aminomethyltransferase (AMT) - coding DNA reference sequence

(used for variant description)

(last modified August 30, 2012)


This file was created to facilitate the description of sequence variants on transcript NM_000481.3 in the AMT gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering AMT transcript NM_000481.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             gagctgccctgaagagtcagccgaaagagctggaggcttcttccctgt       c.-181

 .         .         .         .         .         .                g.5108
 ggttgcgggttcctgcattctctgctctaaatcccagcctgcccttggggctgcccacgc       c.-121

 .         .         .         .         .         .                g.5168
 ccccttcagatcctttgctccggagagagacctgtccgagcagaggcctggactacatct       c.-61

 .         .         .         .         .         .                g.5228
 cccggcgtgcctggcagtgtggtggcctctgtgcgccgtctgcactcgttgcaggcgacg       c.-1

          .         .         .         .         .         .       g.5288
 ATGCAGAGGGCTGTAAGTGTGGTGGCCCGTCTGGGCTTTCGCCTGCAGGCATTCCCCCCG       c.60
 M  Q  R  A  V  S  V  V  A  R  L  G  F  R  L  Q  A  F  P  P         p.20

          .         .         . | 02       .         .         .    g.5437
 GCCTTGTGTCGTCCACTTAGTTGCGCACAG | GAGGTGCTCCGCAGGACACCGCTCTATGAC    c.120
 A  L  C  R  P  L  S  C  A  Q   | E  V  L  R  R  T  P  L  Y  D      p.40

          .         .         .         .         .         .       g.5497
 TTCCACCTGGCCCACGGCGGGAAAATGGTGGCGTTTGCGGGTTGGAGTCTGCCAGTGCAG       c.180
 F  H  L  A  H  G  G  K  M  V  A  F  A  G  W  S  L  P  V  Q         p.60

          .         .         .         .         .         .       g.5557
 TACCGGGACAGTCACACTGACTCGCACCTGCACACACGCCAGCACTGCTCGCTCTTTGAC       c.240
 Y  R  D  S  H  T  D  S  H  L  H  T  R  Q  H  C  S  L  F  D         p.80

          .         | 03         .         .         .         .    g.6148
 GTGTCTCATATGCTGCAG | ACCAAGATACTTGGTAGTGACCGGGTGAAGCTGATGGAGAGT    c.300
 V  S  H  M  L  Q   | T  K  I  L  G  S  D  R  V  K  L  M  E  S      p.100

          .         .         .          | 04        .         .    g.7357
 CTAGTGGTTGGAGACATTGCAGAGCTAAGACCAAACCAG | GGGACACTGTCGCTGTTTACC    c.360
 L  V  V  G  D  I  A  E  L  R  P  N  Q   | G  T  L  S  L  F  T      p.120

          .         .         .         .         .         .       g.7417
 AACGAGGCTGGAGGCATCTTAGATGACTTGATTGTAACCAATACTTCTGAGGGCCACCTG       c.420
 N  E  A  G  G  I  L  D  D  L  I  V  T  N  T  S  E  G  H  L         p.140

          .         .         .         .         .  | 05      .    g.7899
 TATGTGGTGTCCAACGCTGGCTGCTGGGAGAAAGATTTGGCCCTCATGCAG | GACAAGGTC    c.480
 Y  V  V  S  N  A  G  C  W  E  K  D  L  A  L  M  Q   | D  K  V      p.160

          .         .         .         .         .         .       g.7959
 AGGGAGCTTCAGAACCAGGGCAGAGATGTGGGCCTGGAGGTGTTGGATAATGCCCTGCTA       c.540
 R  E  L  Q  N  Q  G  R  D  V  G  L  E  V  L  D  N  A  L  L         p.180

          . | 06       .         .         .         .         .    g.8323
 GCTCTGCAAG | GCCCCACTGCAGCCCAGGTACTACAGGCCGGCGTGGCAGATGACCTGAGG    c.600
 A  L  Q  G |   P  T  A  A  Q  V  L  Q  A  G  V  A  D  D  L  R      p.200

          .         .         .         .         .         .       g.8383
 AAACTGCCCTTCATGACCAGTGCTGTGATGGAGGTGTTTGGCGTGTCTGGCTGCCGCGTG       c.660
 K  L  P  F  M  T  S  A  V  M  E  V  F  G  V  S  G  C  R  V         p.220

          .         .         .       | 07 .         .         .    g.8551
 ACCCGCTGTGGCTACACAGGAGAGGATGGTGTGGAG | ATCTCGGTGCCGGTAGCGGGGGCA    c.720
 T  R  C  G  Y  T  G  E  D  G  V  E   | I  S  V  P  V  A  G  A      p.240

