angiopoietin 2 (ANGPT2) - coding DNA reference sequence

(used for variant description)

(last modified March 21, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_001118887.1 in the ANGPT2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.10, covering ANGPT2 transcript NM_001118887.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                aaagtgattgattcggatactgacactgt       c.-301

 .         .         .         .         .         .                g.5089
 aggatctggggagagaggaacaaaggaccgtgaaagctgctctgtaaaagctgacacagc       c.-241

 .         .         .         .         .         .                g.5149
 cctcccaagtgagcaggactgttcttcccactgcaatctgacagtttactgcatgcctgg       c.-181

 .         .         .         .         .         .                g.5209
 agagaacacagcagtaaaaaccaggtttgctactggaaaaagaggaaagagaagactttc       c.-121

 .         .         .         .         .         .                g.5269
 attgacggacccagccatggcagcgtagcagccctgcgttttagacggcagcagctcggg       c.-61

 .         .         .         .         .         .                g.5329
 actctggacgtgtgtttgccctcaagtttgctaagctgctggtttattactgaagaaaga       c.-1

          .         .         .         .         .         .       g.5389
 ATGTGGCAGATTGTTTTCTTTACTCTGAGCTGTGATCTTGTCTTGGCCGCAGCCTATAAC       c.60
 M  W  Q  I  V  F  F  T  L  S  C  D  L  V  L  A  A  A  Y  N         p.20

          .         .         .         .         .         .       g.5449
 AACTTTCGGAAGAGCATGGACAGCATAGGAAAGAAGCAATATCAGGTCCAGCATGGGTCC       c.120
 N  F  R  K  S  M  D  S  I  G  K  K  Q  Y  Q  V  Q  H  G  S         p.40

          .         .         .         .         .         .       g.5509
 TGCAGCTACACTTTCCTCCTGCCAGAGATGGACAACTGCCGCTCTTCCTCCAGCCCCTAC       c.180
 C  S  Y  T  F  L  L  P  E  M  D  N  C  R  S  S  S  S  P  Y         p.60

          .         .         .         .         .         .       g.5569
 GTGTCCAATGCTGTGCAGAGGGACGCGCCGCTCGAATACGATGACTCGGTGCAGAGGCTG       c.240
 V  S  N  A  V  Q  R  D  A  P  L  E  Y  D  D  S  V  Q  R  L         p.80

          .         .         .         .         | 02         .    g.35788
 CAAGTGCTGGAGAACATCATGGAAAACAACACTCAGTGGCTAATGAAG | CTTGAGAATTAT    c.300
 Q  V  L  E  N  I  M  E  N  N  T  Q  W  L  M  K   | L  E  N  Y      p.100

          .         .         .         .         .         .       g.35848
 ATCCAGGACAACATGAAGAAAGAAATGGTAGAGATACAGCAGAATGCAGTACAGAACCAG       c.360
 I  Q  D  N  M  K  K  E  M  V  E  I  Q  Q  N  A  V  Q  N  Q         p.120

          .         .         .         .         .         .       g.35908
 ACGGCTGTGATGATAGAAATAGGGACAAACCTGTTGAACCAAACAGCGGAGCAAACGCGG       c.420
 T  A  V  M  I  E  I  G  T  N  L  L  N  Q  T  A  E  Q  T  R         p.140

          .         .     | 03   .         .         .         .    g.40623
 AAGTTAACTGATGTGGAAGCCCAA | GTATTAAATCAGACCACGAGACTTGAACTTCAGCTC    c.480
 K  L  T  D  V  E  A  Q   | V  L  N  Q  T  T  R  L  E  L  Q  L      p.160

          .         .         .         .         .         .       g.40683
 TTGGAACACTCCCTCTCGACAAACAAATTGGAAAAACAGATTTTGGACCAGACCAGTGAA       c.540
 L  E  H  S  L  S  T  N  K  L  E  K  Q  I  L  D  Q  T  S  E         p.180

          .         .       | 04 .         .         .         .    g.46887
 ATAAACAAATTGCAAGATAAGAACAG | TTTCCTAGAAAAGAAGGTGCTAGCTATGGAAGAC    c.600
 I  N  K  L  Q  D  K  N  S  |  F  L  E  K  K  V  L  A  M  E  D      p.200

          .         .         .         .         .         .       g.46947
 AAGCACATCATCCAACTACAGTCAATAAAAGAAGAGAAAGATCAGCTACAGGTGTTAGTA       c.660
 K  H  I  I  Q  L  Q  S  I  K  E  E  K  D  Q  L  Q  V  L  V         p.220

