adenomatosis polyposis coli 2 (APC2) - coding DNA reference sequence

(used for variant description)

(last modified November 29, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_005883.2 in the APC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_055243.1, covering APC2 transcript NM_005883.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.8909
                                 gcagcgccgcctgcccaggcccggaccg       c.-181

 .         .         .         .         .         .                g.8969
 ggctttgtccgccccggagcccctgcccgcgccgcggagaccccggagcccgcgcgctcc       c.-121

 .         .         .         .         .         .                g.9029
 gaggccaccccgggccgggatttccggtggggcccgcggagccgcgcagagggaggaggc       c.-61

 .         .         .         .         .  | 02      .             g.11734
 cccagacccaggcgccccgccagcccagctgcacgtaagcgg | acgctgcaggagctgaag    c.-1

          .         .         .         .         .         .       g.11794
 ATGGCGAGCTCCGTGGCGCCCTACGAGCAGCTGGTGAGGCAGGTGGAGGCCTTGAAGGCT       c.60
 M  A  S  S  V  A  P  Y  E  Q  L  V  R  Q  V  E  A  L  K  A         p.20

          .         .         .         .         .         .       g.11854
 GAGAACAGCCACCTGAGGCAGGAGCTAAGGGACAACTCCAGCCACCTGTCCAAGCTGGAG       c.120
 E  N  S  H  L  R  Q  E  L  R  D  N  S  S  H  L  S  K  L  E         p.40

          .         .  | 03      .         .         .         .    g.12018
 ACAGAGACGTCGGGCATGAAG | GAGGTCCTGAAGCACCTACAGGGAAAACTGGAGCAGGAG    c.180
 T  E  T  S  G  M  K   | E  V  L  K  H  L  Q  G  K  L  E  Q  E      p.60

          .         .         .         .         .   | 04     .    g.12171
 GCCCGAGTGCTGGTGTCCTCGGGGCAGACGGAGGTGCTGGAGCAGCTGAAGG | CCCTACAG    c.240
 A  R  V  L  V  S  S  G  Q  T  E  V  L  E  Q  L  K  A |   L  Q      p.80

          .         .         .         .         .         .       g.12231
 ATGGACATCACCAGCCTGTACAACCTCAAGTTCCAGCCGCCCACCCTGGGCCCGGAGCCT       c.300
 M  D  I  T  S  L  Y  N  L  K  F  Q  P  P  T  L  G  P  E  P         p.100

          .         .         .         .         .         .       g.12291
 GCCGCCCGGACCCCCGAGGGCAGCCCAGTACACGGCTCCGGGCCCTCCAAGGACAGCTTT       c.360
 A  A  R  T  P  E  G  S  P  V  H  G  S  G  P  S  K  D  S  F         p.120

          .         .         .         .         .    | 05    .    g.13888
 GGGGAGCTGAGCCGGGCCACCATCCGGCTGCTGGAGGAACTGGACCGGGAACG | GTGTTTC    c.420
 G  E  L  S  R  A  T  I  R  L  L  E  E  L  D  R  E  R  |  C  F      p.140

          .         .         .         .         .         .       g.13948
 CTGCTGAATGAGATTGAGAAGGAGGAGAAGGAGAAGCTCTGGTACTACTCTCAGCTGCAG       c.480
 L  L  N  E  I  E  K  E  E  K  E  K  L  W  Y  Y  S  Q  L  Q         p.160

          .         .         .         .   | 06     .         .    g.14134
 GGCCTGTCCAAGCGCCTGGACGAGCTGCCGCACGTGGAGACG | CAGTTCTCGATGCAGATG    c.540
 G  L  S  K  R  L  D  E  L  P  H  V  E  T   | Q  F  S  M  Q  M      p.180

          .         .         .         .         .         .       g.14194
 GACCTGATCCGGCAGCAGCTTGAGTTCGAGGCCCAGCACATCCGCTCGCTGATGGAGGAG       c.600
 D  L  I  R  Q  Q  L  E  F  E  A  Q  H  I  R  S  L  M  E  E         p.200

          .         .         .          | 07        .         .    g.14829
 CGCTTCGGCACCTCGGACGAGATGGTGCAGCGGGCACAG | ATCCGCGCCTCGCGCCTGGAG    c.660
 R  F  G  T  S  D  E  M  V  Q  R  A  Q   | I  R  A  S  R  L  E      p.220

          .         .         .         .         .        | 08.    g.15041
 CAGATTGACAAGGAGCTGCTGGAGGCGCAGGACCGAGTGCAGCAGACGGAGCCCCAG | GCC    c.720
 Q  I  D  K  E  L  L  E  A  Q  D  R  V  Q  Q  T  E  P  Q   | A      p.240

          .         .         .         .         .         .       g.15101
 TTGCTGGCGGTGAAGTCGGTGCCGGTGGACGAGGACCCCGAGACAGAGGTCCCCACACAC       c.780
 L  L  A  V  K  S  V  P  V  D  E  D  P  E  T  E  V  P  T  H         p.260

          .         .         .       | 09 .         .         .    g.15609
 CCTGAGGATGGCACCCCTCAGCCGGGCAACAGCAAG | GTGGAGGTGGTCTTCTGGCTGTTG    c.840
 P  E  D  G  T  P  Q  P  G  N  S  K   | V  E  V  V  F  W  L  L      p.280

          .         .         .         .         .         .       g.15669
 TCCATGTTGGCGACGCGCGACCAGGAGGATACAGCGCGCACGCTGCTGGCCATGTCCAGC       c.900
 S  M  L  A  T  R  D  Q  E  D  T  A  R  T  L  L  A  M  S  S         p.300

