atrophin 1 (ATN1) - coding DNA reference sequence

(used for variant description)

(last modified May 12, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001007026.1 in the ATN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008047.1, covering ATN1 transcript NM_001007026.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    gacgccatactggacgccaagtgggaggaacttcaaggctgtcccctgcgggcctcc       c.-181

 .         .        | 02.         .         .         .             g.14419
 cgctctgcttctgcgaag | gtttcattgaaaacagatcctgcaaaagttccaggtgcccac    c.-121

 .         .         .         .         .         .                g.14479
 actggaaacttggagatcctgcttcccagaccacagctgtggggaacttggggtggagca       c.-61

 .         .         .         .         .         .                g.14539
 gagaagtttctgtattcagctgcccaggcagaggagaatggggtctccacagcctgaaga       c.-1

          .         .        | 03.         .         .         .    g.14746
 ATGAAGACACGACAGAATAAAGACTCG | ATGTCAATGAGGAGTGGACGGAAGAAAGAGGCC    c.60
 M  K  T  R  Q  N  K  D  S   | M  S  M  R  S  G  R  K  K  E  A      p.20

          .         .         .         .         .         .       g.14806
 CCTGGGCCCCGGGAAGAACTGAGATCGAGGGGCCGGGCCTCCCCTGGAGGGGTCAGCACG       c.120
 P  G  P  R  E  E  L  R  S  R  G  R  A  S  P  G  G  V  S  T         p.40

          .         .         .         .      | 04  .         .    g.15017
 TCCAGCAGTGATGGCAAAGCTGAGAAGTCCAGGCAGACAGCCAAG | AAGGCCCGAGTAGAG    c.180
 S  S  S  D  G  K  A  E  K  S  R  Q  T  A  K   | K  A  R  V  E      p.60

          .         .         .         .         .         .       g.15077
 GAAGCCTCCACCCCAAAGGTCAACAAGCAGGGTCGGAGTGAGGAGATCTCAGAGAGTGAA       c.240
 E  A  S  T  P  K  V  N  K  Q  G  R  S  E  E  I  S  E  S  E         p.80

          .         .         .          | 05        .         .    g.16105
 AGTGAGGAGACCAATGCACCAAAAAAGACCAAAACTGAG | CAGGAACTCCCTCGGCCACAG    c.300
 S  E  E  T  N  A  P  K  K  T  K  T  E   | Q  E  L  P  R  P  Q      p.100

          .         .         .         .         .         .       g.16165
 TCTCCCTCCGATCTGGATAGCTTGGACGGGCGGAGCCTTAATGATGATGGCAGCAGCGAC       c.360
 S  P  S  D  L  D  S  L  D  G  R  S  L  N  D  D  G  S  S  D         p.120

          .         .         .         .         .         .       g.16225
 CCTAGGGATATCGACCAGGACAACCGAAGCACGTCCCCCAGTATCTACAGCCCTGGAAGT       c.420
 P  R  D  I  D  Q  D  N  R  S  T  S  P  S  I  Y  S  P  G  S         p.140

          .         .         .         .         .         .       g.16285
 GTGGAGAATGACTCTGACTCATCTTCTGGCCTGTCCCAGGGCCCAGCCCGCCCCTACCAC       c.480
 V  E  N  D  S  D  S  S  S  G  L  S  Q  G  P  A  R  P  Y  H         p.160

          .         .         .         .         .         .       g.16345
 CCACCTCCACTCTTTCCTCCTTCCCCTCAACCGCCAGACAGCACCCCTCGACAGCCAGAG       c.540
 P  P  P  L  F  P  P  S  P  Q  P  P  D  S  T  P  R  Q  P  E         p.180

          .         .         .         .         .         .       g.16405
 GCTAGCTTTGAACCCCATCCTTCTGTGACACCCACTGGATATCATGCTCCCATGGAGCCC       c.600
 A  S  F  E  P  H  P  S  V  T  P  T  G  Y  H  A  P  M  E  P         p.200

          .         .         .         .         .         .       g.16465
 CCCACATCTCGAATGTTCCAGGCTCCTCCTGGGGCCCCTCCCCCTCACCCACAGCTCTAT       c.660
 P  T  S  R  M  F  Q  A  P  P  G  A  P  P  P  H  P  Q  L  Y         p.220

