activating signal cointegrator 1 complex subunit 1 (ASCC1) - coding DNA reference sequence

(used for variant description)

(last modified July 9, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001198799.2 in the ASCC1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031890.1, covering ASCC1 transcript NM_001198799.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5721
                                 agagaggggagcgctcagaacaccagcg       c.-241

 .         .         .         .         .         .                g.5781
 gctcccaagctaactcctagccacttttcccacccagctgggtccccaggaaactacgcc       c.-181

 .         .         .         .         .         .                g.5841
 atcggcgctgtcccactgcgcaggcgccagccctcggcccgcatgcgcactcggtcaaac       c.-121

 .         .         .         .         .         .                g.5901
 ccggcctggggaaatttcctatcgcacgtctgctgcagcagtctcctgtttctcctccta       c.-61

 .         .         .       | 02 .         .         .             g.8836
 ccttctccatttttctagtccctgcag | ggcataattggaatatcatttggagaaagtgtc    c.-1

          .         .         .         .         .         .       g.8896
 ATGGAAGTTCTGCGTCCACAGCTTATAAGAATTGATGGCCGGAATTACAGGAAGAATCCA       c.60
 M  E  V  L  R  P  Q  L  I  R  I  D  G  R  N  Y  R  K  N  P         p.20

          .         .         .         .         .   | 03     .    g.11311
 GTCCAAGAACAGACCTATCAACATGAAGAAGATGAAGAGGACTTCTATCAAG | GCTCCATG    c.120
 V  Q  E  Q  T  Y  Q  H  E  E  D  E  E  D  F  Y  Q  G |   S  M      p.40

          .         .         .         .         .         .       g.11371
 GAGTGTGCTGATGAGCCCTGTGATGCCTACGAGGTGGAGCAGACCCCACAAGGATTCCGG       c.180
 E  C  A  D  E  P  C  D  A  Y  E  V  E  Q  T  P  Q  G  F  R         p.60

          .         .         .   | 04     .         .         .    g.17657
 TCTACTTTGAGGGCCCCCAGCTTGCTCTATAA | TCTCATTCACTTGAACACATCAAACGAC    c.240
 S  T  L  R  A  P  S  L  L  Y  N  |  L  I  H  L  N  T  S  N  D      p.80

          .         .         .         .         .       | 05 .    g.18614
 TGTGGGTTCCAGAAGATAACTTTGGATTGTCAGAATATTTATACTTGGAAGTCCAG | GCAT    c.300
 C  G  F  Q  K  I  T  L  D  C  Q  N  I  Y  T  W  K  S  R  |  H      p.100

          .         .         .         .         .         .       g.18674
 ATAGTTGGAAAGAGAGGGGACACTAGGAAGAAAATAGAAATGGAGACCAAAACTTCTATT       c.360
 I  V  G  K  R  G  D  T  R  K  K  I  E  M  E  T  K  T  S  I         p.120

          .         .         .     | 06   .         .         .    g.25171
 AGCATTCCTAAACCTGGACAAGACGGGGAAATTG | TAATCACTGGCCAGCATCGAAATGGT    c.420
 S  I  P  K  P  G  Q  D  G  E  I  V |   I  T  G  Q  H  R  N  G      p.140

          .         .         .         .         .         .       g.25231
 GTAATTTCAGCCCGAACACGGATTGATGTTCTTTTGGACACTTTTCGAAGAAAGCAGCCC       c.480
 V  I  S  A  R  T  R  I  D  V  L  L  D  T  F  R  R  K  Q  P         p.160

          .         .         .         .         .         .       g.25291
 TTCACTCACTTCCTTGCCTTTTTCCTCAATGAAGTTGAGGTTCAGGAAGGATTCCTGAGA       c.540
 F  T  H  F  L  A  F  F  L  N  E  V  E  V  Q  E  G  F  L  R         p.180

          .         .         .    | 07    .         .         .    g.60487
 TTCCAGGAGGAAGTACTGGCGAAGTGCTCCATG | GATCATGGGGTTGACAGCAGCATTTTC    c.600
 F  Q  E  E  V  L  A  K  C  S  M   | D  H  G  V  D  S  S  I  F      p.200

          .         .         .         .         .         .       g.60547
 CAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTTTGAGTGAGGAAGAG       c.660
 Q  N  P  K  K  L  H  L  T  I  G  M  L  V  L  L  S  E  E  E         p.220

          .         .         .         .         . | 08       .    g.69156
 ATCCAGCAGACATGTGAGATGCTACAGCAGTGTAAAGAGGAATTCATTAA | TGATATTTCT    c.720
 I  Q  Q  T  C  E  M  L  Q  Q  C  K  E  E  F  I  N  |  D  I  S      p.240

          .         .         .         .         .         .       g.69216
 GGGGGTAAACCCCTAGAAGTGGAGATGGCAGGGATAGAATACATGAATGATGATCCTGGC       c.780
 G  G  K  P  L  E  V  E  M  A  G  I  E  Y  M  N  D  D  P  G         p.260

          .         .         .         .         . | 09       .    g.88963
 ATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCAACAG | GCTACAAGAA    c.840
 M  V  D  V  L  Y  A  K  V  H  M  K  D  G  S  N  R  |  L  Q  E      p.280

          .         .         .         .         .         .       g.89023
 TTAGTTGATCGAGTGCTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAAT       c.900
 L  V  D  R  V  L  E  R  F  Q  A  S  G  L  I  V  K  E  W  N         p.300

