Rho GTPase activating protein 6 (ARHGAP6) - coding DNA reference sequence

(used for variant description)

(last modified August 13, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_013427.2 in the ARHGAP6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012494.1, covering ARHGAP6 transcript NM_013427.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            ggctgggctgcgaatagcgtgttcctctccggc       c.-841

 .         .         .         .         .         .                g.5093
 ggaacacacacacccggccttggggctgtctcctgagctccctcctccacggagagcgct       c.-781

 .         .         .         .         .         .                g.5153
 gagcgccgccgggaattccatcccaccgtgggcacgcagtctttggaggtcccgggcgca       c.-721

 .         .         .         .         .         .                g.5213
 gcacgctcggtgtccccacactgcagcaagacagagaccccgcgggaaccttgagcttgg       c.-661

 .         .         .         .         .         .                g.5273
 aacaacccttgagcctctgcagtcggaagagtgggcgcagcagcccagcggaggccaggc       c.-601

 .         .         .         .         .         .                g.5333
 gcgcaacctcgggcgccggggcaaggagagagtgcagggaggcgcagctcaggcgcccgg       c.-541

 .         .         .         .         .         .                g.5393
 ctcaggagcgggaggaagttctcgcggcgccgggagcgcggtggacgcgccctgggcgca       c.-481

 .         .         .         .         .         .                g.5453
 cgcccaggcagccttctccctggccctcgggactgtcctcgggccgcaaggaggagcttg       c.-421

 .         .         .         .         .         .                g.5513
 ctggagtcttagaggccatccagagccagcgagcaggagcgctgcgtctcccgcctcagc       c.-361

 .         .         .         .         .         .                g.5573
 taggaagggggagtggcgctggcaggctggagctgggaacccagcgagcgcctgaccttc       c.-301

 .         .         .         .         .         .                g.5633
 ctcctcctcttcctgaccctcttcgcgtcttgggctccggaggaaggttctagcggctgc       c.-241

 .         .         .         .         .         .                g.5693
 aggaggtccccagacccattttcctagaaggctggtgatggatctgctgctcctgccgcc       c.-181

 .         .         .         .         .         .                g.5753
 gccggggcacttggagcgcaccggcggcgcgtgagctgggctttgctctccactgccctg       c.-121

 .         .         .         .         .         .                g.5813
 ggcaaaccccgggccagccccgcctggcacctttgcctgagtccctttcggttcccgacc       c.-61

 .         .         .         .         .         .                g.5873
 caaagccaccagcgtccagggagggaggaggaggtggtcctcaggtgcagccccgccgag       c.-1

          .         .         .         .         .         .       g.5933
 ATGTCCGCGCAGAGCCTGCTCCACAGCGTCTTCTCCTGTTCCTCGCCCGCTTCAAGTAGC       c.60
 M  S  A  Q  S  L  L  H  S  V  F  S  C  S  S  P  A  S  S  S         p.20

          .         .         .         .         .         .       g.5993
 GCGGCCTCGGCCAAGGGCTTCTCCAAGAGGAAGCTGCGCCAGACCCGCAGCCTGGACCCG       c.120
 A  A  S  A  K  G  F  S  K  R  K  L  R  Q  T  R  S  L  D  P         p.40

          .         .         .         .         .         .       g.6053
 GCCCTGATCGGCGGCTGCGGGAGCGACGAGGCGGGCGCGGAGGGCAGTGCGCGGGGAGCC       c.180
 A  L  I  G  G  C  G  S  D  E  A  G  A  E  G  S  A  R  G  A         p.60

          .         .         .         .         .         .       g.6113
 ACGGCGGGCCGCCTCTACTCCCCATCACTCCCAGCCGAGAGTCTCGGCCCTCGCTTGGCG       c.240
 T  A  G  R  L  Y  S  P  S  L  P  A  E  S  L  G  P  R  L  A         p.80

          .         .         .         .         .         .       g.6173
 TCCTCTTCCCGGGGTCCGCCCCCCAGGGCCACCAGGCTACCGCCTCCTGGACCTCTTTGC       c.300
 S  S  S  R  G  P  P  P  R  A  T  R  L  P  P  P  G  P  L  C         p.100

          .         .         .         .         .         .       g.6233
 TCGTCCTTCTCCACACCCAGCACCCCGCAGGAGAAGTCACCATCCGGCAGCTTTCACTTT       c.360
 S  S  F  S  T  P  S  T  P  Q  E  K  S  P  S  G  S  F  H  F         p.120

