adaptor-related protein complex 4, beta 1 subunit (AP4B1) - coding DNA reference sequence

(used for variant description)

(last modified February 14, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_006594.3 in the AP4B1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031901.1, covering AP4B1 transcript NM_006594.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               ttccgcagaaagca       c.-241

 .         .         .         .         .         .                g.5074
 agattgggcctatccgcgatgagaacggcgtggagggggaattaaggctggaactggaga       c.-181

 .         .         .         .         .         .                g.5134
 gggaggggtctgcggtcagtcggacgcggcgctggaaatccggcggaggacctagaagta       c.-121

 .         .         .         .         .    | 02    .             g.5342
 gcgggagcgatctgtgggcggggcgaacggcctgccggccgacg | gctcccacatcaggac    c.-61

 .         .         .         .         .         .                g.5402
 gagaaggagccctcgagttaccgtgggagctgtgggagctgccctgtgactcttaggaag       c.-1

          .         .         .         .         .         .       g.5462
 ATGCCGTACCTTGGCTCCGAGGACGTGGTGAAGGAGCTGAAGAAGGCTCTGTGCAATCCT       c.60
 M  P  Y  L  G  S  E  D  V  V  K  E  L  K  K  A  L  C  N  P         p.20

          .         .         .         .         .    | 03    .    g.7264
 CACATTCAAGCTGATAGGCTGCGCTACCGGAATGTCATCCAGCGAGTGATTAG | GTACATG    c.120
 H  I  Q  A  D  R  L  R  Y  R  N  V  I  Q  R  V  I  R  |  Y  M      p.40

          .         .         .         .         .         .       g.7324
 ACTCAAGGCTTGGACATGTCTGGTGTTTTTATGGAAATGGTGAAGGCCAGTGCCACTGTA       c.180
 T  Q  G  L  D  M  S  G  V  F  M  E  M  V  K  A  S  A  T  V         p.60

          .         .         .         .         .         .       g.7384
 GATATTGTCCAGAAGAAGTTGGTTTATCTGTACATGTGCACATATGCTCCCCTGAAACCA       c.240
 D  I  V  Q  K  K  L  V  Y  L  Y  M  C  T  Y  A  P  L  K  P         p.80

          .         .         .         .         .         .       g.7444
 GATCTGGCTCTCCTGGCCATCAATACGCTGTGCAAAGACTGCTCAGACCCCAATCCAATG       c.300
 D  L  A  L  L  A  I  N  T  L  C  K  D  C  S  D  P  N  P  M         p.100

          .         .         .         | 04         .         .    g.8256
 GTGCGAGGGCTGGCGTTACGGAGCATGTGTAGCCTCAG | GATGCCTGGTGTGCAGGAGTAT    c.360
 V  R  G  L  A  L  R  S  M  C  S  L  R  |  M  P  G  V  Q  E  Y      p.120

          .         .         .         .         .         .       g.8316
 ATACAACAGCCTATTCTCAATGGTCTGCGGGATAAGGCTTCATATGTCAGGAGAGTGGCA       c.420
 I  Q  Q  P  I  L  N  G  L  R  D  K  A  S  Y  V  R  R  V  A         p.140

          .         .         .         .          | 05        .    g.8747
 GTCCTTGGATGTGCCAAGATGCATAATCTTCATGGAGACTCTGAAGTAG | ATGGTGCCCTG    c.480
 V  L  G  C  A  K  M  H  N  L  H  G  D  S  E  V  D |   G  A  L      p.160

          .         .         .         .         .         .       g.8807
 GTAAATGAATTATACAGTTTGCTGCGTGACCAGGATCCAATTGTAGTTGTGAACTGCTTG       c.540
 V  N  E  L  Y  S  L  L  R  D  Q  D  P  I  V  V  V  N  C  L         p.180

          .         .         .         .         .         .       g.8867
 AGGTCTCTAGAGGAAATTCTGAAACAGGAAGGAGGCGTTGTCATCAATAAGCCCATTGCT       c.600
 R  S  L  E  E  I  L  K  Q  E  G  G  V  V  I  N  K  P  I  A         p.200

          .        | 06.         .         .         .         .    g.9762
 CACCATCTCTTAAATCG | AATGTCAAAACTGGACCAATGGGGCCAGGCTGAAGTATTGAAC    c.660
 H  H  L  L  N  R  |  M  S  K  L  D  Q  W  G  Q  A  E  V  L  N      p.220

