ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2) - coding DNA reference sequence

(used for variant description)

(last modified December 2, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_001681.3 in the ATP2A2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007097.2, covering ATP2A2 transcript NM_001681.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.4623
                                      ggcagcggccgataaatgctatt       c.-541

 .         .         .         .         .         .                g.4683
 agagcagccgccgcggagccgtccccgacgccacctccttttccttcgccgcagtttcct       c.-481

 .         .         .         .         .         .                g.4743
 ccgccgctgtcgggcgtgcggcgctgagggacccgggcgagcgcgccgcgcaccgccccg       c.-421

 .         .         .         .         .         .                g.4803
 ccggctcgcctccctcgccgcgttccgccctcagtggtctgccgggcgccccctcctccg       c.-361

 .         .         .         .         .         .                g.4863
 gcccgggcggggcctctgatcgcctcaagagagcggggagggggctcgggggccgcggcc       c.-301

 .         .         .         .         .         .                g.4923
 tgccctcccggcgggcggctgagggcgagggaggccctcccttctggcgaggggagggag       c.-241

 .         .         .         .         .         .                g.4983
 ggtgggtcaggagcccccaacccgccctgcggagctcggggccgcgcgaggggcggttgt       c.-181

 .         .         .         .         .         .                g.5043
 ctgggggagggggcgcggggtgattcagcgcccggcgaggcggaagcggccgcaagagga       c.-121

 .         .         .         .         .         .                g.5103
 ggaggggagagcccgtccgcgcctgggctcccggggtggcacgagcccgcggccggagtg       c.-61

 .         .         .         .         .         .                g.5163
 cgaggcggaggcgaggaggccgcggggacgggaggcgaggccggccgggcccccgaagcc       c.-1

          .         .         .         .         .         .       g.5223
 ATGGAGAACGCGCACACCAAGACGGTGGAGGAGGTGCTGGGCCACTTCGGCGTCAACGAG       c.60
 M  E  N  A  H  T  K  T  V  E  E  V  L  G  H  F  G  V  N  E         p.20

          .         .         .         .         .         | 02    g.5979
 AGTACGGGGCTGAGCCTGGAACAGGTCAAGAAGCTTAAGGAGAGATGGGGCTCCAACG | AG    c.120
 S  T  G  L  S  L  E  Q  V  K  K  L  K  E  R  W  G  S  N  E |       p.40

          .       | 03 .         .         .         .         .    g.6130
 TTACCGGCTGAAGAAG | GAAAAACCTTGCTGGAACTTGTGATTGAGCAGTTTGAAGACTTG    c.180
 L  P  A  E  E  G |   K  T  L  L  E  L  V  I  E  Q  F  E  D  L      p.60

          .         .         .          | 04        .         .    g.15414
 CTAGTTAGGATTTTATTACTGGCAGCATGTATATCTTTT | GTTTTGGCTTGGTTTGAAGAA    c.240
 L  V  R  I  L  L  L  A  A  C  I  S  F   | V  L  A  W  F  E  E      p.80

          .         .         .         .         .         .       g.15474
 GGTGAAGAAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCC       c.300
 G  E  E  T  I  T  A  F  V  E  P  F  V  I  L  L  I  L  V  A         p.100

          .         .     | 05   .         .         .         .    g.20008
 AATGCAATTGTGGGTGTATGGCAG | GAAAGAAATGCTGAAAATGCCATCGAAGCCCTTAAG    c.360
 N  A  I  V  G  V  W  Q   | E  R  N  A  E  N  A  I  E  A  L  K      p.120

          .         .         .         .         .         .       g.20068
 GAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCGGATT       c.420
 E  Y  E  P  E  M  G  K  V  Y  R  Q  D  R  K  S  V  Q  R  I         p.140

          .         .         .         .    | 06    .         .    g.46382
 AAAGCTAAAGACATAGTTCCTGGTGATATTGTAGAAATTGCTG | TTGGTGACAAAGTTCCT    c.480
 K  A  K  D  I  V  P  G  D  I  V  E  I  A  V |   G  D  K  V  P      p.160