          .         .         .         .         .         .       g.6293
 GACTATGAGGTTCCCCTGGGTCGCGGCGGCCTCAAGAAGAGCATGGCCTGGGACCTGCCT       c.420
 D  Y  E  V  P  L  G  R  G  G  L  K  K  S  M  A  W  D  L  P         p.140

          .         .         .         .         .         .       g.6353
 TCTGTCCTGGCCGGGCCAGCCAGTAGCCGAAGCGCTTCCAGCATCCTCTGTTCATCCGGG       c.480
 S  V  L  A  G  P  A  S  S  R  S  A  S  S  I  L  C  S  S  G         p.160

          .         .         .         .         .         .       g.6413
 GGAGGCCCCAATGGCATCTTCGCTTCTCCTAGGAGGTGGCTCCAGCAGAGGAAGTTCCAG       c.540
 G  G  P  N  G  I  F  A  S  P  R  R  W  L  Q  Q  R  K  F  Q         p.180

          .         .         .         .         | 02         .    g.416006
 TCCCCACCCGACAGTCGCGGGCACCCCTACGTCGTGTGGAAATCCGAG | GGTGATTTCACC    c.600
 S  P  P  D  S  R  G  H  P  Y  V  V  W  K  S  E   | G  D  F  T      p.200

          .         .         .         .         .         .       g.416066
 TGGAACAGCATGTCAGGCCGCAGTGTACGGCTGAGGTCAGTCCCCATCCAGAGTCTCTCA       c.660
 W  N  S  M  S  G  R  S  V  R  L  R  S  V  P  I  Q  S  L  S         p.220

          .         .         .         .         .         .       g.416126
 GAGCTGGAGAGGGCCCGGCTGCAGGAAGTGGCTTTTTATCAGTTGCAACAGGACTGTGAC       c.720
 E  L  E  R  A  R  L  Q  E  V  A  F  Y  Q  L  Q  Q  D  C  D         p.240

          .         .         | 03         .         .         .    g.473737
 CTGAGCTGTCAGATCACCATTCCCAAAG | ATGGACAAAAGAGAAAGAAATCTTTAAGAAAG    c.780
 L  S  C  Q  I  T  I  P  K  D |   G  Q  K  R  K  K  S  L  R  K      p.260

          .         .         .         . | 04       .         .    g.481737
 AAACTGGATTCACTAGGAAAGGAGAAAAACAAAGACAAAG | AATTCATCCCACAGGCATTT    c.840
 K  L  D  S  L  G  K  E  K  N  K  D  K  E |   F  I  P  Q  A  F      p.280

          .         .         .         .         .         .       g.481797
 GGAATGCCCTTATCCCAAGTCATTGCGAATGACAGGGCCTATAAACTCAAGCAGGACTTG       c.900
 G  M  P  L  S  Q  V  I  A  N  D  R  A  Y  K  L  K  Q  D  L         p.300

          .         .         .         .         .         .       g.481857
 CAGAGGGACGAGCAGAAAGATGCATCTGACTTTGTGGCTTCCCTCCTCCCATTTGGAAAT       c.960
 Q  R  D  E  Q  K  D  A  S  D  F  V  A  S  L  L  P  F  G  N         p.320

          .         .         .         .         .         .       g.481917
 AAAAGACAAAACAAAGAACTCTCAAGCAGTAACTCATCTCTCAGCTCAACCTCAGAAACA       c.1020
 K  R  Q  N  K  E  L  S  S  S  N  S  S  L  S  S  T  S  E  T         p.340

          .         .         .         .         .        | 05.    g.484273
 CCGAATGAGTCAACGTCCCCAAACACCCCGGAACCGGCTCCTCGGGCTAGGAGGAGG | GGT    c.1080
 P  N  E  S  T  S  P  N  T  P  E  P  A  P  R  A  R  R  R   | G      p.360

          .         .         .         .         .         .       g.484333
 GCCATGTCAGTGGATTCTATCACCGATCTTGATGACAATCAGTCTCGACTACTAGAAGCT       c.1140
 A  M  S  V  D  S  I  T  D  L  D  D  N  Q  S  R  L  L  E  A         p.380