          .         .         .         .         .         .       g.15729
 TCGCCCGAGAGCTGCGTGGCCATGCGCCGCTCGGGCTGTCTGCCTCTGCTGCTGCAAATC       c.960
 S  P  E  S  C  V  A  M  R  R  S  G  C  L  P  L  L  L  Q  I         p.320

          .         .         .         .         .         .       g.15789
 CTCCACGGCACCGAGGCCGCGGCCGGGGGTCGCGCCGGGGCCCCAGGGGCACCGGGCGCC       c.1020
 L  H  G  T  E  A  A  A  G  G  R  A  G  A  P  G  A  P  G  A         p.340

          .         .         .         .         .         .       g.15849
 AAGGACGCACGCATGCGCGCCAACGCGGCGCTGCACAACATCGTCTTCTCGCAGCCGGAC       c.1080
 K  D  A  R  M  R  A  N  A  A  L  H  N  I  V  F  S  Q  P  D         p.360

          .         .         .         .         .         .       g.15909
 CAGGGCCTGGCGCGCAAGGAGATGCGCGTCCTGCACGTGCTGGAGCAGATCCGGGCCTAC       c.1140
 Q  G  L  A  R  K  E  M  R  V  L  H  V  L  E  Q  I  R  A  Y         p.380

          .         .         .         .         .         .       g.15969
 TGCGAGACCTGCTGGGACTGGCTGCAGGCCCGAGACGGCGGGCCCGAGGGAGGTGGCGCC       c.1200
 C  E  T  C  W  D  W  L  Q  A  R  D  G  G  P  E  G  G  G  A         p.400

         | 10.         .         .         .         .         .    g.16750
 GGCAGCG | CCCCGATCCCCATCGAGCCGCAGATCTGCCAGGCCACCTGTGCTGTTATGAAG    c.1260
 G  S  A |   P  I  P  I  E  P  Q  I  C  Q  A  T  C  A  V  M  K      p.420

          .         .         .         .    | 11    .         .    g.18930
 CTGTCCTTTGATGAGGAGTACCGCCGTGCCATGAACGAGCTAG | GTGGGCTGCAGGCCGTG    c.1320
 L  S  F  D  E  E  Y  R  R  A  M  N  E  L  G |   G  L  Q  A  V      p.440

          .         .         .         .         .         .       g.18990
 GCAGAGCTGCTGCAGGTTGACTATGAGATGCACAAGATGACCCGGGACCCGCTGAACCTG       c.1380
 A  E  L  L  Q  V  D  Y  E  M  H  K  M  T  R  D  P  L  N  L         p.460

          .         .         .         .         .         .       g.19050
 GCGCTGCGCCGCTACGCGGGCATGACCCTCACCAACCTCACCTTTGGGGACGTTGCCAAC       c.1440
 A  L  R  R  Y  A  G  M  T  L  T  N  L  T  F  G  D  V  A  N         p.480

     | 12    .         .         .         .         .         .    g.19569
 AAG | GCCACCCTGTGTGCGCGCCGCGGCTGCATGGAGGCCATCGTGGCCCAGCTGGCCTCC    c.1500
 K   | A  T  L  C  A  R  R  G  C  M  E  A  I  V  A  Q  L  A  S      p.500

          .         .  | 13      .         .         .         .    g.19808
 GACAGTGAGGAGCTCCACCAG | GTGGTGTCCAGCATCCTTCGGAACTTGTCCTGGAGGGCC    c.1560
 D  S  E  E  L  H  Q   | V  V  S  S  I  L  R  N  L  S  W  R  A      p.520

          .         .         .         .         .         .       g.19868
 GACATCAACAGCAAGAAGGTGCTGAGGGAGGCGGGCAGCGTGACTGCCCTGGTGCAGTGT       c.1620
 D  I  N  S  K  K  V  L  R  E  A  G  S  V  T  A  L  V  Q  C         p.540

          .         | 14         .         .         .         .    g.20737
 GTCCTGCGGGCCACCAAG | GAGTCCACCCTGAAGAGCGTGCTGAGCGCCCTGTGGAATCTG    c.1680
 V  L  R  A  T  K   | E  S  T  L  K  S  V  L  S  A  L  W  N  L      p.560

          .         .         .         .         .         .       g.20797
 TCTGCACACAGCACAGAGAACAAGGCGGCCATCTGCCAGGTGGATGGCGCCCTGGGCTTC       c.1740
 S  A  H  S  T  E  N  K  A  A  I  C  Q  V  D  G  A  L  G  F         p.580

          .         .         .         .         .         .       g.20857
 CTGGTGAGCACCCTGACCTACAAGTGTCAGAGCAACTCGCTGGCCATCATCGAGAGCGGC       c.1800
 L  V  S  T  L  T  Y  K  C  Q  S  N  S  L  A  I  I  E  S  G         p.600

          .         .         .         .         .    | 15    .    g.23894
 GGCGGCATCCTCCGCAATGTGTCCAGCCTCGTCGCCACCCGTGAGGACTACAG | GCAGGTG    c.1860
 G  G  I  L  R  N  V  S  S  L  V  A  T  R  E  D  Y  R  |  Q  V      p.620

          .         .         .         .         .         .       g.23954
 CTCCGGGATCACAACTGTCTGCAGACGCTGCTGCAGCATCTGACTTCGCACAGCCTGACC       c.1920
 L  R  D  H  N  C  L  Q  T  L  L  Q  H  L  T  S  H  S  L  T         p.640

          .         .         .         .         .         .       g.24014
 ATCGTGAGCAACGCGTGCGGCACGCTCTGGAACCTGTCGGCCCGCAGCGCCCGTGACCAG       c.1980
 I  V  S  N  A  C  G  T  L  W  N  L  S  A  R  S  A  R  D  Q         p.660