          .         .         .         .         .         .       g.47007
 TCCAAGCAAAATTCCATCATTGAAGAACTAGAAAAAAAAATAGTGACTGCCACGGTGAAT       c.720
 S  K  Q  N  S  I  I  E  E  L  E  K  K  I  V  T  A  T  V  N         p.240

          .         .         .         .         .         .       g.47067
 AATTCAGTTCTTCAGAAGCAGCAACATGATCTCATGGAGACAGTTAATAACTTACTGACT       c.780
 N  S  V  L  Q  K  Q  Q  H  D  L  M  E  T  V  N  N  L  L  T         p.260

          .          | 05        .         .         .         .    g.48313
 ATGATGTCCACATCAAACT | CTAAGGACCCCACTGTTGCTAAAGAAGAACAAATCAGCTTC    c.840
 M  M  S  T  S  N  S |   K  D  P  T  V  A  K  E  E  Q  I  S  F      p.280

          .         .         .         .         .         .       g.48373
 AGAGACTGTGCTGAAGTATTCAAATCAGGACACACCACGAATGGCATCTACACGTTAACA       c.900
 R  D  C  A  E  V  F  K  S  G  H  T  T  N  G  I  Y  T  L  T         p.300

          .         .        | 06.         .         .         .    g.53518
 TTCCCTAATTCTACAGAAGAGATCAAG | GCCTACTGTGACATGGAAGCTGGAGGAGGCGGG    c.960
 F  P  N  S  T  E  E  I  K   | A  Y  C  D  M  E  A  G  G  G  G      p.320

          .         .         .         .         .         .       g.53578
 TGGACAATTATTCAGCGACGTGAGGATGGCAGCGTTGATTTTCAGAGGACTTGGAAAGAA       c.1020
 W  T  I  I  Q  R  R  E  D  G  S  V  D  F  Q  R  T  W  K  E         p.340

           | 07        .         .         .         .         .    g.54470
 TATAAAGTG | GGATTTGGTAACCCTTCAGGAGAATATTGGCTGGGAAATGAGTTTGTTTCG    c.1080
 Y  K  V   | G  F  G  N  P  S  G  E  Y  W  L  G  N  E  F  V  S      p.360

          .         .         .         .         .         .       g.54530
 CAACTGACTAATCAGCAACGCTATGTGCTTAAAATACACCTTAAAGACTGGGAAGGGAAT       c.1140
 Q  L  T  N  Q  Q  R  Y  V  L  K  I  H  L  K  D  W  E  G  N         p.380

          .         .         .         .         .       | 08 .    g.59205
 GAGGCTTACTCATTGTATGAACATTTCTATCTCTCAAGTGAAGAACTCAATTATAG | GATT    c.1200
 E  A  Y  S  L  Y  E  H  F  Y  L  S  S  E  E  L  N  Y  R  |  I      p.400

          .         .         .         .         .         .       g.59265
 CACCTTAAAGGACTTACAGGGACAGCCGGCAAAATAAGCAGCATCAGCCAACCAGGAAAT       c.1260
 H  L  K  G  L  T  G  T  A  G  K  I  S  S  I  S  Q  P  G  N         p.420

          .         .         .         .         .         .       g.59325
 GATTTTAGCACAAAGGATGGAGACAACGACAAATGTATTTGCAAATGTTCACAAATGCTA       c.1320
 D  F  S  T  K  D  G  D  N  D  K  C  I  C  K  C  S  Q  M  L         p.440

         | 09.         .         .         .         .         .    g.65055
 ACAGGAG | GCTGGTGGTTTGATGCATGTGGTCCTTCCAACTTGAACGGAATGTACTATCCA    c.1380
 T  G  G |   W  W  F  D  A  C  G  P  S  N  L  N  G  M  Y  Y  P      p.460

          .         .         .         .         .         .       g.65115
 CAGAGGCAGAACACAAATAAGTTCAACGGCATTAAATGGTACTACTGGAAAGGCTCAGGC       c.1440
 Q  R  Q  N  T  N  K  F  N  G  I  K  W  Y  Y  W  K  G  S  G         p.480

          .         .         .         .                           g.65163
 TATTCGCTCAAGGCCACAACCATGATGATCCGACCAGCAGATTTCTAA                   c.1488
 Y  S  L  K  A  T  T  M  M  I  R  P  A  D  F  X                     p.495

          .         .         .         .         .         .       g.65223
 acatcccagtccacctgaggaactgtctcgaactattttcaaagacttaagcccagtgca       c.*60