          .         .         .         .         .         .       g.484393
 TTACAACTTTCCTTGCCTGCTGAGGCTCAAAGTAAAAAGGAAAAAGCCAGAGATAAGAAA       c.1200
 L  Q  L  S  L  P  A  E  A  Q  S  K  K  E  K  A  R  D  K  K         p.400

          .         .         .         .         .         .       g.484453
 CTCAGTCTGAATCCTATTTACAGACAGGTCCCTAGGCTGGTGGACAGCTGCTGTCAGCAC       c.1260
 L  S  L  N  P  I  Y  R  Q  V  P  R  L  V  D  S  C  C  Q  H         p.420

          .    | 06    .         .         .         .         .    g.488630
 CTAGAAAAACATG | GCCTCCAGACAGTGGGGATATTCCGAGTTGGAAGCTCAAAAAAGAGA    c.1320
 L  E  K  H  G |   L  Q  T  V  G  I  F  R  V  G  S  S  K  K  R      p.440

           | 07        .         .         .         .         .    g.491300
 GTGAGACAA | TTACGTGAGGAATTTGACCGTGGGATTGATGTCTCTCTGGAGGAGGAGCAC    c.1380
 V  R  Q   | L  R  E  E  F  D  R  G  I  D  V  S  L  E  E  E  H      p.460

          .         .         .         .         .         .       g.491360
 AGTGTTCATGATGTGGCAGCCTTGCTGAAAGAGTTCCTGAGGGACATGCCAGACCCCCTT       c.1440
 S  V  H  D  V  A  A  L  L  K  E  F  L  R  D  M  P  D  P  L         p.480

          .         .         .         . | 08       .         .    g.492473
 CTCACCAGGGAGCTGTACACAGCTTTCATCAACACTCTCT | TGTTGGAGCCGGAGGAACAG    c.1500
 L  T  R  E  L  Y  T  A  F  I  N  T  L  L |   L  E  P  E  E  Q      p.500

          .         .         .         .         .         .       g.492533
 CTGGGCACCTTGCAGCTCCTCATATACCTTCTACCTCCCTGCAACTGCGACACCCTCCAC       c.1560
 L  G  T  L  Q  L  L  I  Y  L  L  P  P  C  N  C  D  T  L  H         p.520

          .         .         .         .         .         .       g.492593
 CGCCTGCTACAGTTCCTCTCCATCGTGGCCAGGCATGCCGATGACAACATCAGCAAAGAT       c.1620
 R  L  L  Q  F  L  S  I  V  A  R  H  A  D  D  N  I  S  K  D         p.540

           | 09        .         .         .         .         .    g.501068
 GGGCAAGAG | GTCACTGGGAATAAAATGACATCTCTAAACTTAGCCACCATATTTGGACCC    c.1680
 G  Q  E   | V  T  G  N  K  M  T  S  L  N  L  A  T  I  F  G  P      p.560

          .         .         .         .         .         .       g.501128
 AACCTGCTGCACAAGCAGAAGTCATCAGACAAAGAATTCTCAGTTCAGAGTTCAGCCCGG       c.1740
 N  L  L  H  K  Q  K  S  S  D  K  E  F  S  V  Q  S  S  A  R         p.580

          .         .         .         .         .         .       g.501188
 GCTGAGGAGAGCACGGCCATCATCGCTGTTGTGCAAAAGATGATTGAAAATTATGAAGCC       c.1800
 A  E  E  S  T  A  I  I  A  V  V  Q  K  M  I  E  N  Y  E  A         p.600

           | 10        .         .         .         .         .    g.514126
 CTGTTCATG | GTTCCCCCAGATCTCCAGAACGAAGTGCTGATCAGCCTGTTAGAGACCGAT    c.1860
 L  F  M   | V  P  P  D  L  Q  N  E  V  L  I  S  L  L  E  T  D      p.620

          .         .         .         .        | 11.         .    g.526466
 CCTGATGTCGTGGACTATTTACTCAGAAGAAAGGCTTCCCAATCATC | AAGCCCTGACATG    c.1920
 P  D  V  V  D  Y  L  L  R  R  K  A  S  Q  S  S  |  S  P  D  M      p.640

          .         .         .         .         .         .       g.526526
 CTGCAGTCGGAAGTTTCCTTTTCCGTGGGAGGGAGGCATTCATCTACAGACTCCAACAAG       c.1980
 L  Q  S  E  V  S  F  S  V  G  G  R  H  S  S  T  D  S  N  K         p.660