          .         .         .         .         .         .       g.24074
 GAGCTGCTGTGGGACCTGGGCGCCGTGGGCATGCTGCGTAATCTGGTGCACTCCAAGCAC       c.2040
 E  L  L  W  D  L  G  A  V  G  M  L  R  N  L  V  H  S  K  H         p.680

          .         .         .         .         .         .       g.24134
 AAGATGATCGCCATGGGCAGCGCCGCCGCCCTGCGCAACCTGCTGGCCCATCGGCCCGCC       c.2100
 K  M  I  A  M  G  S  A  A  A  L  R  N  L  L  A  H  R  P  A         p.700

          .         .         .         .         .         .       g.24194
 AAGCACCAGGCGGCCGCCACCGCCGTGTCCCCAGGCAGCTGCGTGCCCAGCCTGTACGTG       c.2160
 K  H  Q  A  A  A  T  A  V  S  P  G  S  C  V  P  S  L  Y  V         p.720

          .         .         .         .         .         .       g.24254
 CGCAAGCAGCGGGCGCTGGAGGCCGAGCTGGACGCACGGCACCTCGCGCAGGCGCTGGAG       c.2220
 R  K  Q  R  A  L  E  A  E  L  D  A  R  H  L  A  Q  A  L  E         p.740

          .         .         .         .         .         .       g.24314
 CACCTGGAGAAGCAGGGCCCGCCGGCAGCCGAGGCCGCCACTAAGAAGCCGCTGCCGCCC       c.2280
 H  L  E  K  Q  G  P  P  A  A  E  A  A  T  K  K  P  L  P  P         p.760

          .         .         .         .         .         .       g.24374
 CTGCGACACCTGGACGGCCTGGCCCAAGACTATGCTTCCGATTCGGGCTGCTTTGACGAC       c.2340
 L  R  H  L  D  G  L  A  Q  D  Y  A  S  D  S  G  C  F  D  D         p.780

          .         .         .         .         .         .       g.24434
 GACGATGCACCGTCATCCCTGGCTGCGGCCGCGGCCACCGGGGAGCCAGCCAGCCCTGCC       c.2400
 D  D  A  P  S  S  L  A  A  A  A  A  T  G  E  P  A  S  P  A         p.800

          .         .         .         .         .         .       g.24494
 GCGCTGTCCCTCTTCCTGGGCAGCCCCTTCCTGCAGGGGCAGGCGCTGGCTCGCACCCCG       c.2460
 A  L  S  L  F  L  G  S  P  F  L  Q  G  Q  A  L  A  R  T  P         p.820

          .         .         .         .         .         .       g.24554
 CCCACCCGCCGAGGCGGCAAGGAGGCAGAGAAGGACACCAGTGGGGAGGCAGCCGTGGCG       c.2520
 P  T  R  R  G  G  K  E  A  E  K  D  T  S  G  E  A  A  V  A         p.840

          .         .         .         .         .         .       g.24614
 GCCAAGGCCAAGGCCAAGCTGGCGCTTGCAGTGGCGCGCATCGACCAGCTGGTGGAGGAC       c.2580
 A  K  A  K  A  K  L  A  L  A  V  A  R  I  D  Q  L  V  E  D         p.860

          .         .         .         .         .         .       g.24674
 ATCTCCGCCCTGCACACCTCGTCCGACGATAGCTTCAGCCTCAGCTCTGGAGACCCGGGA       c.2640
 I  S  A  L  H  T  S  S  D  D  S  F  S  L  S  S  G  D  P  G         p.880

          .         .         .         .         .         .       g.24734
 CAGGAGGCGCCACGGGAGGGCCGCGCCCAGTCCTGCTCGCCATGCCGCGGCCCGGAGGGC       c.2700
 Q  E  A  P  R  E  G  R  A  Q  S  C  S  P  C  R  G  P  E  G         p.900

          .         .         .         .         .         .       g.24794
 GGGCGGCGAGAGGCAGGAAGCCGGGCGCACCCGCTGCTGCGGCTCAAGGCGGCCCACGCC       c.2760
 G  R  R  E  A  G  S  R  A  H  P  L  L  R  L  K  A  A  H  A         p.920

          .         .         .         .         .         .       g.24854
 AGCCTCTCCAACGACAGCCTCAACAGCGGCAGTGCCAGCGACGGGTACTGCCCACGCGAA       c.2820
 S  L  S  N  D  S  L  N  S  G  S  A  S  D  G  Y  C  P  R  E         p.940

          .         .         .         .         .         .       g.24914
 CATATGCTGCCCTGCCCGCTGGCCGCACTGGCTTCGCGCCGCGAGGACCCCAGGTGTGGG       c.2880
 H  M  L  P  C  P  L  A  A  L  A  S  R  R  E  D  P  R  C  G         p.960

          .         .         .         .         .         .       g.24974
 CAGCCTCGGCCCAGCCGGCTTGACCTTGACCTGCCCGGCTGCCAGGCCGAGCCCCCGGCC       c.2940
 Q  P  R  P  S  R  L  D  L  D  L  P  G  C  Q  A  E  P  P  A         p.980

          .         .         .         .         .         .       g.25034
 CGCGAGGCCACCTCCGCCGACGCCCGCGTGCGCACCATCAAGCTGTCGCCTACCTATCAG       c.3000
 R  E  A  T  S  A  D  A  R  V  R  T  I  K  L  S  P  T  Y  Q         p.1000

          .         .         .         .         .         .       g.25094
 CACGTGCCACTGCTTGAGGGTGCCTCAAGGGCGGGTGCAGAGCCCCTCGCGGGGCCTGGA       c.3060
 H  V  P  L  L  E  G  A  S  R  A  G  A  E  P  L  A  G  P  G         p.1020

