Rho/Rac guanine nucleotide exchange factor (GEF) 18 (ARHGEF18) - coding DNA reference sequence

(used for variant description)

(last modified April 17, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_015318.3 in the ARHGEF18 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_047135.1, covering ARHGEF18 transcript NM_015318.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5026
                                   ctcgcgcggcttcccgcttccggctc       c.-181

 .         .         .         .         .         .                g.5086
 ccagctgctagctactgtggatctgggggggccggacggaggcatcggaggcggctgcga       c.-121

 .         .         .         .         .         | 02             g.50242
 gagtggcagaggagctggcggagagcggcctgcgggcgatcgggccgag | cctcgctcaag    c.-61

 .         .         .         .         .         .                g.50302
 gagcacccccggggcaccctcctgtccgatggcagcccggccctgtccaggaatgtcggt       c.-1

          .         .         .         .         .         .       g.50362
 ATGACGGTCTCTCAGAAAGGGGGTCCCCAGCCAACACCGAGCCCGGCTGGCCCTGGGACG       c.60
 M  T  V  S  Q  K  G  G  P  Q  P  T  P  S  P  A  G  P  G  T         p.20

          | 03         .         .         .         .         .    g.51592
 CAACTCGG | ACCAATCACAGGAGAGATGGATGAAGCCGATTCTGCGTTTTTAAAATTTAAG    c.120
 Q  L  G  |  P  I  T  G  E  M  D  E  A  D  S  A  F  L  K  F  K      p.40

          .         .         .         .         .         .       g.51652
 CAGACAGCTGATGACTCTCTGTCCCTTACATCTCCAAACACCGAGTCCATTTTTGTAGAA       c.180
 Q  T  A  D  D  S  L  S  L  T  S  P  N  T  E  S  I  F  V  E         p.60

   | 04      .         .         .         .         .         .    g.51858
 G | ATCCCTACACCGCCTCGCTGAGGAGTGAGATTGAGTCAGACGGCCACGAGTTTGAAGCT    c.240
 D |   P  Y  T  A  S  L  R  S  E  I  E  S  D  G  H  E  F  E  A      p.80

          .         .         .         .         .         .       g.51918
 GAGTCCTGGAGCCTCGCCGTGGATGCAGCCTACGCCAAGAAGCAAAAGAGGGAGGTGGTG       c.300
 E  S  W  S  L  A  V  D  A  A  Y  A  K  K  Q  K  R  E  V  V         p.100

          .         .   | 05     .         .         .         .    g.54129
 AAAAGACAAGATGTCCTTTATG | AGCTGATGCAGACAGAGGTGCACCACGTGCGGACGCTC    c.360
 K  R  Q  D  V  L  Y  E |   L  M  Q  T  E  V  H  H  V  R  T  L      p.120

          .         .         .         .         .         .       g.54189
 AAGATCATGCTGAAGGTGTACTCCAGGGCCCTGCAGGAGGAGCTGCAGTTCAGCAGCAAG       c.420
 K  I  M  L  K  V  Y  S  R  A  L  Q  E  E  L  Q  F  S  S  K         p.140

          .         .         .         .         .         .       g.54249
 GCCATTGGCCGCCTCTTCCCATGCGCTGACGACCTGCTGGAGACGCACAGCCACTTCCTC       c.480
 A  I  G  R  L  F  P  C  A  D  D  L  L  E  T  H  S  H  F  L         p.160

          .         .         .         .         .         .       g.54309
 GCTCGGCTCAAGGAGCGCCGCCAGGAGTCCCTGGAGGAGGGCAGTGACCGGAATTATGTC       c.540
 A  R  L  K  E  R  R  Q  E  S  L  E  E  G  S  D  R  N  Y  V         p.180

          .         .         .    | 06    .         .         .    g.56957
 ATCCAGAAAATCGGCGACCTCCTGGTTCAGCAG | TTTTCAGGTGAAAATGGGGAGAGAATG    c.600
 I  Q  K  I  G  D  L  L  V  Q  Q   | F  S  G  E  N  G  E  R  M      p.200

          .         .         .         .         .         .       g.57017
 AAAGAAAAGTACGGTGTGTTTTGTAGTGGCCACAATGAAGCTGTTAGTCATTACAAGTTG       c.660
 K  E  K  Y  G  V  F  C  S  G  H  N  E  A  V  S  H  Y  K  L         p.220

          .         .         .          | 07        .         .    g.61057
 CTGCTTCAGCAAAACAAGAAATTTCAAAACTTGATCAAG | AAAATTGGCAACTTCTCCATC    c.720
 L  L  Q  Q  N  K  K  F  Q  N  L  I  K   | K  I  G  N  F  S  I      p.240

