ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3) - coding DNA reference sequence

(used for variant description)

(last modified April 3, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_152296.4 in the ATP1A3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008015.1, covering ATP1A3 transcript NM_152296.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.4974
                                         tcccgcggacgcgggcatat       c.-181

 .         .         .         .         .         .                g.5034
 gaggaggcggaggcggcggccgccgcagcctctgtgcggtgggaccaacggacggacgga       c.-121

 .         .         .         .         .         .                g.5094
 cggacgcgcgcacctaccgaggcgcgggcgctgcagaggctcccagcccaagcctgagcc       c.-61

 .         .         .         .         .         .                g.5154
 tgagcccgccccgaggtccccgccccgcccgcctggctctctcgccgcggagccgccaag       c.-1

        | 02 .         .         .         .         .         .    g.10722
 ATGGGG | GACAAGAAAGATGACAAGGACTCACCCAAGAAGAACAAGGGCAAGGAGCGCCGG    c.60
 M  G   | D  K  K  D  D  K  D  S  P  K  K  N  K  G  K  E  R  R      p.20

          .         .         .    | 03    .         .         .    g.10880
 GACCTGGATGACCTCAAGAAGGAGGTGGCTATG | ACAGAGCACAAGATGTCAGTGGAAGAG    c.120
 D  L  D  D  L  K  K  E  V  A  M   | T  E  H  K  M  S  V  E  E      p.40

          .         .         .    | 04    .         .         .    g.11118
 GTCTGCCGGAAATACAACACAGACTGTGTGCAG | GGTTTGACCCACAGCAAAGCCCAGGAG    c.180
 V  C  R  K  Y  N  T  D  C  V  Q   | G  L  T  H  S  K  A  Q  E      p.60

          .         .         .         .         .         .       g.11178
 ATCCTGGCCCGGGATGGGCCTAACGCACTCACGCCACCGCCTACCACCCCAGAGTGGGTC       c.240
 I  L  A  R  D  G  P  N  A  L  T  P  P  P  T  T  P  E  W  V         p.80

          .         .         .         .         .         .       g.11238
 AAGTTTTGCCGGCAGCTCTTCGGGGGCTTCTCCATCCTGCTGTGGATCGGGGCTATCCTC       c.300
 K  F  C  R  Q  L  F  G  G  F  S  I  L  L  W  I  G  A  I  L         p.100

          .         .         .         .         .        | 05.    g.13004
 TGCTTCCTGGCCTACGGTATCCAGGCGGGCACCGAGGACGACCCCTCTGGTGACAAC | CTG    c.360
 C  F  L  A  Y  G  I  Q  A  G  T  E  D  D  P  S  G  D  N   | L      p.120

          .         .         .         .         .         .       g.13064
 TACCTGGGCATCGTGCTGGCGGCCGTGGTGATCATCACTGGCTGCTTCTCCTACTACCAG       c.420
 Y  L  G  I  V  L  A  A  V  V  I  I  T  G  C  F  S  Y  Y  Q         p.140

          .         .         .         .         .  | 06      .    g.13241
 GAGGCCAAGAGCTCCAAGATCATGGAGTCCTTCAAGAACATGGTGCCCCAG | CAAGCCCTG    c.480
 E  A  K  S  S  K  I  M  E  S  F  K  N  M  V  P  Q   | Q  A  L      p.160

          .         .         .         .         .         .       g.13301
 GTGATCCGGGAAGGTGAGAAGATGCAGGTGAACGCTGAGGAGGTGGTGGTCGGGGACCTG       c.540
 V  I  R  E  G  E  K  M  Q  V  N  A  E  E  V  V  V  G  D  L         p.180

          .         .         .         .         .         .       g.13361
 GTGGAGATCAAGGGTGGAGACCGAGTGCCAGCTGACCTGCGGATCATCTCAGCCCACGGC       c.600
 V  E  I  K  G  G  D  R  V  P  A  D  L  R  I  I  S  A  H  G         p.200

        | 07 .         .         .         .         .         .    g.13861
 TGCAAG | GTGGACAACTCCTCCCTGACTGGCGAATCCGAGCCCCAGACTCGCTCTCCCGAC    c.660
 C  K   | V  D  N  S  S  L  T  G  E  S  E  P  Q  T  R  S  P  D      p.220

