astrotactin 2 (ASTN2) - coding DNA reference sequence

(used for variant description)

(last modified January 13, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_014010.4 in the ASTN2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021409.1, covering ASTN2 transcript NM_014010.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5041
                    ggttcgcttcggcgtccgccgtctccgcagctgcctcctct       c.-61

 .         .         .         .         .         .                g.5101
 tcctccttcgccaccgccgccaccgccgccgccgcccgcagcaccgcagcccctcccgcc       c.-1

          .         .         .         .         .         .       g.5161
 ATGGCCGCCGCCGGCGCCCGGCTCAGCCCCGGCCCCGGCTCGGGGCTCCGGGGGCGGCCG       c.60
 M  A  A  A  G  A  R  L  S  P  G  P  G  S  G  L  R  G  R  P         p.20

          .         .         .         .         .         .       g.5221
 AGGCTCTGCTTCCACCCGGGGCCGCCGCCACTGCTGCCGCTGCTGCTGCTGTTCCTGCTC       c.120
 R  L  C  F  H  P  G  P  P  P  L  L  P  L  L  L  L  F  L  L         p.40

          .         .         .         .         .         .       g.5281
 CTGCTGCCGCCGCCGCCGCTGCTGGCCGGCGCCACCGCCGCTGCCTCGCGGGAGCCCGAC       c.180
 L  L  P  P  P  P  L  L  A  G  A  T  A  A  A  S  R  E  P  D         p.60

          .         .         .         .         .         .       g.5341
 AGCCCGTGCCGGCTGAAGACCGTCACGGTGTCCACACTGCCCGCCCTGCGGGAGAGCGAC       c.240
 S  P  C  R  L  K  T  V  T  V  S  T  L  P  A  L  R  E  S  D         p.80

          .         .         .         .         .         .       g.5401
 ATCGGCTGGAGCGGCGCCCGCGCCGGGGCCGGGGCTGGGACCGGGGCCGGAGCCGCCGCC       c.300
 I  G  W  S  G  A  R  A  G  A  G  A  G  T  G  A  G  A  A  A         p.100

          .         .         .         .         .         .       g.5461
 GCCGCCGCGTCCCCGGGCTCTCCTGGCTCTGCCGGCACCGCCGCCGAGTCGCGCCTCCTG       c.360
 A  A  A  S  P  G  S  P  G  S  A  G  T  A  A  E  S  R  L  L         p.120

          .         .         .         .         .         .       g.5521
 CTCTTTGTGCGTAACGAGCTGCCGGGGCGCATCGCGGTGCAGGACGACCTGGACAACACC       c.420
 L  F  V  R  N  E  L  P  G  R  I  A  V  Q  D  D  L  D  N  T         p.140

          .         .   | 02     .         .         .         .    g.128563
 GAGCTGCCCTTCTTCACCCTGG | AGATGTCTGGCACAGCGGCGGACATCTCGCTGGTGCAC    c.480
 E  L  P  F  F  T  L  E |   M  S  G  T  A  A  D  I  S  L  V  H      p.160

          .         .         .         .         .         .       g.128623
 TGGAGACAGCAGTGGCTGGAGAATGGCACCTTGTACTTCCACGTCTCCATGAGCAGCTCC       c.540
 W  R  Q  Q  W  L  E  N  G  T  L  Y  F  H  V  S  M  S  S  S         p.180

          .         .         .         .         .         .       g.128683
 GGGCAGCTGGCCCAAGCCACCGCCCCCACTCTCCAGGAGCCCTCGGAGATTGTTGAGGAG       c.600
 G  Q  L  A  Q  A  T  A  P  T  L  Q  E  P  S  E  I  V  E  E         p.200

          .         .         . | 03       .         .         .    g.205326
 CAGATGCACATCCTCCACATTTCTGTGATG | GGTGGCCTCATCGCGCTGCTGCTGCTGCTG    c.660
 Q  M  H  I  L  H  I  S  V  M   | G  G  L  I  A  L  L  L  L  L      p.220

          .         .         .         .         .         .       g.205386
 CTGGTGTTCACCGTGGCGCTGTACGCCCAGCGACGTTGGCAGAAGCGTCGCCGCATCCCC       c.720
 L  V  F  T  V  A  L  Y  A  Q  R  R  W  Q  K  R  R  R  I  P         p.240

          .         .         .         .         .         .       g.205446
 CAGAAGAGCGCAAGCACAGAAGCCACTCATGAGATCCACTACATCCCATCTGTGCTGCTG       c.780
 Q  K  S  A  S  T  E  A  T  H  E  I  H  Y  I  P  S  V  L  L         p.260