          .         .         .         .         .         .       g.46442
 GCTGATATAAGGTTAACTTCCATCAAATCTACCACACTAAGAGTTGACCAGTCAATTCTC       c.540
 A  D  I  R  L  T  S  I  K  S  T  T  L  R  V  D  Q  S  I  L         p.180

      | 07   .         .         .         .         .         .    g.49819
 ACAG | GTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGACCCACGAGCTGTC    c.600
 T  G |   E  S  V  S  V  I  K  H  T  D  P  V  P  D  P  R  A  V      p.200

          .         .         . | 08       .         .         .    g.50956
 AACCAAGATAAAAAGAACATGCTGTTTTCT | GGTACAAACATTGCTGCTGGGAAAGCTATG    c.660
 N  Q  D  K  K  N  M  L  F  S   | G  T  N  I  A  A  G  K  A  M      p.220

          .         .         .         .         .         .       g.51016
 GGAGTGGTGGTAGCAACTGGAGTTAACACCGAAATTGGCAAGATCCGGGATGAAATGGTG       c.720
 G  V  V  V  A  T  G  V  N  T  E  I  G  K  I  R  D  E  M  V         p.240

          .         .         .         .         .         .       g.51076
 GCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATTTGGGGAACAGCTT       c.780
 A  T  E  Q  E  R  T  P  L  Q  Q  K  L  D  E  F  G  E  Q  L         p.260

          .         .         .         .         .         .       g.51136
 TCCAAAGTCATCTCCCTTATTTGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAAT       c.840
 S  K  V  I  S  L  I  C  I  A  V  W  I  I  N  I  G  H  F  N         p.280

          .         .         .         .         .         .       g.51196
 GACCCGGTTCATGGAGGGTCCTGGATCAGAGGTGCTATTTACTACTTTAAAATTGCAGTG       c.900
 D  P  V  H  G  G  S  W  I  R  G  A  I  Y  Y  F  K  I  A  V         p.300

          .         .         .         .         .         .       g.51256
 GCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCACCACCTGCCTGGCT       c.960
 A  L  A  V  A  A  I  P  E  G  L  P  A  V  I  T  T  C  L  A         p.320

          .         .         .         .         .         .       g.51316
 CTTGGAACTCGCAGAATGGCAAAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAA       c.1020
 L  G  T  R  R  M  A  K  K  N  A  I  V  R  S  L  P  S  V  E         p.340

          .         .         .         .         .         .       g.51376
 ACCCTTGGTTGTACTTCTGTTATCTGCTCAGACAAGACTGGTACACTTACAACAAACCAG       c.1080
 T  L  G  C  T  S  V  I  C  S  D  K  T  G  T  L  T  T  N  Q         p.360

          .      | 09  .         .         .         .         .    g.56015
 ATGTCAGTCTGCAGG | ATGTTCATTCTGGACAGAGTGGAAGGTGATACTTGTTCCCTTAAT    c.1140
 M  S  V  C  R   | M  F  I  L  D  R  V  E  G  D  T  C  S  L  N      p.380

          .         .         .         .     | 10   .         .    g.56570
 GAGTTTACCATAACTGGATCAACTTATGCACCTATTGGAGAAGT | GCATAAAGATGATAAA    c.1200
 E  F  T  I  T  G  S  T  Y  A  P  I  G  E  V  |  H  K  D  D  K      p.400

          .         .         .         .         .         .       g.56630
 CCAGTGAATTGTCACCAGTATGATGGTCTGGTAGAATTAGCAACAATTTGTGCTCTTTGT       c.1260
 P  V  N  C  H  Q  Y  D  G  L  V  E  L  A  T  I  C  A  L  C         p.420

          .         .        | 11.         .         .         .    g.57418
 AATGACTCTGCTTTGGATTACAATGAG | GCAAAGGGTGTGTATGAAAAAGTTGGAGAAGCT    c.1320
 N  D  S  A  L  D  Y  N  E   | A  K  G  V  Y  E  K  V  G  E  A      p.440

          .         .         .         .         .         .       g.57478
 ACAGAGACTGCTCTCACTTGCCTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAG       c.1380
 T  E  T  A  L  T  C  L  V  E  K  M  N  V  F  D  T  E  L  K         p.460

