armadillo repeat containing 2 (ARMC2) - coding DNA reference sequence

(used for variant description)

(last modified February 13, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_032131.4 in the ARMC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering ARMC2 transcript NM_032131.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5054
       aggcccagtggccgagcggcgtcgtggggttaccccgcccgcgccagcgctgca       c.-121

 .         .         .         .         .         .                g.5114
 tccctggccgctacccggggagagccggaggatgaattgaacctcgcagccgctgctatc       c.-61

 .         .       | 02 .         .         .         .             g.10852
 tccagtgctcatcacag | ggtgtggtgtctatctgaagaatattttactttcaaaggaaag    c.-1

          .         .         .         .         .         .       g.10912
 ATGCTGTCTCCAAATGATAAAATGTTAGGAAAACTGGATCCATTTTATCAACCTTCAGTG       c.60
 M  L  S  P  N  D  K  M  L  G  K  L  D  P  F  Y  Q  P  S  V         p.20

          .         .         .         .         .         .       g.10972
 TCCAAGCAGAAGACCAGTGCAGAAATCATAAGTGAAGCAAGAAATGCATTAAGAACAGTT       c.120
 S  K  Q  K  T  S  A  E  I  I  S  E  A  R  N  A  L  R  T  V         p.40

          .         .         .         .         .         .       g.11032
 AGAACCCAAAGACCATTTACACCACAGGAGGCTCAAAGAAAACTATTCGGACCTGCATCC       c.180
 R  T  Q  R  P  F  T  P  Q  E  A  Q  R  K  L  F  G  P  A  S         p.60

          .         .         .         | 03         .         .    g.14805
 TCAAGAACATCAGAAAATAGACCTCCTTCCTCCTTCAG | CCTCCATGCATCCAGTTTTGAG    c.240
 S  R  T  S  E  N  R  P  P  S  S  F  S  |  L  H  A  S  S  F  E      p.80

          .         .         .         .         .  | 04      .    g.25417
 TCATCTGATTCCAGGCCTATCTCTGGCACACGTCTTAGTCCACTAGAGCTG | AAACCGAAA    c.300
 S  S  D  S  R  P  I  S  G  T  R  L  S  P  L  E  L   | K  P  K      p.100

          .         .         .         .         .         .       g.25477
 GTTCCAGCATCTCCCACCAGAGAGGAGGATTCCTGCTTTTCCTTTCCTAAGCCCCCAGTG       c.360
 V  P  A  S  P  T  R  E  E  D  S  C  F  S  F  P  K  P  P  V         p.120

          .         .         .         .         .         .       g.25537
 GACCCTGCGAAGATTAGAAGAGTAAGCAACGCCAGGGCTCGCTTATTCAGGGCTGCCTCC       c.420
 D  P  A  K  I  R  R  V  S  N  A  R  A  R  L  F  R  A  A  S         p.140

          .         .         .         .    | 05    .         .    g.32744
 CAGCGGGCCCTTCTGCCGGACAGATCCCTTCCTCCCTCCGACT | CAAAGAAGACAGTGGAA    c.480
 Q  R  A  L  L  P  D  R  S  L  P  P  S  D  S |   K  K  T  V  E      p.160

          .         .         .         .         .         .       g.32804
 TCCAAAGAAACAGTTATGATGGGGGACTCTATGGTGAAAATAAATGGGATTTATTTAACA       c.540
 S  K  E  T  V  M  M  G  D  S  M  V  K  I  N  G  I  Y  L  T         p.180

          .         .         .         .         .         .       g.32864
 AAATCAAATGCTATTTGCCACTTAAAGAGTCACCCACTTCAGCTAACTGATGATGGAGGC       c.600
 K  S  N  A  I  C  H  L  K  S  H  P  L  Q  L  T  D  D  G  G         p.200

          .         .         .         .         .         .       g.32924
 TTCAGTGAAATAAAGGAGCAAGAAATGTTCAAAGGAACAACATCTTTACCATCTCATCTC       c.660
 F  S  E  I  K  E  Q  E  M  F  K  G  T  T  S  L  P  S  H  L         p.220