          .         .         .         .         .         .       g.13921
 TGCACTCACGACAACCCCTTGGAGACTCGGAACATCACCTTCTTTTCCACCAACTGTGTG       c.720
 C  T  H  D  N  P  L  E  T  R  N  I  T  F  F  S  T  N  C  V         p.240

      | 08   .         .         .         .         .         .    g.14100
 GAAG | GCACGGCTCGGGGCGTGGTGGTGGCCACGGGCGACCGCACTGTCATGGGCCGTATC    c.780
 E  G |   T  A  R  G  V  V  V  A  T  G  D  R  T  V  M  G  R  I      p.260

          .         .         .         .         .         .       g.14160
 GCCACCCTGGCATCAGGGCTGGAGGTGGGCAAGACGCCCATCGCCATCGAGATTGAGCAC       c.840
 A  T  L  A  S  G  L  E  V  G  K  T  P  I  A  I  E  I  E  H         p.280

          .         .         .         .         .         .       g.14220
 TTCATCCAGCTCATCACCGGCGTGGCTGTCTTCCTGGGTGTCTCCTTCTTCATCCTCTCC       c.900
 F  I  Q  L  I  T  G  V  A  V  F  L  G  V  S  F  F  I  L  S         p.300

          .         .         .         .         .         .       g.14280
 CTCATTCTCGGATACACCTGGCTTGAGGCTGTCATCTTCCTCATCGGCATCATCGTGGCC       c.960
 L  I  L  G  Y  T  W  L  E  A  V  I  F  L  I  G  I  I  V  A         p.320

          .         .         .    | 09    .         .         .    g.17151
 AATGTCCCAGAGGGTCTGCTGGCCACTGTCACT | GTGTGTCTGACGCTGACCGCCAAGCGC    c.1020
 N  V  P  E  G  L  L  A  T  V  T   | V  C  L  T  L  T  A  K  R      p.340

          .         .         .         .         .         .       g.17211
 ATGGCCCGGAAGAACTGCCTGGTGAAGAACCTGGAGGCTGTAGAAACCCTGGGCTCCACG       c.1080
 M  A  R  K  N  C  L  V  K  N  L  E  A  V  E  T  L  G  S  T         p.360

          .         .         .         .         .         .       g.17271
 TCCACCATCTGCTCAGATAAGACAGGGACCCTCACTCAGAACCGCATGACAGTCGCCCAC       c.1140
 S  T  I  C  S  D  K  T  G  T  L  T  Q  N  R  M  T  V  A  H         p.380

          .         .         .         .         .   | 10     .    g.17407
 ATGTGGTTTGACAACCAGATCCACGAGGCTGACACCACTGAGGACCAGTCAG | GGACCTCA    c.1200
 M  W  F  D  N  Q  I  H  E  A  D  T  T  E  D  Q  S  G |   T  S      p.400

          .         .         .         .         .         .       g.17467
 TTTGACAAGAGTTCGCACACCTGGGTGGCCCTGTCTCACATCGCTGGGCTCTGCAATCGC       c.1260
 F  D  K  S  S  H  T  W  V  A  L  S  H  I  A  G  L  C  N  R         p.420

          .         .         .         .   | 11     .         .    g.17612
 GCTGTCTTCAAGGGTGGTCAGGACAACATCCCTGTGCTCAAG | AGGGATGTGGCTGGGGAT    c.1320
 A  V  F  K  G  G  Q  D  N  I  P  V  L  K   | R  D  V  A  G  D      p.440

          .         .         .         .         .         .       g.17672
 GCGTCTGAGTCTGCCCTGCTCAAGTGCATCGAGCTGTCCTCTGGCTCCGTGAAGCTGATG       c.1380
 A  S  E  S  A  L  L  K  C  I  E  L  S  S  G  S  V  K  L  M         p.460

          .         .         .         .         .        | 12.    g.20435
 CGTGAACGCAACAAGAAAGTGGCTGAGATTCCCTTCAATTCCACCAACAAATACCAG | CTC    c.1440
 R  E  R  N  K  K  V  A  E  I  P  F  N  S  T  N  K  Y  Q   | L      p.480

          .         .         .         .         .         .       g.20495
 TCCATCCATGAGACCGAGGACCCCAACGACAACCGATACCTGCTGGTGATGAAGGGTGCC       c.1500
 S  I  H  E  T  E  D  P  N  D  N  R  Y  L  L  V  M  K  G  A         p.500

          .         .         .         .         .         .       g.20555
 CCCGAGCGCATCCTGGACCGCTGCTCCACCATCCTGCTACAGGGCAAGGAGCAGCCTCTG       c.1560
 P  E  R  I  L  D  R  C  S  T  I  L  L  Q  G  K  E  Q  P  L         p.520

