ATPase, Na+/K+ transporting, alpha 2 polypeptide (ATP1A2) - coding DNA reference sequence

(used for variant description)

(last modified July 25, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000702.3 in the ATP1A2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008014.1, covering ATP1A2 transcript NM_000702.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5012
                                                 atttaaagctac       c.-121

 .         .         .         .         .         .                g.5072
 cctgttgctttggctttctctgtctgccagggtctccgactgtcccagacgggctggtgt       c.-61

 .         .         .         .         .         .                g.5132
 gggcttgggatcctcctggtgacctctcccgctaaggtccctcagccactctgccccaag       c.-1

          .   | 02     .         .         .         .         .    g.10224
 ATGGGCCGTGGG | GCTGGCCGTGAGTACTCACCTGCCGCCACCACGGCAGAGAATGGGGGC    c.60
 M  G  R  G   | A  G  R  E  Y  S  P  A  A  T  T  A  E  N  G  G      p.20

          .         .         .         .         .        | 03.    g.10465
 GGCAAGAAGAAACAGAAGGAGAAGGAACTGGATGAGCTGAAGAAGGAGGTGGCAATG | GAT    c.120
 G  K  K  K  Q  K  E  K  E  L  D  E  L  K  K  E  V  A  M   | D      p.40

          .         .         .         .         .        | 04.    g.12486
 GACCACAAGCTGTCCTTGGATGAGCTGGGCCGCAAATACCAAGTGGACCTGTCCAAG | GGC    c.180
 D  H  K  L  S  L  D  E  L  G  R  K  Y  Q  V  D  L  S  K   | G      p.60

          .         .         .         .         .         .       g.12546
 CTCACCAACCAGCGGGCTCAGGACGTTCTGGCTCGAGATGGGCCCAACGCCCTCACACCA       c.240
 L  T  N  Q  R  A  Q  D  V  L  A  R  D  G  P  N  A  L  T  P         p.80

          .         .         .         .         .         .       g.12606
 CCTCCCACAACCCCTGAGTGGGTCAAGTTCTGCCGTCAGCTTTTCGGGGGGTTCTCCATC       c.300
 P  P  T  T  P  E  W  V  K  F  C  R  Q  L  F  G  G  F  S  I         p.100

          .         .         .         .         .         .       g.12666
 CTGCTGTGGATTGGGGCTATCCTCTGCTTCCTGGCCTACGGCATCCAGGCTGCCATGGAG       c.360
 L  L  W  I  G  A  I  L  C  F  L  A  Y  G  I  Q  A  A  M  E         p.120

          .         .  | 05      .         .         .         .    g.13252
 GATGAACCATCCAACGACAAT | CTATATCTGGGTGTGGTGCTGGCAGCTGTGGTCATTGTC    c.420
 D  E  P  S  N  D  N   | L  Y  L  G  V  V  L  A  A  V  V  I  V      p.140

          .         .         .         .         .         .       g.13312
 ACTGGCTGCTTCTCCTACTACCAGGAGGCCAAGAGCTCCAAGATCATGGATTCCTTCAAG       c.480
 T  G  C  F  S  Y  Y  Q  E  A  K  S  S  K  I  M  D  S  F  K         p.160

          .      | 06  .         .         .         .         .    g.13611
 AACATGGTACCTCAG | CAAGCCCTTGTGATCCGGGAGGGAGAGAAGATGCAGATCAACGCA    c.540
 N  M  V  P  Q   | Q  A  L  V  I  R  E  G  E  K  M  Q  I  N  A      p.180

          .         .         .         .         .         .       g.13671
 GAGGAAGTGGTGGTGGGAGACCTGGTGGAGGTGAAGGGTGGAGACCGCGTCCCTGCTGAC       c.600
 E  E  V  V  V  G  D  L  V  E  V  K  G  G  D  R  V  P  A  D         p.200

          .         .         . | 07       .         .         .    g.14436
 CTCCGGATCATCTCTTCTCATGGCTGTAAG | GTGGATAACTCATCCTTAACAGGAGAGTCG    c.660
 L  R  I  I  S  S  H  G  C  K   | V  D  N  S  S  L  T  G  E  S      p.220

          .         .         .         .         .         .       g.14496
 GAGCCCCAGACCCGCTCCCCCGAGTTCACCCATGAGAACCCCCTGGAGACCCGCAATATC       c.720
 E  P  Q  T  R  S  P  E  F  T  H  E  N  P  L  E  T  R  N  I         p.240