          .         .         .         .         .         .       g.16525
 CCTGGGGGCACTGGTGGAGTTTTGTCTGGACCCCCAATGGGTCCCAAGGGGGGAGGGGCT       c.720
 P  G  G  T  G  G  V  L  S  G  P  P  M  G  P  K  G  G  G  A         p.240

          .         .         .         .         .         .       g.16585
 GCCTCATCAGTGGGGGGCCCTAATGGGGGTAAGCAGCACCCCCCACCCACTACTCCCATT       c.780
 A  S  S  V  G  G  P  N  G  G  K  Q  H  P  P  P  T  T  P  I         p.260

          .         .         .         .         .         .       g.16645
 TCAGTATCAAGCTCTGGGGCTAGTGGTGCTCCCCCAACAAAGCCGCCTACCACTCCAGTG       c.840
 S  V  S  S  S  G  A  S  G  A  P  P  T  K  P  P  T  T  P  V         p.280

          .         .         .         .         .         .       g.16705
 GGTGGTGGGAACCTACCTTCTGCTCCACCACCAGCCAACTTCCCCCATGTGACACCGAAC       c.900
 G  G  G  N  L  P  S  A  P  P  P  A  N  F  P  H  V  T  P  N         p.300

          .         .         .         .         .         .       g.16765
 CTGCCTCCCCCACCTGCCCTGAGACCCCTCAACAATGCATCAGCCTCTCCCCCTGGCCTG       c.960
 L  P  P  P  P  A  L  R  P  L  N  N  A  S  A  S  P  P  G  L         p.320

          .         .         .         .         .         .       g.16825
 GGGGCCCAACCACTACCTGGTCATCTGCCCTCTCCCCACGCCATGGGACAGGGTATGGGT       c.1020
 G  A  Q  P  L  P  G  H  L  P  S  P  H  A  M  G  Q  G  M  G         p.340

          .         .         .         .         .         .       g.16885
 GGACTTCCTCCTGGCCCAGAGAAGGGCCCAACTCTGGCTCCTTCACCCCACTCTCTGCCT       c.1080
 G  L  P  P  G  P  E  K  G  P  T  L  A  P  S  P  H  S  L  P         p.360

          .         .         .         .         .         .       g.16945
 CCTGCTTCCTCTTCTGCTCCAGCGCCCCCCATGAGGTTTCCTTATTCATCCTCTAGTAGT       c.1140
 P  A  S  S  S  A  P  A  P  P  M  R  F  P  Y  S  S  S  S  S         p.380

          .         .         .         .         .         .       g.17005
 AGCTCTGCAGCAGCCTCCTCTTCCAGTTCTTCCTCCTCTTCCTCTGCCTCCCCCTTCCCA       c.1200
 S  S  A  A  A  S  S  S  S  S  S  S  S  S  S  A  S  P  F  P         p.400

          .         .         .         .         .         .       g.17065
 GCTTCCCAGGCATTGCCCAGCTACCCCCACTCTTTCCCTCCCCCAACAAGCCTCTCTGTC       c.1260
 A  S  Q  A  L  P  S  Y  P  H  S  F  P  P  P  T  S  L  S  V         p.420

          .         .         .         .         .         .       g.17125
 TCCAATCAGCCCCCCAAGTATACTCAGCCTTCTCTCCCATCCCAGGCTGTGTGGAGCCAG       c.1320
 S  N  Q  P  P  K  Y  T  Q  P  S  L  P  S  Q  A  V  W  S  Q         p.440

          .         .         .         .         .         .       g.17185
 GGTCCCCCACCACCTCCTCCCTATGGCCGCCTCTTAGCCAACAGCAATGCCCATCCAGGC       c.1380
 G  P  P  P  P  P  P  Y  G  R  L  L  A  N  S  N  A  H  P  G         p.460

          .         .         .         .         .         .       g.17245
 CCCTTCCCTCCCTCTACTGGGGCCCAGTCCACCGCCCACCCACCAGTCTCAACACATCAC       c.1440
 P  F  P  P  S  T  G  A  Q  S  T  A  H  P  P  V  S  T  H  H         p.480