          .         .         .         .         .         .       g.25154
 ATCTCTCCAGGGGCCCGGAAGCAGGCCTGGCTGCCGGCAGACCACCTGAGCAAGGTTCCC       c.3120
 I  S  P  G  A  R  K  Q  A  W  L  P  A  D  H  L  S  K  V  P         p.1040

          .         .         .         .         .         .       g.25214
 GAGAAGCTGGCGGCTGCCCCGCTGTCTGTGGCCAGCAAGGCACTGCAGAAACTGGCGGCG       c.3180
 E  K  L  A  A  A  P  L  S  V  A  S  K  A  L  Q  K  L  A  A         p.1060

          .         .         .         .         .         .       g.25274
 CAAGAGGGGCCACTCTCGCTGTCCCGATGCAGCTCCCTTTCCTCGCTGTCCTCGGCCGGC       c.3240
 Q  E  G  P  L  S  L  S  R  C  S  S  L  S  S  L  S  S  A  G         p.1080

          .         .         .         .         .         .       g.25334
 CGCCCAGGCCCCAGCGAGGGTGGTGACCTGGATGACAGTGACTCCTCCCTGGAGGGGCTG       c.3300
 R  P  G  P  S  E  G  G  D  L  D  D  S  D  S  S  L  E  G  L         p.1100

          .         .         .         .         .         .       g.25394
 GAGGAGGCCGGCCCCAGCGAGGCTGAGCTGGACAGCACGTGGCGGGCGCCCGGGGCCACC       c.3360
 E  E  A  G  P  S  E  A  E  L  D  S  T  W  R  A  P  G  A  T         p.1120

          .         .         .         .         .         .       g.25454
 TCGCTGCCCGTAGCCATTCCGGCTCCCCGGCGTAACCGAGGCCGGGGCCTGGGGGTGGAA       c.3420
 S  L  P  V  A  I  P  A  P  R  R  N  R  G  R  G  L  G  V  E         p.1140

          .         .         .         .         .         .       g.25514
 GACGCCACGCCGTCCAGCTCGTCGGAGAACTACGTGCAGGAGACACCGCTTGTGCTGAGC       c.3480
 D  A  T  P  S  S  S  S  E  N  Y  V  Q  E  T  P  L  V  L  S         p.1160

          .         .         .         .         .         .       g.25574
 CGCTGCAGCTCTGTGAGCTCGCTGGGCAGCTTCGAGAGCCCGTCCATCGCCAGCTCCATC       c.3540
 R  C  S  S  V  S  S  L  G  S  F  E  S  P  S  I  A  S  S  I         p.1180

          .         .         .         .         .         .       g.25634
 CCCAGTGAACCTTGCAGCGGGCAGGGCAGCGGCACCATCAGCCCTAGCGAGCTGCCCGAC       c.3600
 P  S  E  P  C  S  G  Q  G  S  G  T  I  S  P  S  E  L  P  D         p.1200

          .         .         .         .         .         .       g.25694
 AGCCCCGGACAGACCATGCCTCCCAGCCGGAGCAAGACGCCACCGCTGGCGCCCGCGCCA       c.3660
 S  P  G  Q  T  M  P  P  S  R  S  K  T  P  P  L  A  P  A  P         p.1220

          .         .         .         .         .         .       g.25754
 CAGGGTCCCCCCGAGGCCACCCAGTTCAGCCTGCAGTGGGAGAGCTACGTGAAGCGCTTC       c.3720
 Q  G  P  P  E  A  T  Q  F  S  L  Q  W  E  S  Y  V  K  R  F         p.1240

          .         .         .         .         .         .       g.25814
 CTGGACATCGCCGACTGCCGGGAGCGCTGCCGGCTGCCATCTGAGCTGGACGCAGGCAGC       c.3780
 L  D  I  A  D  C  R  E  R  C  R  L  P  S  E  L  D  A  G  S         p.1260

          .         .         .         .         .         .       g.25874
 GTGCGCTTTACCGTGGAGAAGCCAGACGAGAACTTCTCGTGCGCCTCCAGCCTCAGCGCG       c.3840
 V  R  F  T  V  E  K  P  D  E  N  F  S  C  A  S  S  L  S  A         p.1280

          .         .         .         .         .         .       g.25934
 CTGGCCTTGCACGAGCACTACGTGCAGCAGGACGTGGAGCTGCGGCTGCTGCCCTCGGCC       c.3900
 L  A  L  H  E  H  Y  V  Q  Q  D  V  E  L  R  L  L  P  S  A         p.1300

          .         .         .         .         .         .       g.25994
 TGCCCCGAGCGCGGCGGGGGCGCCGGGGGCGCCGGCCTCCACTTTGCAGGGCACCGGCGG       c.3960
 C  P  E  R  G  G  G  A  G  G  A  G  L  H  F  A  G  H  R  R         p.1320

          .         .         .         .         .         .       g.26054
 CGGGAGGAGGGGCCGGCGCCCACGGGTTCTCGCCCTCGCGGCGCCGCGGACCAGGAGCTG       c.4020
 R  E  E  G  P  A  P  T  G  S  R  P  R  G  A  A  D  Q  E  L         p.1340

          .         .         .         .         .         .       g.26114
 GAACTGCTGCGGGAGTGCCTGGGAGCCGCCGTGCCTGCCCGGCTGCGCAAGGTGGCCTCC       c.4080
 E  L  L  R  E  C  L  G  A  A  V  P  A  R  L  R  K  V  A  S         p.1360

          .         .         .         .         .         .       g.26174
 GCGCTGGTGCCAGGTCGCCGCGCACTCCCCGTGCCCGTCTACATGTTGGTGCCCGCCCCG       c.4140
 A  L  V  P  G  R  R  A  L  P  V  P  V  Y  M  L  V  P  A  P         p.1380

