aquaporin 4 (AQP4) - coding DNA reference sequence

(used for variant description)

(last modified October 21, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001650.4 in the AQP4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029560.1, covering AQP4 transcript NM_001650.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          gac       c.-61

 .         .         .         .         .         .                g.5063
 tcccagcacacagggagctgcggggcaggcaatgagagctgcactctggctggggaaggc       c.-1

          .         .         .   | 02     .         .         .    g.8184
 ATGAGTGACAGACCCACAGCAAGGCGGTGGGG | TAAGTGTGGACCTTTGTGTACCAGAGAG    c.60
 M  S  D  R  P  T  A  R  R  W  G  |  K  C  G  P  L  C  T  R  E      p.20

          .         .         .         .         .         .       g.8244
 AACATCATGGTGGCTTTCAAAGGGGTCTGGACTCAAGCTTTCTGGAAAGCAGTCACAGCG       c.120
 N  I  M  V  A  F  K  G  V  W  T  Q  A  F  W  K  A  V  T  A         p.40

          .         .         .         .         .         .       g.8304
 GAATTTCTGGCCATGCTTATTTTTGTTCTCCTCAGCCTGGGATCCACCATCAACTGGGGT       c.180
 E  F  L  A  M  L  I  F  V  L  L  S  L  G  S  T  I  N  W  G         p.60

          .         .         .         .         .         .       g.8364
 GGAACAGAAAAGCCTTTACCGGTCGACATGGTTCTCATCTCCCTTTGCTTTGGACTCAGC       c.240
 G  T  E  K  P  L  P  V  D  M  V  L  I  S  L  C  F  G  L  S         p.80

          .         .         .         .         .         .       g.8424
 ATTGCAACCATGGTGCAGTGCTTTGGCCATATCAGCGGTGGCCACATCAACCCTGCAGTG       c.300
 I  A  T  M  V  Q  C  F  G  H  I  S  G  G  H  I  N  P  A  V         p.100

          .         .         .         .         .         .       g.8484
 ACTGTGGCCATGGTGTGCACCAGGAAGATCAGCATCGCCAAGTCTGTCTTCTACATCGCA       c.360
 T  V  A  M  V  C  T  R  K  I  S  I  A  K  S  V  F  Y  I  A         p.120

          .         .         .         .         .         .       g.8544
 GCCCAGTGCCTGGGGGCCATCATTGGAGCAGGAATCCTCTATCTGGTCACACCTCCCAGT       c.420
 A  Q  C  L  G  A  I  I  G  A  G  I  L  Y  L  V  T  P  P  S         p.140

          .         .        | 03.         .         .         .    g.9490
 GTGGTGGGAGGCCTGGGAGTCACCATG | GTTCATGGAAATCTTACCGCTGGTCATGGTCTC    c.480
 V  V  G  G  L  G  V  T  M   | V  H  G  N  L  T  A  G  H  G  L      p.160

          .         .         .         .         .         .       g.9550
 CTGGTTGAGTTGATAATCACATTTCAATTGGTGTTTACTATCTTTGCCAGCTGTGATTCC       c.540
 L  V  E  L  I  I  T  F  Q  L  V  F  T  I  F  A  S  C  D  S         p.180

          .         .         .         .         .         .       g.9610
 AAACGGACTGATGTCACTGGCTCAATAGCTTTAGCAATTGGATTTTCTGTTGCAATTGGA       c.600
 K  R  T  D  V  T  G  S  I  A  L  A  I  G  F  S  V  A  I  G         p.200

          .   | 04     .         .         .         .         .    g.9948
 CATTTATTTGCA | ATCAATTATACTGGTGCCAGCATGAATCCCGCCCGATCCTTTGGACCT    c.660
 H  L  F  A   | I  N  Y  T  G  A  S  M  N  P  A  R  S  F  G  P      p.220

          .         .         .    | 05    .         .         .    g.14290
 GCAGTTATCATGGGAAATTGGGAAAACCATTGG | ATATATTGGGTTGGGCCCATCATAGGA    c.720
 A  V  I  M  G  N  W  E  N  H  W   | I  Y  W  V  G  P  I  I  G      p.240

