adaptor-related protein complex 3, beta 1 subunit (AP3B1) - coding DNA reference sequence

(used for variant description)

(last modified July 24, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_003664.3 in the AP3B1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007268.1, covering AP3B1 transcript NM_003664.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        gagtc       c.-121

 .         .         .         .         .         .                g.5065
 cggaagcgcctgcgcgcgctcctccgtacgagaactagttttgttccgtgccctctggac       c.-61

 .         .         .         .         .         .                g.5125
 tggaaccttttggagagaacccccggcaggaccaaccccgcacccgccagcaccgcggca       c.-1

          .         .         .         .         .         .       g.5185
 ATGTCCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTG       c.60
 M  S  S  N  S  F  P  Y  N  E  Q  S  G  G  G  E  A  T  E  L         p.20

          .         .         .         .         .         .       g.5245
 GGTCAGGAGGCGACCTCAACCATTTCCCCCTCGGGGGCCTTCGGCCTCTTTAGCAGCGAT       c.120
 G  Q  E  A  T  S  T  I  S  P  S  G  A  F  G  L  F  S  S  D         p.40

          | 02         .         .         .         .         .    g.32161
 TTGAAGAA | GAATGAAGATCTAAAGCAAATGTTAGAGAGCAACAAAGATTCTGCTAAACTG    c.180
 L  K  K  |  N  E  D  L  K  Q  M  L  E  S  N  K  D  S  A  K  L      p.60

          .         .     | 03   .         .         .         .    g.58804
 GATGCTATGAAGCGGATTGTTGGG | ATGATTGCAAAAGGGAAAAATGCATCTGAACTGTTT    c.240
 D  A  M  K  R  I  V  G   | M  I  A  K  G  K  N  A  S  E  L  F      p.80

          .         .         .          | 04        .         .    g.71486
 CCTGCTGTTGTGAAGAATGTGGCCAGTAAAAATATTGAG | ATCAAGAAGTTGGTATATGTT    c.300
 P  A  V  V  K  N  V  A  S  K  N  I  E   | I  K  K  L  V  Y  V      p.100

          .         .         .         .         .         .       g.71546
 TACCTGGTTCGATATGCTGAAGAACAGCAGGATCTTGCACTCCTGTCCATAAGCACTTTT       c.360
 Y  L  V  R  Y  A  E  E  Q  Q  D  L  A  L  L  S  I  S  T  F         p.120

          .      | 05  .         .         .         .         .    g.72217
 CAGCGAGCTCTGAAG | GACCCAAACCAACTAATTCGTGCAAGCGCTTTGAGAGTTCTGTCA    c.420
 Q  R  A  L  K   | D  P  N  Q  L  I  R  A  S  A  L  R  V  L  S      p.140

          .         .         .         .         .         .       g.72277
 AGTATTAGAGTGCCAATTATTGTACCTATCATGATGCTTGCTATTAAGGAAGCTTCTGCT       c.480
 S  I  R  V  P  I  I  V  P  I  M  M  L  A  I  K  E  A  S  A         p.160

          .         .         .         .         .       | 06 .    g.74100
 GACTTATCACCATATGTTAGGAAGAATGCAGCCCATGCAATACAAAAATTATACAG | CCTT    c.540
 D  L  S  P  Y  V  R  K  N  A  A  H  A  I  Q  K  L  Y  S  |  L      p.180

          .         .         .         .         .         .       g.74160
 GATCCAGAGCAGAAGGAAATGTTAATTGAAGTAATTGAAAAACTTCTGAAAGATAAAAGC       c.600
 D  P  E  Q  K  E  M  L  I  E  V  I  E  K  L  L  K  D  K  S         p.200

     | 07    .         .         .         .         .         .    g.83524
 ACA | TTGGTAGCTGGCAGTGTTGTGATGGCTTTTGAAGAAGTATGCCCGGACAGAATAGAT    c.660
 T   | L  V  A  G  S  V  V  M  A  F  E  E  V  C  P  D  R  I  D      p.220

          .         .         .         .         .         .       g.83584
 CTGATTCATAAAAATTACCGCAAGCTATGTAACTTACTAGTGGATGTTGAAGAGTGGGGG       c.720
 L  I  H  K  N  Y  R  K  L  C  N  L  L  V  D  V  E  E  W  G         p.240