          .         .         .         .         .         .       g.26234
 GCCCCGGCCCAGGAGGACGACTCCTGCACTGACTCCGCGGAGGGCACGCCGGTCAACTTC       c.4200
 A  P  A  Q  E  D  D  S  C  T  D  S  A  E  G  T  P  V  N  F         p.1400

          .         .         .         .         .         .       g.26294
 TCTAGCGCCGCCTCGCTCAGCGACGAGACGCTGCAGGGACCCCCCAGGGACCAGCCCGGG       c.4260
 S  S  A  A  S  L  S  D  E  T  L  Q  G  P  P  R  D  Q  P  G         p.1420

          .         .         .         .         .         .       g.26354
 GGACCAGCGGGCAGGCAAAGACCCACCGGCCGCCCCACCTCTGCCAGACAGGCCATGGGG       c.4320
 G  P  A  G  R  Q  R  P  T  G  R  P  T  S  A  R  Q  A  M  G         p.1440

          .         .         .         .         .         .       g.26414
 CACCGGCACAAGGCGGGAGGCGCCGGCCGCAGCGCGGAGCAGTCTCGGGGCGCGGGCAAG       c.4380
 H  R  H  K  A  G  G  A  G  R  S  A  E  Q  S  R  G  A  G  K         p.1460

          .         .         .         .         .         .       g.26474
 AACAGAGCAGGGCTGGAGCTGCCCCTGGGCCGGCCCCCGAGCGCCCCCGCAGACAAGGAC       c.4440
 N  R  A  G  L  E  L  P  L  G  R  P  P  S  A  P  A  D  K  D         p.1480

          .         .         .         .         .         .       g.26534
 GGCTCAAAGCCCGGCCGGACCCGCGGGGACGGGGCGCTCCAGTCGCTGTGCCTCACGACG       c.4500
 G  S  K  P  G  R  T  R  G  D  G  A  L  Q  S  L  C  L  T  T         p.1500

          .         .         .         .         .         .       g.26594
 CCCACTGAGGAGGCCGTGTACTGCTTCTACGGCAACGACTCGGACGAGGAGCCCCCGGCG       c.4560
 P  T  E  E  A  V  Y  C  F  Y  G  N  D  S  D  E  E  P  P  A         p.1520

          .         .         .         .         .         .       g.26654
 GCCGCGCCCACGCCAACCCACCGGCGCACATCGGCCATCCCTCGCGCTTTTACGCGGGAG       c.4620
 A  A  P  T  P  T  H  R  R  T  S  A  I  P  R  A  F  T  R  E         p.1540

          .         .         .         .         .         .       g.26714
 CGTCCGCAGGGCCGGAAGGAGGCCCCTGCCCCGTCCAAGGCTGCACCAGCTGCCCCGCCG       c.4680
 R  P  Q  G  R  K  E  A  P  A  P  S  K  A  A  P  A  A  P  P         p.1560

          .         .         .         .         .         .       g.26774
 CCCGCCCGGACCCAGCCCAGCCTCATTGCTGACGAGACCCCGCCCTGCTACTCCCTGAGC       c.4740
 P  A  R  T  Q  P  S  L  I  A  D  E  T  P  P  C  Y  S  L  S         p.1580

          .         .         .         .         .         .       g.26834
 TCCTCCGCCAGCTCCCTCAGCGAGCCCGAGCCCTCGGAGCCGCCGGCCGTCCATCCACGA       c.4800
 S  S  A  S  S  L  S  E  P  E  P  S  E  P  P  A  V  H  P  R         p.1600

          .         .         .         .         .         .       g.26894
 GGCCGGGAGCCCGCGGTCACCAAGGACCCGGGCCCAGGAGGCGGACGCGACAGCTCGCCC       c.4860
 G  R  E  P  A  V  T  K  D  P  G  P  G  G  G  R  D  S  S  P         p.1620

          .         .         .         .         .         .       g.26954
 AGCCCGCGGGCCGCGGAGGAGCTTCTGCAGCGGTGCATCAGCTCGGCCCTGCCCAGGCGC       c.4920
 S  P  R  A  A  E  E  L  L  Q  R  C  I  S  S  A  L  P  R  R         p.1640

          .         .         .         .         .         .       g.27014
 CGGCCCCCCGTGTCTGGCCTGCGGCGCCGCAAGCCCCGAGCCACCCGGCTGGATGAGCGG       c.4980
 R  P  P  V  S  G  L  R  R  R  K  P  R  A  T  R  L  D  E  R         p.1660

          .         .         .         .         .         .       g.27074
 CCCGCAGAGGGGTCCCGGGAACGCGGCGAGGAGGCAGCGGGCTCGGACCGGGCCTCCGAC       c.5040
 P  A  E  G  S  R  E  R  G  E  E  A  A  G  S  D  R  A  S  D         p.1680

          .         .         .         .         .         .       g.27134
 CTGGATAGCGTGGAGTGGCGCGCCATCCAGGAGGGCGCCAATTCAATTGTCACGTGGCTG       c.5100
 L  D  S  V  E  W  R  A  I  Q  E  G  A  N  S  I  V  T  W  L         p.1700

          .         .         .         .         .         .       g.27194
 CACCAGGCAGCAGCTGCCACGCGGGAGGCCTCGTCCGAGTCCGACTCCATCCTGTCCTTC       c.5160
 H  Q  A  A  A  A  T  R  E  A  S  S  E  S  D  S  I  L  S  F         p.1720

          .         .         .         .         .         .       g.27254
 GTATCCGGGCTGTCAGTGGGATCCACCCTACAGCCCCCCAAGCACAGGAAGGGACGACAG       c.5220
 V  S  G  L  S  V  G  S  T  L  Q  P  P  K  H  R  K  G  R  Q         p.1740