          .         .         .         .         .         .       g.205506
 GGTCCCCAGGCGCGGGAGAGCTTCCGTTCATCCCGGCTGCAAACCCACAATTCCGTCATT       c.840
 G  P  Q  A  R  E  S  F  R  S  S  R  L  Q  T  H  N  S  V  I         p.280

          .         .         .         .         .         .       g.205566
 GGCGTGCCCATCCGGGAGACTCCCATCCTGGATGACTATGACTGTGAGGAGGATGAGGAG       c.900
 G  V  P  I  R  E  T  P  I  L  D  D  Y  D  C  E  E  D  E  E         p.300

          .         .         .         .         .         .       g.205626
 CCACCTAGGCGGGCCAACCATGTCTCCCGCGAGGACGAGTTTGGCAGCCAGGTGACCCAC       c.960
 P  P  R  R  A  N  H  V  S  R  E  D  E  F  G  S  Q  V  T  H         p.320

          .         .         .         .         .      | 04  .    g.323892
 ACTCTGGACAGTCTGGGACATCCAGGGGAAGAGAAGGTGGACTTTGAGAAGAAAG | GAGGA    c.1020
 T  L  D  S  L  G  H  P  G  E  E  K  V  D  F  E  K  K  G |   G      p.340

          .         .         .         .         .         .       g.323952
 ATCAGCTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTG       c.1080
 I  S  F  G  R  A  K  G  T  S  G  S  E  A  D  D  E  T  Q  L         p.360

          .         .         .         .    | 05    .         .    g.380090
 ACATTCTACACGGAGCAGTACCGCAGTCGCCGCCGCAGCAAAG | GTTTGCTGAAAAGCCCA    c.1140
 T  F  Y  T  E  Q  Y  R  S  R  R  R  S  K  G |   L  L  K  S  P      p.380

          .         .         .         .         .         .       g.380150
 GTGAACAAGACAGCCCTGACACTGATTGCTGTGAGTTCCTGCATCCTGGCCATGGTGTGT       c.1200
 V  N  K  T  A  L  T  L  I  A  V  S  S  C  I  L  A  M  V  C         p.400

          .         .         .         .         .         .       g.380210
 GGCAGCCAGATGTCTTGTCCACTCACTGTGAAGGTGACTCTGCATGTGCCCGAGCACTTC       c.1260
 G  S  Q  M  S  C  P  L  T  V  K  V  T  L  H  V  P  E  H  F         p.420

          . | 06       .         .         .         .         .    g.411829
 ATAGCAGATG | GAAGCAGCTTCGTGGTGAGTGAAGGGAGCTACCTGGACATCTCCGACTGG    c.1320
 I  A  D  G |   S  S  F  V  V  S  E  G  S  Y  L  D  I  S  D  W      p.440

          .         .         .         .         .         .       g.411889
 TTAAACCCGGCCAAGCTTTCCCTGTATTACCAGATCAATGCCACCTCCCCATGGGTGAGG       c.1380
 L  N  P  A  K  L  S  L  Y  Y  Q  I  N  A  T  S  P  W  V  R         p.460

          .         .         .         .         .         | 07    g.443255
 GACCTCTGTGGACAAAGGACGACAGATGCCTGTGAGCAGCTCTGCGACCCAGAAACCG | GA    c.1440
 D  L  C  G  Q  R  T  T  D  A  C  E  Q  L  C  D  P  E  T  G |       p.480

          .         .         .         .         .         .       g.443315
 GAGTGCAGCTGTCATGAAGGCTATGCCCCTGACCCTGTTCACAGACACCTGTGTGTGCGC       c.1500
 E  C  S  C  H  E  G  Y  A  P  D  P  V  H  R  H  L  C  V  R         p.500

          .         .    | 08    .         .         .         .    g.443887
 AGTGACTGGGGACAGAGTGAAGG | ACCTTGGCCCTACACGACACTTGAGAGGGGCTATGAT    c.1560
 S  D  W  G  Q  S  E  G  |  P  W  P  Y  T  T  L  E  R  G  Y  D      p.520

          .         .         .         | 09         .         .    g.444715
 CTGGTGACAGGGGAGCAAGCCCCTGAAAAGATTCTCAG | GTCTACTTTCAGCTTGGGCCAA    c.1620
 L  V  T  G  E  Q  A  P  E  K  I  L  R  |  S  T  F  S  L  G  Q      p.540