          .         .         .         .         .         .       g.83644
 CAGGTTGTCATAATCCACATGCTAACTCGATATGCTCGGACACAGTTTGTCAGCCCTTGG       c.780
 Q  V  V  I  I  H  M  L  T  R  Y  A  R  T  Q  F  V  S  P  W         p.260

        | 08 .         .         .         .         .         .    g.118096
 AAAGAG | GGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAATCTGATGATGATCAG    c.840
 K  E   | G  D  E  L  E  D  N  G  K  N  F  Y  E  S  D  D  D  Q      p.280

          .         .         .         .         .         .       g.118156
 AAGGAAAAGACTGACAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTA       c.900
 K  E  K  T  D  K  K  K  K  P  Y  T  M  D  P  D  H  R  L  L         p.300

          .         .         .         .   | 09     .         .    g.122286
 ATTAGAAATACAAAGCCTTTGCTTCAGAGCAGGAATGCTGCG | GTGGTTATGGCAGTTGCT    c.960
 I  R  N  T  K  P  L  L  Q  S  R  N  A  A   | V  V  M  A  V  A      p.320

          .         .         .         .         .         .       g.122346
 CAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTTCTAAATCACTAGTG       c.1020
 Q  L  Y  W  H  I  S  P  K  S  E  A  G  I  I  S  K  S  L  V         p.340

          .         . | 10       .         .         .         .    g.123906
 CGTTTACTTCGTAGCAATAG | GGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATG    c.1080
 R  L  L  R  S  N  R  |  E  V  Q  Y  I  V  L  Q  N  I  A  T  M      p.360

          .      | 11  .         .         .         .         .    g.124052
 TCAATTCAAAGAAAG | GGGATGTTTGAACCTTATCTGAAGAGTTTCTATGTTAGGTCAACT    c.1140
 S  I  Q  R  K   | G  M  F  E  P  Y  L  K  S  F  Y  V  R  S  T      p.380

          .         .        | 12.         .         .         .    g.134065
 GATCCAACTATGATCAAGACACTGAAG | CTTGAAATTTTGACAAACTTGGCAAATGAAGCC    c.1200
 D  P  T  M  I  K  T  L  K   | L  E  I  L  T  N  L  A  N  E  A      p.400

          .         .         . | 13       .         .         .    g.136783
 AACATATCAACTCTTCTTCGAGAATTTCAG | ACCTATGTGAAAAGCCAGGATAAACAATTT    c.1260
 N  I  S  T  L  L  R  E  F  Q   | T  Y  V  K  S  Q  D  K  Q  F      p.420

          .         .         .         .         .         .       g.136843
 GCAGCAGCCACTATTCAGACTATAGGCAGATGTGCAACCAACATCTTGGAAGTCACTGAC       c.1320
 A  A  A  T  I  Q  T  I  G  R  C  A  T  N  I  L  E  V  T  D         p.440

          .         .         .         .    | 14    .         .    g.143354
 ACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATG | AAATAGTTGTTGCTGAA    c.1380
 T  C  L  N  G  L  V  C  L  L  S  N  R  D  E |   I  V  V  A  E      p.460

          .         .         .         .         .         .       g.143414
 AGTGTGGTTGTTATAAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATT       c.1440
 S  V  V  V  I  K  K  L  L  Q  M  Q  P  A  Q  H  G  E  I  I         p.480

          .         .         .    | 15    .         .         .    g.158412
 AAACATATGGCCAAACTCCTGGACAGTATCACT | GTTCCTGTTGCTAGAGCAAGTATTCTT    c.1500
 K  H  M  A  K  L  L  D  S  I  T   | V  P  V  A  R  A  S  I  L      p.500

          .         .         .         .         .         .       g.158472
 TGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTGATGTTTTGAGGAAG       c.1560
 W  L  I  G  E  N  C  E  R  V  P  K  I  A  P  D  V  L  R  K         p.520

          .         .         .         .         .         .       g.158532
 ATGGCTAAAAGCTTCACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGA       c.1620
 M  A  K  S  F  T  S  E  D  D  L  V  K  L  Q  I  L  N  L  G         p.540

          .         .         . | 16       .         .         .    g.170427
 GCAAAATTGTATTTAACCAACTCCAAACAG | ACAAAATTGCTTACCCAGTACATATTAAAT    c.1680
 A  K  L  Y  L  T  N  S  K  Q   | T  K  L  L  T  Q  Y  I  L  N      p.560

          .         .         .         .         .         .       g.170487
 CTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGATTTATTAGGCAGCTT       c.1740
 L  G  K  Y  D  Q  N  Y  D  I  R  D  R  T  R  F  I  R  Q  L         p.580