          .         .         .         .         .         .       g.27314
 GCGGAGGGAGAAATGGGCAGTGCCCGGCGGCCAGAGAAAAGGGGCGCAGCCTCAGTCAAG       c.5280
 A  E  G  E  M  G  S  A  R  R  P  E  K  R  G  A  A  S  V  K         p.1760

          .         .         .         .         .         .       g.27374
 ACCAGCGGGAGCCCCCGTTCCCCTGCAGGCCCCGAGAAGCCACGTGGCACACAGAAGACC       c.5340
 T  S  G  S  P  R  S  P  A  G  P  E  K  P  R  G  T  Q  K  T         p.1780

          .         .         .         .         .         .       g.27434
 ACGCCCGGGGTGCCAGCTGTGCTCCGGGGACGAACAGTGATCTACGTCCCCAGCCCGGCA       c.5400
 T  P  G  V  P  A  V  L  R  G  R  T  V  I  Y  V  P  S  P  A         p.1800

          .         .         .         .         .         .       g.27494
 CCCCGTGCCCAGCCCAAAGGGACCCCCGGCCCCCGCGCCACACCGCGGAAGGTGGCGCCC       c.5460
 P  R  A  Q  P  K  G  T  P  G  P  R  A  T  P  R  K  V  A  P         p.1820

          .         .         .         .         .         .       g.27554
 CCTTGCCTGGCACAGCCCGCGGCTCCAGCCAAAGTCCCGAGCCCCGGGCAGCAGCGGTCG       c.5520
 P  C  L  A  Q  P  A  A  P  A  K  V  P  S  P  G  Q  Q  R  S         p.1840

          .         .         .         .         .         .       g.27614
 CGGAGCCTACACCGGCCTGCCAAGACCTCGGAGCTGGCGACGCTGAGCCAGCCCCCCAGA       c.5580
 R  S  L  H  R  P  A  K  T  S  E  L  A  T  L  S  Q  P  P  R         p.1860

          .         .         .         .         .         .       g.27674
 AGCGCCACACCGCCCGCCCGCCTCGCCAAGACCCCCTCCTCCAGCTCCTCCCAGACCTCG       c.5640
 S  A  T  P  P  A  R  L  A  K  T  P  S  S  S  S  S  Q  T  S         p.1880

          .         .         .         .         .         .       g.27734
 CCCGCCTCCCAGCCCCTGCCCAGAAAGCGCCCCCCGGTCACCCAGGCTGCTGGGGCCCTG       c.5700
 P  A  S  Q  P  L  P  R  K  R  P  P  V  T  Q  A  A  G  A  L         p.1900

          .         .         .         .         .         .       g.27794
 CCCGGCCCCGGAGCCTCCCCGGTGCCCAAAACGCCGGCGCGCACCCTTCTGGCGAAGCAG       c.5760
 P  G  P  G  A  S  P  V  P  K  T  P  A  R  T  L  L  A  K  Q         p.1920

          .         .         .         .         .         .       g.27854
 CACAAGACGCAGAGATCGCCCGTGCGGATCCCGTTCATGCAGAGGCCGGCCCGGCGTGGG       c.5820
 H  K  T  Q  R  S  P  V  R  I  P  F  M  Q  R  P  A  R  R  G         p.1940

          .         .         .         .         .         .       g.27914
 CCGCCACCGCTGGCTCGGGCAGTCCCGGAGCCGGGCCCCAGGGGCCGGGCGGGGACCGAG       c.5880
 P  P  P  L  A  R  A  V  P  E  P  G  P  R  G  R  A  G  T  E         p.1960

          .         .         .         .         .         .       g.27974
 GCGGGCCCGGGGGCGCGCGGGGGCCGCCTGGGCCTGGTGCGTGTGGCCTCAGCCCTCTCC       c.5940
 A  G  P  G  A  R  G  G  R  L  G  L  V  R  V  A  S  A  L  S         p.1980

          .         .         .         .         .         .       g.28034
 AGCGGCAGCGAGTCCTCCGACCGCTCGGGCTTCCGGCGACAGCTAACCTTCATCAAGGAG       c.6000
 S  G  S  E  S  S  D  R  S  G  F  R  R  Q  L  T  F  I  K  E         p.2000

          .         .         .         .         .         .       g.28094
 TCGCCGGGCTTGCGGCGCCGCCGCTCCGAGCTGTCCTCGGCCGAGTCCGCGGCCTCTGCC       c.6060
 S  P  G  L  R  R  R  R  S  E  L  S  S  A  E  S  A  A  S  A         p.2020

          .         .         .         .         .         .       g.28154
 CCCCAGGGCGCCTCGCCCCGCCGCGGCCGGCCCGCGCTGCCCGCCGTCTTCCTCTGCTCC       c.6120
 P  Q  G  A  S  P  R  R  G  R  P  A  L  P  A  V  F  L  C  S         p.2040

          .         .         .         .         .         .       g.28214
 TCGCGCTGCGAAGAGCTCCGAGCGGCACCCCGGCAGGGCCCGGCCCCGGCCCGGCAGCGG       c.6180
 S  R  C  E  E  L  R  A  A  P  R  Q  G  P  A  P  A  R  Q  R         p.2060

          .         .         .         .         .         .       g.28274
 CCCCCCGCGGCCCGACCCAGCCCTGGCGAGCGCCCTGCCCGGCGCACCACCTCCGAGAGC       c.6240
 P  P  A  A  R  P  S  P  G  E  R  P  A  R  R  T  T  S  E  S         p.2080

          .         .         .         .         .         .       g.28334
 CCGTCCCGCCTGCCTGTGCGCGCGCCCGCCGCCCGGCCGGAGACTGTCAAGCGCTACGCG       c.6300
 P  S  R  L  P  V  R  A  P  A  A  R  P  E  T  V  K  R  Y  A         p.2100