          .         .         .         .         .         .       g.17305
 CATCACCACCAGCAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG       c.1500
 H  H  H  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q  Q         p.500

          .         .         .         .         .         .       g.17365
 CAGCAGCATCACGGAAACTCTGGGCCCCCTCCTCCTGGAGCATTTCCCCACCCACTGGAG       c.1560
 Q  Q  H  H  G  N  S  G  P  P  P  P  G  A  F  P  H  P  L  E         p.520

          .         .         .         .         .         .       g.17425
 GGCGGTAGCTCCCACCACGCACACCCTTACGCCATGTCTCCCTCCCTGGGGTCTCTGAGG       c.1620
 G  G  S  S  H  H  A  H  P  Y  A  M  S  P  S  L  G  S  L  R         p.540

          .         .         .         .         .         .       g.17485
 CCCTACCCACCAGGGCCAGCACACCTGCCCCCACCTCACAGCCAGGTGTCCTACAGCCAA       c.1680
 P  Y  P  P  G  P  A  H  L  P  P  P  H  S  Q  V  S  Y  S  Q         p.560

          .         .         .         .         .         .       g.17545
 GCAGGCCCCAATGGCCCTCCAGTCTCTTCCTCTTCCAACTCTTCCTCTTCCACTTCTCAA       c.1740
 A  G  P  N  G  P  P  V  S  S  S  S  N  S  S  S  S  T  S  Q         p.580

          .         .         .         .         .         .       g.17605
 GGGTCCTACCCATGTTCACACCCCTCCCCTTCCCAGGGCCCTCAAGGGGCGCCCTACCCT       c.1800
 G  S  Y  P  C  S  H  P  S  P  S  Q  G  P  Q  G  A  P  Y  P         p.600

          .         .         .         .         .         .       g.17665
 TTCCCACCGGTGCCTACGGTCACCACCTCTTCGGCTACCCTTTCCACGGTCATTGCCACC       c.1860
 F  P  P  V  P  T  V  T  T  S  S  A  T  L  S  T  V  I  A  T         p.620

          .         .         .         .         .         .       g.17725
 GTGGCTTCCTCGCCAGCAGGCTACAAAACGGCCTCCCCACCTGGGCCCCCACCGTACGGA       c.1920
 V  A  S  S  P  A  G  Y  K  T  A  S  P  P  G  P  P  P  Y  G         p.640

          .         .         .         .         .         .       g.17785
 AAGAGAGCCCCGTCCCCGGGGGCCTACAAGACAGCCACCCCACCCGGATACAAACCCGGG       c.1980
 K  R  A  P  S  P  G  A  Y  K  T  A  T  P  P  G  Y  K  P  G         p.660

          .         .         .         .         .         .       g.17845
 TCGCCTCCCTCCTTCCGAACGGGGACCCCACCGGGCTATCGAGGAACCTCGCCACCTGCA       c.2040
 S  P  P  S  F  R  T  G  T  P  P  G  Y  R  G  T  S  P  P  A         p.680

          .         .         .         .         .         .       g.17905
 GGCCCAGGGACCTTCAAGCCGGGCTCGCCCACCGTGGGACCTGGGCCCCTGCCACCTGCG       c.2100
 G  P  G  T  F  K  P  G  S  P  T  V  G  P  G  P  L  P  P  A         p.700

          .         .         .         .         .         .       g.17965
 GGGCCCTCAGGCCTGCCATCGCTGCCACCACCACCTGCGGCCCCTGCCTCAGGGCCGCCC       c.2160
 G  P  S  G  L  P  S  L  P  P  P  P  A  A  P  A  S  G  P  P         p.720

          .         .         .         .         .         .       g.18025
 CTGAGCGCCACGCAGATCAAACAGGAGCCGGCTGAGGAGTATGAGACCCCCGAGAGCCCG       c.2220
 L  S  A  T  Q  I  K  Q  E  P  A  E  E  Y  E  T  P  E  S  P         p.740

          .         .         .         .         .         .       g.18085
 GTGCCCCCAGCCCGCAGCCCCTCGCCCCCTCCCAAGGTGGTAGATGTACCCAGCCATGCC       c.2280
 V  P  P  A  R  S  P  S  P  P  P  K  V  V  D  V  P  S  H  A         p.760