          .         .         .         .         .         .       g.61117
 GTGCGGCGGCTTGGCGTGCAGGAGTGCATTCTCCTGGTTACACAACGCATAACCAAATAC       c.780
 V  R  R  L  G  V  Q  E  C  I  L  L  V  T  Q  R  I  T  K  Y         p.260

          .         .         .        | 08.         .         .    g.63377
 CCAGTGCTGGTGGAGCGCATCATCCAGAACACGGAAG | CTGGCACTGAGGACTATGAAGAC    c.840
 P  V  L  V  E  R  I  I  Q  N  T  E  A |   G  T  E  D  Y  E  D      p.280

          .         .         .         .         .         .       g.63437
 CTGACCCAGGCCTTGAACCTCATCAAAGATATCATCTCACAAGTGGACGCCAAGGTCAGT       c.900
 L  T  Q  A  L  N  L  I  K  D  I  I  S  Q  V  D  A  K  V  S         p.300

          .         .         .         .         .         .       g.63497
 GAGTGTGAGAAGGGCCAGCGCCTCAGGGAGATCGCAGGGAAGATGGACCTGAAGTCTTCC       c.960
 E  C  E  K  G  Q  R  L  R  E  I  A  G  K  M  D  L  K  S  S         p.320

          .         .         .         .         .         .       g.63557
 AGCAAACTCAAGAACGGGCTCACCTTCCGCAAGGAAGACATGCTTCAGCGGCAGCTCCAC       c.1020
 S  K  L  K  N  G  L  T  F  R  K  E  D  M  L  Q  R  Q  L  H         p.340

          .         .         .         .       | 09 .         .    g.66228
 CTGGAGGGCATGCTATGCTGGAAGACCACATCAGGGCGCTTGAAAG | ATATCCTGGCTATC    c.1080
 L  E  G  M  L  C  W  K  T  T  S  G  R  L  K  D |   I  L  A  I      p.360

          .         .         .         .         .         .       g.66288
 CTGCTGACCGACGTACTTTTGCTGCTACAAGAAAAAGATCAGAAATACGTCTTTGCTTCT       c.1140
 L  L  T  D  V  L  L  L  L  Q  E  K  D  Q  K  Y  V  F  A  S         p.380

     | 10    .         .         .         .         .         .    g.68456
 GTG | GACTCAAAGCCACCCGTCATCTCGTTACAAAAGCTCATCGTGAGGGAAGTGGCCAAC    c.1200
 V   | D  S  K  P  P  V  I  S  L  Q  K  L  I  V  R  E  V  A  N      p.400

          .         .         .         .         .         .       g.68516
 GAGGAGAAAGCGATGTTTCTGATCAGCGCCTCCTTGCAAGGGCCGGAGATGTATGAAATC       c.1260
 E  E  K  A  M  F  L  I  S  A  S  L  Q  G  P  E  M  Y  E  I         p.420

          .         .         .         .         .         .       g.68576
 TACACGAGCTCCAAAGAGGACAGGAACGCCTGGATGGCCCACATCCAAAGGGCTGTGGAG       c.1320
 Y  T  S  S  K  E  D  R  N  A  W  M  A  H  I  Q  R  A  V  E         p.440

    | 11     .         .         .         .         .         .    g.69848
 AG | CTGCCCTGACGAGGAGGAGGGGCCCTTCAGCCTGCCCGAAGAGGAAAGGAAGGTGGTC    c.1380
 S  |  C  P  D  E  E  E  G  P  F  S  L  P  E  E  E  R  K  V  V      p.460

          .         .         .     | 12   .         .         .    g.72065
 GAGGCCCGCGCCACGAGACTCCGGGACTTTCAAG | AGCGGTTGAGCATGAAAGACCAGCTG    c.1440
 E  A  R  A  T  R  L  R  D  F  Q  E |   R  L  S  M  K  D  Q  L      p.480

          .         .         .         .         .         .       g.72125
 ATCGCACAGAGCCTCCTAGAGAAACAGCAGATCTACCTGGAGATGGCCGAGATGGGCGGC       c.1500
 I  A  Q  S  L  L  E  K  Q  Q  I  Y  L  E  M  A  E  M  G  G         p.500

          .         .         .         .         .         .       g.72185
 CTCGAAGACCTGCCCCAGCCCCGAGGCCTATTCCGTGGAGGGGACCCATCCGAGACCCTG       c.1560
 L  E  D  L  P  Q  P  R  G  L  F  R  G  G  D  P  S  E  T  L         p.520