          .         .         .         .         .         .       g.526586
 GCCTCCAGCGGAGACATCTCCCCTTATGACAACAACTCCCCAGTGCTGTCTGAGCGCTCC       c.2040
 A  S  S  G  D  I  S  P  Y  D  N  N  S  P  V  L  S  E  R  S         p.680

          .         .         .         .         .         .       g.526646
 CTGCTGGCTATGCAAGAGGACGCGGCCCCGGGGGGCTCGGAGAAGCTTTACAGAGTGCCA       c.2100
 L  L  A  M  Q  E  D  A  A  P  G  G  S  E  K  L  Y  R  V  P         p.700

          .         .         .         .         .         .       g.526706
 GGGCAGTTTATGCTGGTGGGCCACTTGTCGTCGTCAAAGTCAAGGGAAAGTTCTCCTGGA       c.2160
 G  Q  F  M  L  V  G  H  L  S  S  S  K  S  R  E  S  S  P  G         p.720

          .       | 12 .         .         .         .         .    g.528432
 CCAAGGCTTGGGAAAG | ATCTGTCAGAGGAGCCTTTCGATATCTGGGGAACTTGGCATTCA    c.2220
 P  R  L  G  K  D |   L  S  E  E  P  F  D  I  W  G  T  W  H  S      p.740

          .         .         .        | 13.         .         .    g.531194
 ACATTAAAAAGCGGATCCAAAGACCCAGGAATGACAG | GTTCCTCTGGAGACATTTTTGAA    c.2280
 T  L  K  S  G  S  K  D  P  G  M  T  G |   S  S  G  D  I  F  E      p.760

          .         .         .         .         .         .       g.531254
 AGCAGCTCCCTAAGAGCGGGGCCCTGCTCCCTTTCTCAAGGGAACCTGTCCCCAAATTGG       c.2340
 S  S  S  L  R  A  G  P  C  S  L  S  Q  G  N  L  S  P  N  W         p.780

          .         .         .         .         .         .       g.531314
 CCTCGGTGGCAGGGGAGCCCCGCAGAGCTGGACAGCGACACGCAGGGGGCTCGGAGGACT       c.2400
 P  R  W  Q  G  S  P  A  E  L  D  S  D  T  Q  G  A  R  R  T         p.800

          .         .         .         .         .         .       g.531374
 CAGGCCGCAGCCCCCGCGACGGAGGGCAGGGCCCACCCTGCGGTGTCGCGCGCCTGCAGC       c.2460
 Q  A  A  A  P  A  T  E  G  R  A  H  P  A  V  S  R  A  C  S         p.820

          .         .         .         .         .         .       g.531434
 ACGCCCCACGTCCAGGTGGCAGGGAAAGCCGAGCGGCCCACGGCCAGGTCGGAGCAGTAC       c.2520
 T  P  H  V  Q  V  A  G  K  A  E  R  P  T  A  R  S  E  Q  Y         p.840

          .         .         .         .         .         .       g.531494
 TTGACCCTGAGCGGCGCCCACGACCTCAGCGAGAGTGAGCTGGATGTGGCCGGGCTGCAG       c.2580
 L  T  L  S  G  A  H  D  L  S  E  S  E  L  D  V  A  G  L  Q         p.860

          .         .         .         .         .         .       g.531554
 AGCCGGGCCACACCTCAGTGCCAAAGACCCCATGGGAGTGGGAGGGATGACAAGCGGCCC       c.2640
 S  R  A  T  P  Q  C  Q  R  P  H  G  S  G  R  D  D  K  R  P         p.880

          .         .         .         .         .         .       g.531614
 CCGCCTCCATACCCGGGCCCAGGGAAGCCCGCGGCAGCGGCAGCCTGGATCCAGGGGCCC       c.2700
 P  P  P  Y  P  G  P  G  K  P  A  A  A  A  A  W  I  Q  G  P         p.900

          .         .         .         .         .         .       g.531674
 CCGGAAGGCGTGGAGACACCCACGGACCAGGGAGGCCAAGCAGCCGAGCGAGAGCAGCAG       c.2760
 P  E  G  V  E  T  P  T  D  Q  G  G  Q  A  A  E  R  E  Q  Q         p.920