          .     | 06   .         .         .         .         .    g.18428
 AGTCAGTCTGCCAG | GTTCAACAAACACCTGGATCGCGGCTTCAACTCGTGCGCGCGCAGC    c.2340
 S  Q  S  A  R  |  F  N  K  H  L  D  R  G  F  N  S  C  A  R  S      p.780

          .         .         .         .         .         .       g.18488
 GACCTGTACTTCGTGCCACTGGAGGGCTCCAAGCTGGCCAAGAAGCGGGCCGACCTGGTG       c.2400
 D  L  Y  F  V  P  L  E  G  S  K  L  A  K  K  R  A  D  L  V         p.800

          .         .         .         .         .         .       g.18548
 GAGAAGGTGCGGCGCGAGGCCGAGCAGCGCGCGCGCGAAGAAAAGGAGCGCGAGCGCGAG       c.2460
 E  K  V  R  R  E  A  E  Q  R  A  R  E  E  K  E  R  E  R  E         p.820

          .         .         .         .         .        | 07.    g.19021
 CGGGAACGCGAGAAAGAGCGCGAGCGCGAGAAGGAGCGCGAGCTTGAACGCAGCGTG | AAG    c.2520
 R  E  R  E  K  E  R  E  R  E  K  E  R  E  L  E  R  S  V   | K      p.840

          .         .         .         .         .         .       g.19081
 TTGGCTCAGGAGGGCCGTGCTCCGGTGGAATGCCCATCTCTGGGCCCAGTGCCCCATCGC       c.2580
 L  A  Q  E  G  R  A  P  V  E  C  P  S  L  G  P  V  P  H  R         p.860

          .         .         .         .         .         .       g.19141
 CCTCCATTTGAACCGGGCAGTGCGGTGGCTACAGTGCCCCCCTACCTGGGTCCTGACACT       c.2640
 P  P  F  E  P  G  S  A  V  A  T  V  P  P  Y  L  G  P  D  T         p.880

          .         .         .         .         .         .       g.19201
 CCAGCCTTGCGCACTCTCAGTGAATATGCCCGGCCTCATGTCATGTCTCCTGGCAATCGC       c.2700
 P  A  L  R  T  L  S  E  Y  A  R  P  H  V  M  S  P  G  N  R         p.900

          .         .         .         .         .         .       g.19261
 AACCATCCATTCTACGTGCCCCTGGGGGCAGTGGACCCGGGGCTCCTGGGTTACAATGTC       c.2760
 N  H  P  F  Y  V  P  L  G  A  V  D  P  G  L  L  G  Y  N  V         p.920

          .         .         .         .         .         .       g.19321
 CCGGCCCTGTACAGCAGTGATCCAGCTGCCCGGGAGAGGGAACGGGAAGCCCGTGAACGA       c.2820
 P  A  L  Y  S  S  D  P  A  A  R  E  R  E  R  E  A  R  E  R         p.940

          .         .         .         .         .         .       g.19381
 GACCTCCGTGACCGCCTCAAGCCTGGCTTTGAGGTGAAGCCTAGTGAGCTGGAACCCCTA       c.2880
 D  L  R  D  R  L  K  P  G  F  E  V  K  P  S  E  L  E  P  L         p.960

          .         .         .         .         .         .       g.19441
 CATGGGGTCCCTGGGCCGGGCTTGGATCCCTTTCCCCGACATGGGGGCCTGGCTCTGCAG       c.2940
 H  G  V  P  G  P  G  L  D  P  F  P  R  H  G  G  L  A  L  Q         p.980

          .         .         .         .         .         .       g.19501
 CCTGGCCCACCTGGCCTGCACCCTTTCCCCTTTCATCCGAGCCTGGGGCCCCTGGAGCGA       c.3000
 P  G  P  P  G  L  H  P  F  P  F  H  P  S  L  G  P  L  E  R         p.1000

          .         .         .         .         .         .       g.19561
 GAACGTCTAGCGCTGGCAGCTGGGCCAGCCCTGCGGCCTGACATGTCCTATGCTGAGCGG       c.3060
 E  R  L  A  L  A  A  G  P  A  L  R  P  D  M  S  Y  A  E  R         p.1020