          .         .         .         .         .         .       g.20615
 GACGAGGAAATGAAGGAGGCCTTCCAGAATGCCTACCTTGAGCTCGGTGGCCTGGGCGAG       c.1620
 D  E  E  M  K  E  A  F  Q  N  A  Y  L  E  L  G  G  L  G  E         p.540

          . | 13       .         .         .         .         .    g.20954
 CGCGTGCTTG | GTTTCTGCCATTATTACCTGCCCGAGGAGCAGTTCCCCAAGGGCTTTGCC    c.1680
 R  V  L  G |   F  C  H  Y  Y  L  P  E  E  Q  F  P  K  G  F  A      p.560

          .         .         .         .         .         .       g.21014
 TTCGACTGTGATGACGTGAACTTCACCACGGACAACCTCTGCTTTGTGGGCCTCATGTCC       c.1740
 F  D  C  D  D  V  N  F  T  T  D  N  L  C  F  V  G  L  M  S         p.580

          .         .         .         .         .         .       g.21074
 ATGATCGACCCACCCCGGGCAGCCGTCCCTGACGCGGTGGGCAAGTGTCGCAGCGCAGGC       c.1800
 M  I  D  P  P  R  A  A  V  P  D  A  V  G  K  C  R  S  A  G         p.600

        | 14 .         .         .         .         .         .    g.21212
 ATCAAG | GTCATCATGGTCACCGGCGATCACCCCATCACGGCCAAGGCCATTGCCAAGGGT    c.1860
 I  K   | V  I  M  V  T  G  D  H  P  I  T  A  K  A  I  A  K  G      p.620

          .         .         .         .         .         .       g.21272
 GTGGGCATCATCTCTGAGGGCAACGAGACTGTGGAGGACATCGCCGCCCGGCTCAACATT       c.1920
 V  G  I  I  S  E  G  N  E  T  V  E  D  I  A  A  R  L  N  I         p.640

          .         .    | 15    .         .         .         .    g.22701
 CCCGTCAGCCAGGTTAACCCCCG | GGATGCCAAGGCCTGCGTGATCCACGGCACCGACCTC    c.1980
 P  V  S  Q  V  N  P  R  |  D  A  K  A  C  V  I  H  G  T  D  L      p.660

          .         .         .         .         .         .       g.22761
 AAGGACTTCACCTCCGAGCAAATCGACGAGATCCTGCAGAATCACACCGAGATCGTCTTC       c.2040
 K  D  F  T  S  E  Q  I  D  E  I  L  Q  N  H  T  E  I  V  F         p.680

          .         .         .         .         .     | 16   .    g.23439
 GCCCGCACATCCCCCCAGCAGAAGCTCATCATTGTGGAGGGCTGTCAGAGACAG | GGTGCA    c.2100
 A  R  T  S  P  Q  Q  K  L  I  I  V  E  G  C  Q  R  Q   | G  A      p.700

          .         .         .         .         .         .       g.23499
 ATTGTGGCTGTGACCGGGGATGGTGTGAACGACTCCCCCGCTCTGAAGAAGGCCGACATT       c.2160
 I  V  A  V  T  G  D  G  V  N  D  S  P  A  L  K  K  A  D  I         p.720

          .         .         .         .         .         .       g.23559
 GGGGTGGCCATGGGCATCGCTGGCTCTGACGTCTCCAAGCAGGCAGCTGACATGATCCTG       c.2220
 G  V  A  M  G  I  A  G  S  D  V  S  K  Q  A  A  D  M  I  L         p.740

          .         .         .         .    | 17    .         .    g.28705
 CTGGACGACAACTTTGCCTCCATCGTCACAGGGGTGGAGGAGG | GCCGCCTGATCTTCGAC    c.2280
 L  D  D  N  F  A  S  I  V  T  G  V  E  E  G |   R  L  I  F  D      p.760

          .         .         .         .         .         .       g.28765
 AACCTAAAGAAGTCCATTGCCTACACCCTGACCAGCAATATCCCGGAGATCACGCCCTTC       c.2340
 N  L  K  K  S  I  A  Y  T  L  T  S  N  I  P  E  I  T  P  F         p.780

          .         .         .         .         .         .       g.28825
 CTGCTGTTCATCATGGCCAACATCCCGCTGCCCCTGGGCACCATCACCATCCTCTGCATC       c.2400
 L  L  F  I  M  A  N  I  P  L  P  L  G  T  I  T  I  L  C  I         p.800

