asparagine synthetase (glutamine-hydrolyzing) (ASNS) - coding DNA reference sequence

(used for variant description)

(last modified December 19, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_001673.4 in the ASNS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering ASNS transcript NM_001673.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5011
                                                  agtcctgctcc       c.-241

 .         .         .         .         .         .                g.5071
 gccccggacaccccgcggccccgcccctgtgcgcgctggttggtcctcgcaggcatgatg       c.-181

 .         .         .         .         .         .                g.5131
 aaacttcccgcacgcgttacaggagccaggtcggtataagcgccagcggcctcgccgccc       c.-121

 .         .         .         .         .         .                g.5191
 gtcaagctgtccacatccctggcctcagcccgccacatcaccctgacctgcttacgccca       c.-61

 . | 02       .         .         .       | 03 .         .          g.8386
 g | attttcttcaatcacatctgaataaatcacttgaag | aaagcttatagcttcattgcacc c.-1

          .         .         .         .         .         .       g.8446
 ATGTGTGGCATTTGGGCGCTGTTTGGCAGTGATGATTGCCTTTCTGTTCAGTGTCTGAGT       c.60
 M  C  G  I  W  A  L  F  G  S  D  D  C  L  S  V  Q  C  L  S         p.20

          .         .         .         .         .         .       g.8506
 GCTATGAAGATTGCACACAGAGGTCCAGATGCATTCCGTTTTGAGAATGTCAATGGATAC       c.120
 A  M  K  I  A  H  R  G  P  D  A  F  R  F  E  N  V  N  G  Y         p.40

          .         .         .         .         .         .       g.8566
 ACCAACTGCTGCTTTGGATTTCACCGGTTGGCGGTAGTTGACCCGCTGTTTGGAATGCAG       c.180
 T  N  C  C  F  G  F  H  R  L  A  V  V  D  P  L  F  G  M  Q         p.60

          .         .         .         .         .         .       g.8626
 CCAATTCGAGTGAAGAAATATCCGTATTTGTGGCTCTGTTACAATGGTGAAATCTACAAC       c.240
 P  I  R  V  K  K  Y  P  Y  L  W  L  C  Y  N  G  E  I  Y  N         p.80

           | 04        .         .         .         .         .    g.13097
 CATAAGAAG | ATGCAACAGCATTTTGAATTTGAATACCAGACCAAAGTGGATGGTGAGATA    c.300
 H  K  K   | M  Q  Q  H  F  E  F  E  Y  Q  T  K  V  D  G  E  I      p.100

          .         .         .         .         .         .       g.13157
 ATCCTTCATCTTTATGACAAAGGAGGAATTGAGCAAACAATTTGTATGTTGGATGGTGTG       c.360
 I  L  H  L  Y  D  K  G  G  I  E  Q  T  I  C  M  L  D  G  V         p.120

          .         .         .         .         .         .       g.13217
 TTTGCATTTGTTTTACTGGATACTGCCAATAAGAAAGTGTTCCTGGGTAGAGATACATAT       c.420
 F  A  F  V  L  L  D  T  A  N  K  K  V  F  L  G  R  D  T  Y         p.140

          .         .         .         .         .         .       g.13277
 GGAGTCAGACCTTTGTTTAAAGCAATGACAGAAGATGGATTTTTGGCTGTATGTTCAGAA       c.480
 G  V  R  P  L  F  K  A  M  T  E  D  G  F  L  A  V  C  S  E         p.160

         | 05.         .         .         .         .         .    g.18197
 GCTAAAG | GTCTTGTTACATTGAAGCACTCCGCGACTCCCTTTTTAAAAGTGGAGCCTTTT    c.540
 A  K  G |   L  V  T  L  K  H  S  A  T  P  F  L  K  V  E  P  F      p.180

          .         .         .         .         .         .       g.18257
 CTTCCTGGACACTATGAAGTTTTGGATTTAAAGCCAAATGGCAAAGTTGCATCCGTGGAA       c.600
 L  P  G  H  Y  E  V  L  D  L  K  P  N  G  K  V  A  S  V  E         p.200

          .         .         .         .         .         .       g.18317
 ATGGTTAAATATCATCACTGTCGGGATGTACCCCTGCACGCCCTCTATGACAATGTGGAG       c.660
 M  V  K  Y  H  H  C  R  D  V  P  L  H  A  L  Y  D  N  V  E         p.220

          .    | 06    .         .         .         .         .    g.18634
 AAACTCTTTCCAG | GTTTTGAGATAGAAACTGTGAAGAACAACCTCAGGATCCTTTTTAAT    c.720
 K  L  F  P  G |   F  E  I  E  T  V  K  N  N  L  R  I  L  F  N      p.240

          .         .         .         .         .      | 07  .    g.19142
 AATGCTGTAAAGAAACGTTTGATGACAGACAGAAGGATTGGCTGCCTTTTATCAG | GGGGC    c.780
 N  A  V  K  K  R  L  M  T  D  R  R  I  G  C  L  L  S  G |   G      p.260

          .         .         .         .         .         .       g.19202
 TTGGACTCCAGCTTGGTTGCTGCCACTCTGTTGAAGCAGCTGAAAGAAGCCCAAGTACAG       c.840
 L  D  S  S  L  V  A  A  T  L  L  K  Q  L  K  E  A  Q  V  Q         p.280

