ADP-ribosylation factor 1 (ARF1) - coding DNA reference sequence

(used for variant description)

(last modified November 5, 2023)

This file was created to facilitate the description of sequence variants on transcript NM_001658.3 in the ARF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering ARF1 transcript NM_001658.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                         .         .                g.5023
                                      ccttacccggcgtgccccgcgcc       c.-121

 .         .         .         .         .         .                g.5083
 cggaggcgctgacgtggccgccgtcagagccgccatcttgtgggagcaaaaccaacgcct       c.-61

 .         .         .   | 02     .         .         .             g.19455
 ggctcggagcagcagcctctgag | gtgtccctggccagtgtccttccacctgtccacaagc    c.-1

          .         .         .         .         .         .       g.19515
 ATGGGGAACATCTTCGCCAACCTCTTCAAGGGCCTTTTTGGCAAAAAAGAAATGCGCATC       c.60
 M  G  N  I  F  A  N  L  F  K  G  L  F  G  K  K  E  M  R  I         p.20

          .         .         .         .         .         .       g.19575
 CTCATGGTGGGCCTGGATGCTGCAGGGAAGACCACGATCCTCTACAAGCTTAAGCTGGGT       c.120
 L  M  V  G  L  D  A  A  G  K  T  T  I  L  Y  K  L  K  L  G         p.40

          .         .         | 03         .         .         .    g.19714
 GAGATCGTGACCACCATTCCCACCATAG | GCTTCAACGTGGAAACCGTGGAGTACAAGAAC    c.180
 E  I  V  T  T  I  P  T  I  G |   F  N  V  E  T  V  E  Y  K  N      p.60

          .         .         .         .         .         .       g.19774
 ATCAGCTTCACTGTGTGGGACGTGGGTGGCCAGGACAAGATCCGGCCCCTGTGGCGCCAC       c.240
 I  S  F  T  V  W  D  V  G  G  Q  D  K  I  R  P  L  W  R  H         p.80

          .          | 04        .         .         .         .    g.19972
 TACTTCCAGAACACACAAG | GCCTGATCTTCGTGGTGGACAGCAATGACAGAGAGCGTGTG    c.300
 Y  F  Q  N  T  Q  G |   L  I  F  V  V  D  S  N  D  R  E  R  V      p.100

          .         .         .         .         .         .       g.20032
 AACGAGGCCCGTGAGGAGCTCATGAGGATGCTGGCCGAGGACGAGCTCCGGGATGCTGTC       c.360
 N  E  A  R  E  E  L  M  R  M  L  A  E  D  E  L  R  D  A  V         p.120

          .         .     | 05   .         .         .         .    g.20228
 CTCCTGGTGTTCGCCAACAAGCAG | GACCTCCCCAACGCCATGAATGCGGCCGAGATCACA    c.420
 L  L  V  F  A  N  K  Q   | D  L  P  N  A  M  N  A  A  E  I  T      p.140

          .         .         .         .         .         .       g.20288
 GACAAGCTGGGGCTGCACTCACTACGCCACAGGAACTGGTACATTCAGGCCACCTGCGCC       c.480
 D  K  L  G  L  H  S  L  R  H  R  N  W  Y  I  Q  A  T  C  A         p.160

          .         .         .         .         .         .       g.20348
 ACCAGCGGCGACGGGCTCTATGAAGGACTGGACTGGCTGTCCAATCAGCTCCGGAACCAG       c.540
 T  S  G  D  G  L  Y  E  G  L  D  W  L  S  N  Q  L  R  N  Q         p.180

                                                                    g.20354
 AAGTGA                                                             c.546
 K  X                                                               p.181

          .         .         .         .         .         .       g.20414
 acgcgacccccctccctctcactcctcttgccctctgctttactctcatgtggcaaacgt       c.*60

          .         .         .         .         .         .       g.20474
 gcggctcgtggtgtgagtgccagaagctgcctccgtggtttggtcaccgtgtgcatcgca       c.*120

          .         .         .         .         .         .       g.20534
 ccgtgctgtaaatgtggcagacgcagcctgcggccaggctttttatttaatgtaaatagt       c.*180

          .         .         .         .         .         .       g.20594
 ttttgtttccaatgaggcagtttctggtactcctatgcaatattactcagctttttttat       c.*240

          .         .         .         .         .         .       g.20654
 tgtaaaaagaaaaatcaactcactgttcagtgctgagaggggatgtaggcccatgggcac       c.*300

          .         .         .         .         .         .       g.20714
 ctggcctccaggagtcgctgtgttgggagagccggccacgcccttggctttagagctgtg       c.*360

          .         .         .         .         .         .       g.20774
 ttgaaatccattttggtggttggtttttaacccaaactcagtgcattttttaaaatagtt       c.*420

          .         .         .         .         .         .       g.20834
 aagaatccaagtcgagaacacttgaacacacagaagggagaccccgcctagcatagattt       c.*480

          .         .         .         .         .         .       g.20894
 gcagttacggcctggatgccagtcgccagcccagctgttcccctcgggaacatgaggtgg       c.*540

          .         .         .         .         .         .       g.20954
 tggtggcgcagcagactgcgatcaattctgcatggtcacagtagagatccccgcaactcg       c.*600

          .         .         .         .         .         .       g.21014
 cttgtccttgggtcaccctgcattccatagccatgtgcttgtccctgtgctcccacggtt       c.*660

          .         .         .         .         .         .       g.21074
 cccaggggccaggctgggagcccacagccaccccactatgccgcaggccgccctacccac       c.*720

          .         .         .         .         .         .       g.21134
 cttcaggcagcctatgggacgcagggccccatctgtccctcggtcgccgtgtggccagag       c.*780

          .         .         .         .         .         .       g.21194
 tgggtccgtcgtccccaacactcgtgctcgctcagacactttggcaggatgtctggggcc       c.*840

          .         .         .         .         .         .       g.21254
 tcaccagcaggagcgcgtgcaagccgggcaggcggtccacctagacccacagcccctcgg       c.*900

          .         .         .         .         .         .       g.21314
 gagcaccccacctctgtgtgtgatgtagctttctctccctcagcctgcaagggtccgatt       c.*960

          .         .         .         .         .         .       g.21374
 tgccatcgaaaaagacaacctctacttttttcttttgtattttgataaacactgaagctg       c.*1020

          .         .         .         .         .         .       g.21434
 gagctgttaaatttatcttggggaaacctcagaactggtctatttggtgtcgtggaacct       c.*1080

          .         .         .         .         .         .       g.21494
 cttactgctttcaatacacgattagtaatcaactgttttgtatacttgttttcagttttc       c.*1140

          .         .         .         .         .                 g.21553
 atttcgacaaacaagcactgtaattatagctattagaataaaatctcttaactatttca        c.*1199

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The ADP-ribosylation factor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.