          .         | 18         .         .         .         .    g.28964
 GATCTGGGCACTGACATG | GTCCCTGCCATCTCACTGGCGTACGAGGCTGCCGAAAGCGAC    c.2460
 D  L  G  T  D  M   | V  P  A  I  S  L  A  Y  E  A  A  E  S  D      p.820

          .         .         .         .         .         .       g.29024
 ATCATGAAGAGACAGCCCAGGAACCCGCGGACGGACAAATTGGTCAATGAGAGACTCATC       c.2520
 I  M  K  R  Q  P  R  N  P  R  T  D  K  L  V  N  E  R  L  I         p.840

          .         .   | 19     .         .         .         .    g.29688
 AGCATGGCCTACGGGCAGATTG | GAATGATCCAGGCTCTCGGTGGCTTCTTCTCTTACTTT    c.2580
 S  M  A  Y  G  Q  I  G |   M  I  Q  A  L  G  G  F  F  S  Y  F      p.860

          .         .         .         .         .         .       g.29748
 GTGATCCTGGCAGAAAATGGCTTCTTGCCCGGCAACCTGGTGGGCATCCGGCTGAACTGG       c.2640
 V  I  L  A  E  N  G  F  L  P  G  N  L  V  G  I  R  L  N  W         p.880

          .         .         .         .         | 20         .    g.30327
 GATGACCGCACCGTCAATGACCTGGAAGACAGTTACGGGCAGCAGTGG | ACATACGAGCAG    c.2700
 D  D  R  T  V  N  D  L  E  D  S  Y  G  Q  Q  W   | T  Y  E  Q      p.900

          .         .         .         .         .         .       g.30387
 AGGAAGGTGGTGGAGTTCACCTGCCACACGGCCTTCTTTGTGAGCATCGTTGTCGTCCAG       c.2760
 R  K  V  V  E  F  T  C  H  T  A  F  F  V  S  I  V  V  V  Q         p.920

          .         .         .         .         .          | 21    g.31468
 TGGGCCGATCTGATCATCTGCAAGACCCGGAGGAACTCGGTCTTCCAGCAGGGCATGAA | G    c.2820
 W  A  D  L  I  I  C  K  T  R  R  N  S  V  F  Q  Q  G  M  K  |      p.940

          .         .         .         .         .         .       g.31528
 AACAAGATCCTGATCTTCGGGCTGTTTGAGGAGACGGCCCTGGCTGCCTTCCTGTCCTAC       c.2880
 N  K  I  L  I  F  G  L  F  E  E  T  A  L  A  A  F  L  S  Y         p.960

          .         .         .         .  | 22      .         .    g.31909
 TGCCCCGGCATGGACGTGGCCCTGCGCATGTACCCTCTCAA | GCCCAGCTGGTGGTTCTGT    c.2940
 C  P  G  M  D  V  A  L  R  M  Y  P  L  K  |  P  S  W  W  F  C      p.980

          .         .         .         .         .         .       g.31969
 GCCTTCCCCTACAGTTTCCTCATCTTCGTCTACGACGAAATCCGCAAACTCATCCTGCGC       c.3000
 A  F  P  Y  S  F  L  I  F  V  Y  D  E  I  R  K  L  I  L  R         p.1000

          .    | 23    .         .         .                        g.32312
 AGGAACCCAGGGG | GTTGGGTGGAGAAGGAAACCTACTACTGA                      c.3042
 R  N  P  G  G |   W  V  E  K  E  T  Y  Y  X                        p.1013

          .         .         .         .         .         .       g.32372
 cctcagccccaccacatcgcccatctcttccccgtcccccaggcccaggaccgcccctgt       c.*60

          .         .         .         .         .         .       g.32432
 cagtccccccaattttgtattctggggggaggagccctctcttcctgtggccccaccttg       c.*120

          .         .         .         .         .         .       g.32492
 gcccccaccccctccactatctcctgccgcccccactctggctggcttctctcccctgcc       c.*180

          .         .         .         .         .         .       g.32552
 ccaaacctctctcctctctcttttctgtgtcagtttctctccctctcctcacccctctat       c.*240

          .         .         .         .         .         .       g.32612
 ccattcctcccgccccagccacctccctgggctcttttttactccccttcagccccccgg       c.*300

          .         .         .         .         .                 g.32667
 ctgatgccatctctggttctggacaattatcaaatatatcagtggggagagagaa            c.*355

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ATPase, Na+/K+ transporting, alpha 3 polypeptide protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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