          .         .         .         .         .         .       g.444775
 GGCCTCTGGCTTCCTGTCAGCAAAAGCTTTGTGGTTCCGCCTGTGGAGCTGTCCATCAAC       c.1680
 G  L  W  L  P  V  S  K  S  F  V  V  P  P  V  E  L  S  I  N         p.560

          .         .         .         .         .       | 10 .    g.556309
 CCCCTGGCCAGCTGCAAGACCGATGTGCTCGTCACGGAAGACCCTGCAGATGTCAG | GGAA    c.1740
 P  L  A  S  C  K  T  D  V  L  V  T  E  D  P  A  D  V  R  |  E      p.580

          .         .         .         .         .         .       g.556369
 GAAGCGATGCTGTCCACATACTTTGAAACCATCAATGACCTGCTGTCTTCCTTCGGGCCA       c.1800
 E  A  M  L  S  T  Y  F  E  T  I  N  D  L  L  S  S  F  G  P         p.600

          .         .         .         .         .         .       g.556429
 GTTCGTGACTGCTCTCGGAACAATGGGGGCTGCACTCGCAACTTCAAGTGTGTGTCTGAC       c.1860
 V  R  D  C  S  R  N  N  G  G  C  T  R  N  F  K  C  V  S  D         p.620

          .         .        | 11.         .         .         .    g.599288
 CGGCAGGTGGATTCCTCGGGATGTGTG | TGCCCTGAGGAGCTGAAACCCATGAAGGATGGC    c.1920
 R  Q  V  D  S  S  G  C  V   | C  P  E  E  L  K  P  M  K  D  G      p.640

          .         .         .         .         .         .       g.599348
 TCTGGCTGCTACGACCACTCCAAAGGCATTGACTGCTCTGATGGCTTTAATGGCGGCTGT       c.1980
 S  G  C  Y  D  H  S  K  G  I  D  C  S  D  G  F  N  G  G  C         p.660

          .         .         .         .         .         .       g.599408
 GAGCAGCTGTGCCTGCAGCAGACGCTGCCCCTGCCCTACGATGCCACTTCGAGCACCATC       c.2040
 E  Q  L  C  L  Q  Q  T  L  P  L  P  Y  D  A  T  S  S  T  I         p.680

          .     | 12   .         .         .         .         .    g.614264
 TTCATGTTCTGCGG | TTGCGTGGAGGAGTACAAACTGGCTCCTGATGGAAAATCCTGCTTA    c.2100
 F  M  F  C  G  |  C  V  E  E  Y  K  L  A  P  D  G  K  S  C  L      p.700

          .         .         .         .         .         .       g.614324
 ATGCTCTCAGATGTCTGCGAGGGCCCCAAGTGCCTCAAACCTGACTCCAAATTCAATGAT       c.2160
 M  L  S  D  V  C  E  G  P  K  C  L  K  P  D  S  K  F  N  D         p.720

          .         .         .         .         .         .       g.614384
 ACCCTCTTTGGAGAGATGCTACATGGTTACAACAACCGGACCCAGCATGTGAACCAAGGC       c.2220
 T  L  F  G  E  M  L  H  G  Y  N  N  R  T  Q  H  V  N  Q  G         p.740

          .         .    | 13    .         .         .         .    g.686552
 CAAGTCTTCCAGATGACCTTTAG | GGAGAACAACTTCATCAAGGACTTTCCCCAGCTGGCC    c.2280
 Q  V  F  Q  M  T  F  R  |  E  N  N  F  I  K  D  F  P  Q  L  A      p.760

          .         .         .         .         .         .       g.686612
 GATGGGCTGTTGGTGATCCCGCTGCCGGTGGAGGAGCAGTGCCGGGGGGTCCTCTCCGAG       c.2340
 D  G  L  L  V  I  P  L  P  V  E  E  Q  C  R  G  V  L  S  E         p.780

          .         .         | 14         .         .         .    g.690974
 CCCCTTCCAGACCTCCAACTGCTCACTG | GAGATATCAGGTATGATGAGGCCATGGGTTAC    c.2400
 P  L  P  D  L  Q  L  L  T  G |   D  I  R  Y  D  E  A  M  G  Y      p.800

          .         .         .         .         .         .       g.691034
 CCCATGGTGCAGCAGTGGCGGGTCCGGAGCAACCTCTACCGTGTGAAGCTCAGCACCATC       c.2460
 P  M  V  Q  Q  W  R  V  R  S  N  L  Y  R  V  K  L  S  T  I         p.820