          .         .         | 08         .         .         .    g.16854
 TGTTTCTTCTCCACCAACTGTGTTGAAG | GCACTGCCAGGGGCATTGTGATTGCCACAGGA    c.780
 C  F  F  S  T  N  C  V  E  G |   T  A  R  G  I  V  I  A  T  G      p.260

          .         .         .         .         .         .       g.16914
 GACCGGACGGTGATGGGCCGCATAGCTACTCTCGCCTCAGGCCTGGAGGTTGGGCGGACA       c.840
 D  R  T  V  M  G  R  I  A  T  L  A  S  G  L  E  V  G  R  T         p.280

          .         .         .         .         .         .       g.16974
 CCCATAGCAATGGAGATTGAACACTTCATCCAGCTGATCACAGGGGTCGCTGTATTCCTG       c.900
 P  I  A  M  E  I  E  H  F  I  Q  L  I  T  G  V  A  V  F  L         p.300

          .         .         .         .         .         .       g.17034
 GGGGTCTCCTTCTTCGTGCTCTCCCTCATCCTGGGCTACAGCTGGCTGGAGGCAGTCATC       c.960
 G  V  S  F  F  V  L  S  L  I  L  G  Y  S  W  L  E  A  V  I         p.320

          .         .         .         .         .        | 09.    g.17925
 TTCCTCATCGGCATCATAGTGGCCAACGTGCCTGAGGGGCTTCTGGCCACTGTCACT | GTG    c.1020
 F  L  I  G  I  I  V  A  N  V  P  E  G  L  L  A  T  V  T   | V      p.340

          .         .         .         .         .         .       g.17985
 TGCCTGACCCTGACAGCCAAGCGCATGGCACGGAAGAACTGCCTGGTGAAGAACCTGGAG       c.1080
 C  L  T  L  T  A  K  R  M  A  R  K  N  C  L  V  K  N  L  E         p.360

          .         .         .         .         .         .       g.18045
 GCGGTGGAGACGCTGGGCTCCACGTCCACCATCTGCTCGGACAAGACGGGCACCCTCACC       c.1140
 A  V  E  T  L  G  S  T  S  T  I  C  S  D  K  T  G  T  L  T         p.380

          .         .         .         .         .         .       g.18105
 CAGAACCGCATGACCGTCGCCCACATGTGGTTCGACAACCAAATCCATGAGGCTGACACC       c.1200
 Q  N  R  M  T  V  A  H  M  W  F  D  N  Q  I  H  E  A  D  T         p.400

          .       | 10 .         .         .         .         .    g.18294
 ACCGAAGATCAGTCTG | GGGCCACTTTTGACAAACGATCCCCTACGTGGACGGCCCTGTCT    c.1260
 T  E  D  Q  S  G |   A  T  F  D  K  R  S  P  T  W  T  A  L  S      p.420

          .         .         .         .         .         .       g.18354
 CGAATTGCTGGTCTCTGCAACCGCGCCGTCTTCAAGGCAGGACAGGAGAACATCTCCGTG       c.1320
 R  I  A  G  L  C  N  R  A  V  F  K  A  G  Q  E  N  I  S  V         p.440

        | 11 .         .         .         .         .         .    g.18590
 TCTAAG | CGGGACACAGCTGGTGATGCCTCTGAGTCAGCTCTGCTCAAGTGCATTGAGCTC    c.1380
 S  K   | R  D  T  A  G  D  A  S  E  S  A  L  L  K  C  I  E  L      p.460

          .         .         .         .         .         .       g.18650
 TCCTGTGGCTCAGTGAGGAAAATGAGAGACAGAAACCCCAAGGTGGCAGAGATTCCTTTC       c.1440
 S  C  G  S  V  R  K  M  R  D  R  N  P  K  V  A  E  I  P  F         p.480

          .         .  | 12      .         .         .         .    g.19411
 AACTCTACCAACAAGTACCAG | CTGTCTATCCACGAGCGAGAAGACAGCCCCCAGAGCCAC    c.1500
 N  S  T  N  K  Y  Q   | L  S  I  H  E  R  E  D  S  P  Q  S  H      p.500

          .         .         .         .         .         .       g.19471
 GTGCTGGTGATGAAGGGGGCCCCAGAGCGCATTCTGGACCGGTGCTCCACCATCCTGGTG       c.1560
 V  L  V  M  K  G  A  P  E  R  I  L  D  R  C  S  T  I  L  V         p.520

          .         .         .         .         .         .       g.19531
 CAGGGCAAGGAGATCCCGCTCGACAAGGAGATGCAAGATGCCTTTCAAAATGCCTACATG       c.1620
 Q  G  K  E  I  P  L  D  K  E  M  Q  D  A  F  Q  N  A  Y  M         p.540