          .         .         .         .         .         .       g.9822
 TTTCTGCTACGCTACCAACCCCGCAGTGAGGAAGAACTATTTGACATTCTCAATCTGTTG       c.720
 F  L  L  R  Y  Q  P  R  S  E  E  E  L  F  D  I  L  N  L  L         p.240

          .         .         .         .         .         .       g.9882
 GATAGTTTCCTCAAGAGCAGTAGCCCAGGTGTGGTGATGGGAGCTACCAAACTTTTTCTG       c.780
 D  S  F  L  K  S  S  S  P  G  V  V  M  G  A  T  K  L  F  L         p.260

          .         .         .         .         .         .       g.9942
 ATCTTGGCAAAAATGTTTCCCCACGTACAAACTGATGTCCTTGTGCGGGTCAAGGGACCT       c.840
 I  L  A  K  M  F  P  H  V  Q  T  D  V  L  V  R  V  K  G  P         p.280

          .         .         .         .         .         .       g.10002
 TTGCTAGCTGCCTGTTCTTCAGAGAGCCGTGAGCTCTGTTTTGTTGCTCTTTGTCATGTA       c.900
 L  L  A  A  C  S  S  E  S  R  E  L  C  F  V  A  L  C  H  V         p.300

          .         .         .         .         .         .       g.10062
 CGCCAGATCTTGCATAGTTTACCAGGTCACTTTAGCAGCCACTACAAAAAGTTTTTTTGC       c.960
 R  Q  I  L  H  S  L  P  G  H  F  S  S  H  Y  K  K  F  F  C         p.320

          .         .         .         .         .         .       g.10122
 TCCTACTCGGAGCCCCACTACATCAAACTACAGAAAGTGGAGGTGCTGTGTGAACTGGTG       c.1020
 S  Y  S  E  P  H  Y  I  K  L  Q  K  V  E  V  L  C  E  L  V         p.340

          .         .         .         .         .         .       g.10182
 AACGATGAGAATGTGCAGCAGGTGCTAGAGGAGCTTCGAGGGTACTGCACGGATGTGTCT       c.1080
 N  D  E  N  V  Q  Q  V  L  E  E  L  R  G  Y  C  T  D  V  S         p.360

          .         .         .     | 07   .         .         .    g.11344
 GCGGACTTTGCACAGGCTGCCATCTTTGCCATAG | GTGGCATTGCCAGGACTTACACAGAT    c.1140
 A  D  F  A  Q  A  A  I  F  A  I  G |   G  I  A  R  T  Y  T  D      p.380

          .         .         .         .         .         | 08    g.12178
 CAATGTGTTCAGATTTTAACAGAGTTGCTGGGTCTTCGACAAGAGCACATTACCACAG | TG    c.1200
 Q  C  V  Q  I  L  T  E  L  L  G  L  R  Q  E  H  I  T  T  V |       p.400

          .         .         .         .         .         .       g.12238
 GTGGTGCAGACTTTCCGAGACCTGGTTTGGTTGTGTCCTCAGTGTACTGAAGCTGTATGT       c.1260
 V  V  Q  T  F  R  D  L  V  W  L  C  P  Q  C  T  E  A  V  C         p.420

          .         .         .         .   | 09     .         .    g.13672
 CAGGCCCTGCCCGGCTGTGAAGAGAACATTCAAGATAGTGAG | GGGAAGCAAGCACTTATT    c.1320
 Q  A  L  P  G  C  E  E  N  I  Q  D  S  E   | G  K  Q  A  L  I      p.440

          .         .         .         .         .         .       g.13732
 TGGCTACTTGGTGTCCATGGGGAAAGAATTCCTAATGCTCCTTATGTGTTAGAGGACTTT       c.1380
 W  L  L  G  V  H  G  E  R  I  P  N  A  P  Y  V  L  E  D  F         p.460

          .         .         .         .         .         .       g.13792
 GTTGAGAATGTGAAGTCGGAAACATTTCCAGCTGTTAAGATGGAGCTGCTCACTGCTTTG       c.1440
 V  E  N  V  K  S  E  T  F  P  A  V  K  M  E  L  L  T  A  L         p.480

          .         .         .         .         .         .       g.13852
 CTGCGCCTTTTCCTCTCCCGACCTGCTGAGTGCCAGGACATGCTAGGACGTTTGTTGTAT       c.1500
 L  R  L  F  L  S  R  P  A  E  C  Q  D  M  L  G  R  L  L  Y         p.500

          . | 10       .         .         .         .         .    g.14131
 TACTGCATAG | AGGAAGAAAAAGATATGGCTGTACGGGACCGAGGTCTCTTCTATTATCGC    c.1560
 Y  C  I  E |   E  E  K  D  M  A  V  R  D  R  G  L  F  Y  Y  R      p.520