          .         .         .         .         .         .       g.65283
 ctgaaagtcacggctgcgcactgtgtcctcttccaccacagagggcgtgtgctcggtgct       c.*120

          .         .         .         .         .         .       g.65343
 gacgggacccacatgctccagattagagcctgtaaactttatcacttaaacttgcatcac       c.*180

          .         .         .         .         .         .       g.65403
 ttaacggaccaaagcaagaccctaaacatccataattgtgattagacagaacacctatgc       c.*240

          .         .         .         .         .         .       g.65463
 aaagatgaacccgaggctgagaatcagactgacagtttacagacgctgctgtcacaacca       c.*300

          .         .         .         .         .         .       g.65523
 agaatgttatgtgcaagtttatcagtaaataactggaaaacagaacacttatgttataca       c.*360

          .         .         .         .         .         .       g.65583
 atacagatcatcttggaactgcattcttctgagcactgtttatacactgtgtaaataccc       c.*420

          .         .         .         .         .         .       g.65643
 atatgtcctgaattcaccatcactatcacaattaaaaggaagaaaaaaactctctaagcc       c.*480

          .         .         .         .         .         .       g.65703
 ataaaaagacatattcagggatattctgagaaggggttactagaagtttaatatttggaa       c.*540

          .         .         .         .         .         .       g.65763
 aaacagttagtgcatttttactccatctcttaggtgctttaaatttttatttcaaaaaca       c.*600

          .         .         .         .         .         .       g.65823
 gcgtatttacatttatgttgacagcttagttataagttaatgctcaaatacgtatttcaa       c.*660

          .         .         .         .         .         .       g.65883
 atttatatggtagaaacttccagaatctctgaaattatcaacagaaacgtgccattttag       c.*720

          .         .         .         .         .         .       g.65943
 tttatatgcagaccgtactatttttttctgcctgattgttaaatatgaaggtatttttag       c.*780

          .         .         .         .         .         .       g.66003
 taattaaatataacttattaggggatatgcctatgtttaacttttatgataatatttaca       c.*840

          .         .         .         .         .         .       g.66063
 attttataatttgtttccaaaagacctaattgtgccttgtgataaggaaacttcttactt       c.*900

          .         .         .         .         .         .       g.66123
 ttaatgatgaggaaaattatacatttcattctatgacaaagaaactttactatcttctca       c.*960

          .         .         .         .         .         .       g.66183
 ctattctaaaacagaggtctgttttctttcctagtaagatatatttttatagaactagac       c.*1020

          .         .         .         .         .         .       g.66243
 tacaatttaatttctggttgagaaaagccttctatttaagaaatttacaaagctatatgt       c.*1080

          .         .         .         .         .         .       g.66303
 ctcaagattcacccttaaatttacttaaggaaaaaaataattgacactagtaagtttttt       c.*1140

          .         .         .         .         .         .       g.66363
 tatgtcaatcagcaaactgaaaaaaaaaaaagggtttcaaagtgcaaaaacaaaatctga       c.*1200

          .         .         .         .         .         .       g.66423
 tgttcataatatatttaaatatttaccaaaaatttgagaacacagggctgggcgcagtgg       c.*1260

          .         .         .         .         .         .       g.66483
 ctcacacctataatcccagtacattggtaggcaaggtgggcagatcacctgaggtcagga       c.*1320

          .         .         .         .         .         .       g.66543
 gttcaagaccagcctggacaacatggtgaaaccctgtctctactaaataatacaaaaatt       c.*1380

          .         .         .         .         .         .       g.66603
 agccaggcgtgctggcgggcacctgtaatcccagctactcgggaggctgaggcagggaga       c.*1440

          .         .         .         .         .         .       g.66663
 attgcttgcaccagggaggtagaggttgcagtgagccaagatcgcaccactgcactccag       c.*1500

          .         .         .         .         .         .       g.66723
 ccggggcaacagagcaagactccatctcaaaaaaaaaaaaaaaaaaagaaagaaaagaaa       c.*1560

          .         .         .         .         .         .       g.66783
 atttgagaacacagctttatactcgggactacaaaaccataaactcctggagttttaact       c.*1620

          .         .         .         .         .         .       g.66843
 ccttttgaaattttcatagtacaattaatactaatgaacatttgtgtaaagctttataat       c.*1680

          .         .         .         .         .         .       g.66903
 ttaaaggcaatttctcatatattcttttctgaatcatttgcaaggaagttcagagtccag       c.*1740