          .         .         .          | 12        .         .    g.62675
 GGTCTTTCTAAAATAGAACGTGCAAATGCCTGCAACTCA | GTCATTAAACAGCTGATGAAA    c.1440
 G  L  S  K  I  E  R  A  N  A  C  N  S   | V  I  K  Q  L  M  K      p.480

          .         .         .         .         .         .       g.62735
 AAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGTTTACTGTACACCA       c.1500
 K  E  F  T  L  E  F  S  R  D  R  K  S  M  S  V  Y  C  T  P         p.500

          .         .         .         .   | 13     .         .    g.62894
 AATAAACCAAGCAGGACATCAATGAGCAAGATGTTTGTGAAG | GGTGCTCCTGAAGGTGTC    c.1560
 N  K  P  S  R  T  S  M  S  K  M  F  V  K   | G  A  P  E  G  V      p.520

          .         .         .         .         .         .       g.62954
 ATTGACAGGTGCACCCACATTCGAGTTGGAAGTACTAAGGTTCCTATGACCTCTGGAGTC       c.1620
 I  D  R  C  T  H  I  R  V  G  S  T  K  V  P  M  T  S  G  V         p.540

          .         .         .         .         .         .       g.63014
 AAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGACACACTGCGATGC       c.1680
 K  Q  K  I  M  S  V  I  R  E  W  G  S  G  S  D  T  L  R  C         p.560

          .         .         .         .         .         .       g.63074
 CTGGCCCTGGCCACTCATGACAACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCT       c.1740
 L  A  L  A  T  H  D  N  P  L  R  R  E  E  M  H  L  E  D  S         p.580

          .         .  | 14      .         .         .         .    g.64071
 GCCAACTTTATTAAATATGAG | ACCAATCTGACCTTCGTTGGCTGCGTGGGCATGCTGGAT    c.1800
 A  N  F  I  K  Y  E   | T  N  L  T  F  V  G  C  V  G  M  L  D      p.600

          .         .         .         .         .         .       g.64131
 CCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGCAGGCATCCGGGTC       c.1860
 P  P  R  I  E  V  A  S  S  V  K  L  C  R  Q  A  G  I  R  V         p.620

          .         .         .         .         .         .       g.64191
 ATCATGATCACTGGGGACAACAAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATC       c.1920
 I  M  I  T  G  D  N  K  G  T  A  V  A  I  C  R  R  I  G  I         p.640

          .         .         .         .         .         .       g.64251
 TTCGGGCAGGATGAGGACGTGACGTCAAAAGCTTTCACAGGCCGGGAGTTTGATGAACTC       c.1980
 F  G  Q  D  E  D  V  T  S  K  A  F  T  G  R  E  F  D  E  L         p.660

          .         .         .         .         .         .       g.64311
 AACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGCTCGAGTTGAACCC       c.2040
 N  P  S  A  Q  R  D  A  C  L  N  A  R  C  F  A  R  V  E  P         p.680

          .         .         .         .         .        | 15.    g.65604
 TCCCACAAGTCTAAAATCGTAGAATTTCTTCAGTCTTTTGATGAGATTACAGCTATG | ACT    c.2100
 S  H  K  S  K  I  V  E  F  L  Q  S  F  D  E  I  T  A  M   | T      p.700

          .         .         .         .         .         .       g.65664
 GGCGATGGCGTGAACGATGCTCCTGCTCTGAAGAAAGCCGAGATTGGCATTGCTATGGGC       c.2160
 G  D  G  V  N  D  A  P  A  L  K  K  A  E  I  G  I  A  M  G         p.720

          .         .         .         .         .         .       g.65724
 TCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGATGACAACTTCTCC       c.2220
 S  G  T  A  V  A  K  T  A  S  E  M  V  L  A  D  D  N  F  S         p.740

          .         .         .         .         .         .       g.65784
 ACCATTGTGGCTGCCGTTGAGGAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATC       c.2280
 T  I  V  A  A  V  E  E  G  R  A  I  Y  N  N  M  K  Q  F  I         p.760

          .         .         .         | 16         .         .    g.66627
 CGCTACCTCATCTCGTCCAACGTCGGGGAAGTTGTCTG | TATTTTCCTGACAGCAGCCCTT    c.2340
 R  Y  L  I  S  S  N  V  G  E  V  V  C  |  I  F  L  T  A  A  L      p.780

