  C         p.80

          .         .         .         .         .         .       g.11981
 CCGATTTCTCATCATGAGATGCAAGCACACATATTCCATCTGGAGACTCTGTCCACCTCC       c.300
 P  I  S  H  H  E  M  Q  A  H  I  F  H  L  E  T  L  S  T  S         p.100

          .     | 04   .         .         .         .         .    g.13691
 ACAGAAGCCAGGAG | AAAAAAGCGTTTCCAAGGACGGAAGACTGTTAATTTGTCCATTCCA    c.360
 T  E  A  R  R  |  K  K  R  F  Q  G  R  K  T  V  N  L  S  I  P      p.120

          .         .         .         .         .         .       g.13751
 CTAAGTGAAACATCTTCCACCAAACTGTCCCACATTGATGAATACATTTCCTCATCTCCA       c.420
 L  S  E  T  S  S  T  K  L  S  H  I  D  E  Y  I  S  S  S  P         p.140

          .         .         .         .         .         .       g.13811
 ACCTACCAGACCGTGCCTGATTTTCAGAGAGTGCAGATTACTGGTGACTATGCCTCTGGG       c.480
 T  Y  Q  T  V  P  D  F  Q  R  V  Q  I  T  G  D  Y  A  S  G         p.160

  | 05       .         .         .         .         .         .    g.16251
  | GTTACAGTTGAAGATTTTGAAATTGTTTGCAAAGGTCTGTATCGGGCACTATGCATACGT    c.540
  | V  T  V  E  D  F  E  I  V  C  K  G  L  Y  R  A  L  C  I  R      p.180

          .         .         .         .         .         .       g.16311
 GAGAAATACATGCAGAAGTCGTTTCAGAGGTTCCCTAAAACCCCTTCCAAATACTTGCGG       c.600
 E  K  Y  M  Q  K  S  F  Q  R  F  P  K  T  P  S  K  Y  L  R         p.200

          .         .         .         .       | 06 .         .    g.20091
 AACATTGATGGTGAGGCTTGGGTAGCAAATGAGAGCTTCTATCCAG | TCTTTACTCCTCCT    c.660
 N  I  D  G  E  A  W  V  A  N  E  S  F  Y  P  V |   F  T  P  P      p.220

          .         .         .         .         .         .       g.20151
 GTGAAGAAGGGAGAGGACCCCTTCCGAACAGACAACCTTCCTGAAAACCTGGGCTATCAC       c.720
 V  K  K  G  E  D  P  F  R  T  D  N  L  P  E  N  L  G  Y  H         p.240

          .         .         .         .         .         .       g.20211
 CTCAAAATGAAGGACGGTGTAGTTTACGTCTATCCTAATGAAGCAGCAGTCAGCAAAGAT       c.780
 L  K  M  K  D  G  V  V  Y  V  Y  P  N  E  A  A  V  S  K  D         p.260

          .         .         .         .         .         .       g.20271
 GAGCCTAAGCCACTTCCTTACCCAAATCTGGACACCTTCTTAGACGATATGAATTTTTTA       c.840
 E  P  K  P  L  P  Y  P  N  L  D  T  F  L  D  D  M  N  F  L         p.280

          .         .       | 07 .         .         .         .    g.20881
 CTTGCTTTAATTGCTCAAGGACCTGT | TAAGACCTATACCCACCGGCGCCTGAAGTTCCTC    c.900
 L  A  L  I  A  Q  G  P  V  |  K  T  Y  T  H  R  R  L  K  F  L      p.300

          .         .         .         .         .         .       g.20941
 TCCTCCAAGTTCCAGGTCCATCAGATGCTTAACGAGATGGACGAGTTAAAGGAGCTGAAA       c.960
 S  S  K  F  Q  V  H  Q  M  L  N  E  M  D  E  L  K  E  L  K         p.320

          .         .         .       | 08 .         .         .    g.22052
 AACAACCCCCACCGAGATTTTTATAACTGCAGGAAG | GTGGACACCCATATCCATGCAGCC    c.1020
 N  N  P  H  R  D  F  Y  N  C  R  K   | V  D  T  H  I  H  A  A      p.340

          .         .         .         .         .         .       g.22112
 GCTTGCATGAACCAGAAACATCTGCTGCGTTTTATTAAGAAATCTTACCAAATTGATGCT       c.1080
 A  C  M  N  Q  K  H  L  L  R  F  I  K  K  S  Y  Q  I  D  A         p.360

          .         .         .         .         .         .       g.22172
 GACAGAGTGGTCTATAGCACCAAAGAGAAGAATCTGACCCTAAAGGAACTTTTTGCTAAA       c.1140
 D  R  V  V  Y  S  T  K  E  K  N  L  T  L  K  E  L  F  A  K         p.380

          .         .         .         .         .  | 09      .    g.22523
 TTAAAAATGCATCCTTATGACCTGACTGTTGATTCTCTGGATGTTCATGCT | GGACGCCAG    c.1200
 L  K  M  H  P  Y  D  L  T  V  D  S  L  D  V  H  A   | G  R  Q      p.400

          .         .         .         .         .         .       g.22583
 ACCTTCCAGCGTTTTGATAAGTTCAATGACAAATATAATCCTGTAGGAGCAAGTGAGCTA       c.1260
 T  F  Q  R  F  D  K  F  N  D  K  Y  N  P  V  G  A  S  E  L         p.420