          .  | 06      .         .         .         .         .    g.51100
 AAGAATGGAGG | GGACCAGGGGAAGAGACATGCGAGGGCCTCATCATGCCCCAGTAGCTCA    c.720
 K  N  G  G  |  D  Q  G  K  R  H  A  R  A  S  S  C  P  S  S  S      p.240

          .         .         | 07         .         .         .    g.56310
 GACCTGAGCAGGCTGCAAACCAAAGCAG | TCCCAAAAGCTGACCTGCAAGAAGAGGACGCA    c.780
 D  L  S  R  L  Q  T  K  A  V |   P  K  A  D  L  Q  E  E  D  A      p.260

          .         .         .         .         .         .       g.56370
 GAAATAGAAGTAGACGAAGTCTTTTGGAATACAAGGATTGTACCGATTTTGCGTGAATTA       c.840
 E  I  E  V  D  E  V  F  W  N  T  R  I  V  P  I  L  R  E  L         p.280

         | 08.         .         .         .         .         .    g.60867
 GAAAAGG | AAGAAAACATTGAAACGGTTTGTGCTGCTTGCACACAACTTCATCATGCTTTA    c.900
 E  K  E |   E  N  I  E  T  V  C  A  A  C  T  Q  L  H  H  A  L      p.300

          .         .         .         .         .         .       g.60927
 GAGGAAGGAAACATGCTTGGAAATAAATTTAAGGGAAGAAGTATTCTCCTGAAGACCCTG       c.960
 E  E  G  N  M  L  G  N  K  F  K  G  R  S  I  L  L  K  T  L         p.320

          .         .         .         .         .         .       g.60987
 TGTAAACTAGTTGATGTTGGTTCAGACTCGCTCAGCCTTAAACTTGCAAAAATAATTCTA       c.1020
 C  K  L  V  D  V  G  S  D  S  L  S  L  K  L  A  K  I  I  L         p.340

     | 09    .         .         .         .         .         .    g.67540
 GCA | CTTAAAGTGAGTAGAAAGAATCTTCTTAATGTCTGCAAACTTATATTTAAAATTAGC    c.1080
 A   | L  K  V  S  R  K  N  L  L  N  V  C  K  L  I  F  K  I  S      p.360

          .         .         .         .       | 10 .         .    g.68933
 AGGAATGAGAAGAATGATTCTTTGATTCAAAATGACAGCATTCTGG | AATCATTATTGGAG    c.1140
 R  N  E  K  N  D  S  L  I  Q  N  D  S  I  L  E |   S  L  L  E      p.380

          .         .         .         .         .         .       g.68993
 GTACTAAGAAGTGAAGACCTGCAAACTAACATGGAAGCTTTTTTATACTGTATGGGGTCT       c.1200
 V  L  R  S  E  D  L  Q  T  N  M  E  A  F  L  Y  C  M  G  S         p.400

          .         .         .         .         .         .       g.69053
 ATAAAGTTCATTTCTGGAAATCTGGGATTTCTTAATGAAATGATCAGCAAAGGTGCTGTG       c.1260
 I  K  F  I  S  G  N  L  G  F  L  N  E  M  I  S  K  G  A  V         p.420

          .         .         .         .         .         .       g.69113
 GAAATACTGATAAATTTGATAAAACAAATAAATGAGAACATCAAGAAATGTGGTACATTT       c.1320
 E  I  L  I  N  L  I  K  Q  I  N  E  N  I  K  K  C  G  T  F         p.440

          .         .         . | 11       .         .         .    g.84702
 TTGCCTAATTCGGGCCACTTGCTAGTCCAG | GTGACTGCTACATTGAGAAACTTGGTTGAT    c.1380
 L  P  N  S  G  H  L  L  V  Q   | V  T  A  T  L  R  N  L  V  D      p.460

          .         .         .         .         .         .       g.84762
 TCATCATTAGTAAGAAGTAAGTTCCTAAACATCAGTGCCCTTCCCCAGCTCTGCACGGCA       c.1440
 S  S  L  V  R  S  K  F  L  N  I  S  A  L  P  Q  L  C  T  A         p.480