          .         .         .         .         .         .       g.19262
 TATCCTCTCCAGACATTTGCAATTGGCATGGAAGACAGCCCCGATTTACTGGCTGCTAGA       c.900
 Y  P  L  Q  T  F  A  I  G  M  E  D  S  P  D  L  L  A  A  R         p.300

     | 08    .         .         .         .         .         .    g.20783
 AAG | GTGGCAGATCATATTGGAAGTGAACATTATGAAGTCCTTTTTAACTCTGAGGAAGGC    c.960
 K   | V  A  D  H  I  G  S  E  H  Y  E  V  L  F  N  S  E  E  G      p.320

          .         .         .         .         .         .       g.20843
 ATTCAGGCTCTGGATGAAGTCATATTTTCCTTGGAAACTTATGACATTACAACAGTTCGT       c.1020
 I  Q  A  L  D  E  V  I  F  S  L  E  T  Y  D  I  T  T  V  R         p.340

          . | 09       .         .         .         .         .    g.22133
 GCTTCAGTAG | GTATGTATTTAATTTCCAAGTATATTCGGAAGAACACAGATAGCGTGGTG    c.1080
 A  S  V  G |   M  Y  L  I  S  K  Y  I  R  K  N  T  D  S  V  V      p.360

          .         .         .         .         .        | 10.    g.22865
 ATCTTCTCTGGAGAAGGATCAGATGAACTTACGCAGGGTTACATATATTTTCACAAG | GCT    c.1140
 I  F  S  G  E  G  S  D  E  L  T  Q  G  Y  I  Y  F  H  K   | A      p.380

          .         .         .         .         .         .       g.22925
 CCTTCTCCTGAAAAAGCCGAGGAGGAGAGTGAGAGGCTTCTGAGGGAACTCTATTTGTTT       c.1200
 P  S  P  E  K  A  E  E  E  S  E  R  L  L  R  E  L  Y  L  F         p.400

          .         .         .         | 11         .         .    g.24178
 GATGTTCTCCGCGCAGATCGAACTACTGCTGCCCATGG | TCTTGAACTGAGAGTCCCATTT    c.1260
 D  V  L  R  A  D  R  T  T  A  A  H  G  |  L  E  L  R  V  P  F      p.420

          .         .         .         .         .         .       g.24238
 CTAGATCATCGATTTTCTTCCTATTACTTGTCTCTGCCACCAGAAATGAGAATTCCAAAG       c.1320
 L  D  H  R  F  S  S  Y  Y  L  S  L  P  P  E  M  R  I  P  K         p.440

  | 12       .         .         .         .         .         .    g.24387
  | AATGGGATAGAAAAACATCTCCTGAGAGAGACGTTTGAGGATTCCAATCTGATACCCAAA    c.1380
  | N  G  I  E  K  H  L  L  R  E  T  F  E  D  S  N  L  I  P  K      p.460

          .         .         .         .         .         .       g.24447
 GAGATTCTCTGGCGACCAAAAGAAGCCTTCAGTGATGGAATAACTTCAGTTAAGAATTCC       c.1440
 E  I  L  W  R  P  K  E  A  F  S  D  G  I  T  S  V  K  N  S         p.480

          .         .         .       | 13 .         .         .    g.25098
 TGGTTTAAGATTTTACAGGAATACGTTGAACATCAG | GTTGATGATGCAATGATGGCAAAT    c.1500
 W  F  K  I  L  Q  E  Y  V  E  H  Q   | V  D  D  A  M  M  A  N      p.500

          .         .         .         .         .         .       g.25158
 GCAGCCCAGAAATTTCCCTTCAATACTCCTAAAACCAAAGAAGGATATTACTACCGTCAA       c.1560
 A  A  Q  K  F  P  F  N  T  P  K  T  K  E  G  Y  Y  Y  R  Q         p.520

          .         .         .         .         .         .       g.25218
 GTCTTTGAACGCCATTACCCAGGCCGGGCTGACTGGCTGAGCCATTACTGGATGCCCAAG       c.1620
 V  F  E  R  H  Y  P  G  R  A  D  W  L  S  H  Y  W  M  P  K         p.540

          .         .         .         .         .         .       g.25278
 TGGATCAATGCCACTGACCCTTCTGCCCGCACGCTGACCCACTACAAGTCAGCTGTCAAA       c.1680
 W  I  N  A  T  D  P  S  A  R  T  L  T  H  Y  K  S  A  V  K         p.560

                                                                    g.25284
 GCTTAG                                                             c.1686
 A  X                                                               p.561

          .         .         .         .         .         .       g.25344
 gtggtctttatgctgtaatgtgaaagcaaatatttcttcgtgttggatggggactgtggg       c.*60

          .         .         .         .         .         .       g.25404
 tagataggggaacaatgagagtcaactcaggctaacttgggtgtgaaaaaaataaaagtc       c.*120

          .         .                                               g.25426
 ctaaatctaaaccattgctgta                                             c.*142

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Asparagine synthetase (glutamine-hydrolyzing) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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