ADP-ribosylation factor-like 6 (ARL6) - coding DNA reference sequence

(used for variant description)

(last modified February 27, 2022)

This file was created to facilitate the description of sequence variants on transcript NM_001278293.1 in the ARL6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering ARL6 transcript NM_001278293.1.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.4774
                                                         aact       c.-481

 .         .         .         .         .         .                g.4834
 cccatgatgctacgccgggaactgcccggctcctcgcaggaaataggcagctcaccctgc       c.-421

 .         .         .         .         .         .                g.4894
 cacctgtgcacacatttttcttcaatgtatagttcctcggcgcgcctctgaccttttccc       c.-361

 .         .         .         .         .         .                g.4954
 ggagctcttcaatcccagaagctatagcacaacggctgaatcgccaggacccccggggag       c.-301

 .         .         .         .         .         .                g.5014
 gcgtggcttcaggaccggaagaagctcctgttgccaagggaacggtgcctgccaaggcgc       c.-241

 .         .         .         .         .         .                g.5074
 ctgctcagcgactgatgcacagactgctgcagaggctgccggttttcccaacttctagag       c.-181

 .         .         .         .         .         .                g.5134
 acggctttgctcattaccaggcatccttcccatgtaggcatcgagaagaaggctgaggga       c.-121

 .         .         .         .         .         .                g.5194
 ccctcgcaccagatttccatcccggagaccgatacgagtgcgtccattcctgttgccagc       c.-61

 .         .         .         .   | 02     .         .             g.8357
 tcctgcgccctccggactaacctcaaaaaccag | ctggtttgtaaatatttgaatcacatt    c.-1

          .         .         .         .         .         .       g.8417
 ATGGGATTGCTAGACAGACTTTCAGTCTTGCTTGGCCTGAAGAAGAAGGAGGTTCATGTT       c.60
 M  G  L  L  D  R  L  S  V  L  L  G  L  K  K  K  E  V  H  V         p.20

          .         .         .         .         .         .       g.8477
 TTGTGCCTTGGGCTAGATAATAGTGGCAAAACGACGATCATTAACAAACTTAAACCTTCA       c.120
 L  C  L  G  L  D  N  S  G  K  T  T  I  I  N  K  L  K  P  S         p.40

     | 03    .         .         .         .         .         .    g.20465
 AAT | GCTCAATCTCAAAATATCCTTCCAACAATAGGATTCAGCATAGAGAAATTCAAATCA    c.180
 N   | A  Q  S  Q  N  I  L  P  T  I  G  F  S  I  E  K  F  K  S      p.60

       | 04  .         .         .         .         .         .    g.20919
 TCCAG | TTTGTCATTTACAGTGTTTGACATGTCAGGTCAAGGAAGATACAGAAATCTCTGG    c.240
 S  S  |  L  S  F  T  V  F  D  M  S  G  Q  G  R  Y  R  N  L  W      p.80

          .     | 05   .         .         .         .         .    g.25250
 GAACACTATTATAA | AGAAGGCCAAGCTATTATTTTTGTCATTGATAGTAGTGATAGATTA    c.300
 E  H  Y  Y  K  |  E  G  Q  A  I  I  F  V  I  D  S  S  D  R  L      p.100

          .         .         .         .          | 06        .    g.28250
 AGAATGGTTGTGGCCAAAGAAGAACTCGATACTCTTCTGAATCATCCAG | ATATTAAACAC    c.360
 R  M  V  V  A  K  E  E  L  D  T  L  L  N  H  P  D |   I  K  H      p.120

          .         .         .         .         .         .       g.28310
 CGTCGAATTCCAATCTTATTCTTTGCAAATAAAATGGATCTTAGAGATGCAGTGACATCT       c.420
 R  R  I  P  I  L  F  F  A  N  K  M  D  L  R  D  A  V  T  S         p.140

          .         .         .         .         .          | 07    g.32021
 GTAAAAGTGTCTCAGTTGCTGTGTTTAGAGAACATCAAAGATAAACCCTGGCATATTTG | T    c.480
 V  K  V  S  Q  L  L  C  L  E  N  I  K  D  K  P  W  H  I  C  |      p.160

          .         .         .         .         .      | 08  .    g.38278
 GCTAGTGATGCCATAAAAGGAGAAGGCTTGCAAGAAGGTGTAGACTGGCTTCAAG | ATCAG    c.540
 A  S  D  A  I  K  G  E  G  L  Q  E  G  V  D  W  L  Q  D |   Q      p.180

          .         .                                               g.38299
 ATCCAGACTGTGAAGACATGA                                              c.561
 I  Q  T  V  K  T  X                                                p.186

          .         .         .         .         .         .       g.38359
 aaagataatagttggaaacctcagcaattttcaattcaaggaatctatctaagacaaata       c.*60

          .         .         .         .         .         .       g.38419
 gaatacattttgtaaaagatgtttatgcatcaaaaaatataattttctgcttgcatttat       c.*120

          .         .         .         .         .         .       g.38479
 ggactctgacctttttaagaacataggacttcaggtatgctaatttggccattaattatt       c.*180

          .         .         .         .         .         .       g.38539
 taaaaactaaatattccctcaaaagggctccctagaattatcaagttcttagtgaaggtc       c.*240

          .         .         .         .         .         .       g.38599
 tacatttgattgtacgtagaatgtttaaaagtcagttataagccatctcatcccatcata       c.*300

          .         .         .         .         .         .       g.38659
 atttatgatatgtttaatatattttattttttaattgtctttttaaaaaatttagtttat       c.*360

          .         .         .         .         .         .       g.38719
 gactttgcagtatgaattgtgcttgtgaaaaagaactttaaatatttataagggaccatg       c.*420

          .         .         .         .         .         .       g.38779
 ggtaattaatatatattcaatttttactatgtgtcactgtcaataaaatgtaaaatataa       c.*480

                                                                    g.38785
 tgtgcc                                                             c.*486

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The ADP-ribosylation factor-like 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.