          .         .         .         .         .       | 12 .    g.93488
 ATGGAACAGTACAAGGGTGACAAGGACGTCTGTACCAATATTGCCAGAATATTCAG | CAAA    c.1500
 M  E  Q  Y  K  G  D  K  D  V  C  T  N  I  A  R  I  F  S  |  K      p.500

          .         .         .         .         .         .       g.93548
 CTTACTTCTTACCGTGACTGCTGCACAGCCTTGGCCAGCTATTCCAGATGTTATGCCTTA       c.1560
 L  T  S  Y  R  D  C  C  T  A  L  A  S  Y  S  R  C  Y  A  L         p.520

          .         .         .       | 13 .         .         .    g.109641
 TTTCTGAATCTAATTAACAAATACCAGAAGAAGCAG | GATTTAGTCGTCCGTGTTGTTTTT    c.1620
 F  L  N  L  I  N  K  Y  Q  K  K  Q   | D  L  V  V  R  V  V  F      p.540

          .         .         .         .         .         .       g.109701
 ATTCTTGGCAACCTGACGGCAAAAAATAACCAGGCTCGTGAACAATTTTCCAAAGAGAAA       c.1680
 I  L  G  N  L  T  A  K  N  N  Q  A  R  E  Q  F  S  K  E  K         p.560

          .         .         .         .         .         .       g.109761
 GGGAGCATCCAAACTCTGCTGTCATTATTCCAGACGTTCCATCAGCTGGATCTGCATTCC       c.1740
 G  S  I  Q  T  L  L  S  L  F  Q  T  F  H  Q  L  D  L  H  S         p.580

          .         .         .         .         .         .       g.109821
 CAGAAGCCGGTGGGCCAACGAGGCGAGCAGCACAGGGCGCAGAGGCCGCCGTCAGAGGCA       c.1800
 Q  K  P  V  G  Q  R  G  E  Q  H  R  A  Q  R  P  P  S  E  A         p.600

          .         .         .         .         .         .       g.109881
 GAGGACGTGCTCATCAAGCTGACTCGTGTGCTGGCCAACATTGCCATCCACCCGGGCGTG       c.1860
 E  D  V  L  I  K  L  T  R  V  L  A  N  I  A  I  H  P  G  V         p.620

          .         .         .         .         .      | 14  .    g.118161
 GGCCCGGTGCTGGCCGCCAACCCGGGGATAGTGGGCCTGCTCCTGACCACGCTGG | AATAC    c.1920
 G  P  V  L  A  A  N  P  G  I  V  G  L  L  L  T  T  L  E |   Y      p.640

          .         .         .         .         .         .       g.118221
 AAGTCACTTGATGATTGTGAGGAGCTGGTGATCAATGCTACAGCGACAATCAACAATTTA       c.1980
 K  S  L  D  D  C  E  E  L  V  I  N  A  T  A  T  I  N  N  L         p.660

          .         .         .         .         .         | 15    g.118600
 TCTTACTACCAAGTGAAGAATTCCATAATTCAAGACAAAAAGCTATATATTGCTGAAT | TG    c.2040
 S  Y  Y  Q  V  K  N  S  I  I  Q  D  K  K  L  Y  I  A  E  L |       p.680

          .         .         .         .         .         .       g.118660
 CTCTTAAAGCTTCTTGTCAGTAACAACATGGATGGAATCCTGGAGGCTGTGCGTGTTTTC       c.2100
 L  L  K  L  L  V  S  N  N  M  D  G  I  L  E  A  V  R  V  F         p.700

          .         .         .         .         .   | 16     .    g.120772
 GGAAATCTCTCCCAGGACCATGATGTCTGCGATTTCATTGTGCAGAACAATG | TCCACAGG    c.2160
 G  N  L  S  Q  D  H  D  V  C  D  F  I  V  Q  N  N  V |   H  R      p.720