          .         .         .  | 13      .         .         .    g.19721
 GAGCTGGGGGGACTTGGGGAGCGTGTGCTGG | GATTCTGTCAACTGAATCTGCCATCTGGA    c.1680
 E  L  G  G  L  G  E  R  V  L  G |   F  C  Q  L  N  L  P  S  G      p.560

          .         .         .         .         .         .       g.19781
 AAGTTTCCTCGGGGCTTCAAATTCGACACGGATGAGCTGAACTTTCCCACGGAGAAGCTT       c.1740
 K  F  P  R  G  F  K  F  D  T  D  E  L  N  F  P  T  E  K  L         p.580

          .         .         .         .         .         .       g.19841
 TGCTTTGTGGGGCTCATGTCTATGATTGACCCTCCCCGGGCTGCTGTGCCAGATGCTGTG       c.1800
 C  F  V  G  L  M  S  M  I  D  P  P  R  A  A  V  P  D  A  V         p.600

          .         .        | 14.         .         .         .    g.23787
 GGCAAGTGCCGAAGCGCAGGCATCAAG | GTGATCATGGTAACCGGGGATCACCCTATCACA    c.1860
 G  K  C  R  S  A  G  I  K   | V  I  M  V  T  G  D  H  P  I  T      p.620

          .         .         .         .         .         .       g.23847
 GCCAAGGCCATTGCCAAAGGCGTGGGCATCATATCAGAGGGTAACGAGACTGTGGAGGAC       c.1920
 A  K  A  I  A  K  G  V  G  I  I  S  E  G  N  E  T  V  E  D         p.640

          .         .         .         .     | 15   .         .    g.24431
 ATTGCAGCCCGGCTCAACATTCCCATGAGTCAAGTCAACCCCAG | AGAAGCCAAGGCATGC    c.1980
 I  A  A  R  L  N  I  P  M  S  Q  V  N  P  R  |  E  A  K  A  C      p.660

          .         .         .         .         .         .       g.24491
 GTGGTGCACGGCTCTGACCTGAAGGACATGACATCGGAGCAGCTCGATGAGATCCTCAAG       c.2040
 V  V  H  G  S  D  L  K  D  M  T  S  E  Q  L  D  E  I  L  K         p.680

          .         .         .         .         .         .       g.24551
 AACCACACAGAGATCGTCTTTGCTCGAACGTCTCCCCAGCAGAAGCTCATCATTGTGGAG       c.2100
 N  H  T  E  I  V  F  A  R  T  S  P  Q  Q  K  L  I  I  V  E         p.700

          .      | 16  .         .         .         .         .    g.24749
 GGATGTCAGAGGCAG | GGAGCCATTGTGGCCGTGACGGGTGACGGGGTGAACGACTCCCCT    c.2160
 G  C  Q  R  Q   | G  A  I  V  A  V  T  G  D  G  V  N  D  S  P      p.720

          .         .         .         .         .         .       g.24809
 GCATTGAAGAAGGCTGACATTGGCATTGCCATGGGCATCTCTGGCTCTGACGTCTCTAAG       c.2220
 A  L  K  K  A  D  I  G  I  A  M  G  I  S  G  S  D  V  S  K         p.740

          .         .         .         .         .         .       g.24869
 CAGGCAGCCGACATGATCCTGCTGGATGACAACTTTGCCTCCATCGTCACGGGGGTGGAG       c.2280
 Q  A  A  D  M  I  L  L  D  D  N  F  A  S  I  V  T  G  V  E         p.760

      | 17   .         .         .         .         .         .    g.25165
 GAGG | GCCGCCTGATCTTTGACAACTTGAAGAAATCCATCGCCTACACCCTGACCAGCAAC    c.2340
 E  G |   R  L  I  F  D  N  L  K  K  S  I  A  Y  T  L  T  S  N      p.780

          .         .         .         .         .         .       g.25225
 ATCCCCGAGATCACCCCCTTCCTGCTGTTCATCATTGCCAACATCCCCCTACCTCTGGGC       c.2400
 I  P  E  I  T  P  F  L  L  F  I  I  A  N  I  P  L  P  L  G         p.800

          .         .         .          | 18        .         .    g.25538
 ACTGTGACCATCCTTTGCATTGACCTGGGCACAGATATG | GTCCCTGCCATCTCCTTGGCC    c.2460
 T  V  T  I  L  C  I  D  L  G  T  D  M   | V  P  A  I  S  L  A      p.820

          .         .         .         .         .         .       g.25598
 TATGAGGCAGCTGAGAGTGATATCATGAAGCGGCAGCCACGAAACTCCCAGACGGACAAG       c.2520
 Y  E  A  A  E  S  D  I  M  K  R  Q  P  R  N  S  Q  T  D  K         p.840