          .         .         .         .         .         .       g.531734
 GTCACGCAGAAAAAACTGAGCAGCGCCAACTCCCTGCCAGCGGGCGAGCAGGACAGTCCG       c.2820
 V  T  Q  K  K  L  S  S  A  N  S  L  P  A  G  E  Q  D  S  P         p.940

          .         .         .         .         .         .       g.531794
 CGCCTGGGGGACGCTGGCTGGCTCGACTGGCAGAGAGAGCGCTGGCAGATCTGGGAGCTC       c.2880
 R  L  G  D  A  G  W  L  D  W  Q  R  E  R  W  Q  I  W  E  L         p.960

          .         .         .         .                           g.531839
 CTGTCGACCGACAACCCCGATGCCCTGCCCGAGACGCTGGTCTGA                      c.2925
 L  S  T  D  N  P  D  A  L  P  E  T  L  V  X                        p.974

          .         .         .         .         .         .       g.531899
 gcccgcacccagccgagccccccctgccccgagccccccgccctccagcccaggggggac       c.*60

          .         .         .         .         .         .       g.531959
 cgtgggtggtggccactggcacacttagtgttcttctttcacacttctcaaaagtgacac       c.*120

          .         .         .         .         .         .       g.532019
 aagagaaatccagttcacctacagaggtagagcactcacgcccccgccattgagaataag       c.*180

          .         .         .         .         .         .       g.532079
 gttccattgcgtagccagccttaggaaaaacaaacagaacccaaaccagatggcaatgtc       c.*240

          .         .         .         .         .         .       g.532139
 caatctaaaaacgtccctcttggctctataatataagatacaactcttgcttggtatagc       c.*300

          .         .         .         .         .         .       g.532199
 ctaaccgtatttatgtgtcttcggttttgactattgtgtattctgtaacagattatgtat       c.*360

          .         .         .         .         .         .       g.532259
 aatcatatatgatatattcacaaagagaaaacaaaaggaacttttaaaaaaaaaatcact       c.*420

          .         .         .         .         .         .       g.532319
 tcacttatattaagcaatgagatatactaaacaatgagattctatagaatgttctagaat       c.*480

          .         .         .         .         .         .       g.532379
 gtgcacaagcgggtttctgtgcttttgccatagctttataactggggataacccttcctt       c.*540

          .         .         .         .         .         .       g.532439
 cgataccaaacactaacaagaggaagcagaatatgagaagccatatttttacataggagt       c.*600

          .         .         .         .         .         .       g.532499
 cagatacaaaaagaaaaatcactgaatgcttttagatattgaatacgttttcaggaaaat       c.*660

          .         .         .         .         .         .       g.532559
 gctaaatctgatagattacgaaatatatttttagaacttgtttagaaaggattcagttaa       c.*720

          .         .         .         .         .         .       g.532619
 ccaaacaagaaaaaggcagtgcctcacaaagaaattaagaagttgtccgtcccacgttac       c.*780

          .         .         .         .         .         .       g.532679
 atcaaattcagttttatataggccatatataatatatatttataatgtataatttttatg       c.*840

          .         .         .         .         .         .       g.532739
 tatttttcaaaactacaaactggaatccaactataaagtgtttaagaatctacacagaat       c.*900

          .         .         .         .         .         .       g.532799
 attcaaattatagaacatgttttttccctttgccccataatcagtatttgccaaattaca       c.*960

          .         .         .         .         .         .       g.532859
 tgcaattccttaaaaactaaatcacatttggtaaaaggcctacagctttgtacttacatt       c.*1020

          .         .         .         .         .         .       g.532919
 gtgccaaaggctgaggaaatgttttctttcgtaattttatgtgtattgtaaaatgttcta       c.*1080

          .         .         .         .         .         .       g.532979
 ccgtactttagtagtttgaagtttttcaagtgcataactatttttgaccagcagatggcg       c.*1140

          .         .         .         .         .         .       g.533039
 atacgcttcagtattttatgcaattttttttcacttctgaagggaaagtgtattataaaa       c.*1200

          .         .         .         .         .         .       g.533099
 aaagattttttttttttttataaaacatgctactcttaattttcatgttggtgatgaaat       c.*1260

          .         .         .         .         .         .       g.533159
 tcccagtggtgtttcttaaggttctatcttgtgccatgatgaataaaaagttaagcaaag       c.*1320

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Rho GTPase activating protein 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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