          .         .         .         .         .         .       g.28394
 TCGCTGCCGCACATCAGCGTGGCCCGCAGGCCCGACGGCGCCGTCCCCGCGGCCCCTGCC       c.6360
 S  L  P  H  I  S  V  A  R  R  P  D  G  A  V  P  A  A  P  A         p.2120

          .         .         .         .         .         .       g.28454
 TCAGCCGACGCCGCGCGCCGCAGCAGCGACGGGGAGCCCCGGCCGCTCCCCAGGGTGGCC       c.6420
 S  A  D  A  A  R  R  S  S  D  G  E  P  R  P  L  P  R  V  A         p.2140

          .         .         .         .         .         .       g.28514
 GCGCCGGGCACGACCTGGCGGCGCATCCGAGATGAGGACGTGCCCCACATCCTGCGCAGC       c.6480
 A  P  G  T  T  W  R  R  I  R  D  E  D  V  P  H  I  L  R  S         p.2160

          .         .         .         .         .         .       g.28574
 ACGCTTCCCGCCACGGCCCTGCCACTGCGGGGCTCCACGCCCGAGGACGCCCCGGCCGGG       c.6540
 T  L  P  A  T  A  L  P  L  R  G  S  T  P  E  D  A  P  A  G         p.2180

          .         .         .         .         .         .       g.28634
 CCCCCGCCGCGCAAGACCAGCGACGCCGTGGTCCAGACCGAGGAGGTCGCCGCCCCCAAG       c.6600
 P  P  P  R  K  T  S  D  A  V  V  Q  T  E  E  V  A  A  P  K         p.2200

          .         .         .         .         .         .       g.28694
 ACCAACTCCAGCACGTCCCCGAGCCTGGAGACCAGGGAGCCCCCCGGGGCCCCCGCCGGC       c.6660
 T  N  S  S  T  S  P  S  L  E  T  R  E  P  P  G  A  P  A  G         p.2220

          .         .         .         .         .         .       g.28754
 GGCCAGCTCTCCCTCCTCGGCAGCGACGTGGACGGTCCCAGCCTCGCCAAGGCTCCCATC       c.6720
 G  Q  L  S  L  L  G  S  D  V  D  G  P  S  L  A  K  A  P  I         p.2240

          .         .         .         .         .         .       g.28814
 TCCGCACCCTTCGTGCACGAGGGCCTGGGGGTCGCCGTGGGGGGCTTCCCCGCCAGCCGG       c.6780
 S  A  P  F  V  H  E  G  L  G  V  A  V  G  G  F  P  A  S  R         p.2260

          .         .         .         .         .         .       g.28874
 CACGGCTCCCCCAGCCGCTCGGCCCGAGTACCCCCCTTCAACTATGTGCCCAGCCCCATG       c.6840
 H  G  S  P  S  R  S  A  R  V  P  P  F  N  Y  V  P  S  P  M         p.2280

          .         .         .         .         .         .       g.28934
 GTGGTCGCAGCCACCACCGACTCGGCCGCGGAGAAAGCCCCGGCCACTGCCTCCGCCACC       c.6900
 V  V  A  A  T  T  D  S  A  A  E  K  A  P  A  T  A  S  A  T         p.2300

          .                                                         g.28946
 CTCCTGGAATAG                                                       c.6912
 L  L  E  X                                                         p.2303

          .         .         .         .         .         .       g.29006
 tggcctaggccggccttctggaacgttctctcccggccctgcggcgcggtctggctgccc       c.*60

          .         .         .         .         .         .       g.29066
 catgggcctgcgctgtagacgtcccccataggtcgccccagggcctctgcccacccgagc       c.*120

          .         .         .         .         .         .       g.29126
 cccaccactctcagaacccccgcccagcgcacggcgacctcgcgcctcaccggaagacct       c.*180

          .         .         .         .         .         .       g.29186
 tgcctctgtgccgcggaggtccaggaggaaacggggcggccgctaggcctcaagtcccga       c.*240

          .         .         .         .         .         .       g.29246
 ccgtggagcgctggcaagggcgtcctggcccagccctgagcgcgcggcccttcccctgtc       c.*300

          .         .         .         .         .         .       g.29306
 ggaagccgttgcttgaccccgggcgagggaggcggtagcctccgggtccgggtctgggtc       c.*360

          .         .         .         .         .         .       g.29366
 tgggtccgctgcttcgcagggacagcgctggggaggtgacggcgcccgccgcaggtgggg       c.*420

          .         .         .         .         .         .       g.29426
 cgaggctgggggagggcggcgccgcggcgggcctgccagctgggggcctttgcggcgcgc       c.*480

          .         .         .         .         .         .       g.29486
 aggggcgaagcctgtaatcactgcagccgccggtaattcgctaatgagggctttgcaggg       c.*540

          .         .         .         .         .         .       g.29546
 attgttttcattctcagccccagctgtgggagtgcgggtgggggtgtggccgagccccgg       c.*600

          .         .         .         .         .         .       g.29606
 caggaagccccgcccagacggtgttcagggaacccggagcccaagcgctccggcggagcc       c.*660

          .         .         .         .         .         .       g.29666
 caaaagggtgggggtgggaggggcagaggccaacggatccccctgcctgtcgcacccctt       c.*720

          .         .         .         .         .         .       g.29726
 ggcgggagacgggaaggcagcgggctgcgtacgatgggaccctggtgcagacgccgggcc       c.*780

          .         .         .         .         .         .       g.29786
 ggctgacatttggaccccatcccagaggagatgctggctaccagctggggcgaccccaag       c.*840

          .         .         .         .         .         .       g.29846
 ggtcgctggagtcagtatcggcccggcgcagccgcggcgggcgaggccaatggaaaggag       c.*900

