ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1) - coding DNA reference sequence

(used for variant description)

(last modified March 25, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000701.7 in the ATP1A1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_047036.1, covering ATP1A1 transcript NM_000701.7.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.6027
                      gacgtttcgcggcgtgggcggggccagcacgcaggttgc       c.-301

 .         .         .         .         .         .                g.6087
 atattttaggaagtgaggaggaggcgcgggctggagctgcggcggggtctggggcgcaga       c.-241

 .         .         .         .         .         .                g.6147
 gcagcggcgggaggaggcggacacgtggcaacagcggtagcagcccgggcggcggcagca       c.-181

 .         .         .         .         .         .                g.6207
 acagcggcggcggcatcggcccgagccgccggccgccctcccaccctcccgccccgcggc       c.-121

 .         .         .         .         .         .                g.6267
 agccctagctccctccacttggctcccctggtcccgctcgctcggccgggagctgctctg       c.-61

 .         .         .         .         .         .                g.6327
 tgcttttctctctgattctccagcgacaggacccggcgccgggcactgagcaccgccacc       c.-1

          .   | 02     .         .         .         .         .    g.16877
 ATGGGGAAGGGG | GTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGAT    c.60
 M  G  K  G   | V  G  R  D  K  Y  E  P  A  A  V  S  E  Q  G  D      p.20

          .         .         .         .         .         .       g.16937
 AAAAAGGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCT       c.120
 K  K  G  K  K  G  K  K  D  R  D  M  D  E  L  K  K  E  V  S         p.40

     | 03    .         .         .         .         .         .    g.17655
 ATG | GATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGC    c.180
 M   | D  D  H  K  L  S  L  D  E  L  H  R  K  Y  G  T  D  L  S      p.60

     | 04    .         .         .         .         .         .    g.20160
 CGG | GGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTC    c.240
 R   | G  L  T  S  A  R  A  A  E  I  L  A  R  D  G  P  N  A  L      p.80

          .         .         .         .         .         .       g.20220
 ACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTC       c.300
 T  P  P  P  T  T  P  E  W  I  K  F  C  R  Q  L  F  G  G  F         p.100

          .         .         .         .         .         .       g.20280
 TCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCT       c.360
 S  M  L  L  W  I  G  A  I  L  C  F  L  A  Y  S  I  Q  A  A         p.120

          .         .        | 05.         .         .         .    g.20979
 ACAGAAGAGGAACCTCAAAACGATAAT | CTGTACCTGGGTGTGGTGCTATCAGCCGTTGTA    c.420
 T  E  E  E  P  Q  N  D  N   | L  Y  L  G  V  V  L  S  A  V  V      p.140

          .         .         .         .         .         .       g.21039
 ATCATAACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCC       c.480
 I  I  T  G  C  F  S  Y  Y  Q  E  A  K  S  S  K  I  M  E  S         p.160

          .         .  | 06      .         .         .         .    g.21492
 TTCAAAAACATGGTCCCTCAG | CAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATA    c.540
 F  K  N  M  V  P  Q   | Q  A  L  V  I  R  N  G  E  K  M  S  I      p.180

          .         .         .         .         .         .       g.21552
 AATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCT       c.600
 N  A  E  E  V  V  V  G  D  L  V  E  V  K  G  G  D  R  I  P         p.200

          .         .         .       | 07 .         .         .    g.21741
 GCTGACCTCAGAATCATATCTGCAAATGGCTGCAAG | GTGGATAACTCCTCGCTCACTGGT    c.660
 A  D  L  R  I  I  S  A  N  G  C  K   | V  D  N  S  S  L  T  G      p.220

          .         .         .         .         .         .       g.21801
 GAATCAGAACCCCAGACTAGGTCTCCAGATTTCACAAATGAAAACCCCCTGGAGACGAGG       c.720
 E  S  E  P  Q  T  R  S  P  D  F  T  N  E  N  P  L  E  T  R         p.240

          .         .         .     | 08   .         .         .    g.22280
 AACATTGCCTTCTTTTCAACCAATTGTGTTGAAG | GCACCGCACGTGGTATTGTTGTCTAC    c.780
 N  I  A  F  F  S  T  N  C  V  E  G |   T  A  R  G  I  V  V  Y      p.260

          .         .         .         .         .         .       g.22340
 ACTGGGGATCGCACTGTGATGGGAAGAATTGCCACACTTGCTTCTGGGCTGGAAGGAGGC       c.840
 T  G  D  R  T  V  M  G  R  I  A  T  L  A  S  G  L  E  G  G         p.280

          .         .         .         .         .         .       g.22400
 CAGACCCCCATTGCTGCAGAAATTGAACATTTTATCCACATCATCACGGGTGTGGCTGTG       c.900
 Q  T  P  I  A  A  E  I  E  H  F  I  H  I  I  T  G  V  A  V         p.300

