adaptor-related protein complex 1, beta 1 subunit (AP1B1) - coding DNA reference sequence

(used for variant description)

(last modified October 23, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001127.3 in the AP1B1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000022.10, covering AP1B1 transcript NM_001127.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      cccgcgc       c.-181

 .         .         .         .         .         .                g.5067
 gcgggcagctcacttccgcccggcaggtgacagccgcggggctccgagccgccggcagcc       c.-121

 .         .         .         .         .         .                g.5127
 cggacgcaccgggagagcgagaggtggaggccgcggacattttggtgccaagccgaaccg       c.-61

 .         .         .         .   | 02     .         .             g.26340
 agccggggcgccgggagctattgggacctgcgg | aagcctggctacagataagggaccaaa    c.-1

          .         .         .        | 03.         .         .    g.30500
 ATGACTGACTCAAAATATTTCACCACGACCAAGAAAG | GGGAGATCTTCGAGCTGAAGGCA    c.60
 M  T  D  S  K  Y  F  T  T  T  K  K  G |   E  I  F  E  L  K  A      p.20

          .         .         .         .         .         .       g.30560
 GAGCTCAACAGTGACAAGAAGGAGAAGAAGAAGGAGGCAGTGAAGAAAGTGATTGCATCG       c.120
 E  L  N  S  D  K  K  E  K  K  K  E  A  V  K  K  V  I  A  S         p.40

          .         .    | 04    .         .         .         .    g.33661
 ATGACCGTGGGCAAAGATGTCAG | TGCCCTCTTCCCCGATGTGGTCAACTGCATGCAGACG    c.180
 M  T  V  G  K  D  V  S  |  A  L  F  P  D  V  V  N  C  M  Q  T      p.60

          .         .         .         .         .         .       g.33721
 GACAACCTGGAGCTGAAGAAGCTAGTATACCTCTACTTGATGAATTACGCCAAGAGTCAG       c.240
 D  N  L  E  L  K  K  L  V  Y  L  Y  L  M  N  Y  A  K  S  Q         p.80

          .         .         .          | 05        .         .    g.34633
 CCTGACATGGCCATTATGGCCGTCAACACCTTTGTGAAG | GACTGTGAGGACCCCAACCCC    c.300
 P  D  M  A  I  M  A  V  N  T  F  V  K   | D  C  E  D  P  N  P      p.100

          .         .         .         .         .         .       g.34693
 CTCATCCGAGCCCTGGCAGTGCGGACCATGGGCTGCATCCGCGTTGACAAGATCACAGAG       c.360
 L  I  R  A  L  A  V  R  T  M  G  C  I  R  V  D  K  I  T  E         p.120

          .         .         .         .         .         .       g.34753
 TACCTGTGCGAGCCACTCCGGAAGTGCCTGAAGGACGAGGATCCATATGTGCGCAAGACA       c.420
 Y  L  C  E  P  L  R  K  C  L  K  D  E  D  P  Y  V  R  K  T         p.140

          .         .         .         .         .         .       g.34813
 GCAGCTGTGTGCGTGGCCAAGCTCCACGACATCAACGCCCAGCTGGTGGAGGACCAGGGC       c.480
 A  A  V  C  V  A  K  L  H  D  I  N  A  Q  L  V  E  D  Q  G         p.160

          .         .         .         .      | 06  .         .    g.36982
 TTCCTGGACACCCTTAAAGACCTCATCTCCGACTCTAACCCCATG | GTGGTGGCCAATGCA    c.540
 F  L  D  T  L  K  D  L  I  S  D  S  N  P  M   | V  V  A  N  A      p.180

          .         .         .         .         .         .       g.37042
 GTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAAC       c.600
 V  A  A  L  S  E  I  A  E  S  H  P  S  S  N  L  L  D  L  N         p.200

          .         .         .         .         .         .       g.37102
 CCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAGTGGGGCCAGATC       c.660
 P  Q  S  I  N  K  L  L  T  A  L  N  E  C  T  E  W  G  Q  I         p.220