          .         .         .        | 13.         .         .    g.73728
 CAGGGGGAGCTAATTCTCAAGTCGGCCATGAGCGAGA | TCGAGGGCATCCAGAGCCTGATC    c.1620
 Q  G  E  L  I  L  K  S  A  M  S  E  I |   E  G  I  Q  S  L  I      p.540

          .         .         .         .         .         .       g.73788
 TGCAGGCAGCTGGGCAGCGCCAACGGCCAGGCGGAAGACGGAGGCAGCTCCACAGGCCCG       c.1680
 C  R  Q  L  G  S  A  N  G  Q  A  E  D  G  G  S  S  T  G  P         p.560

          .         .         .         .         .      | 14  .    g.74452
 CCCAGGAGGGCTGAGACCTTCGCGGGCTACGACTGCACAAACAGCCCCACCAAGA | ATGGC    c.1740
 P  R  R  A  E  T  F  A  G  Y  D  C  T  N  S  P  T  K  N |   G      p.580

          .         .         .         .         .         .       g.74512
 AGTTTCAAGAAGAAAGTCAGCAGCACTGACCCCAGGCCCCGAGACTGGCGAGGCCCCCCA       c.1800
 S  F  K  K  K  V  S  S  T  D  P  R  P  R  D  W  R  G  P  P         p.600

          .         .         .         .         .         .       g.74572
 AACAGCCCGGACTTGAAGCTCAGTGACAGTGACATTCCTGGGAGCTCTGAGGAATCGCCG       c.1860
 N  S  P  D  L  K  L  S  D  S  D  I  P  G  S  S  E  E  S  P         p.620

        | 15 .         .         .         .         .         .    g.76859
 CAGGTG | GTGGAGGCGCCAGGCACGGAATCCGATCCCCGTCTGCCCACCGTCCTGGAGTCG    c.1920
 Q  V   | V  E  A  P  G  T  E  S  D  P  R  L  P  T  V  L  E  S      p.640

     | 16    .         .         .         .         .  | 17      . g.77110
 GAG | CTTGTCCAGCGGATCCAGACACTGTCCCAGCTGCTCCTGAACCTTCAG | GCGGTAATC c.1980
 E   | L  V  Q  R  I  Q  T  L  S  Q  L  L  L  N  L  Q   | A  V  I   p.660

          .         .         .         .         .         .       g.77170
 GCCCACCAGGACAGCTATGTGGAGACGCAGCGGGCTGCCATCCAGGAGCGGGAGAAGCAG       c.2040
 A  H  Q  D  S  Y  V  E  T  Q  R  A  A  I  Q  E  R  E  K  Q         p.680

          .         .         .         .         .         .       g.77230
 TTCCGGCTGCAGTCGACGCGTGGGAACCTGCTGCTGGAGCAGGAGCGGCAACGCAACTTC       c.2100
 F  R  L  Q  S  T  R  G  N  L  L  L  E  Q  E  R  Q  R  N  F         p.700

          .         .         .         .         .         .       g.77290
 GAGAAGCAGCGGGAGGAGCGCGCGGCCCTGGAGAAGCTGCAGAGCCAGCTGCGGCACGAG       c.2160
 E  K  Q  R  E  E  R  A  A  L  E  K  L  Q  S  Q  L  R  H  E         p.720

          .         .         .         .         .         .       g.77350
 CAGCAGCGCTGGGAGCGCGAGCGCCAGTGGCAGCACCAGGAGCTGGAGCGTGCGGGCGCG       c.2220
 Q  Q  R  W  E  R  E  R  Q  W  Q  H  Q  E  L  E  R  A  G  A         p.740

          .         .         .         .         .         .       g.77410
 CGGCTGCAGGAGCGCGAGGGCGAGGCGCGGCAGCTACGCGAGCGGCTGGAGCAGGAGCGG       c.2280
 R  L  Q  E  R  E  G  E  A  R  Q  L  R  E  R  L  E  Q  E  R         p.760

          .         .         .         .         .         .       g.77470
 GCCGAGCTGGAGCGCCAGCGCCAGGCCTACCAGCACGACCTGGAGCGGCTGCGCGAGGCC       c.2340
 A  E  L  E  R  Q  R  Q  A  Y  Q  H  D  L  E  R  L  R  E  A         p.780