          .    | 15    .         .         .         .         .    g.694135
 ACCCTCGCAGCAG | GCTTCACTAATGTTCTCAAGATCCTGACCAAGGAGAGCAGTCGGGAG    c.2520
 T  L  A  A  G |   F  T  N  V  L  K  I  L  T  K  E  S  S  R  E      p.840

          .         .         .         .         .         .       g.694195
 GAGCTGCTGTCCTTCATCCAGCACTATGGCTCCCACTACATCGCAGAGGCCCTCTATGGC       c.2580
 E  L  L  S  F  I  Q  H  Y  G  S  H  Y  I  A  E  A  L  Y  G         p.860

          .         .         .         .         .         .       g.694255
 TCAGAGCTCACCTGCATCATCCACTTTCCCAGCAAGAAGGTCCAGCAGCAGCTGTGGCTC       c.2640
 S  E  L  T  C  I  I  H  F  P  S  K  K  V  Q  Q  Q  L  W  L         p.880

          .    | 16    .         .         .         .         .    g.768292
 CAGTATCAGAAAG | AGACCACAGAGCTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTC    c.2700
 Q  Y  Q  K  E |   T  T  E  L  G  S  K  K  E  L  K  S  M  P  F      p.900

          .         .         .         .         .         .       g.768352
 ATCACCTACCTCTCAGGTTTGCTGACAGCCCAGATGCTGTCAGATGACCAGCTCATTTCA       c.2760
 I  T  Y  L  S  G  L  L  T  A  Q  M  L  S  D  D  Q  L  I  S         p.920

          .         .         .         .         .         .       g.768412
 GGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCACCTTTGCCGC       c.2820
 G  V  E  I  R  C  E  E  K  G  R  C  P  S  T  C  H  L  C  R         p.940

          .         .         .         .         .         .       g.768472
 CGGCCAGGCAAGGAGCAGCTGAGCCCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTG       c.2880
 R  P  G  K  E  Q  L  S  P  T  P  V  L  L  E  I  N  R  V  V         p.960

          .         .         .          | 17        .         .    g.799616
 CCACTTTATACCCTCATCCAAGACAATGGCACAAAGGAG | GCCTTCAAGAGTGCACTGATG    c.2940
 P  L  Y  T  L  I  Q  D  N  G  T  K  E   | A  F  K  S  A  L  M      p.980

          .         .         .         .         .         .       g.799676
 AGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGGTGTGACCTC       c.3000
 S  S  Y  W  C  S  G  K  G  D  V  I  D  D  W  C  R  C  D  L         p.1000

          .         .         .         .         .    | 18    .    g.801573
 AGCGCCTTTGATGCCAATGGGCTCCCCAACTGCAGCCCCCTTCTGCAGCCGGT | GCTGCGG    c.3060
 S  A  F  D  A  N  G  L  P  N  C  S  P  L  L  Q  P  V  |  L  R      p.1020

          .         .         .         .         .         .       g.801633
 CTGTCCCCAACAGTGGAGCCCTCCAGTACTGTGGTCTCCTTGGAGTGGGTGGATGTTCAG       c.3120
 L  S  P  T  V  E  P  S  S  T  V  V  S  L  E  W  V  D  V  Q         p.1040

          .         .         .         .         .         .       g.801693
 CCAGCTATTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTGGATGAATAC       c.3180
 P  A  I  G  T  K  V  S  D  Y  I  L  Q  H  K  K  V  D  E  Y         p.1060

          .         .   | 19     .         .         .         .    g.932576
 ACAGACACTGACCTGTACACAG | GAGAATTCCTGAGTTTTGCTGATGACTTACTCTCTGGC    c.3240
 T  D  T  D  L  Y  T  G |   E  F  L  S  F  A  D  D  L  L  S  G      p.1080

          .         .         .         .         .         .       g.932636
 CTGGGCACATCTTGTGTAGCAGCTGGTCGAAGCCATGGAGAGGTCCCTGAAGTCAGTATC       c.3300
 L  G  T  S  C  V  A  A  G  R  S  H  G  E  V  P  E  V  S  I         p.1100

          .         .         .         .     | 20   .         .    g.977501
 TACTCAGTCATCTTCAAGTGTCTGGAGCCCGACGGTCTCTACAA | GTTCACTCTGTATGCT    c.3360
 Y  S  V  I  F  K  C  L  E  P  D  G  L  Y  K  |  F  T  L  Y  A      p.1120

