anoctamin 1, calcium activated chloride channel (ANO1) - coding DNA reference sequence

(used for variant description)

(last modified March 25, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_018043.5 in the ANO1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering ANO1 transcript NM_018043.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        aaagg       c.-301

 .         .         .         .         .         .                g.5065
 cgggccggctggcgtccaagttcctgaccaggcgcgggccggcccgcgggaccagcagcc       c.-241

 .         .         .         .         .         .                g.5125
 gggtggcggcgcgatcggccccgagaggctcaggcgccccccgcatcgagcgcgcgggcc       c.-181

 .         .         .         .         .         .                g.5185
 gggcgggccagggcggcgggcggagcgggaggcggccacgtccccggcgggcctgggcgc       c.-121

 .         .         .         .         .         .                g.5245
 ggggaggcccggccccctgcgagcgcgccgcgaacgctgcggtctccgcccgcagaggcc       c.-61

 .         .         .         .         .         .                g.5305
 gccggggccgtggatggggagggcgcgccgcccggcggtcccagcgcacaggcggccacg       c.-1

          .         .         .         .         .         .       g.5365
 ATGAGGGTCAACGAGAAGTACTCGACGCTCCCGGCCGAGGACCGCAGCGTCCACATCATC       c.60
 M  R  V  N  E  K  Y  S  T  L  P  A  E  D  R  S  V  H  I  I         p.20

          .         .         .         .         | 02         .    g.14462
 AACATCTGCGCCATCGAGGACATCGGCTACCTGCCGTCCGAGGGCACG | CTGCTGAACTCC    c.120
 N  I  C  A  I  E  D  I  G  Y  L  P  S  E  G  T   | L  L  N  S      p.40

          .         .         .         .         .         .       g.14522
 TTATCTGTGGACCCTGATGCCGAGTGCAAGTATGGCCTGTACTTCAGGGACGGCCGGCGC       c.180
 L  S  V  D  P  D  A  E  C  K  Y  G  L  Y  F  R  D  G  R  R         p.60

          .         .         .         .         .         .       g.14582
 AAGGTGGACTACATCCTGGTGTACCATCACAAGAGGCCCTCGGGCAACCGGACCCTGGTC       c.240
 K  V  D  Y  I  L  V  Y  H  H  K  R  P  S  G  N  R  T  L  V         p.80

          .         .         .         .         .         .       g.14642
 AGGAGGGTGCAGCACAGCGACACCCCCTCTGGGGCTCGCAGCGTCAAGCAGGACCACCCC       c.300
 R  R  V  Q  H  S  D  T  P  S  G  A  R  S  V  K  Q  D  H  P         p.100

          .         .         .         .         .         .       g.14702
 CTGCCGGGCAAGGGGGCGTCGCTGGATGCAGGCTCGGGGGAGCCCCCGATGGACTACCAC       c.360
 L  P  G  K  G  A  S  L  D  A  G  S  G  E  P  P  M  D  Y  H         p.120

          .         .         .         .         .         .       g.14762
 GAGGATGACAAGCGCTTCCGCAGGGAGGAGTACGAGGGCAACCTCCTGGAGGCGGGCCTG       c.420
 E  D  D  K  R  F  R  R  E  E  Y  E  G  N  L  L  E  A  G  L         p.140

          .         .  | 03      .         .         .         .    g.29803
 GAGCTGGAGCGGGACGAGGAC | ACTAAAATCCACGGAGTCGGGTTTGTGAAAATCCATGCC    c.480
 E  L  E  R  D  E  D   | T  K  I  H  G  V  G  F  V  K  I  H  A      p.160

          .         .         .         .         .         .       g.29863
 CCCTGGAACGTGCTGTGCAGAGAGGCCGAGTTTCTGAAACTGAAGATGCCGACGAAGAAG       c.540
 P  W  N  V  L  C  R  E  A  E  F  L  K  L  K  M  P  T  K  K         p.180

  | 04       .         .         .         .         .         .    g.30757
  | ATGTACCACATTAATGAGACCCGTGGCCTCCTGAAAAAAATCAACTCTGTGCTCCAGAAA    c.600
  | M  Y  H  I  N  E  T  R  G  L  L  K  K  I  N  S  V  L  Q  K      p.200

