anoctamin 10 (ANO10) - coding DNA reference sequence

(used for variant description)

(last modified January 26, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_018075.3 in the ANO10 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_028216.1, covering ANO10 transcript NM_018075.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          gaccgcatctaggccccgccgcgtccgccacgcccagcgctcggcggcgcc       c.-121

 .         .         .         .         .         .                g.5111
 cgccccactggcctggcccgccccccgcaccgagcactctttcgcccggcctccggttct       c.-61

 .         .         .         .         .         | 02             g.21216
 cgccggctctcggacccgcctccgaagacgtggagcgctgcggcggctg | atttgtcaaag    c.-1

          .         .         .         .         .         .       g.21276
 ATGAAAGTGACCTTATCAGCTTTGGATACTTCTGAGAGTTCTTTCACACCTTTGGTGGTC       c.60
 M  K  V  T  L  S  A  L  D  T  S  E  S  S  F  T  P  L  V  V         p.20

          .         .         .         .         .         .       g.21336
 ATAGAACTTGCTCAGGATGTCAAAGAAGAAACCAAAGAATGGCTGAAAAACAGAATTATA       c.120
 I  E  L  A  Q  D  V  K  E  E  T  K  E  W  L  K  N  R  I  I         p.40

          .          | 03        .         .         .         .    g.26528
 GCTAAAAAAAAAGATGGAG | GTGCCCAGTTGTTGTTTAGACCATTGTTAAATAAATATGAA    c.180
 A  K  K  K  D  G  G |   A  Q  L  L  F  R  P  L  L  N  K  Y  E      p.60

          .         .         .         .         .         .       g.26588
 CAAGAAACACTAGAAAATCAGAACTTATATCTTGTTGGTGCCTCCAAGATTAGAATGTTA       c.240
 Q  E  T  L  E  N  Q  N  L  Y  L  V  G  A  S  K  I  R  M  L         p.80

          .         .         .         .         .         .       g.26648
 CTAGGGGCAGAAGCAGTGGGATTGGTAAAAGAGTGCAATGATAACACCATGAGAGCCTTC       c.300
 L  G  A  E  A  V  G  L  V  K  E  C  N  D  N  T  M  R  A  F         p.100

          .         .         .        | 04.         .         .    g.28425
 ACATACAGAACCAGACAGAACTTCAAAGGTTTTGATG | ATAACAATGATGATTTCCTGACA    c.360
 T  Y  R  T  R  Q  N  F  K  G  F  D  D |   N  N  D  D  F  L  T      p.120

          .         .         .         .         .         .       g.28485
 ATGGCAGAATGTCAATTCATTATCAAACATGAACTTGAAAATCTTAGAGCTAAAGATGAA       c.420
 M  A  E  C  Q  F  I  I  K  H  E  L  E  N  L  R  A  K  D  E         p.140

          .         .         .         .         .   | 05     .    g.46604
 AAAATGATCCCTGGTTACCCTCAGGCAAAGTTGTATCCAGGAAAATCATTGT | TGAGAAGA    c.480
 K  M  I  P  G  Y  P  Q  A  K  L  Y  P  G  K  S  L  L |   R  R      p.160

          .         .         .         .         .         .       g.46664
 TTGCTCACGTCTGGCATCGTGATTCAGGTGTTTCCACTGCATGACAGTGAAGCCCTGAAG       c.540
 L  L  T  S  G  I  V  I  Q  V  F  P  L  H  D  S  E  A  L  K         p.180

          .         .         .         .         .   | 06     .    g.49815
 AAGCTTGAGGACACCTGGTACACTCGGTTTGCTTTGAAGTATCAGCCCATAG | ACAGTATT    c.600
 K  L  E  D  T  W  Y  T  R  F  A  L  K  Y  Q  P  I  D |   S  I      p.200

          .         .         .         .         .         .       g.49875
 CGTGGCTACTTTGGGGAAACAATTGCTCTGTACTTTGGATTTTTGGAGTATTTCACTTTT       c.660
 R  G  Y  F  G  E  T  I  A  L  Y  F  G  F  L  E  Y  F  T  F         p.220

