arrestin 3, retinal (X-arrestin) (ARR3) - coding DNA reference sequence

(used for variant description)

(last modified April 24, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_004312.2 in the ARR3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_050734.1, covering ARR3 transcript NM_004312.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5008
                                                     gagctgga       c.-61

 .         .         .          | 02        .         .             g.6051
 gactgatgtgaacttcatctctctccccag | aaaaggctcaacatcaactatatagccaac    c.-1

          | 03         .         .          | 04        .         . g.6529
 ATGTCCAA | GGTGTTTAAGAAGACCAGCTCCAATGGGAAG | CTCTCCATCTACCTGGGGAAA c.60
 M  S  K  |  V  F  K  K  T  S  S  N  G  K   | L  S  I  Y  L  G  K   p.20

          .         .         .         . | 05       .         .    g.6785
 CGGGACTTCGTGGACCATGTGGACACGGTGGAACCCATTG | ACGGTGTTGTCCTGGTTGAT    c.120
 R  D  F  V  D  H  V  D  T  V  E  P  I  D |   G  V  V  L  V  D      p.40

          .         .      | 06  .         .         .         .    g.12782
 CCTGAGTACTTAAAATGTCGAAAGT | TGTTTGTCATGTTGACATGTGCCTTTCGCTATGGC    c.180
 P  E  Y  L  K  C  R  K  L |   F  V  M  L  T  C  A  F  R  Y  G      p.60

          .         .         .         .         .         .       g.12842
 CGTGATGACTTGGAAGTGATTGGTCTGACGTTCCGAAAAGATCTGTATGTGCAGACCCTG       c.240
 R  D  D  L  E  V  I  G  L  T  F  R  K  D  L  Y  V  Q  T  L         p.80

          .         .         .         .         .         .       g.12902
 CAAGTGGTCCCAGCTGAATCCAGCAGCCCTCAGGGGCCCCTCACAGTCCTACAGGAGCGA       c.300
 Q  V  V  P  A  E  S  S  S  P  Q  G  P  L  T  V  L  Q  E  R         p.100

          .         .         .         .      | 07  .         .    g.13113
 CTACTGCACAAGCTAGGGGACAATGCCTACCCCTTTACCCTGCAG | ATGGTGACCAACCTG    c.360
 L  L  H  K  L  G  D  N  A  Y  P  F  T  L  Q   | M  V  T  N  L      p.120

          .         .         .         .      | 08  .         .    g.13349
 CCCTGTTCTGTGACACTGCAGCCAGGTCCTGAAGATGCAGGAAAG | CCCTGTGGGATTGAC    c.420
 P  C  S  V  T  L  Q  P  G  P  E  D  A  G  K   | P  C  G  I  D      p.140

          .         .         .         .         .    | 09    .    g.14066
 TTTGAAGTGAAGAGTTTCTGTGCTGAAAACCCAGAGGAGACAGTCTCCAAGAG | AGACTAT    c.480
 F  E  V  K  S  F  C  A  E  N  P  E  E  T  V  S  K  R  |  D  Y      p.160

          .         .         .         .         .         .       g.14126
 GTGCGGCTGGTTGTCCGGAAAGTACAATTTGCACCACCGGAGGCAGGCCCTGGCCCCTCA       c.540
 V  R  L  V  V  R  K  V  Q  F  A  P  P  E  A  G  P  G  P  S         p.180

          .         .         .         .         .         .       g.14186
 GCCCAGACCATCCGCCGCTTCCTTCTGTCAGCTCAGCCCCTACAACTCCAGGCCTGGATG       c.600
 A  Q  T  I  R  R  F  L  L  S  A  Q  P  L  Q  L  Q  A  W  M         p.200

           | 10        .         .         .         .         .    g.14432
 GACAGGGAG | GTTCACTACCACGGAGAACCCATCTCTGTCAATGTTTCTATCAACAACTGC    c.660
 D  R  E   | V  H  Y  H  G  E  P  I  S  V  N  V  S  I  N  N  C      p.220

          .         .         .     | 11   .         .         .    g.14757
 ACCAACAAGGTCATCAAAAAAATCAAGATTTCAG | TTGACCAGATCACAGATGTTGTCCTG    c.720
 T  N  K  V  I  K  K  I  K  I  S  V |   D  Q  I  T  D  V  V  L      p.240

          .         .         .         .        | 12.         .    g.15182
 TATTCACTAGACAAGTACACCAAGACTGTGTTCATTCAGGAATTCAC | GGAGACTGTAGCT    c.780
 Y  S  L  D  K  Y  T  K  T  V  F  I  Q  E  F  T  |  E  T  V  A      p.260

          .         .         .         .         .         .       g.15242
 GCTAATTCCAGCTTCTCCCAGAGCTTTGCAGTAACCCCAATCCTGGCTGCCAGCTGCCAG       c.840
 A  N  S  S  F  S  Q  S  F  A  V  T  P  I  L  A  A  S  C  Q         p.280

          .         .         .         .         .         .       g.15302
 AAACGGGGCCTGGCACTGGATGGCAAACTTAAGCATGAAGATACCAACCTGGCCTCTAGC       c.900
 K  R  G  L  A  L  D  G  K  L  K  H  E  D  T  N  L  A  S  S         p.300

       | 13  .         .         .         .         .         .    g.16915
 ACAAT | TATTAGACCGGGAATGGACAAAGAGCTGCTGGGGATCCTGGTGTCCTACAAAGTC    c.960
 T  I  |  I  R  P  G  M  D  K  E  L  L  G  I  L  V  S  Y  K  V      p.320

          .         .          | 14        .         .    | 15    . g.17438
 AGAGTCAACCTGATGGTGTCCTGTGGTGG | CATCCTAGGAGACCTGACAGCCAG | CGATGTT c.1020
 R  V  N  L  M  V  S  C  G  G  |  I  L  G  D  L  T  A  S  |  D  V   p.340

          .         .         .         .       | 16 .       | 17 . g.18345
 GGTGTGGAGCTACCCTTGGTCCTGATCCATCCGAAGCCATCTCATG | AGGCCGCTAG | CTCT c.1080
 G  V  E  L  P  L  V  L  I  H  P  K  P  S  H  E |   A  A  S  |  S   p.360

          .         .         .         .         .         .       g.18405
 GAGGACATAGTCATCGAGGAGTTTACGCGGAAAGGCGAGGAGGAGAGCCAGAAGGCTGTG       c.1140
 E  D  I  V  I  E  E  F  T  R  K  G  E  E  E  S  Q  K  A  V         p.380

          .         .                                               g.18432
 GAGGCTGAGGGAGATGAGGGGAGCTGA                                        c.1167
 E  A  E  G  D  E  G  S  X                                          p.388

          .         .         .         .         .         .       g.18492
 gcacctcgctctggtgcccgtctgtgtgggagcccccactgtaacactctaataaatcag       c.*60

          .                                                         g.18506
 tttgttcagatgtg                                                     c.*74

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Arrestin 3, retinal (X-arrestin) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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