          .         .         .         .         .         .       g.14350
 GCTGTCCTCGCTGGTGGCCTTTATGAGTATGTCTTCTGTCCAGATGTTGAATTCAAACGT       c.780
 A  V  L  A  G  G  L  Y  E  Y  V  F  C  P  D  V  E  F  K  R         p.260

          .         .         .         .         .         .       g.14410
 CGTTTTAAAGAAGCCTTCAGCAAAGCTGCCCAGCAAACAAAAGGAAGCTACATGGAGGTG       c.840
 R  F  K  E  A  F  S  K  A  A  Q  Q  T  K  G  S  Y  M  E  V         p.280

          .         .         .         .         .         .       g.14470
 GAGGACAACAGGAGTCAGGTAGAGACGGATGACCTGATTCTAAAACCTGGAGTGGTGCAT       c.900
 E  D  N  R  S  Q  V  E  T  D  D  L  I  L  K  P  G  V  V  H         p.300

          .         .         .         .         .         .       g.14530
 GTGATTGACGTTGACCGGGGAGAGGAGAAGAAGGGGAAAGACCAATCTGGAGAGGTATTG       c.960
 V  I  D  V  D  R  G  E  E  K  K  G  K  D  Q  S  G  E  V  L         p.320

          .                                                         g.14542
 TCTTCAGTATGA                                                       c.972
 S  S  V  X                                                         p.323

          .         .         .         .         .         .       g.14602
 ctagaagatcgcactgaaagcagacaagactccttagaactgtcctcagatttccttcca       c.*60

          .         .         .         .         .         .       g.14662
 cccattaaggaaacagatttgttataaattagaaatgtgcaggtttgttgtttcatgtca       c.*120

          .         .         .         .         .         .       g.14722
 tattactcagtctaaacaataaatatttcataatttacaaaggaggaacggaagaaacct       c.*180

          .         .         .         .         .         .       g.14782
 attgtgaattccaaatctaaaaaaagaaatatttttaaaatgttcttaagcaaatatata       c.*240

          .         .         .         .         .         .       g.14842
 cctattttatctagttacctttcattaacaaccaattttaaccgtgtgtcaagatttggt       c.*300

          .         .         .         .         .         .       g.14902
 taagtcttgcctgacagaactcaaagacacgtctatcagcttattccttctctactggaa       c.*360

          .         .         .         .         .         .       g.14962
 tattggtatagtcaattcttatttgaatatttattctattaaactgagtttaacaatggc       c.*420

          .         .         .         .         .         .       g.15022
 aaaatacagtatgtcacagtcatgcacattcaagagagaaaatataacaagttcttttat       c.*480

          .         .         .         .         .         .       g.15082
 gagcaatcccttatgcatagactaccttggcaaaagagcattagcaagtgtcactgctca       c.*540

          .         .         .         .         .         .       g.15142
 tcagttacttccttccatttatatcacaaatacccaagtttcaattctaacttcatttca       c.*600

          .         .         .         .         .         .       g.15202
 tggtatttcttcctcctcaatgcccaaggtaatgtgggactaaagcccagaaatttgaaa       c.*660

          .         .         .         .         .         .       g.15262
 agaatattcagaaatccttcccaaatcataagggcacctattgagattcaagacaagcag       c.*720

          .         .         .         .         .         .       g.15322
 actcgtaaaatcttgtagaggcagaggcaaagttatcatcatacaaaaatcacaaacaaa       c.*780

          .         .         .         .         .         .       g.15382
 aaggagatctgtattcgggtatcaaacggttgatctgttttcagtgcacaccctcaaatg       c.*840

          .         .         .         .         .         .       g.15442
 caccacaccagttttacgatctaagcttttaacccctttaccactttgcttatttttaaa       c.*900

          .         .         .         .         .         .       g.15502
 aaatttattggcaaaactggggattttgtttgtaactttggttatctatatttaaacatt       c.*960

          .         .         .         .         .         .       g.15562
 agctgagacatatttttgataacaagaacttagctagttgagtcctggctttttgttgat       c.*1020

          .         .         .         .         .         .       g.15622
 tattaagctgtgttcactctagaaggtgtaaaggccctgtcccaatctctgctctctcac       c.*1080