          .         .         .         .         .       | 07 .    g.38716
 TTCATCCTGGACTGCCTCGCCAACTATATGCCCAAGGACGACCGCGAGGCCCAGAG | CATC    c.720
 F  I  L  D  C  L  A  N  Y  M  P  K  D  D  R  E  A  Q  S  |  I      p.240

          .         .         .         .         .         .       g.38776
 TGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTG       c.780
 C  E  R  V  T  P  R  L  S  H  A  N  S  A  V  V  L  S  A  V         p.260

          .         .         .         .         .         .       g.38836
 AAGGTGCTGATGAAGTTCATGGAGATGTTGTCTAAGGACTTGGACTACTACGGCACACTG       c.840
 K  V  L  M  K  F  M  E  M  L  S  K  D  L  D  Y  Y  G  T  L         p.280

          .         .         .         .         .         .       g.38896
 CTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGAGCCAGAGCTGCAGTAT       c.900
 L  K  K  L  A  P  P  L  V  T  L  L  S  A  E  P  E  L  Q  Y         p.300

          .         .         .         | 08         .         .    g.41780
 GTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAG | GCCTGAGATCCTGAAGCATGAG    c.960
 V  A  L  R  N  I  N  L  I  V  Q  K  R  |  P  E  I  L  K  H  E      p.320

          .         .         .         .         .         .       g.41840
 ATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGAC       c.1020
 M  K  V  F  F  V  K  Y  N  D  P  I  Y  V  K  L  E  K  L  D         p.340

          .         .         .          | 09        .         .    g.42338
 ATCATGATCCGCCTGGCCTCTCAGGCCAACATCGCCCAG | GTGTTGGCAGAGCTGAAAGAG    c.1080
 I  M  I  R  L  A  S  Q  A  N  I  A  Q   | V  L  A  E  L  K  E      p.360

          .         .         .         .         .         .       g.42398
 TACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGCCGCTGC       c.1140
 Y  A  T  E  V  D  V  D  F  V  R  K  A  V  R  A  I  G  R  C         p.380

          .      | 10  .         .         .         .         .    g.43478
 GCCATCAAGGTGGAG | CAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAG    c.1200
 A  I  K  V  E   | Q  S  A  E  R  C  V  S  T  L  L  D  L  I  Q      p.400

          .         .         .         .         .         .       g.43538
 ACCAAGGTCAACTATGTGGTCCAGGAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAG       c.1260
 T  K  V  N  Y  V  V  Q  E  A  I  V  V  I  K  D  I  F  R  K         p.420

          .  | 11      .         .         .         .         .    g.44249
 TACCCCAACAA | GTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTCCCTGGAT    c.1320
 Y  P  N  K  |  Y  E  S  V  I  A  T  L  C  E  N  L  D  S  L  D      p.440

          .         .         .         .         .         .       g.44309
 GAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGAC       c.1380
 E  P  E  A  R  A  A  M  I  W  I  V  G  E  Y  A  E  R  I  D         p.460

          .         .         .         .         .        | 12.    g.51203
 AACGCAGATGAGCTGCTGGAGAGCTTCCTCGAGGGCTTCCATGACGAGAGCACACAG | GTC    c.1440
 N  A  D  E  L  L  E  S  F  L  E  G  F  H  D  E  S  T  Q   | V      p.480

          .         .         .         .         .         .       g.51263
 CAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGAGACCCAG       c.1500
 Q  L  Q  L  L  T  A  I  V  K  L  F  L  K  K  P  T  E  T  Q         p.500

          .         .         .       | 13 .         .         .    g.51847
 GAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAG | GACTCAGATAACCCAGACCTGCGG    c.1560
 E  L  V  Q  Q  V  L  S  L  A  T  Q   | D  S  D  N  P  D  L  R      p.520

          .         .         .         .         .         .       g.51907
 GACCGTGGCTACATCTACTGGCGCCTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTG       c.1620
 D  R  G  Y  I  Y  W  R  L  L  S  T  D  P  V  A  A  K  E  V         p.540

          .         .         .         .         .         .       g.51967
 GTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATCGAGCCCACACTGTTA       c.1680
 V  L  A  E  K  P  L  I  S  E  E  T  D  L  I  E  P  T  L  L         p.560