          .         .         .         .         .         .       g.30817
 ATCACAGATCCCATCCAGCCCAAAGTGGCTGAGCACAGGCCCCAGACCATGAAGAGACTC       c.660
 I  T  D  P  I  Q  P  K  V  A  E  H  R  P  Q  T  M  K  R  L         p.220

          .         .         .   | 05     .         .         .    g.32460
 TCCTATCCCTTCTCCCGGGAGAAGCAGCATCT | ATTTGACTTGTCTGATAAGGATTCCTTT    c.720
 S  Y  P  F  S  R  E  K  Q  H  L  |  F  D  L  S  D  K  D  S  F      p.240

          .         .        | 06.         .         .         .    g.35084
 TTCGACAGCAAAACCCGGAGCACGATT | GTCTATGAGATCTTGAAGAGAACGACGTGTACA    c.780
 F  D  S  K  T  R  S  T  I   | V  Y  E  I  L  K  R  T  T  C  T      p.260

          .          | 07        .         .         .         .    g.38446
 AAGGCCAAGTACAGCATGG | GCATCACGAGCCTGCTGGCCAATGGTGTGTACGCGGCTGCA    c.840
 K  A  K  Y  S  M  G |   I  T  S  L  L  A  N  G  V  Y  A  A  A      p.280

          .      | 08  .         .         .         .        | 09. g.51051
 TACCCACTGCACGAT | GGAGACTACAACGGTGAAAACGTCGAGTTCAACGACAGAAAA | CTC c.900
 Y  P  L  H  D   | G  D  Y  N  G  E  N  V  E  F  N  D  R  K   | L   p.300

          .         .         .         .         .         .       g.51111
 CTGTACGAAGAGTGGGCACGCTATGGAGTTTTCTATAAGTACCAGCCCATCGACCTGGTC       c.960
 L  Y  E  E  W  A  R  Y  G  V  F  Y  K  Y  Q  P  I  D  L  V         p.320

    | 10     .         .         .         .         .         .    g.52817
 AG | GAAGTATTTTGGGGAGAAGATCGGCCTGTACTTCGCCTGGCTGGGCGTGTACACCCAG    c.1020
 R  |  K  Y  F  G  E  K  I  G  L  Y  F  A  W  L  G  V  Y  T  Q      p.340

          .         .         .         .         .         .       g.52877
 ATGCTCATCCCTGCCTCCATCGTGGGAATCATTGTCTTCCTGTACGGATGCGCCACCATG       c.1080
 M  L  I  P  A  S  I  V  G  I  I  V  F  L  Y  G  C  A  T  M         p.360

          .        | 11.         .         .         .         .    g.58660
 GATGAAAACATCCCCAG | CATGGAGATGTGTGACCAGAGACACAATATCACCATGTGCCCG    c.1140
 D  E  N  I  P  S  |  M  E  M  C  D  Q  R  H  N  I  T  M  C  P      p.380

          .         .         .         .         .         .       g.58720
 CTTTGCGACAAGACCTGCAGCTACTGGAAGATGAGCTCAGCCTGCGCCACGGCCCGCGCC       c.1200
 L  C  D  K  T  C  S  Y  W  K  M  S  S  A  C  A  T  A  R  A         p.400

          .         .         .         .         .         | 12    g.76410
 AGCCACCTCTTCGACAACCCCGCCACGGTCTTCTTCTCTGTCTTCATGGCCCTCTGGG | CT    c.1260
 S  H  L  F  D  N  P  A  T  V  F  F  S  V  F  M  A  L  W  A |       p.420

          .         .         .         .         .         .       g.76470
 GCCACCTTCATGGAGCACTGGAAGCGGAAACAGATGCGACTCAACTACCGCTGGGACCTC       c.1320
 A  T  F  M  E  H  W  K  R  K  Q  M  R  L  N  Y  R  W  D  L         p.440

          .         .  | 13      .    | 14    .         .         . g.79782
 ACGGGCTTTGAAGAGGAAGAG | GAGGCTGTCAAG | GATCATCCTAGAGCTGAATACGAAGCC c.1380
 T  G  F  E  E  E  E   | E  A  V  K   | D  H  P  R  A  E  Y  E  A   p.460