          .         .         .         .         .         .       g.49935
 GCATTAATCCCCATGGCTGTCATTGGGTTACCTTACTACTTGTTTGTGTGGGAAGACTAT       c.720
 A  L  I  P  M  A  V  I  G  L  P  Y  Y  L  F  V  W  E  D  Y         p.240

          .         .         .         .         .         .       g.49995
 GACAAGTACGTGATCTTTGCCTCGTTCAACCTCATCTGGTCCACGGTGATTCTGGAACTG       c.780
 D  K  Y  V  I  F  A  S  F  N  L  I  W  S  T  V  I  L  E  L         p.260

          .         .         .         .         .         .       g.50055
 TGGAAGCGTGGCTGTGCCAACATGACCTACAGGTGGGGGACACTGCTCATGAAGAGAAAG       c.840
 W  K  R  G  C  A  N  M  T  Y  R  W  G  T  L  L  M  K  R  K         p.280

          .         .         .         .         .         .       g.50115
 TTTGAGGAGCCCCGGCCAGGATTTCATGGTGTCTTGGGTATCAATTCCATCACTGGGAAG       c.900
 F  E  E  P  R  P  G  F  H  G  V  L  G  I  N  S  I  T  G  K         p.300

          .         .         .         .         .         .       g.50175
 GAGGAGCCTCTGTACCCCAGCTACAAGAGACAGTTGCGCATTTACCTGGTCTCCCTGCCA       c.960
 E  E  P  L  Y  P  S  Y  K  R  Q  L  R  I  Y  L  V  S  L  P         p.320

          .         .         .         .         .         .       g.50235
 TTCGTGTGCCTCTGCCTCTATTTCTCACTGTATGTCATGATGATTTACTTCGACATGGAG       c.1020
 F  V  C  L  C  L  Y  F  S  L  Y  V  M  M  I  Y  F  D  M  E         p.340

          .         .         .         .         .         .       g.50295
 GTTTGGGCCTTGGGTCTACATGAGAACAGCGGGTCTGAGTGGACCAGTGTCCTGTTGTAT       c.1080
 V  W  A  L  G  L  H  E  N  S  G  S  E  W  T  S  V  L  L  Y         p.360

          .         .         .         .         .         .       g.50355
 GTGCCCAGCATCATCTATGCCATTGTGATTGAGATCATGAATCGTCTCTATCGATATGCT       c.1140
 V  P  S  I  I  Y  A  I  V  I  E  I  M  N  R  L  Y  R  Y  A         p.380

          .         .   | 07     .         .         .         .    g.52242
 GCCGAGTTTTTAACTTCATGGG | AGAATCACAGATTGGAATCTGCCTATCAGAACCATCTA    c.1200
 A  E  F  L  T  S  W  E |   N  H  R  L  E  S  A  Y  Q  N  H  L      p.400

          .         | 08         .         .         .         .    g.61383
 ATTCTGAAAGTTTTAGTG | TTCAACTTCCTCAATTGCTTTGCCTCACTCTTCTATATTGCC    c.1260
 I  L  K  V  L  V   | F  N  F  L  N  C  F  A  S  L  F  Y  I  A      p.420

          .         .         .    | 09    .         .         .    g.65693
 TTTGTCTTGAAAGATATGAAGCTTTTGCGCCAG | AGCTTGGCCACTCTCCTAATTACCTCC    c.1320
 F  V  L  K  D  M  K  L  L  R  Q   | S  L  A  T  L  L  I  T  S      p.440

          .         .         .         .         .         .       g.65753
 CAGATCCTCAACCAAATTATGGAATCTTTTCTTCCTTATTGGCTCCAAAGGAAGCATGGT       c.1380
 Q  I  L  N  Q  I  M  E  S  F  L  P  Y  W  L  Q  R  K  H  G         p.460

          .         .         .         .         .         .       g.65813
 GTGCGGGTGAAGAGGAAGGTGCAGGCTTTAAAGGCAGACATTGATGCTACATTATATGAA       c.1440
 V  R  V  K  R  K  V  Q  A  L  K  A  D  I  D  A  T  L  Y  E         p.480

          .         .         .       | 10 .         .         .    g.71623
 CAAGTCATCCTGGAAAAAGAAATGGGAACTTATTTG | GGCACCTTTGATGATTACTTGGAG    c.1500
 Q  V  I  L  E  K  E  M  G  T  Y  L   | G  T  F  D  D  Y  L  E      p.500