          .         .         .         .         .         .       g.52027
 GACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCC       c.1740
 D  E  L  I  C  Y  I  G  T  L  A  S  V  Y  H  K  P  P  S  A         p.580

          .         .         .         .         .       | 14 .    g.52730
 TTTGTGGAGGGGGGCCGGGGCGTCGTGCACAAGAGCCTGCCACCTCGCACGGCCTC | GAGT    c.1800
 F  V  E  G  G  R  G  V  V  H  K  S  L  P  P  R  T  A  S  |  S      p.600

          .         .         .         .         .         .       g.52790
 GAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAGCCAGAT       c.1860
 E  S  A  E  S  P  E  T  A  P  T  G  A  P  P  G  E  Q  P  D         p.620

          .         .         .         .         .         .       g.52850
 GTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCA       c.1920
 V  I  P  A  Q  G  D  L  L  G  D  L  L  N  L  D  L  G  P  P         p.640

          .         .         .         .         .         .       g.52910
 GTGAGCGGCCCACCCCTGGCCACCTCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGC       c.1980
 V  S  G  P  P  L  A  T  S  S  V  Q  M  G  A  V  D  L  L  G         p.660

          .         | 15         .          | 16        .         . g.54471
 GGTGGCCTTGACAGCCTG | ATGGGGGATGAGCCTGAAGGG | ATTGGGGGCACCAACTTCGTG c.2040
 G  G  L  D  S  L   | M  G  D  E  P  E  G   | I  G  G  T  N  F  V   p.680

          .         .         .         .         .         .       g.54531
 GCACCTCCAACAGCAGCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGT       c.2100
 A  P  P  T  A  A  V  P  A  N  L  G  A  P  I  G  S  G  L  S         p.700

          .         .         .         .         .         .       g.54591
 GACCTCTTTGACCTGACCAGTGGCGTGGGCACCCTGTCAGGATCATATGTGGCCCCCAAA       c.2160
 D  L  F  D  L  T  S  G  V  G  T  L  S  G  S  Y  V  A  P  K         p.720

     | 17    .         .         .         .         .         .    g.59230
 GCA | GTCTGGCTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGC    c.2220
 A   | V  W  L  P  A  M  K  A  K  G  L  E  I  S  G  T  F  T  R      p.740

          .         .         .         .         .         .       g.59290
 CAGGTGGGCTCCATCTCCATGGACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACC       c.2280
 Q  V  G  S  I  S  M  D  L  Q  L  T  N  K  A  L  Q  V  M  T         p.760

          .         .          | 18        .         .         .    g.61698
 GACTTTGCCATCCAGTTCAACCGCAACAG | CTTTGGCCTGGCCCCCGCCACCCCCCTCCAG    c.2340
 D  F  A  I  Q  F  N  R  N  S  |  F  G  L  A  P  A  T  P  L  Q      p.780

          .         .         .         .         .         .       g.61758
 GTCCACGCGCCACTCAGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTG       c.2400
 V  H  A  P  L  S  P  N  Q  T  V  E  I  S  L  P  L  S  T  V         p.800

          .         .         .          | 19        .         .    g.62071
 GGCTCGGTCATGAAGATGGAGCCTCTGAACAACCTCCAG | GTGGCCGTGAAGAACAACATC    c.2460
 G  S  V  M  K  M  E  P  L  N  N  L  Q   | V  A  V  K  N  N  I      p.820

          .         .         .         .         .         .       g.62131
 GATGTCTTCTACTTCAGCACCTTGTACCCACTGCACATCCTCTTTGTGGAGGACGGGAAG       c.2520
 D  V  F  Y  F  S  T  L  Y  P  L  H  I  L  F  V  E  D  G  K         p.840

      | 20   .         .         .         .         .         .    g.62930
 ATGG | ACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAATGAGAATGAGGCCCAG    c.2580
 M  D |   R  Q  M  F  L  A  T  W  K  D  I  P  N  E  N  E  A  Q      p.860

          .         .         .  | 21      .         .         .    g.63080
 TTCCAGATCAGAGACTGCCCCCTCAATGCAG | AGGCTGCGAGCAGCAAGCTGCAGAGCAGC    c.2640
 F  Q  I  R  D  C  P  L  N  A  E |   A  A  S  S  K  L  Q  S  S      p.880