          .         .         .         .         .         .       g.120832
 TTCATGATGGCGCTGCTGGATGCTCAGCATCAGGATATCTGCTTTTCTGCCTGTGGTGTT       c.2220
 F  M  M  A  L  L  D  A  Q  H  Q  D  I  C  F  S  A  C  G  V         p.740

          .         .         .         .         .         .       g.120892
 CTCCTCAATCTCACTGTGGATAAAGACAAGCGTGTCATCTTGAAAGAAGGAGGTGGCATT       c.2280
 L  L  N  L  T  V  D  K  D  K  R  V  I  L  K  E  G  G  G  I         p.760

       | 17  .         .         .         .         .         .    g.121619
 AAAAA | GTTAGTGGACTGTTTAAGAGATTTGGGTCCTACTGATTGGCAGCTGGCCTGCTTG    c.2340
 K  K  |  L  V  D  C  L  R  D  L  G  P  T  D  W  Q  L  A  C  L      p.780

          .         .         .         .         .         .       g.121679
 GTTTGTAAAACTTTATGGAACTTCAGTGAAAACATCACTAATGCTTCGTCATGTTTTGGA       c.2400
 V  C  K  T  L  W  N  F  S  E  N  I  T  N  A  S  S  C  F  G         p.800

          .         .         .         .       | 18 .         .    g.129955
 AATGAAGACACCAACACACTCTTACTCTTGCTCTCATCATTTTTAG | ATGAAGAACTAGCA    c.2460
 N  E  D  T  N  T  L  L  L  L  L  S  S  F  L  D |   E  E  L  A      p.820

          .         .         .         .         .         .       g.130015
 CTGGATGGCAGTTTTGATCCAGACCTAAAAAACTATCACAAACTCCATTGGGAAACAGAA       c.2520
 L  D  G  S  F  D  P  D  L  K  N  Y  H  K  L  H  W  E  T  E         p.840

          .         .         .         .         .         .       g.130075
 TTCAAACCTGTGGCACAGCAGCTTCTAAACCGAATTCAGAGACATCACACCTTCCTGGAA       c.2580
 F  K  P  V  A  Q  Q  L  L  N  R  I  Q  R  H  H  T  F  L  E         p.860

          .         .                                               g.130099
 CCCCTGCCCATTCCCTCTTTCTAA                                           c.2604
 P  L  P  I  P  S  F  X                                             p.867

          .         .         .         .         .         .       g.130159
 catgatgcagattaacagtagaaacgagaactcacgtctccctcattcttaagaactggt       c.*60

          .         .         .         .         .         .       g.130219
 aacaaacgtgaacatttttttcagcattaacaaatgtggaaagtttttcaagaactggtt       c.*120

          .         .         .         .         .         .       g.130279
 ttagtgagtagctgaagtattttttaaaattaagcatttcttcttgttaggtattatgga       c.*180

          .         .         .         .         .         .       g.130339
 aaaatgaatatacacattatatttcctgttgagagaaatgtaagatgaaaatatgtgcat       c.*240

          .         .         .         .         .         .       g.130399
 tttcaagtaaatgactttttcttctattctctattaaacaatttagttctagtcttaaaa       c.*300

          .         .         .         .         .         .       g.130459
 tcttgatttaacaattttggaattgaagtgttcataagttaaatgaactgtgcaatgaag       c.*360

          .         .         .         .         .         .       g.130519
 gctgttagattatatagaaagaagggtaggcaacatgagtggaacacgttacaacatagg       c.*420

          .         .         .         .         .         .       g.130579
 atctgtactaattcttactatgtcaaataataaatgctctcattaggtaccagtattttt       c.*480

          .         .         .         .         .         .       g.130639
 ttggtctttatattaagagaaggagtaagcagaaaaacttaaagaaaactgctttgggcc       c.*540

          .         .         .         .         .         .       g.130699
 atctgttctttattaaataagtaaaatagataaaatgagagtatattttcatttgaaata       c.*600

          .         .         .                                     g.130734
 aaatgactggactaagacagtccttctaattgtaa                                c.*635

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Armadillo repeat containing 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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