          .         .         .         .         .         .       g.14191
 CTCCTCTTAGTTGGCATTGATGAAGTTAAGCGGATTCTGTGTAGCCCTAAATCTGACCCT       c.1620
 L  L  L  V  G  I  D  E  V  K  R  I  L  C  S  P  K  S  D  P         p.540

          .         .         .         .         .         .       g.14251
 ACTCTTGGACTTTTGGAGGATCCGGCAGAAAGACCTGTGAATAGCTGGGCCTCAGACTTC       c.1680
 T  L  G  L  L  E  D  P  A  E  R  P  V  N  S  W  A  S  D  F         p.560

          .         .         .         .         .         .       g.14311
 AACACACTGGTGCCAGTGTATGGCAAAGCCCACTGGGCAACTATCTCTAAATGCCAGGGG       c.1740
 N  T  L  V  P  V  Y  G  K  A  H  W  A  T  I  S  K  C  Q  G         p.580

          .         .         .         .         .   | 11     .    g.14635
 GCAGAGCGTTGTGACCCAGAGCTTCCTAAAACTTCATCCTTTGCCGCATCAG | GACCCTTG    c.1800
 A  E  R  C  D  P  E  L  P  K  T  S  S  F  A  A  S  G |   P  L      p.600

          .         .         .         .         .         .       g.14695
 ATTCCTGAAGAGAACAAGGAGAGGGTACAAGAACTCCCTGATTCTGGAGCCCTCATGCTA       c.1860
 I  P  E  E  N  K  E  R  V  Q  E  L  P  D  S  G  A  L  M  L         p.620

          .         .         .         .         .         .       g.14755
 GTCCCCAATCGCCAGCTTACTGCTGATTATTTTGAGAAAACTTGGCTTAGCCTTAAAGTT       c.1920
 V  P  N  R  Q  L  T  A  D  Y  F  E  K  T  W  L  S  L  K  V         p.640

          .         .         .         .         .         .       g.14815
 GCTCATCAGCAAGTGTTGCCTTGGCGGGGAGAATTCCATCCTGACACCCTCCAGATGGCT       c.1980
 A  H  Q  Q  V  L  P  W  R  G  E  F  H  P  D  T  L  Q  M  A         p.660

          .         .         .         .         .         .       g.14875
 CTTCAAGTAGTGAACATCCAGACCATCGCAATGAGTAGGGCTGGGTCTCGGCCATGGAAA       c.2040
 L  Q  V  V  N  I  Q  T  I  A  M  S  R  A  G  S  R  P  W  K         p.680

          .         .         .         .         .         .       g.14935
 GCATACCTCAGTGCTCAGGATGATACTGGCTGTCTGTTCTTAACAGAACTGCTATTGGAG       c.2100
 A  Y  L  S  A  Q  D  D  T  G  C  L  F  L  T  E  L  L  L  E         p.700

          .         .         .         .         .         .       g.14995
 CCTGGAAACTCAGAAATGCAGATCTCTGTGAAACAAAATGAAGCAAGAACGGAGACGCTG       c.2160
 P  G  N  S  E  M  Q  I  S  V  K  Q  N  E  A  R  T  E  T  L         p.720

          .         .         .         .         .         .       g.15055
 AATAGTTTTATTTCTGTATTAGAAACTGTGATTGGAACAATTGAAGAAATAAAATCATAA       c.2220
 N  S  F  I  S  V  L  E  T  V  I  G  T  I  E  E  I  K  S  X         p.739

          .         .         .         .         .         .       g.15115
 cagagtcttgttgcttgtctagagtaagatgaataactattacactttcttagtctttcc       c.*60

          .         .         .         .         .         .       g.15175
 tattagagctgccagtaagtccagataatatcagatacaaaggagagtggaaaatctaga       c.*120

          .         .         .         .         .         .       g.15235
 aatcaggattcttaagtttttggccaaagaacattgattcattcctttcattcctattgg       c.*180

          .         .         .         .         .         .       g.15295
 caattgaccccatttttcagtgatgatgttgtagaggttaatgttggtaaggagatgcgt       c.*240

          .         .         .         .         .         .       g.15355
 tgaggatgggatttggattatttcctaatcaattttaggaattgtgttagtaattaaaga       c.*300

          .                                                         g.15372
 tggctgatgtgtggaaa                                                  c.*317

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Adaptor-related protein complex 4, beta 1 subunit protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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