          .         .         .         .    | 19    .         .    g.25857
 CTGGTGAATGAGAGGCTCATCAGCATGGCCTACGGACAGATCG | GGATGATCCAGGCACTG    c.2580
 L  V  N  E  R  L  I  S  M  A  Y  G  Q  I  G |   M  I  Q  A  L      p.860

          .         .         .         .         .         .       g.25917
 GGTGGCTTCTTCACCTACTTTGTGATCCTGGCAGAGAACGGTTTCCTGCCATCACGGCTA       c.2640
 G  G  F  F  T  Y  F  V  I  L  A  E  N  G  F  L  P  S  R  L         p.880

          .         .         .         .         .         .       g.25977
 CTGGGAATCCGCCTCGACTGGGATGACCGGACCATGAATGATCTGGAGGACAGCTATGGA       c.2700
 L  G  I  R  L  D  W  D  D  R  T  M  N  D  L  E  D  S  Y  G         p.900

           | 20        .         .         .         .         .    g.26222
 CAGGAGTGG | ACCTATGAGCAGCGGAAGGTGGTGGAGTTCACGTGCCACACGGCATTCTTT    c.2760
 Q  E  W   | T  Y  E  Q  R  K  V  V  E  F  T  C  H  T  A  F  F      p.920

          .         .         .         .         .         .       g.26282
 GCCAGCATCGTGGTGGTGCAGTGGGCTGACCTCATCATCTGCAAGACCCGCCGCAACTCA       c.2820
 A  S  I  V  V  V  Q  W  A  D  L  I  I  C  K  T  R  R  N  S         p.940

          .         . | 21       .         .         .         .    g.28950
 GTCTTCCAGCAGGGCATGAA | GAACAAGATCCTGATTTTTGGGCTCCTGGAGGAGACGGCG    c.2880
 V  F  Q  Q  G  M  K  |  N  K  I  L  I  F  G  L  L  E  E  T  A      p.960

          .         .         .         .         .         .       g.29010
 TTGGCTGCCTTTCTCTCTTACTGCCCAGGCATGGGTGTAGCCCTCCGCATGTACCCGCTC       c.2940
 L  A  A  F  L  S  Y  C  P  G  M  G  V  A  L  R  M  Y  P  L         p.980

    | 22     .         .         .         .         .         .    g.29221
 AA | AGTCACCTGGTGGTTCTGCGCCTTCCCCTACAGCCTCCTCATCTTCATCTATGATGAG    c.3000
 K  |  V  T  W  W  F  C  A  F  P  Y  S  L  L  I  F  I  Y  D  E      p.1000

          .         .         .     | 23   .         .         .    g.30590
 GTCCGAAAGCTCATCCTGCGGCGGTATCCTGGTG | GCTGGGTGGAGAAGGAGACATACTAC    c.3060
 V  R  K  L  I  L  R  R  Y  P  G  G |   W  V  E  K  E  T  Y  Y      p.1020

                                                                    g.30593
 TGA                                                                c.3063
 X                                                                  p.1020

          .         .         .         .         .         .       g.30653
 ccccattggaagaagaaccaggcatggaaagatggggagctctggaggtgttgtggggat       c.*60

          .         .         .         .         .         .       g.30713
 ggtgatggagagggatggaaataacgggtggcattgggtggcaacatttggggagagata       c.*120

          .         .         .         .         .         .       g.30773
 atgaggcaactcagcaggctaagttgcggggtatataaattggggtgatgaccccataga       c.*180

          .         .         .         .         .         .       g.30833
 cctaactgtgaacaatcagattagacactatgtgttagagtccccccgaccagatccttt       c.*240

          .         .         .         .         .         .       g.30893
 tccatcccactccactatgttgtctattttttctgaggaattaagggttaccccaccctg       c.*300

          .         .         .         .         .         .       g.30953
 cccactcccatcccttcaaccccacttcctactgtaatagatcagcatccaaaagcagga       c.*360

          .         .         .         .         .         .       g.31013
 acccatctaaaccagaaggaagccctctcagatcaccccagcctcactccatttcccact       c.*420

          .         .         .         .         .         .       g.31073
 tccacccccgttagcttcctgcaggactctatccctggcttccccttcagaccttgcaat       c.*480

          .         .         .         .         .         .       g.31133
 cacaaaaggttcttctggtgagtgcaagagcctgagactggaaaaggtggacttgtctcc       c.*540

          .         .         .         .         .         .       g.31193
 cagtcgaggctggtaagggaccttcagggagagctgggcagacaggtgggagatggaggt       c.*600