          .         .         .         .         .         .       g.22643
 CGGGACCTCTACTTGAAGACAGACAATTACATTAATGGGGAATATTTTGCCACTATCATC       c.1320
 R  D  L  Y  L  K  T  D  N  Y  I  N  G  E  Y  F  A  T  I  I         p.440

     | 10    .         .         .         .         .         .    g.23098
 AAG | GAGGTAGGTGCGGACCTGGTGGAGGCCAAGTACCAGCATGCTGAGCCCCGCCTGTCC    c.1380
 K   | E  V  G  A  D  L  V  E  A  K  Y  Q  H  A  E  P  R  L  S      p.460

          .         .         .         .         .         .       g.23158
 ATCTATGGCCGCAGTCCTGATGAGTGGAGCAAACTCTCCTCCTGGTTCGTCTGCAATCGC       c.1440
 I  Y  G  R  S  P  D  E  W  S  K  L  S  S  W  F  V  C  N  R         p.480

          .         .         .         .        | 11.         .    g.24565
 ATCCACTGCCCCAACATGACATGGATGATCCAGGTTCCCAGGATCTA | TGATGTGTTCCGT    c.1500
 I  H  C  P  N  M  T  W  M  I  Q  V  P  R  I  Y  |  D  V  F  R      p.500

          .         .         .         .         .         .       g.24625
 TCCAAGAATTTCCTTCCACATTTTGGAAAAATGCTGGAGAATATTTTCATGCCAGTGTTT       c.1560
 S  K  N  F  L  P  H  F  G  K  M  L  E  N  I  F  M  P  V  F         p.520

          .         .         .         .         .     | 12   .    g.24868
 GAGGCCACCATCAACCCCCAGGCTGACCCAGAACTCAGTGTCTTCCTCAAGCAT | ATCACT    c.1620
 E  A  T  I  N  P  Q  A  D  P  E  L  S  V  F  L  K  H   | I  T      p.540

          .         .         .         .         .         .       g.24928
 GGCTTTGACAGTGTGGATGATGAGTCCAAACACAGTGGCCACATGTTCTCCTCCAAGAGT       c.1680
 G  F  D  S  V  D  D  E  S  K  H  S  G  H  M  F  S  S  K  S         p.560

          .         .         .         .         .         .       g.24988
 CCCAAGCCCCAGGAGTGGACATTGGAAAAGAATCCATCTTACACTTACTATGCCTACTAC       c.1740
 P  K  P  Q  E  W  T  L  E  K  N  P  S  Y  T  Y  Y  A  Y  Y         p.580

          .         .         .         | 13         .         .    g.25705
 ATGTATGCAAACATCATGGTGCTCAACAGCCTGAGAAA | GGAACGAGGCATGAATACGTTT    c.1800
 M  Y  A  N  I  M  V  L  N  S  L  R  K  |  E  R  G  M  N  T  F      p.600

          .         .         .         .         .         .       g.25765
 CTGTTCCGACCTCACTGTGGAGAAGCTGGAGCCCTCACCCATCTCATGACAGCATTCATG       c.1860
 L  F  R  P  H  C  G  E  A  G  A  L  T  H  L  M  T  A  F  M         p.620

          .         .         .          | 14        .         .    g.26494
 ATAGCAGATGATATCTCTCATGGCCTAAATTTAAAAAAG | AGTCCCGTGCTACAGTACTTG    c.1920
 I  A  D  D  I  S  H  G  L  N  L  K  K   | S  P  V  L  Q  Y  L      p.640

          .         .         .         .         .         .       g.26554
 TTTTTCTTAGCCCAAATTCCCATCGCCATGTCACCACTAAGTAACAATAGCCTATTTCTA       c.1980
 F  F  L  A  Q  I  P  I  A  M  S  P  L  S  N  N  S  L  F  L         p.660

          .         .         .         .         .         .       g.26614
 GAGTATGCCAAAAATCCTTTTTTGGATTTCCTTCAGAAAGGGCTAATGATCTCACTGTCT       c.2040
 E  Y  A  K  N  P  F  L  D  F  L  Q  K  G  L  M  I  S  L  S         p.680

          .         .         .    | 15    .         .         .    g.26833
 ACAGATGACCCAATGCAATTCCACTTTACCAAG | GAGCCCCTAATGGAAGAATATGCTATT    c.2100
 T  D  D  P  M  Q  F  H  F  T  K   | E  P  L  M  E  E  Y  A  I      p.700

          .         .         .         .         .         .       g.26893
 GCTGCACAAGTCTTCAAGCTGAGCACCTGTGATATGTGCGAAGTGGCAAGGAACAGTGTC       c.2160
 A  A  Q  V  F  K  L  S  T  C  D  M  C  E  V  A  R  N  S  V         p.720

          .         .     | 16   .         .         .         .    g.27319
 TTGCAGTGTGGAATTTCTCATGAG | GAGAAAGTAAAGTTTCTGGGCGACAATTACCTTGAG    c.2220
 L  Q  C  G  I  S  H  E   | E  K  V  K  F  L  G  D  N  Y  L  E      p.740

          .         .         .         .         .         .       g.27379
 GAAGGCCCTGCTGGAAATGATATCCGGAGGACAAATGTAGCCCAAATCCGCATGGCCTAT       c.2280
 E  G  P  A  G  N  D  I  R  R  T  N  V  A  Q  I  R  M  A  Y         p.760

          .         .         .         .         .         .       g.27439
 CGCTATGAAACCTGGTGTTATGAACTCAATTTAATTGCTGAGGGTCTTAAATCAACAGAA       c.2340
 R  Y  E  T  W  C  Y  E  L  N  L  I  A  E  G  L  K  S  T  E         p.780

                                                                    g.27442
 TAA                                                                c.2343
 X                                                                  p.780

          .                                                         g.27458
 aaaaaagtaaaccaaa                                                   c.*16

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Adenosine monophosphate deaminase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 21c
©2004-2019 Leiden University Medical Center