          .         .         .         .      | 15  .         .    g.82624
 AGAGTCTTGGAGAAGTCTCTGAAGAAAGAGTCCAGAAACAAAGAG | AAGCGCCGGCATATT    c.1440
 R  V  L  E  K  S  L  K  K  E  S  R  N  K  E   | K  R  R  H  I      p.480

          .         .         .         .         .         .       g.82684
 CCAGAGGAGTCAACAAACAAATGGAAGCAGAGGGTTAAGACAGCCATGGCGGGGGTGAAA       c.1500
 P  E  E  S  T  N  K  W  K  Q  R  V  K  T  A  M  A  G  V  K         p.500

     | 16    .         .         .         .         .         .    g.83702
 TTG | ACTGACAAAGTGAAGCTGACATGGAGAGATCGGTTCCCAGCCTACCTCACTAACTTG    c.1560
 L   | T  D  K  V  K  L  T  W  R  D  R  F  P  A  Y  L  T  N  L      p.520

          .         | 17         .         .         .         .    g.87901
 GTCTCCATCATCTTCATG | ATTGCAGTGACGTTTGCCATCGTCCTCGGCGTCATCATCTAC    c.1620
 V  S  I  I  F  M   | I  A  V  T  F  A  I  V  L  G  V  I  I  Y      p.540

          .         .         .         .         .         .       g.87961
 AGAATCTCCATGGCCGCCGCCTTGGCCATGAACTCCTCCCCCTCCGTGCGGTCCAACATC       c.1680
 R  I  S  M  A  A  A  L  A  M  N  S  S  P  S  V  R  S  N  I         p.560

          .         .         .         .         .         .       g.88021
 CGGGTCACAGTCACAGCCACCGCAGTCATCATCAACCTAGTGGTCATCATCCTCCTGGAC       c.1740
 R  V  T  V  T  A  T  A  V  I  I  N  L  V  V  I  I  L  L  D         p.580

          .         .         .         . | 18       .         .    g.88340
 GAGGTGTATGGCTGCATAGCCCGATGGCTCACCAAGATCG | AGGTCCCAAAGACGGAGAAA    c.1800
 E  V  Y  G  C  I  A  R  W  L  T  K  I  E |   V  P  K  T  E  K      p.600

          .         .         .         .         .         .       g.88400
 AGCTTTGAGGAGAGGCTGATCTTCAAGGCTTTCCTGCTGAAGTTTGTGAATTCCTACACC       c.1860
 S  F  E  E  R  L  I  F  K  A  F  L  L  K  F  V  N  S  Y  T         p.620

          .         .         .   | 19     .         .         .    g.90009
 CCCATCTTTTACGTGGCGTTCTTCAAAGGCCG | GTTTGTTGGACGCCCGGGCGACTACGTG    c.1920
 P  I  F  Y  V  A  F  F  K  G  R  |  F  V  G  R  P  G  D  Y  V      p.640

          .         .         . | 20       .         .         .    g.92198
 TACATTTTCCGTTCCTTCCGAATGGAAGAG | TGTGCGCCAGGGGGCTGCCTGATGGAGCTA    c.1980
 Y  I  F  R  S  F  R  M  E  E   | C  A  P  G  G  C  L  M  E  L      p.660

          .         .         .         .         .         .       g.92258
 TGCATCCAGCTCAGCATCATCATGCTGGGGAAACAGCTGATCCAGAACAACCTGTTCGAG       c.2040
 C  I  Q  L  S  I  I  M  L  G  K  Q  L  I  Q  N  N  L  F  E         p.680

          .  | 21      .         .         .         .         .    g.93989
 ATCGGCATCCC | GAAGATGAAGAAGCTCATCCGCTACCTGAAGCTGAAGCAGCAGAGCCCC    c.2100
 I  G  I  P  |  K  M  K  K  L  I  R  Y  L  K  L  K  Q  Q  S  P      p.700

          .         .         .         .         .         .       g.94049
 CCTGACCACGAGGAGTGTGTGAAGAGGAAACAGCGGTACGAGGTGGATTACAACCTGGAG       c.2160
 P  D  H  E  E  C  V  K  R  K  Q  R  Y  E  V  D  Y  N  L  E         p.720