          .         .         .         .         .         .       g.22460
 TTCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCT       c.960
 F  L  G  V  S  F  F  I  L  S  L  I  L  E  Y  T  W  L  E  A         p.320

          .         .         .         .         .         .       g.22520
 GTCATCTTCCTCATCGGTATCATCGTAGCCAATGTGCCGGAAGGTTTGCTGGCCACTGTC       c.1020
 V  I  F  L  I  G  I  I  V  A  N  V  P  E  G  L  L  A  T  V         p.340

     | 09    .         .         .         .         .         .    g.23085
 ACG | GTCTGTCTGACACTTACTGCCAAACGCATGGCAAGGAAAAACTGCTTAGTGAAGAAC    c.1080
 T   | V  C  L  T  L  T  A  K  R  M  A  R  K  N  C  L  V  K  N      p.360

          .         .         .         .         .         .       g.23145
 TTAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACT       c.1140
 L  E  A  V  E  T  L  G  S  T  S  T  I  C  S  D  K  T  G  T         p.380

          .         .         .         .         .         .       g.23205
 CTGACTCAGAACCGGATGACAGTGGCCCACATGTGGTTTGACAATCAAATCCATGAAGCT       c.1200
 L  T  Q  N  R  M  T  V  A  H  M  W  F  D  N  Q  I  H  E  A         p.400

          .         .   | 10     .         .         .         .    g.23635
 GATACGACAGAGAATCAGAGTG | GTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCT    c.1260
 D  T  T  E  N  Q  S  G |   V  S  F  D  K  T  S  A  T  W  L  A      p.420

          .         .         .         .         .         .       g.23695
 CTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTA       c.1320
 L  S  R  I  A  G  L  C  N  R  A  V  F  Q  A  N  Q  E  N  L         p.440

          .   | 11     .         .         .         .         .    g.25717
 CCTATTCTTAAG | CGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATA    c.1380
 P  I  L  K   | R  A  V  A  G  D  A  S  E  S  A  L  L  K  C  I      p.460

          .         .         .         .         .         .       g.25777
 GAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATA       c.1440
 E  L  C  C  G  S  V  K  E  M  R  E  R  Y  A  K  I  V  E  I         p.480

          .         .        | 12.         .         .         .    g.26379
 CCCTTCAACTCCACCAACAAGTACCAG | TTGTCTATTCATAAGAACCCCAACACATCGGAG    c.1500
 P  F  N  S  T  N  K  Y  Q   | L  S  I  H  K  N  P  N  T  S  E      p.500

          .         .         .         .         .         .       g.26439
 CCCCAACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGATCCTAGACCGTTGCAGCTCT       c.1560
 P  Q  H  L  L  V  M  K  G  A  P  E  R  I  L  D  R  C  S  S         p.520

          .         .         .         .         .         .       g.26499
 ATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGCCTTTCAGAAC       c.1620
 I  L  L  H  G  K  E  Q  P  L  D  E  E  L  K  D  A  F  Q  N         p.540

          .         .         .         . | 13       .         .    g.27945
 GCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAG | GTTTCTGCCACCTCTTTCTG    c.1680
 A  Y  L  E  L  G  G  L  G  E  R  V  L  G |   F  C  H  L  F  L      p.560

          .         .         .         .         .         .       g.28005
 CCAGATGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATC       c.1740
 P  D  E  Q  F  P  E  G  F  Q  F  D  T  D  D  V  N  F  P  I         p.580

          .         .         .         .         .         .       g.28065
 GATAATCTGTGCTTTGTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCT       c.1800
 D  N  L  C  F  V  G  L  I  S  M  I  D  P  P  R  A  A  V  P         p.600

          .         .         .       | 14 .         .         .    g.29437
 GATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAG | GTCATCATGGTCACAGGAGACCAT    c.1860
 D  A  V  G  K  C  R  S  A  G  I  K   | V  I  M  V  T  G  D  H      p.620

          .         .         .         .         .         .       g.29497
 CCAATCACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACC       c.1920
 P  I  T  A  K  A  I  A  K  G  V  G  I  I  S  E  G  N  E  T         p.640

          .         .         .         .         .    | 15    .    g.30710
 GTGGAAGACATTGCTGCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAG | GGATGCC    c.1980
 V  E  D  I  A  A  R  L  N  I  P  V  S  Q  V  N  P  R  |  D  A      p.660

          .         .         .         .         .         .       g.30770
 AAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGAC       c.2040
 K  A  C  V  V  H  G  S  D  L  K  D  M  T  S  E  Q  L  D  D         p.680

          .         .         .         .         .         .       g.30830
 ATTTTGAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATC       c.2100
 I  L  K  Y  H  T  E  I  V  F  A  R  T  S  P  Q  Q  K  L  I         p.700