          .         .         .         .         .         .       g.170547
 ATTGTTCCGAATGTAAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCA       c.1800
 I  V  P  N  V  K  S  G  A  L  S  K  Y  A  K  K  I  F  L  A         p.600

          .         .         .        | 17.         .         .    g.171567
 CAAAAGCCTGCACCACTGCTTGAGTCTCCTTTTAAAG | ATAGAGATCATTTCCAGCTTGGC    c.1860
 Q  K  P  A  P  L  L  E  S  P  F  K  D |   R  D  H  F  Q  L  G      p.620

          .         .         .         .         .         .       g.171627
 ACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAATTATCTAATTGGCCA       c.1920
 T  L  S  H  T  L  N  I  K  A  T  G  Y  L  E  L  S  N  W  P         p.640

          .         .         .         .         | 18         .    g.183482
 GAGGTGGCGCCCGACCCATCAGTTCGAAATGTAGAAGTAATAGAGTTG | GCAAAAGAATGG    c.1980
 E  V  A  P  D  P  S  V  R  N  V  E  V  I  E  L   | A  K  E  W      p.660

          .         .         .         .         .         .       g.183542
 ACCCCAGCAGGAAAAGCAAAGCAAGAGAATTCTGCTAAGAAGTTTTATTCTGAATCTGAG       c.2040
 T  P  A  G  K  A  K  Q  E  N  S  A  K  K  F  Y  S  E  S  E         p.680

          .         .         .        | 19.         .         .    g.185804
 GAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTG | AGAGTGAATCTGGAAGTGAAAGT    c.2100
 E  E  E  D  S  S  D  S  S  S  D  S  E |   S  E  S  G  S  E  S      p.700

          .         .         .         .         .         .       g.185864
 GGAGAACAAGGCGAAAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCC       c.2160
 G  E  Q  G  E  S  G  E  E  G  D  S  N  E  D  S  S  E  D  S         p.720

          .         .         .         .         .         .       g.185924
 TCCAGTGAGCAGGACAGTGAGAGTGGACGGGAGTCAGGCCTAGAAAACAAAAGAACAGCC       c.2220
 S  S  E  Q  D  S  E  S  G  R  E  S  G  L  E  N  K  R  T  A         p.740

          .         .          | 20        .         .         .    g.189381
 AAGAGGAACTCAAAAGCCAAAGGAAAAAG | TGATTCTGAAGATGGGGAGAAGGAAAATGAA    c.2280
 K  R  N  S  K  A  K  G  K  S  |  D  S  E  D  G  E  K  E  N  E      p.760

          .         .         .         .         .         .       g.189441
 AAATCTAAAACTTCAGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCC       c.2340
 K  S  K  T  S  D  S  S  N  D  E  S  S  S  I  E  D  S  S  S         p.780

          .         .         .         .         .        | 21.    g.198682
 GATTCTGAATCAGAGTCAGAACCTGAAAGTGAATCTGAATCCAGAAGAGTCACTAAG | GAG    c.2400
 D  S  E  S  E  S  E  P  E  S  E  S  E  S  R  R  V  T  K   | E      p.800

          .         .         .         .         .         .       g.198742
 AAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATGTTTCACTTCTAGAT       c.2460
 K  E  K  K  T  K  Q  D  R  T  P  L  T  K  D  V  S  L  L  D         p.820

          . | 22       .         .         .         .         .    g.210255
 CTGGATGATT | TTAACCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCA    c.2520
 L  D  D  F |   N  P  V  S  T  P  V  A  L  P  T  P  A  L  S  P      p.840

          .         .         .         .         .        | 23.    g.260433
 AGTTTGATGGCTGATCTTGAAGGTTTACACTTGTCAACTTCCTCTTCAGTCATCAGT | GTC    c.2580
 S  L  M  A  D  L  E  G  L  H  L  S  T  S  S  S  V  I  S   | V      p.860

          .         .         .         .         .         .       g.260493
 AGTACTCCTGCATTTGTACCAACGAAAACTCACGTGCTGCTTCATCGAATGAGTGGAAAA       c.2640
 S  T  P  A  F  V  P  T  K  T  H  V  L  L  H  R  M  S  G  K         p.880

          .         .         .         .         .         .       g.260553
 GGACTAGCTGCCCATTATTTCTTTCCAAGACAGCCTTGCATTTTTGGTGATAAGATGGTC       c.2700
 G  L  A  A  H  Y  F  F  P  R  Q  P  C  I  F  G  D  K  M  V         p.900