          .         .         .        | 22.         .         .    g.97608
 CCCTTCGCGGGCCTCACCCCAGAGTACATGGAAATGA | TCATCCAGTTTGGCTTCGTCACC    c.2220
 P  F  A  G  L  T  P  E  Y  M  E  M  I |   I  Q  F  G  F  V  T      p.740

          .         .         .         .         .         .       g.97668
 CTGTTTGTCGCCTCCTTCCCCCTGGCCCCACTGTTTGCGCTGCTGAACAACATCATCGAG       c.2280
 L  F  V  A  S  F  P  L  A  P  L  F  A  L  L  N  N  I  I  E         p.760

          .         .         .         .         .         .       g.97728
 ATCCGCCTGGACGCCAAAAAGTTTGTCACTGAGCTCCGAAGGCCGGTAGCTGTCAGAGCC       c.2340
 I  R  L  D  A  K  K  F  V  T  E  L  R  R  P  V  A  V  R  A         p.780

          . | 23       .         .         .         .         .    g.106752
 AAAGACATCG | GAATCTGGTACAATATCCTCAGAGGCATTGGGAAGCTTGCTGTCATCATC    c.2400
 K  D  I  G |   I  W  Y  N  I  L  R  G  I  G  K  L  A  V  I  I      p.800

     | 24    .         .         .         .         .         .    g.109257
 AAT | GCCTTCGTGATCTCCTTCACGTCTGACTTCATCCCGCGCCTGGTGTACCTCTACATG    c.2460
 N   | A  F  V  I  S  F  T  S  D  F  I  P  R  L  V  Y  L  Y  M      p.820

          .         .         .         .         .         .       g.109317
 TACAGTAAGAACGGGACCATGCACGGCTTCGTCAACCACACCCTCTCCTCCTTCAACGTC       c.2520
 Y  S  K  N  G  T  M  H  G  F  V  N  H  T  L  S  S  F  N  V         p.840

          .         .         .         .         .         .       g.109377
 AGTGACTTCCAGAACGGCACGGCCCCCAATGACCCCCTGGACCTGGGCTACGAGGTGCAG       c.2580
 S  D  F  Q  N  G  T  A  P  N  D  P  L  D  L  G  Y  E  V  Q         p.860

          | 25         .         .         .         .         .    g.112340
 ATCTGCAG | GTATAAAGACTACCGAGAGCCGCCGTGGTCGGAAAACAAGTACGACATCTCC    c.2640
 I  C  R  |  Y  K  D  Y  R  E  P  P  W  S  E  N  K  Y  D  I  S      p.880

          .         .         .         .         .     | 26   .    g.114442
 AAGGACTTCTGGGCCGTCCTGGCAGCCCGGCTGGCGTTTGTCATCGTCTTCCAG | AACCTG    c.2700
 K  D  F  W  A  V  L  A  A  R  L  A  F  V  I  V  F  Q   | N  L      p.900

          .         .         .         .         .         .       g.114502
 GTCATGTTCATGAGCGACTTTGTGGACTGGGTCATCCCGGACATCCCCAAGGACATCAGC       c.2760
 V  M  F  M  S  D  F  V  D  W  V  I  P  D  I  P  K  D  I  S         p.920

          .         .         .         .         .         .       g.114562
 CAGCAGATCCACAAGGAGAAGGTGCTCATGGTGGAGCTGTTCATGCGGGAGGAGCAAGAC       c.2820
 Q  Q  I  H  K  E  K  V  L  M  V  E  L  F  M  R  E  E  Q  D         p.940

          .         .         .         .         .         .       g.114622
 AAGCAGCAGCTGCTGGAAACCTGGATGGAGAAGGAGCGGCAGAAGGACGAGCCGCCGTGC       c.2880
 K  Q  Q  L  L  E  T  W  M  E  K  E  R  Q  K  D  E  P  P  C         p.960

          .         .         .         .         .         .       g.114682
 AACCACCACAACACCAAAGCCTGCCCAGACAGCCTCGGCAGCCCAGCCCCCAGCCATGCC       c.2940
 N  H  H  N  T  K  A  C  P  D  S  L  G  S  P  A  P  S  H  A         p.980

          .         .                                               g.114703
 TACCACGGGGGCGTCCTGTAG                                              c.2961
 Y  H  G  G  V  L  X                                                p.986