          .         .     | 16   .         .         .         .    g.31472
 ATTGTGGAAGGCTGCCAAAGACAG | GGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAAT    c.2160
 I  V  E  G  C  Q  R  Q   | G  A  I  V  A  V  T  G  D  G  V  N      p.720

          .         .         .         .         .         .       g.31532
 GACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGAT       c.2220
 D  S  P  A  L  K  K  A  D  I  G  V  A  M  G  I  A  G  S  D         p.740

          .         .         .         .         .         .       g.31592
 GTGTCCAAGCAAGCTGCTGACATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACT       c.2280
 V  S  K  Q  A  A  D  M  I  L  L  D  D  N  F  A  S  I  V  T         p.760

          .    | 17    .         .         .         .         .    g.31792
 GGAGTAGAGGAAG | GTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTA    c.2340
 G  V  E  E  G |   R  L  I  F  D  N  L  K  K  S  I  A  Y  T  L      p.780

          .         .         .         .         .         .       g.31852
 ACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTA       c.2400
 T  S  N  I  P  E  I  T  P  F  L  I  F  I  I  A  N  I  P  L         p.800

          .         .         .         .         | 18         .    g.32247
 CCACTGGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATG | GTTCCTGCCATC    c.2460
 P  L  G  T  V  T  I  L  C  I  D  L  G  T  D  M   | V  P  A  I      p.820

          .         .         .         .         .         .       g.32307
 TCCCTGGCTTATGAGCAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAA       c.2520
 S  L  A  Y  E  Q  A  E  S  D  I  M  K  R  Q  P  R  N  P  K         p.840

          .         .         .         .         .   | 19     .    g.33684
 ACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTG | GAATGATC    c.2580
 T  D  K  L  V  N  E  R  L  I  S  M  A  Y  G  Q  I  G |   M  I      p.860

          .         .         .         .         .         .       g.33744
 CAGGCCCTGGGAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCA       c.2640
 Q  A  L  G  G  F  F  T  Y  F  V  I  L  A  E  N  G  F  L  P         p.880

          .         .         .         .         .         .       g.33804
 ATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGAC       c.2700
 I  H  L  L  G  L  R  V  D  W  D  D  R  W  I  N  D  V  E  D         p.900

          .         | 20         .         .         .         .    g.33987
 AGCTACGGGCAGCAGTGG | ACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACA    c.2760
 S  Y  G  Q  Q  W   | T  Y  E  Q  R  K  I  V  E  F  T  C  H  T      p.920

          .         .         .         .         .         .       g.34047
 GCCTTCTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATCTGTAAGACCAGG       c.2820
 A  F  F  V  S  I  V  V  V  Q  W  A  D  L  V  I  C  K  T  R         p.940

          .         .          | 21        .         .         .    g.34400
 AGGAATTCGGTCTTCCAGCAGGGGATGAA | GAACAAGATCTTGATATTTGGCCTCTTTGAA    c.2880
 R  N  S  V  F  Q  Q  G  M  K  |  N  K  I  L  I  F  G  L  F  E      p.960

          .         .         .         .         .         .       g.34460
 GAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATG       c.2940
 E  T  A  L  A  A  F  L  S  Y  C  P  G  M  G  V  A  L  R  M         p.980

          .  | 22      .         .         .         .         .    g.36748
 TATCCCCTCAA | ACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTA    c.3000
 Y  P  L  K  |  P  T  W  W  F  C  A  F  P  Y  S  L  L  I  F  V      p.1000

          .         .         .         .    | 23    .         .    g.37248
 TATGACGAAGTCAGAAAACTCATCATCAGGCGACGCCCTGGCG | GCTGGGTGGAGAAGGAA    c.3060
 Y  D  E  V  R  K  L  I  I  R  R  R  P  G  G |   W  V  E  K  E      p.1020

          .                                                         g.37260
 ACCTACTATTAG                                                       c.3072
 T  Y  Y  X                                                         p.1023

          .         .         .         .         .         .       g.37320
 ccccccgtcctgcacgccgtggagcatcaggccacacactctgcatccgacacccacccc       c.*60

          .         .         .         .         .         .       g.37380
 ctctttgtgtacttcagtcttggagtttggaactctaccctggtaggaaagcaccgcagc       c.*120

          .         .         .         .         .         .       g.37440
 atgtggggaagcaagacgtcctggaatgaagcatgtagctctatggggggaggggggagg       c.*180

          .         .         .         .         .         .       g.37500
 gctgcctgaaaaccatccatctgtggaaatgacagcggggaaggtttttatgtgcctttt       c.*240

          .         .         .         .         .         .       g.37560
 tgtttttgtaaaaaaggaacacccggaaagactgaaagaatacattttatatctggattt       c.*300

          .         .         .                                     g.37590
 ttacaaataaagatggctattataatggaa                                     c.*330

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ATPase, Na+/K+ transporting, alpha 1 polypeptide protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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