          .         .         .         .         .         .       g.8611
 GTTCACCTGGCAACAGCTATTCTGAAAAACCCAGAGGTGAAGCTGGCAGGGCTGGCAGCC       c.780
 V  H  L  A  T  A  I  L  K  N  P  E  V  K  L  A  G  L  A  A         p.260

          .         .         .         .         .         .       g.8671
 AGGGACAGCCTGCGCCTGGAGGCAGGCCTCTGCCTGTATGGGAATGACATTGATGAACAC       c.840
 R  D  S  L  R  L  E  A  G  L  C  L  Y  G  N  D  I  D  E  H         p.280

          .         .         .        | 08.         .         .    g.9728
 ACTACACCTGTGGAGGGCAGCCTCAGTTGGACACTGG | GGAAGCGCCGCCGAGCTGCTATG    c.900
 T  T  P  V  E  G  S  L  S  W  T  L  G |   K  R  R  R  A  A  M      p.300

          .         .         .         .         .         .       g.9788
 GACTTCCCTGGAGCCAAGGTCATTGTTCCCCAGCTGAAGGGCAGGGTGCAGCGGAGGCGT       c.960
 D  F  P  G  A  K  V  I  V  P  Q  L  K  G  R  V  Q  R  R  R         p.320

          .         .         .         .         .         .       g.9848
 GTGGGGTTGATGTGTGAGGGGGCCCCCATGCGGGCACACAGTCCCATCCTGAACATGGAG       c.1020
 V  G  L  M  C  E  G  A  P  M  R  A  H  S  P  I  L  N  M  E         p.340

          .    | 09    .         .         .         .         .    g.10007
 GGTACCAAGATTG | GTACTGTGACTAGTGGCTGCCCCTCCCCCTCTCTGAAGAAGAATGTG    c.1080
 G  T  K  I  G |   T  V  T  S  G  C  P  S  P  S  L  K  K  N  V      p.360

          .         .         .         .         .         .       g.10067
 GCGATGGGTTATGTGCCCTGCGAGTACAGTCGTCCAGGGACAATGCTGCTGGTAGAGGTG       c.1140
 A  M  G  Y  V  P  C  E  Y  S  R  P  G  T  M  L  L  V  E  V         p.380

          .         .         .         .         .         .       g.10127
 CGGCGGAAGCAGCAGATGGCTGTAGTCAGCAAGATGCCCTTTGTGCCCACAAACTACTAT       c.1200
 R  R  K  Q  Q  M  A  V  V  S  K  M  P  F  V  P  T  N  Y  Y         p.400

          .                                                         g.10139
 ACCCTCAAGTGA                                                       c.1212
 T  L  K  X                                                         p.403

          .         .         .         .         .         .       g.10199
 agctggctcagggtggggctgtcccttccaggagttttgcccctacaaggggttagtcaa       c.*60

          .         .         .         .         .         .       g.10259
 gaagctgaggcagaactcactgggggtgggcagttaaggtggaggctgattctaattgtc       c.*120

          .         .         .         .         .         .       g.10319
 tggttgaggggccacaccacctattccccccacctaactcatgccattccagcttccttc       c.*180

          .         .         .         .         .         .       g.10379
 aggaccctgcttctgagtgacggaccagctcacacaatgtcttgtttcagtccatgatcc       c.*240

          .         .         .         .         .         .       g.10439
 cactgacctactcttgcctgctggagggtaatgagaagctttggttctgccatctctccc       c.*300

          .         .         .         .         .         .       g.10499
 actctgccaggtgctggctgtggagcaaaggctcacctttgtggagaggataaaacctgc       c.*360

          .         .         .         .         .         .       g.10559
 ccaacctacctcaccatggtttttcacattgcaaagggtaataacatgggcagtgcggac       c.*420

          .         .         .         .         .         .       g.10619
 ttaggctaccccctccagtttgctttccgtaaatgcaaattgtccttactgcaagtcagg       c.*480

          .         .         .         .         .         .       g.10679
 aatgattgctgactcacagtagggctgctatgcctgtgtgtaaacttggggatggctgag       c.*540

          .         .         .         .         .         .       g.10739
 ggaacatagactcactcttccacattcccaagttggtctagtgtgctgcccagtagcaaa       c.*600

          .         .         .         .         .         .       g.10799
 ccatggcagactcaccacctattctgagttccagggctgctgtagggcagggtgggcttc       c.*660

          .         .         .         .         .         .       g.10859
 ctcccagacttgccttaccctgggctgatctttgcccctggtatgcattaatggactcca       c.*720

          .         .         .         .                           g.10901
 ctgaatcctgaaaaaaaaattaaacttccttcttacttgcca                         c.*762

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Aminomethyltransferase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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