          .         .         .         .         .         .       g.977561
 GTGGATACACGAGGGAGGCACTCAGAGCTAAGCACGGTGACCCTGAGGACGGCCTGTCCA       c.3420
 V  D  T  R  G  R  H  S  E  L  S  T  V  T  L  R  T  A  C  P         p.1140

          .         .      | 21  .         .         .         .    g.979281
 CTGGTAGATGACAACAAGGCAGAAG | AAATAGCTGACAAGATCTACAATCTGTACAATGGG    c.3480
 L  V  D  D  N  K  A  E  E |   I  A  D  K  I  Y  N  L  Y  N  G      p.1160

          .         .         .         .         .         .       g.979341
 TACACAAGTGGAAAGGAGCAGCAGATGGCCTACAACACACTGATGGAGGTCTCAGCCTCG       c.3540
 Y  T  S  G  K  E  Q  Q  M  A  Y  N  T  L  M  E  V  S  A  S         p.1180

          .         .         .         .         .         .       g.979401
 ATGCTGTTCCGAGTCCAGCACCACTACAACTCTCACTATGAAAAGTTTGGCGACTTCGTC       c.3600
 M  L  F  R  V  Q  H  H  Y  N  S  H  Y  E  K  F  G  D  F  V         p.1200

          .         .          | 22        .         .         .    g.993981
 TGGAGAAGTGAGGATGAGCTGGGGCCCAG | GAAGGCCCACCTGATTCTACGGCGACTGGAG    c.3660
 W  R  S  E  D  E  L  G  P  R  |  K  A  H  L  I  L  R  R  L  E      p.1220

          .         .         .         .         .         .       g.994041
 AGGGTGAGTAGCCACTGCTCCAGCCTCCTGCGGAGTGCCTACATCCAGAGCCGCGTGGAA       c.3720
 R  V  S  S  H  C  S  S  L  L  R  S  A  Y  I  Q  S  R  V  E         p.1240

          .         .         .         .         .         .       g.994101
 ACAGTGCCCTATCTTTTCTGCCGCAGCGAGGAGGTCCGGCCTGCAGGCATGGTGTGGTAT       c.3780
 T  V  P  Y  L  F  C  R  S  E  E  V  R  P  A  G  M  V  W  Y         p.1260

          .         .         .         .         .         .       g.994161
 AGCATCCTCAAGGACACCAAAATCACGTGTGAGGAGAAGATGGTGTCAATGGCCCGAAAC       c.3840
 S  I  L  K  D  T  K  I  T  C  E  E  K  M  V  S  M  A  R  N         p.1280

          .         .                                               g.994188
 ACGTACGGGGAGTCCAAGGGCCGGTGA                                        c.3867
 T  Y  G  E  S  K  G  R  X                                          p.1288

          .         .         .         .         .         .       g.994248
 gggagggtattgccctccgtgagcacagagactctccatgggagggggagcagtattctc       c.*60

          .         .         .         .         .         .       g.994308
 ctggatcctggggcctgggtgggctgggggacagctgaggatgggcctagcagatgaagc       c.*120

          .         .         .         .         .         .       g.994368
 ttgccagcaaggccaaagcaaacggtttctcctgtggatagtggacagagacctttgtaa       c.*180

          .         .         .         .         .         .       g.994428
 ccaatggaattattcatttttctctatcttttattttttcaaagatattatttgactcta       c.*240

          .         .         .         .         .         .       g.994488
 tcaaaagtctctcctttttaaaccttttcttatggatggctgtcaatcccgaggcagaag       c.*300

          .         .         .         .         .         .       g.994548
 ttttcaggtggagaccaagcggcctttgctcttcttccttcttcctgccacactctgctt       c.*360

          .         .         .         .         .         .       g.994608
 tcttcctgccatggacccctggaggagacctatggagggacagttttgacctgaccccta       c.*420

          .         .         .         .         .         .       g.994668
 gaggagacagttttgacctcttcagcaccaggaaggaagctctgaggatggttgcagtga       c.*480

          .         .         .         .         .         .       g.994728
 ggaagcatgggtctttaaggacttctctctcttttttgctggacattattgagtttgtgg       c.*540

          .         .         .         .         .         .       g.994788
 gaccctgcctcttcctgctacctgtgggtctgcccagagtccctgcaggcctgtccatgc       c.*600

          .         .                                               g.994814
 attaaaaattcctattgtctctcttt                                         c.*626

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Astrotactin 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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