          .         .         .         .         .         .       g.15682
 ttctcgtgacatttgttgataatctttactgcaagtgtaatgatatttgagtgaattaaa       c.*1140

          .         .         .         .         .         .       g.15742
 atgcatgacagacaaggtacaacatggttgcagaataaaagggtgaggacatcagatcac       c.*1200

          .         .         .         .         .         .       g.15802
 tctgtattcaaagcttactagacgaacaatctttcatttctggatatattgtagctaacc       c.*1260

          .         .         .         .         .         .       g.15862
 caacacatttttaaactatttttgttactgactcacttacttgtcaaaataattggtttt       c.*1320

          .         .         .         .         .         .       g.15922
 tctgtcctgctttgccttttgtcactagaatgttctccagaaaccccagtttctgtcatc       c.*1380

          .         .         .         .         .         .       g.15982
 ttaactgtctagtctagccgttaacttagacaaagaagtgcaaatgtcaatttcactaaa       c.*1440

          .         .         .         .         .         .       g.16042
 caaaagctattagaagtaaagcagaaacctatcactgcaaggagtgacttgtaaataact       c.*1500

          .         .         .         .         .         .       g.16102
 gatgatcaagggctgtcttctctcaagcatggttccaactctgtgtcactttttagcgtt       c.*1560

          .         .         .         .         .         .       g.16162
 aatggcagttgtgtgtctgtggcagtgagataatggaccactattaaacctgattctctt       c.*1620

          .         .         .         .         .         .       g.16222
 cggtgctaggaaagagtgatgtgtgagattcccagagagtcgtcacaccagtgttatgcc       c.*1680

          .         .         .         .         .         .       g.16282
 tgggagtgccactggcataccgcaggtgcctaaatcccaggcccctttctcagggggcgt       c.*1740

          .         .         .         .         .         .       g.16342
 ggccacaccacacactgcgccagtgacacatagttacttcctggctgggacggcacctat       c.*1800

          .         .         .         .         .         .       g.16402
 agaaactagggtacaaatctcccaaagatggtttgcaccgtcatttcaaatgtttgcaca       c.*1860

          .         .         .         .         .         .       g.16462
 atataccacttagaggcttaaaatcagggtggttcagttcaaaaggtaatatcaaccgtc       c.*1920

          .         .         .         .         .         .       g.16522
 agcaaacatgtcagtttaaaaataagttcggttaacaaggaagtgttaagcagatttttt       c.*1980

          .         .         .         .         .         .       g.16582
 gaatacacttacaatatactggcttataatcatttttattctgccatatggtttatttca       c.*2040

          .         .         .         .         .         .       g.16642
 tatacactcacttttacactcacttccaattatagcattcaataagttacggttaaagaa       c.*2100

          .         .         .         .         .         .       g.16702
 aagtgaatggtgtttttgtaatttgttttctagtagctagcagagagcctggcacatagt       c.*2160

          .         .         .         .         .         .       g.16762
 atgtattcaaaacaagtgtgttaattaataaaaatatataaatctcatttgagatttaag       c.*2220

          .         .         .         .         .         .       g.16822
 aatataaataattttcttttaatctttattttgctcaatatttaataggaagtatgattt       c.*2280

          .         .         .         .         .         .       g.16882
 caaggactactaaaggaaggcaatatacatgtgaaaaccataaaatacattttttgcatt       c.*2340

          .         .         .         .         .         .       g.16942
 ctactatttttaggggcatgaaatgaatgaaagctttagcacttttttgcccctacatat       c.*2400

          .         .         .         .         .         .       g.17002
 gagacaacatattttgtatttcactcaaggctctgccagtaaaaagtaatgaaattgtac       c.*2460

          .         .         .         .         .         .       g.17062
 ctttctaatgacatctatgcagcaggggtctatcgccttgtggatggcaccaaattatcc       c.*2520

          .         .         .         .         .         .       g.17122
 aagtgtattaggagactggggcttttttctttaatcccttcttattaatgaagtgcatag       c.*2580

          .         .         .         .         .         .       g.17182
 tgctgctcccaggagaccactgctgacagatacacagagaagagatcagagaggaaaaac       c.*2640