          .         .         .         .         .         .       g.260613
 TCTATACAAATAACACTGAATAACACTACTGATCGAAAGATAGAAAATATCCACATAGGG       c.2760
 S  I  Q  I  T  L  N  N  T  T  D  R  K  I  E  N  I  H  I  G         p.920

          .         .         .         .          | 24        .    g.265270
 GAAAAAAAACTTCCTATAGGCATGAAAATGCATGTTTTTAATCCAATAG | ACTCTCTTGAG    c.2820
 E  K  K  L  P  I  G  M  K  M  H  V  F  N  P  I  D |   S  L  E      p.940

          .         .         .         .         .         .       g.265330
 CCTGAGGGATCCATTACAGTTTCAATGGGTATTGACTTTTGTGATTCTACTCAGACTGCC       c.2880
 P  E  G  S  I  T  V  S  M  G  I  D  F  C  D  S  T  Q  T  A         p.960

          .     | 25   .         .         .         .         .    g.278961
 AGTTTCCAGTTGTG | TACCAAGGATGATTGCTTCAATGTTAATATTCAGCCACCTGTTGGA    c.2940
 S  F  Q  L  C  |  T  K  D  D  C  F  N  V  N  I  Q  P  P  V  G      p.980

          .         .         .         .         .   | 26     .    g.284164
 GAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAAAGAGCAAG | GAGTGCTA    c.3000
 E  L  L  L  P  V  A  M  S  E  K  D  F  K  K  E  Q  G |   V  L      p.1000

          .         .         .         .         .         .       g.284224
 ACAGGAATGAATGAAACTTCTGCTGTAATCATTGCTGCACCACAGAATTTCACTCCCTCT       c.3060
 T  G  M  N  E  T  S  A  V  I  I  A  A  P  Q  N  F  T  P  S         p.1020

          .         .         .         .         .         .       g.284284
 GTGATCTTTCAGAAGGTTGTAAATGTAGCCAATGTAGGTGCAGTCCCTTCTGGCCAGGAT       c.3120
 V  I  F  Q  K  V  V  N  V  A  N  V  G  A  V  P  S  G  Q  D         p.1040

          .  | 27      .         .         .         .         .    g.296698
 AATATACACAG | GTTTGCAGCTAAAACTGTGCACAGTGGGTCATTGATGCTAGTCACAGTG    c.3180
 N  I  H  R  |  F  A  A  K  T  V  H  S  G  S  L  M  L  V  T  V      p.1060

          .         .         .         .         .         .       g.296758
 GAACTGAAGGAAGGCTCTACAGCCCAGCTTATCATAAACACTGAGAAAACTGTGATTGGC       c.3240
 E  L  K  E  G  S  T  A  Q  L  I  I  N  T  E  K  T  V  I  G         p.1080

          .         .         .         .                           g.296803
 TCTGTTCTGCTGCGGGAACTGAAGCCTGTCCTGTCTCAGGGGTAA                      c.3285
 S  V  L  L  R  E  L  K  P  V  L  S  Q  G  X                        p.1094

          .         .         .         .         .         .       g.296863
 cctgcttacatctggactttagaatctggcacacaacaaaagtgcctggcatccactact       c.*60

          .         .         .         .         .         .       g.296923
 gctgcctttcatttataataatagcccttccatctggcagtgggggtagaatacactctt       c.*120

          .         .         .         .         .         .       g.296983
 gacattcttgtctcctgctttagaatgctagtgtgtatctatcatgtatgcaatactttc       c.*180

          .         .         .         .         .         .       g.297043
 cccctttttgctttgctaaccaaagagcatatattttactgtcagttgtctcaactcttg       c.*240

          .         .         .         .         .         .       g.297103
 aatccatgtggcgttttctctgtcctgctgcttcttttggcctcctcgttttccttctct       c.*300

          .         .         .         .         .         .       g.297163
 ttttcgacaatggtagacatgaatgagatatttaaagttcattggaaatcttcttcccta       c.*360

          .         .         .         .         .         .       g.297223
 cagcagtaagcaaaaattagcaaagagatagtctaaatggcctctcagcttggtatgtga       c.*420

          .         .         .         .         .         .       g.297283
 aaatgagatcacatactttttaaatccaaatacaaaagcatagtctctgcaagattttgt       c.*480

          .         .         .         .         .         .       g.297343
 tctttgaatttcttgatattgtaattgattattgataactgtcatcatgaaattatctct       c.*540

          .         .         .                                     g.297379
 caataataagataaataaactagcatatgaatcata                               c.*576

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Adaptor-related protein complex 3, beta 1 subunit protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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