          .         .         .         .         .         .       g.77530
 CAGCGTGCCGTGGAGCGCGAGCGGGAGCGCCTGGAGCTGCTGCGCCGCCTCAAGAAGCAG       c.2400
 Q  R  A  V  E  R  E  R  E  R  L  E  L  L  R  R  L  K  K  Q         p.800

          .         .         .         .   | 18     .         .    g.78730
 AACACCGCGCCAGGCGCGCTGCCGCCCGACACACTGGCCGAG | GCCCAGCCCCCAAGCCAC    c.2460
 N  T  A  P  G  A  L  P  P  D  T  L  A  E   | A  Q  P  P  S  H      p.820

          .         .         .         .         .         .       g.78790
 CCTCCCAGCTTCAACGGGGAAGGGCTGGAGGGCCCTCGTGTGAGCATGCTGCCATCCGGC       c.2520
 P  P  S  F  N  G  E  G  L  E  G  P  R  V  S  M  L  P  S  G         p.840

          .         .         .         .         .         .       g.78850
 GTGGGGCCAGAGTACGCAGAGCGCCCCGAGGTGGCTCGCCGGGACAGCGCCCCCACCGAG       c.2580
 V  G  P  E  Y  A  E  R  P  E  V  A  R  R  D  S  A  P  T  E         p.860

          .         .         .         .         .         .       g.78910
 AACCGGCTGGCCAAGAGCGATGTGCCCATCCAGCTGCTCAGCGCCACCAACCAGTTCCAG       c.2640
 N  R  L  A  K  S  D  V  P  I  Q  L  L  S  A  T  N  Q  F  Q         p.880

          .         .         .         .         .         .       g.78970
 AGGCAGGCGGCCGTGCAGCAGCAGATCCCCACCAAGCTGGCGGCCTCCACCAAGGGTGGC       c.2700
 R  Q  A  A  V  Q  Q  Q  I  P  T  K  L  A  A  S  T  K  G  G         p.900

          .         .         .         .          | 19        .    g.79802
 AAGGACAAGGGCGGCAAGAGCAGGGGCTCTCAGCGCTGGGAGAGCTCAG | CGTCCTTCGAC    c.2760
 K  D  K  G  G  K  S  R  G  S  Q  R  W  E  S  S  A |   S  F  D      p.920

          .         .         .         .         .         .       g.79862
 CTGAAGCAGCAGCTGCTGCTCAACAAGCTCATGGGGAAAGATGAGAGCACCTCACGGAAC       c.2820
 L  K  Q  Q  L  L  L  N  K  L  M  G  K  D  E  S  T  S  R  N         p.940

          .         .         .         .         .      | 20  .    g.80018
 CGCCGCTCGCTGAGCCCTATCCTGCCCGGCAGACACAGTCCTGCGCCCCCACCAG | ACCCT    c.2880
 R  R  S  L  S  P  I  L  P  G  R  H  S  P  A  P  P  P  D |   P      p.960

          .         .         .         .         .         .       g.80078
 GGCTTCCCCGCCCCGAGCCCACCGCCAGCTGACAGCCCCTCCGAGGGCTTCTCTCTCAAG       c.2940
 G  F  P  A  P  S  P  P  P  A  D  S  P  S  E  G  F  S  L  K         p.980

          .         .         .         .         .         .       g.80138
 GCCGGGGGCACAGCCCTCCTGCCCGGGCCCCCAGCTCCCTCGCCACTGCCGGCCACACCA       c.3000
 A  G  G  T  A  L  L  P  G  P  P  A  P  S  P  L  P  A  T  P         p.1000

          .         .         .         .                           g.80186
 CTCAGCGCCAAGGAGGACGCCAGCAAAGAAGACGTCATCTTCTTCTAA                   c.3048
 L  S  A  K  E  D  A  S  K  E  D  V  I  F  F  X                     p.1015

          .        | 21.         .         .         .         .    g.80467
 aagggccgtgactcaag | gaaagtttttaatggaaagttgagccagaactaaaccagggag    c.*60

          .         .         .         .         .         .       g.80527
 ctgtctgaaatcatagcaccccatccgggtggcggggagatcaactccgagctgtttttc       c.*120

          .         .         .         .         .         .       g.80587
 cgaggcagtgaggaacggtgccggctctgcacggagctgaggacaggacagaccttgctt       c.*180

          .         .         .         .         .         .       g.80647
 tgagaaggagctgccggccggggccacgctccacagccgccgcgcgacagtggagccaag       c.*240

          .         .         .         .         .         .       g.80707
 ggttagggcaccaggaggggccaggtggcgtcggcagcatctgtccccagaatcaggcag       c.*300