          .         .         .         .         .         .       g.66963
 tctgtaactagcatctactatatgtctgtcttcaccttacagtgttctaccattattttt       c.*1800

          .         .         .         .         .         .       g.67023
 tctttattccatttcaaaatctaatttattttaccccaacttctccccaccacttgacgt       c.*1860

          .         .         .         .         .         .       g.67083
 agttttagaacacacaggtgttgctacatatttggagtcaatgatggactctggcaaagt       c.*1920

          .         .         .         .         .         .       g.67143
 caaggctctgttttatttccaccaaggtgcacttttccaacaactatttaactagttaag       c.*1980

          .         .         .         .         .         .       g.67203
 aacctccctatcttagaactgtatctactttatatttaagaaggttttatgaattcaaca       c.*2040

          .         .         .         .         .         .       g.67263
 acggtatcatggccttgtatcaagttgaaaaacaactgaaaataagaaaatttcacagcc       c.*2100

          .         .         .         .         .         .       g.67323
 tcgaaagacaacaacaagtttctaggatatctcaatgacaagagtgatggatacttaggt       c.*2160

          .         .         .         .         .         .       g.67383
 agggaaacgctaatgcaggaaaaactggcaacaacacaatttatatcaattctctttgta       c.*2220

          .         .         .         .         .         .       g.67443
 ggcaggtgataaaaaattcaaggacaaatctcattatgtcattgtgcatcatatataatc       c.*2280

          .         .         .         .         .         .       g.67503
 tcttatgagcgagaatggggggaatttgtgtttttactttacacttcaattccttacacg       c.*2340

          .         .         .         .         .         .       g.67563
 gtatttcaaacaaacagttttgctgagaggagcttttgtctctccttaagaaaatgttta       c.*2400

          .         .         .         .         .         .       g.67623
 taaagctgaaaggaaatcaaacagtaatcttaaaaatgaaaacaaaacaacccaacaacc       c.*2460

          .         .         .         .         .         .       g.67683
 tagataactacagtgatcagggagcacagttcaactccttgttatgttttagtcatatgg       c.*2520

          .         .         .         .         .         .       g.67743
 cctactcaaacagctaaataacaacaccagtggcagataaaaatcaccatttatctttca       c.*2580

          .         .         .         .         .         .       g.67803
 gctattaatcttttgaatgaataaactgtgacaaacaaattaacatttttgaacatgaaa       c.*2640

          .         .         .         .         .         .       g.67863
 ggcaacttctgcacaatcctgtatccaagcaaactttaaattatccacttaattattact       c.*2700

          .         .         .         .         .         .       g.67923
 taatcttaaaaaaaattagaacccagaacttttcaatgaagcatttgaaagttgaagtgg       c.*2760

          .         .         .         .         .         .       g.67983
 aatttaggaaagccataaaaatataaatactgttatcacagcaccagcaagccataatct       c.*2820

          .         .         .         .         .         .       g.68043
 ttatacctatcagttctatttctattaacagtaaaaacattaagcaagatataagactac       c.*2880

          .         .         .         .         .         .       g.68103
 ctgcccaagaattcagtcttttttcatttttgtttttctcagttctgaggatgttaatcg       c.*2940

          .         .         .         .         .         .       g.68163
 tcaaattttctttggactgcattcctcactactttttgcacaatggtctcacgttctcac       c.*3000

          .         .         .         .         .         .       g.68223
 atttgttctcgcgaataaattgataaaaggtgttaagttctgtgaatgtctttttaatta       c.*3060

          .         .         .         .         .         .       g.68283
 tgggcataattgtgcttgactggataaaaacttaagtccacccttatgtttataataatt       c.*3120

          .         .         .         .         .         .       g.68343
 tcttgagaacagcaaactgcatttaccatcgtaaaacaacatctgacttacgggagctgc       c.*3180

          .         .         .         .         .         .       g.68403
 agggaagtggtgagacagttcgaacggctcctcagaaatccagtgacccaattctaaaga       c.*3240

          .         .         .         .         .         .       g.68463
 ccatagcacctgcaagtgacacaacaagcagatttattatacatttattagccttagcag       c.*3300

          .         .         .         .         .         .       g.68523
 gcaataaaccaagaatcactttgaagacacagcaaaaagtgatacactccgcagatctga       c.*3360

          .         .         .         .         .         .       g.68583
 aatagatgtgttctcagacaacaaagtcccttcagaatcttcatgttgcataaatgttat       c.*3420

          .         .         .                                     g.68613
 gaatattaataaaaagttgattgagaaaaa                                     c.*3450

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Angiopoietin 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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