          .         .         .         .         .         .       g.71683
 TTATTCCTGCAGTTTGGTTATGTGAGCCTTTTCTCCTGTGTTTACCCATTAGCAGCTGCC       c.1560
 L  F  L  Q  F  G  Y  V  S  L  F  S  C  V  Y  P  L  A  A  A         p.520

          .         .         .         .         .         .       g.71743
 TTTGCTGTGTTAAATAACTTCACTGAAGTAAATTCAGATGCCTTAAAAATGTGCAGGGTC       c.1620
 F  A  V  L  N  N  F  T  E  V  N  S  D  A  L  K  M  C  R  V         p.540

          .         .         .         .         | 11         .    g.77232
 TTCAAACGTCCATTCTCAGAACCTTCAGCCAATATTGGTGTGTGGCAG | TTGGCTTTTGAA    c.1680
 F  K  R  P  F  S  E  P  S  A  N  I  G  V  W  Q   | L  A  F  E      p.560

          .         .         .         .         .         .       g.77292
 ACGATGAGTGTTATATCTGTGGTCACTAACTGTGCGCTGATTGGAATGTCACCACAAGTG       c.1740
 T  M  S  V  I  S  V  V  T  N  C  A  L  I  G  M  S  P  Q  V         p.580

          .         .         .         .         .        | 12.    g.194344
 AATGCAGTCTTTCCAGAATCAAAAGCAGACCTCATTTTGATTGTAGTAGCAGTGGAG | CAC    c.1800
 N  A  V  F  P  E  S  K  A  D  L  I  L  I  V  V  A  V  E   | H      p.600

          .         .         .         .         .         .       g.194404
 GCACTCCTGGCTTTAAAGTTTATACTTGCATTTGCCATACCTGATAAGCCACGGCATATC       c.1860
 A  L  L  A  L  K  F  I  L  A  F  A  I  P  D  K  P  R  H  I         p.620

          .         .         .         .         .     | 13   .    g.260100
 CAGATGAAACTAGCCAGACTGGAATTTGAGTCTTTGGAGGCACTCAAGCAGCAG | CAAATG    c.1920
 Q  M  K  L  A  R  L  E  F  E  S  L  E  A  L  K  Q  Q   | Q  M      p.640

          .         .         .         .         .         .       g.260160
 AAGCTCGTGACCGAGAACCTGAAGGAGGAACCAATGGAAAGCGGGAAGGAGAAGGCAACC       c.1980
 K  L  V  T  E  N  L  K  E  E  P  M  E  S  G  K  E  K  A  T         p.660

                                                                    g.260163
 TGA                                                                c.1983
 X                                                                  p.660

          .         .         .         .         .         .       g.260223
 gtgcccagcgtgcccagctgccctgttggcagaggcctgtgtctgtgccacacctgccac       c.*60

          .         .         .         .         .         .       g.260283
 ggtggcagggggggtacccggggcagcatcgtggctcctgaacccagacccaatgcttag       c.*120

          .         .         .         .         .         .       g.260343
 ccaaacgaagtggctcccatgtggcaagcacccttctcagtttcgcagtggcttggctcg       c.*180

          .         .         .         .         .         .       g.260403
 ggatccttggcagttcccccagccccaccctgtctgctccttcccagttccttcccgggc       c.*240

          .         .         .         .         .         .       g.260463
 cccacacgctgctccagctgccaactttgctgcagagccactgccgcccttgagcctctc       c.*300

          .         .         .         .         .         .       g.260523
 accatgagtgagccaccagctctccacgttcccctcatagcagtgtcactcccaacccca       c.*360

          .         .         .         .         .         .       g.260583
 ccatggcccagggacccgtggacaggttggggatggggtgtgtgcccactgtgctcatca       c.*420

          .         .         .         .         .         .       g.260643
 caggagcctcagttgagagtgagcggggtacagtaaggcagtgcttcccacactggacct       c.*480

          .         .         .         .         .         .       g.260703
 ctttcctggttctcttttgcaatacattaacagaccctttatcaacataaacaatagtaa       c.*540

          .         .         .         .                           g.260743
 ctgagctattaaaggcaacctctctgactccttctgccta                           c.*580

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Anoctamin 10 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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