          .         .         .         .         .         .       g.29906
 actgaggggagtcccggcagtgagcccgaggccctgggacctggagcccgcgctggcctc       c.*960

          .         .         .         .         .         .       g.29966
 tccccagcggagcctgcacgttacggagaccatcacatgtgggcgtggtcagtgcccagg       c.*1020

          .         .         .         .         .         .       g.30026
 accgcaccgctgctcatcttgtcccttttcaattcccttctggttcatgatgcataaagc       c.*1080

          .         .         .         .         .         .       g.30086
 gctaggccctagaactccagaaacagcacagctggggcggggacccagccttgccctcca       c.*1140

          .         .         .         .         .         .       g.30146
 cccgaggctctgggacaaggcgggaggttcgggggccttccggcaggtgaacgcagggct       c.*1200

          .         .         .         .         .         .       g.30206
 ggagagtatttggtgccagatgaggtgaaagcttatagaagggcctgaggggctcggctg       c.*1260

          .         .         .         .         .         .       g.30266
 cctcatcccctggcgggggaggctgggagctgggcctcctgcgtggggtgggactcgcag       c.*1320

          .         .         .         .         .         .       g.30326
 gggccgggtctccgtgactggggcaacgcctcgtcctgcagagggagccgacgacctctt       c.*1380

          .         .         .         .         .         .       g.30386
 ttctgcagaaaagctccagcaggcgctgccttcacccacggatctgcccaggctgaaggc       c.*1440

          .         .         .         .         .         .       g.30446
 acacgctcaatgccccacgtgccttctccaggaggaacgaagcagggtttgagggttggg       c.*1500

          .         .         .         .         .         .       g.30506
 tggatggagctcagaaggaaaccccagccccaccacggatgacaccatccctcccgtccc       c.*1560

          .         .         .         .         .         .       g.30566
 atccccagcatgggcaaggccagcctttctggcagaaggagctgtcctcaactcagggcc       c.*1620

          .         .         .         .         .         .       g.30626
 gctgtgagcaaagctgaccccagcccccacccccagttaacactgctgcttctctgaatg       c.*1680

          .         .         .         .         .         .       g.30686
 catgtcacgctgcaccccatgctccgggcccacaccctgcaggacaaggagctccagaca       c.*1740

          .         .         .         .         .         .       g.30746
 ggacgtccataagtcaccgaggtgtgccacccagcaggtgctggaggtgcccaatgctcc       c.*1800

          .         .         .         .         .         .       g.30806
 ctcctaggacctcgcagccaggcaaggctgtcaggttgttttgggggaagagggggtcat       c.*1860

          .         .         .         .         .         .       g.30866
 ggatggctgagcagagagcggggaaaatgcaggctgagtggggcgacctcctgcctgcca       c.*1920

          .         .         .         .         .         .       g.30926
 ggagccccctttcaggacacagcgggggtctcacacttgctgtccccatccatggcccga       c.*1980

          .         .         .         .         .         .       g.30986
 gggggaacctggtggtctcttctgagcttttggacttggggatgccaaacacgtgctcac       c.*2040

          .         .         .         .         .         .       g.31046
 cctcacactcgccccggcccgctgcgcccctaattgccaaagggtagggaaatggcgaag       c.*2100

          .         .         .         .         .         .       g.31106
 ccagccaccaggtcgctggtgacagggccagggttatgcaggaaggtggtgcggcattgc       c.*2160

          .         .         .         .         .         .       g.31166
 cttccacatatgtaagtctctgggcggcgccctcccagctccctgcctctgtttccccat       c.*2220

          .         .         .         .         .         .       g.31226
 gtgggccgtggggaactcccagagctacctcttgggggagcgtggtggcagcgatgatgg       c.*2280

          .         .         .         .         .         .       g.31286
 ggagacgcctggaagctcacagaacttgggtctggctggctcctgcccgtgacgccttgc       c.*2340

          .         .         .         .         .         .       g.31346
 ccagcagcaaggtgcgcaacatggctgccagccccgcctcccacccccaccccgagtcct       c.*2400

          .         .         .         .         .         .       g.31406
 gagctcactttcgccttctccatcccctgccgtgggggccacagccacacctcaccgccc       c.*2460

          .         .         .         .         .         .       g.31466
 agtccagctgtctccagaaggggacaggcagtccgcggtctctggacaatcaactcaagg       c.*2520

          .         .         .         .         .         .       g.31526
 tacgcccactgcaaggcctccctcccaccgcggcccctgcctggccacctggcctctctg       c.*2580

          .         .         .         .         .         .       g.31586
 caccagggtgacaaggggtcctcgtctgccccccaatgctccagggccagtcctaaggag       c.*2640

          .         .         .         .         .         .       g.31646
 ctgagggtctgaggacgcagggagggtggaggtgtcctgaggctgatggacagtgaccgc       c.*2700

          .         .         .         .         .         .       g.31706
 cactggcccccaacatgaccacacgtgggtgctgaactcggggcgccgtgcccaccggca       c.*2760

          .         .         .         .         .         .       g.31766
 tggtcctcccgagctccgacagcattacctcacccggccccatctgttgccccggtccag       c.*2820

          .         .         .         .         .         .       g.31826
 ccctgatggcgcgcgcctggtctgtctgattcccctagccgccaccccacgtttctgtac       c.*2880

          .         .         .         .         .         .       g.31886
 cgggtctctgcagtgttaaacggacgtgtaaatagtggtaaatagtgaaagcctgtcctt       c.*2940

          .         .         .         .         .         .       g.31946
 ccctaaatgtaaagccatctgtccggcgtaaggacgacaccgtcagctgtccgactcgca       c.*3000

          .         .         .                                     g.31977
 cacatttaataaactgagctcttgcattgcc                                    c.*3031

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Adenomatosis polyposis coli 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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