          .         .         .         .         .         .       g.17242
 tgggaagacataaatgaattatacccagccatgaaacaatgccaactgtctcttccctaa       c.*2700

          .         .         .         .         .         .       g.17302
 ggaagagtacaagtaccctaaaattgaaaggtggtccctacactgaaaacgcacatagtt       c.*2760

          .         .         .         .         .         .       g.17362
 tgtcaaaagtgtacaaaagggaaagagtcttattttaagctttcaggctttcttaaaaac       c.*2820

          .         .         .         .         .         .       g.17422
 ttggggaccagaatttcaatgtatgtttccattgttgaagataacattttcttcaaagag       c.*2880

          .         .         .         .         .         .       g.17482
 ccttaaccttttgtactggaaggaaatattttctggacttaagtagttgcctaaatttaa       c.*2940

          .         .         .         .         .         .       g.17542
 gattcctacactttatttctgccattgatgcttttcctaaacccttatactatcttttta       c.*3000

          .         .         .         .         .         .       g.17602
 ttatctgagccttttcctaatgcagctcataggtgctagctagagctgctgctcagtatt       c.*3060

          .         .         .         .         .         .       g.17662
 gaagactttacaaggagattagaaatctttggaaaacatatgtgatgaaattgagctata       c.*3120

          .         .         .         .         .         .       g.17722
 tgatttatcagagatctgattccaaagagcacagaatactgttctcagaccatgaaacca       c.*3180

          .         .         .         .         .         .       g.17782
 gacaacacatgtattggtttaaactcgataatgacaggaaaattccaaactagagcagta       c.*3240

          .         .         .         .         .         .       g.17842
 aattcaaatggtaagatgaatcctagaaggcctctgattgcagcatgttgacaccaacct       c.*3300

          .         .         .         .         .         .       g.17902
 cacgttacgaacaattcacagagaatttgcctttgtggcaactgaagatggaagtctggg       c.*3360

          .         .         .         .         .         .       g.17962
 gggcacagacaaccttatcaaacaatataaaagccaatataaattctcataagcactata       c.*3420

          .         .         .         .         .         .       g.18022
 gaatttgcaaattcagaacattttatacctaaaagtaattctgtctttcctaaagtgttt       c.*3480

          .         .         .         .         .         .       g.18082
 ttaacatgaaaattagtaggaagatgtggttactatttggaaagtgtaatgtaacaaaac       c.*3540

          .         .         .         .         .         .       g.18142
 tctcttttgttaccacaaattttgtgagtttagtactctacagattgccccataagagca       c.*3600

          .         .         .         .         .         .       g.18202
 gtagcttttgaaactcataattctctgaaataaatgaaagacatttaattcaaggatcaa       c.*3660

          .         .         .         .         .         .       g.18262
 aaattgtggccatctttgcaaatgactacctatagcctgtgaaaatacatttcaaaaaat       c.*3720

          .         .         .         .         .         .       g.18322
 gttatgtgcaatgaacactaaatttaagagcagttacagtgtgactcactcatgtttaaa       c.*3780

          .         .         .         .         .         .       g.18382
 aaaaatcgaagagctaaaaaatacgtctaatttatgtaacccattggaatgtatttctag       c.*3840

          .         .         .         .         .         .       g.18442
 gttctcttcaggattaattaaataaacatgcaatttatgaaaacatataaacaattattt       c.*3900

          .         .         .         .         .         .       g.18502
 atcacttttatgacccaaatcacaataaaattgtcatttaggataaactggggagaatag       c.*3960

          .         .         .         .         .         .       g.18562
 actgaacatatggttatattcacagttatttattaacttaaatgttattccaacattaga       c.*4020

          .         .         .         .         .         .       g.18622
 gctaatgttaaaaagatttaaactgtaacgtctaatatttggaataatatattaaagtat       c.*4080

          .         .         .         .         .         .       g.18682
 tagcactgtggttgattttcttgaattatgttgcatcttgtactactaagcttgtgaaaa       c.*4140

          .         .                                               g.18710
 taaacatttggatgttttaaaaggtaaa                                       c.*4168

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Aquaporin 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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