          .         .         .         .         .         .       g.63140
 AACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATGCTCTACCAGTCCCTG       c.2700
 N  I  F  T  V  A  K  R  N  V  E  G  Q  D  M  L  Y  Q  S  L         p.900

          .         .         .         .         .         .       g.63200
 AAGCTGACCAACGGCATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGC       c.2760
 K  L  T  N  G  I  W  V  L  A  E  L  R  I  Q  P  G  N  P  S         p.920

        | 22 .      | 23  .         .         .         .         . g.64733
 TGCACG | GACTTAGAG | CTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTAC c.2820
 C  T   | D  L  E   | L  S  L  K  C  R  A  P  E  V  S  Q  H  V  Y   p.940

          .         .         .                                     g.64763
 CAGGCCTACGAGACCATCCTCAAGAACTGA                                     c.2850
 Q  A  Y  E  T  I  L  K  N  X                                       p.949

          .         .         .         .         .         .       g.64823
 gaccccggccagcgcccaccccagccttctgcccgccccatcgaggaggcccctcggggg       c.*60

          .         .         .         .         .         .       g.64883
 cagcacatcttcctcctcgcaggagggaccaggcggggctccaggccactcagtgggctc       c.*120

          .         .         .         .         .         .       g.64943
 cctggtcctgatggcagaacccacccgatccctggggtagggcaccaccccctcctgggg       c.*180

          .         .         .         .         .         .       g.65003
 tgagagcgcagtgcactcccgtgctctgggacacccctgctcctgtggctgtgatgtggg       c.*240

          .         .         .         .         .         .       g.65063
 gttaagtgaggtggggaccaaaggaaacagagccagagcagccacagaagctgtgcctga       c.*300

          .         .         .         .         .         .       g.65123
 agggtgagtgtggagcttgcccctccggctcacagccccggcagcccctggctccttggt       c.*360

          .         .         .         .         .         .       g.65183
 ctctccggttggtgttaaagggccctccactgccacctctcatgggatggaccctgccaa       c.*420

          .         .         .         .         .         .       g.65243
 cctggcctgggtgtgcagggaggggttccccttggtaccaggagagctgctcacttaggg       c.*480

          .         .         .         .         .         .       g.65303
 cctggggctcaaggagctgtaggtgccggcagaggggcagagctaggctgggaggagccc       c.*540

          .         .         .         .         .         .       g.65363
 agggcctgcaccacccacttgcaaccaccaggctggtgccctgcagctgtgccagttggg       c.*600

          .         .         .         .         .         .       g.65423
 ccacagcctcccgagtgctgacccacatggtcaagaccaggcagaagctcccagagcccc       c.*660

          .         .         .         .         .         .       g.65483
 tgtctcgggctccccaccgactggcagctgcactatccccaactccccacttctgcccca       c.*720

          .         .         .         .         .         .       g.65543
 agggtggtcactgcctgtgatacattcctcagtgtcgcctctgagcccaggcctcctgcc       c.*780

          .         .         .         .         .         .       g.65603
 acaaagactgggccgagagatggggctgggtaagcgggtgcgcctcctgtttgggtttct       c.*840

          .         .         .         .         .         .       g.65663
 tcggggtttctctgtagtgtctgctgccctcctcctggcctcccaggtttcagttgtgtc       c.*900

          .         .         .         .         .         .       g.65723
 tgacagagcattaggttttcctgttactgctgtgtaataataaagaaagattcggctttt       c.*960

          .         .         .         .         .         .       g.65783
 ggcaatcacggacacttttttcccctccaccgaatgtcaggattgaaagctgcctccgag       c.*1020

          .         .         .         .         .         .       g.65843
 tggttggggatggttttctgaccctacggtaactagatctaatatatatcatcagaaaat       c.*1080

          .         .         .         .         .         .       g.65903
 atatattgtatgtttactcttattttcagaaagagaaaatgaataaaaatgatgacatca       c.*1140

                                                                    g.65904
 a                                                                  c.*1141

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Adaptor-related protein complex 1, beta 1 subunit protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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