          .         .         .         .         .         .       g.31253
 agggctggctggaggaaggaaacaacaaaggaagtgaggtagtgccaatgacaggacatt       c.*660

          .         .         .         .         .         .       g.31313
 tgacatgagtctccagatagatgtcgtggactccagctctacgtcccacattttagaata       c.*720

          .         .         .         .         .         .       g.31373
 ccccaccagcagaacaaactcagatctcatcagggtagcagcagaggcaggaccagaagg       c.*780

          .         .         .         .         .         .       g.31433
 caatcaagagcttccagaaatgccacacttgtgtgccacagagttccccgctgacccttg       c.*840

          .         .         .         .         .         .       g.31493
 gttaggggtcctcttagtccacaaggtccggatgtcactcatgtacttaataacacttca       c.*900

          .         .         .         .         .         .       g.31553
 ccttctgtaatactaagtcctcagagctccatgctgttctgaaagggatggccacaagtt       c.*960

          .         .         .         .         .         .       g.31613
 ctttcccagcctcttccattccctttcttttcatgcccatcccgatgaacctgcatcatt       c.*1020

          .         .         .         .         .         .       g.31673
 ccccgacactgccaagccaaccctggaaaaggagttcgctggccattggctagaatcagg       c.*1080

          .         .         .         .         .         .       g.31733
 gtggagaagttccctgaaccttcctgtctcccagggacatgtatgcttccagggacaagc       c.*1140

          .         .         .         .         .         .       g.31793
 ttaggtcatgaacatggtcagaacctttggacaagaggaaaaatactaagagatttgctt       c.*1200

          .         .         .         .         .         .       g.31853
 tttctgggtgcggtggctcatgcctgtaatcccagcactttgggaggccgaggcaggtgg       c.*1260

          .         .         .         .         .         .       g.31913
 atcatgaggtcaggagttcgaggcgagcctggccaacatggtgaaaccctgtctctacta       c.*1320

          .         .         .         .         .         .       g.31973
 aaagtacaaaaaattagccagtcatggtggcacacgcctgtaatctcagctactcaggag       c.*1380

          .         .         .         .         .         .       g.32033
 gctgaggcaggagaattgcttgaacctgtgaggaagaggttgcagtgagctgagatcgtg       c.*1440

          .         .         .         .         .         .       g.32093
 ccattacactccagcctgggcgaaagggtgagactccatctcaaaaaaaaaaaaaatgat       c.*1500

          .         .         .         .         .         .       g.32153
 ttgcttttgacgtcttaggtggcagggctgttccctccaggcaaatgcccttcaaaccga       c.*1560

          .         .         .         .         .         .       g.32213
 cgatcattgtgcccacttaccctgggctggagagttggtttcaggttcctacaggagata       c.*1620

          .         .         .         .         .         .       g.32273
 gctttctttcccttactccctatctaacacttttgctctgcaggcagccttgcccattct       c.*1680

          .         .         .         .         .         .       g.32333
 ctaagcctggcttagaaggcactgggaatgtcctgtagagagagacctagataggtcatg       c.*1740

          .         .         .         .         .         .       g.32393
 caagtgagaaagacatctgaggaaaatggaagacctaaggcagacaggaaggaagcacaa       c.*1800

          .         .         .         .         .         .       g.32453
 aagacaagcattgggtcagacccataaaccacctcccaaaggctgtcatttcattgcact       c.*1860

          .         .         .         .         .         .       g.32513
 ggaattttgctttatcagaagcaaggaagtaagggagtcattgccttgggcctgggaatc       c.*1920

          .         .         .         .         .         .       g.32573
 taagtgggagacaatattaatttggatccgattaattggagattactaactgtggacaaa       c.*1980

          .         .         .         .         .         .       g.32633
 agtttatctttgcacaatcaataaaaatggcatttttttagtaaattaagagcataaaca       c.*2040

          .         .         .         .         .         .       g.32693
 atattgctagaggtggcatgtttagtctaccaaaaacaatacttttcaggcactttagaa       c.*2100

          .         .         .         .         .         .       g.32753
 atatccttttagaagcagcgagtgcatgggctaattatcatcaatctttatgtatttgtt       c.*2160

          .         .         .         .         .         .       g.32813
 aaagaaacatctacaggatctttattggtgaccttttgtaagacattagtttgaggtact       c.*2220

          .         .         .         .                           g.32862
 acctatgtacttgaaaataataaagtggcatttctttatgaaaaaaaaa                  c.*2269

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ATPase, Na+/K+ transporting, alpha 2 polypeptide protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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