          .         .         .         .         .         .       g.19621
 CTGGCAGCTGAGAGGCAGCACGCAGAAAGGGTGGCGGCCCTGGGCAATGACCCACTGGCC       c.3120
 L  A  A  E  R  Q  H  A  E  R  V  A  A  L  G  N  D  P  L  A         p.1040

          .         .         .         .         .         .       g.19681
 CGGCTGCAGATGCTCAATGTGACTCCCCATCACCACCAGCACTCCCACATCCACTCGCAC       c.3180
 R  L  Q  M  L  N  V  T  P  H  H  H  Q  H  S  H  I  H  S  H         p.1060

          .         .         .     | 08   .         .         .    g.21443
 CTGCACCTGCACCAGCAAGATGCTATCCATGCAG | CCTCTGCCTCGGTGCACCCTCTCATT    c.3240
 L  H  L  H  Q  Q  D  A  I  H  A  A |   S  A  S  V  H  P  L  I      p.1080

          .         .         .         .         .         .       g.21503
 GACCCCCTGGCCTCAGGGTCTCACCTTACCCGGATCCCCTACCCAGCTGGAACTCTCCCT       c.3300
 D  P  L  A  S  G  S  H  L  T  R  I  P  Y  P  A  G  T  L  P         p.1100

          .         .         .         .         .         | 09    g.21913
 AACCCCCTGCTTCCTCACCCTCTGCACGAGAACGAAGTTCTTCGTCACCAGCTCTTTG | CT    c.3360
 N  P  L  L  P  H  P  L  H  E  N  E  V  L  R  H  Q  L  F  A |       p.1120

          .         .         .         .         .         .       g.21973
 GCCCCTTACCGGGACCTGCCGGCCTCCCTTTCTGCCCCGATGTCAGCAGCTCATCAGCTG       c.3420
 A  P  Y  R  D  L  P  A  S  L  S  A  P  M  S  A  A  H  Q  L         p.1140

          .         .         .         .         .         .       g.22033
 CAGGCCATGCACGCACAGTCAGCTGAGCTGCAGCGCTTGGCGCTGGAACAGCAGCAGTGG       c.3480
 Q  A  M  H  A  Q  S  A  E  L  Q  R  L  A  L  E  Q  Q  Q  W         p.1160

          .         .         .         .         .          | 10    g.22285
 CTGCATGCCCATCACCCGCTGCACAGTGTGCCGCTGCCTGCCCAGGAGGACTACTACAG | T    c.3540
 L  H  A  H  H  P  L  H  S  V  P  L  P  A  Q  E  D  Y  Y  S  |      p.1180

          .         .         .                                     g.22318
 CACCTGAAGAAGGAAAGCGACAAGCCACTGTAG                                  c.3573
 H  L  K  K  E  S  D  K  P  L  X                                    p.1190

          .         .         .         .         .         .       g.22378
 aacctgcgatcaagagagcaccatggctcctacattggaccttggagcacccccaccctc       c.*60

          .         .         .         .         .         .       g.22438
 cccccaccgtgcccttggcctgccacccagagccaagagggtgctgctcagttgcagggc       c.*120

          .         .         .         .         .         .       g.22498
 ctccgcagctggacagagagtgggggagggagggacagacagaaggccaaggcccgatgt       c.*180

          .         .         .         .         .         .       g.22558
 ggtgtgcagaggtggggaggtggcgaggatggggacagaaagcgcacagaatcttggacc       c.*240

          .         .         .         .         .         .       g.22618
 aggtctctcttccttgtcccccctgcttttctcctcccccatgcccaacccctgtggccg       c.*300

          .         .         .         .         .         .       g.22678
 ccgcccctcccctgccccgttggtgtgattatttcatctgttagatgtggctgttttgcg       c.*360

          .         .         .         .         .         .       g.22738
 tagcatcgtgtgccacccctgcccctccccgatccctgtgtgcgcgccccctctgcaatg       c.*420

          .         .         .         .         .         .       g.22798
 tatgccccttgccccttccccacactaataatttatatatataaatatctatatgacgct       c.*480

          .         .         .         .         .         .       g.22858
 cttaaaaaaacatcccaaccaaaaccaaccaaacaaaaacatcctcacaactccccagga       c.*540

                                                                    g.22859
 a                                                                  c.*541

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Atrophin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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