          .         .         .         .         .      | 10  .    g.93972
 AGTGTGAAACTGCATGCTACAGTTATGAATACACTATTCAGGAAAGACCCCAATG | CTGAA    c.960
 S  V  K  L  H  A  T  V  M  N  T  L  F  R  K  D  P  N  A |   E      p.320

          .         .         .         .         .         .       g.94032
 GGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGGAAAGAGAATCATTT       c.1020
 G  R  Y  N  L  Y  T  A  E  G  K  Y  I  F  K  E  R  E  S  F         p.340

          .         .  | 11      .         .         .         .    g.119206
 GATGGCCGAAATATTTTAAAG | AGCTTTGCCTTGTTGCCCAGGCTGGAGTACAATGATGCA    c.1080
 D  G  R  N  I  L  K   | S  F  A  L  L  P  R  L  E  Y  N  D  A      p.360

          .         .         .         .         .         .       g.119266
 ATCTCCGCTCACTGCAACCTGTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCC       c.1140
 I  S  A  H  C  N  L  C  L  P  G  S  S  D  S  P  A  S  A  S         p.380

          .          | 12        .         .         .         .    g.119763
 CAAGTAGCTGGGATTACAG | GTGTCTCTGATGCATATTCTCAGAGCCTACCAGGAAAATCC    c.1200
 Q  V  A  G  I  T  G |   V  S  D  A  Y  S  Q  S  L  P  G  K  S      p.400

                                                                g.119766
 TAG |                                                             c.1204
 X                                                               p.400

          .         .         .      | 13  .         .         .    g.124709
 aatcgagaagggcttgggacacagagagctagtgg | ttgtttgagaacttctactttggct    c.*60

          .         .         .         .         .         .       g.124769
 ccctaaagctgaattcaattcacatctctcagaggttcaccgtagacagctttggaaact       c.*120

          .         .         .         .         .         .       g.124829
 acgcttcctgtggacaaattgacttctcctgaggtggatcttggaaagcactagaaacta       c.*180

          .         .         .         .         .         .       g.124889
 aacatcttcaccaggtgctgaagaaaagtgtcttcgttttaattgccaagcagggatgtg       c.*240

          .         .         .         .         .         .       g.124949
 gacatttggatggtgactttcctgggtggttccccatagattcaccattgcctctaatgg       c.*300

          .         .         .         .         .         .       g.125009
 tgtctacacccgtcatactaccagctgagatggtggtgggcataaggagaatttgtgcct       c.*360

          .         .         .         .         .         .       g.125069
 ataacccttagtgtgttctggttttttttcttttaatttttaaattgtcgtaaaatactc       c.*420

          .         .         .         .         .         .       g.125129
 ataaaacatactgtcttcaccatttttaagtgcacagttcagtaacgttaactgttaata       c.*480

          .         .         .         .         .         .       g.125189
 cattcataatgctgtgtggccgtcaccgccgtccatctccataggcttctcagcttgtaa       c.*540

          .         .         .         .         .         .       g.125249
 aatggaaactgtacccattaaacagtaattcccactcctcccagcccccgcagccaccat       c.*600

          .         .         .         .         .         .       g.125309
 tctgctttctgtctctctggttttgactattctcagtatctcatataagtggaatcatac       c.*660

          .         .         .         .         .         .       g.125369
 agtgacttgtctttttgtgactggcttatttcacttagcataatgtcctcaaggttcatc       c.*720

          .         .         .         .         .         .       g.125429
 catgttgtgtcaggtgacaggatttccttcctgtattatacatataatggaatgttccgt       c.*780

          .         .         .         .         .         .       g.125489
 tacatgtgcgtaccacactctgttcctccatcagtgaacacttggcttgcttcctcttga       c.*840

          .         .         .         .         .         .       g.125549
 ctattgggagtagtgctaatacagacacgggggtgcaaatatctctttgagactctgcct       c.*900

          .         .         .         .         .         .       g.125609
 ttaattcctttaccacccagagttttatctttagcaaaataaccattaaagttgtttgcc       c.*960

          .         .         .         .         .         .       g.125669
 ttttactttgcttggtctatcattttcctaccaaagtttgtcctcttaatatttgttgga       c.*1020

          .         .         .         .         .         .       g.125729
 ttcctgttccttcaccccatccccaccctcatcttcccatgcccctgatggagttgcagt       c.*1080

          .         .         .         .         .         .       g.125789
 gttgcagcccttttttgtttacttttcaaggcagcagcaaaagaaactgatgatatcagc       c.*1140

          .         .         .         .         .         .       g.125849
 aggactgtgcagagttccctggaagaatgtcagccacaggaggccctcactcctccctca       c.*1200

          .         .         .         .         .         .       g.125909
 ccacggaccagcagagggaggcgggaatgctggggagccccagcctcccacccctgcctc       c.*1260

          .         .         .         .         .         .       g.125969
 ctcacattcttcctccctccatgtcctctccttcttctccttccttattcttgccttgat       c.*1320

          .         .         .         .         .         .       g.126029
 tctttctctctttatattctttaactgcacttctgaactctgtgttaagttgctacattg       c.*1380

          .         .         .         .         .         .       g.126089
 tgaggactgtgtctaacagtgagatttattattgggactgcacaaatcacttgtgaataa       c.*1440

          .                                                         g.126103
 aatgtttaacggtg                                                     c.*1454

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Activating signal cointegrator 1 complex subunit 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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