          .         .         .         .         .         .       g.80767
 aatccacttcccaaacagagccccacgcaggttcaccatgaacctcagggtcagggaatg       c.*360

          .         .         .         .         .         .       g.80827
 agccaggcacgggggcatgggcagagagggccacggggcagggcccactgagggaacatc       c.*420

          .         .         .         .         .         .       g.80887
 agtggccctccagtcaggttctgtgggtttggaagcccatcgtgaaaggggctgaccttt       c.*480

          .         .         .         .         .         .       g.80947
 gcccctttttacttggcattggttttgaaaccagctgtttcccaaactctgcttcccaag       c.*540

          .         .         .         .         .         .       g.81007
 ggcaaccgttgctgttcacacgctcagcctgtctgggggagcgggcctctagcttcagcc       c.*600

          .         .         .         .         .         .       g.81067
 agggcgggtacacaccctgggcacagggtcctcagcccccgggaaatgagctcccagggc       c.*660

          .         .         .         .         .         .       g.81127
 tggcgtcccaccttccaggtgggggctggcacatcacagactgtcgagagcgccatgtcc       c.*720

          .         .         .         .         .         .       g.81187
 cagggcatgcagaggatgcacctagagacgttgcagcaagtggacaagtggccgctgtgc       c.*780

          .         .         .         .         .         .       g.81247
 gggcccctcgcttgtagtgagctgttgcagcttacggtccgttccctggaggggtggagg       c.*840

          .         .         .         .         .         .       g.81307
 aaggaggtgttgggcagcatcaaaggtgctgggacatcccagggtggtgagatccatcca       c.*900

          .         .         .         .         .         .       g.81367
 cgatccagctccggtggagaaagggcccatgtcaagccttgttctgcaccccaagcattg       c.*960

          .         .         .         .         .         .       g.81427
 gtggtaggactgggtcctggctgatcgtccttgttcccagtggggtacatgtgagcccct       c.*1020

          .         .         .         .         .         .       g.81487
 gccagggccaagtccttctcccgaacccagggtcctgggaactgcagatcccggggggat       c.*1080

          .         .         .         .         .         .       g.81547
 tcagcccttctcccactgtgctggcagaggcactcctgtgacgctgaatacagtgaacag       c.*1140

          .         .         .         .         .         .       g.81607
 ggacattcccgccactcggggacagatgggcacaagggaggggaaactccatcaggaagt       c.*1200

          .         .         .         .         .         .       g.81667
 gctcccctgggcagaggcgcccactgggtgctgtgggctcaggagggggcggggcaggag       c.*1260

          .         .         .         .         .         .       g.81727
 ctggtgccaaccgggaaccagagccccacagccatacagcccattggtgacaaggtcctg       c.*1320

          .         .         .         .         .         .       g.81787
 agaacacagtggccaggtgtccccaggctcctggcccctccgacgacctcaactctgccc       c.*1380

          .         .         .         .         .         .       g.81847
 agcccggtccctggccatcagcgacgctgtccgccccccgtcagatcccatgtgtgccat       c.*1440

          .         .         .         .         .         .       g.81907
 gtttatcatcagtgttttgtatttttgtactgagtatcggagcactttacagaagctgac       c.*1500

          .         .         .         .         .         .       g.81967
 tgtacattcctgttctgttgtgaagagaacattcccagaccctggcaccctcctgagccg       c.*1560

          .         .         .         .         .         .       g.82027
 gcgtgtgccggtccagccctccgagatgccacaattccttggatgggggagaagttcaag       c.*1620

          .         .         .         .         .         .       g.82087
 gaatttctgctcggccacgcggtgggaaccccgcgtccccgccatgtggcagaggggtct       c.*1680

          .         .         .         .         .         .       g.82147
 cagtcgtgctaggcatcgggcggcagcgccgacagcccttccctcgccagtgcccctcgg       c.*1740

          .         .         .         .         .         .       g.82207
 ccactcctgggttggagcccgattttatttgtaaagttgacagtcgagcaaatgttccta       c.*1800

          .         .         .         .         .         .       g.82267
 ttttcgtgggatctgcacacgtctttgtcagttgtggtcatgatcttagtcacctgctaa       c.*1860

          .         .         .         .         .         .       g.82327
 ttatttttacaatgattacaacatttcctcactgcgggatatttctgacccgctttagaa       c.*1920

          .         .         .         .                           g.82373
 cttaagacctgattctagcaataaacgtgtccgagatgagcggtga                     c.*1966

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Rho/Rac guanine nucleotide exchange factor (GEF) 18 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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