          .         .         .         .         .         .       g.114763
 ctatgccagcggggctgggcaggccagccgggcatcctgaccgatgggcaccctctccca       c.*60

          .         .         .         .         .         .       g.114823
 gggcaggcggcttcccgctcccaccagggcccggtgggtcctgggttttctgcaaacatg       c.*120

          .         .         .         .         .         .       g.114883
 gaggaccactttctgataggacattttcctttcttctttctgttttctttcccttgtttt       c.*180

          .         .         .         .         .         .       g.114943
 tgcacaaagccattatgcagggaatattttttaatctgtagtattcaagatgaatcaaaa       c.*240

          .         .         .         .         .         .       g.115003
 tgatggctggtaatacggcaataaggtagcaaaggcaggtgctttgcagaaagaatgctt       c.*300

          .         .         .         .         .         .       g.115063
 ggaaacttgagtctccctagaggtgaaaagtgagcagaggcccgtagaaaccctcctctg       c.*360

          .         .         .         .         .         .       g.115123
 aatcctcctaattccttaagatagatgcaaaatggtaagccgaggcatcgcgcaaaagct       c.*420

          .         .         .         .         .         .       g.115183
 ggtgcgatgcttcagggaaaatggaaaacccacgcaagaataatgattgattccggttcc       c.*480

          .         .         .         .         .         .       g.115243
 aaaaggtgtcacctacctgtttcagaaaagttagactttccatcgccttttccttccatc       c.*540

          .         .         .         .         .         .       g.115303
 agttgagtggctgagagagaagtgcctcatccctgagccacacagggggcgtgggagcat       c.*600

          .         .         .         .         .         .       g.115363
 cccagttatccctggaaagctagaaggggacagaggtgtccctgattaagcaggaaacag       c.*660

          .         .         .         .         .         .       g.115423
 cacccttggcgtccccagcaggctccccactgtcagccacacacctgcccccatcacacc       c.*720

          .         .         .         .         .         .       g.115483
 aagccgacctcagagttgttcatcttccttatgggacaaaaccggttgaccagaaaatgg       c.*780

          .         .         .         .         .         .       g.115543
 gcagagagagatgacctcggaagcatttccacagatggtgtcagggtttcaagaagtctt       c.*840

          .         .         .         .         .         .       g.115603
 agggcttccaggggtcccctggaagctttagaatatttatgggttttttttcaaatatca       c.*900

          .         .         .         .         .         .       g.115663
 attatatggtagattgaggattttttttctgtagctcaaaggtggagggagtttattagt       c.*960

          .         .         .         .         .         .       g.115723
 taaccaaatatcgttgagaggaatttaaaatactgttactaccaaagatttttattaata       c.*1020

          .         .         .         .         .         .       g.115783
 aaggcttatattttggtaacacttctctatatttttactcacaggaatgtcactgttgga       c.*1080

          .         .         .         .         .         .       g.115843
 caattattttaaaagtgtataaaaccaagtctcataaatgatatgagtgatctaaatttg       c.*1140

          .         .         .         .         .         .       g.115903
 cagcaatgatactaaacaactctctgaaatttctcaagcaccaagagaaacatcatttta       c.*1200

          .         .         .         .         .         .       g.115963
 gcaaaggccaggaggaaaaatagaaataaatttgtcttgaagatctcattgatgtgatgt       c.*1260

          .         .         .         .         .         .       g.116023
 tacattccctttaatctgccaactgtggtcaaagttcataggtgtcgtacatttccatta       c.*1320

          .         .         .         .         .         .       g.116083
 tttgctaaaatcatgcaatctgatgcttctcttttctcttgtacagtaagtagtttgaag       c.*1380

          .         .         .         .         .         .       g.116143
 tgggttttgtatataaatactgtattaaaaattaggcaattaccaaaaatccttttatgg       c.*1440

          .         .         .         .         .         .       g.116203
 aaaccatttttttaaaaagtgaatgtacacaaatccacagaggactgtggctggacattc       c.*1500

          .         .         .         .                           g.116244
 atctaaataaatttgaatatacgacacttttctcacttgaa                          c.*1541

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Anoctamin 1, calcium activated chloride channel protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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