          .         .         .         .         .         .       g.66687
 GGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCTGGTGACAGATGGC       c.2400
 G  F  P  E  A  L  I  P  V  Q  L  L  W  V  N  L  V  T  D  G         p.800

          .         .         .         .         .         .       g.66747
 CTGCCTGCCACTGCACTGGGGTTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCC       c.2460
 L  P  A  T  A  L  G  F  N  P  P  D  L  D  I  M  N  K  P  P         p.820

          .         .         .         .         .         .       g.66807
 CGGAACCCAAAGGAACCATTGATCAGCGGGTGGCTCTTTTTCCGTTACTTGGCTATTGGC       c.2520
 R  N  P  K  E  P  L  I  S  G  W  L  F  F  R  Y  L  A  I  G         p.840

   | 17      .         .         .         .         .         .    g.68318
 T | GTTACGTCGGCGCTGCTACCGTGGGTGCTGCTGCATGGTGGTTCATTGCTGCTGACGGT    c.2580
 C |   Y  V  G  A  A  T  V  G  A  A  A  W  W  F  I  A  A  D  G      p.860

          .         .        | 18.         .         .         .    g.68655
 GGTCCAAGAGTGTCCTTCTACCAGCTG | AGTCATTTCCTACAGTGTAAAGAGGACAACCCG    c.2640
 G  P  R  V  S  F  Y  Q  L   | S  H  F  L  Q  C  K  E  D  N  P      p.880

          .         .         .         .         .         .       g.68715
 GACTTTGAAGGCGTGGATTGTGCAATCTTTGAATCCCCATACCCGATGACAATGGCGCTC       c.2700
 D  F  E  G  V  D  C  A  I  F  E  S  P  Y  P  M  T  M  A  L         p.900

          .         .         .         .  | 19      .         .    g.69393
 TCTGTTCTAGTAACTATAGAAATGTGTAACGCCCTCAACAG | CTTGTCCGAAAACCAGTCC    c.2760
 S  V  L  V  T  I  E  M  C  N  A  L  N  S  |  L  S  E  N  Q  S      p.920

          .         .         .         .         .         .       g.69453
 TTGCTGAGGATGCCCCCCTGGGAGAACATCTGGCTCGTGGGCTCCATCTGCCTGTCCATG       c.2820
 L  L  R  M  P  P  W  E  N  I  W  L  V  G  S  I  C  L  S  M         p.940

          .         .         .          | 20        .         .    g.69595
 TCACTCCACTTCCTGATCCTCTATGTCGAACCCTTGCCA | CTCATCTTCCAGATCACACCG    c.2880
 S  L  H  F  L  I  L  Y  V  E  P  L  P   | L  I  F  Q  I  T  P      p.960

          .         .         .         .         .         .       g.69655
 CTGAACGTGACCCAGTGGCTGATGGTGCTGAAAATCTCCTTGCCCGTGATTCTCATGGAT       c.2940
 L  N  V  T  Q  W  L  M  V  L  K  I  S  L  P  V  I  L  M  D         p.980

          .         .         .         . | 21       .              g.73685
 GAGACGCTCAAGTTTGTGGCCCGCAACTACCTGGAACCTG | CAATACTGGAGTAA          c.2994
 E  T  L  K  F  V  A  R  N  Y  L  E  P  A |   I  L  E  X            p.997

          .         .         .         .         .         .       g.73745
 ccgcttcctaaaccattttgcagaaatgtaagggtgttcggttgcgtgcatgtgcgtttt       c.*60

          .         .         .         .         .         .       g.73805
 tagcaacacatctaccaaccctgtgcatgactgatgttggggaaaaagaaaagtaaaaaa       c.*120

          .         .         .         .         .         .       g.73865
 cttcccaactcactttgtgttatgtggaggaaatgtgtattaccaatggggttgttagct       c.*180

          .         .         .         .         .         .       g.73925
 tttaaatcaaaatactgattacagatgtacaatttagcttaatcagaaagcctctccaga       c.*240

          .         .         .         .         .         .       g.73985
 gaagtttggtttctttgctgcaagaggaatgaggctctgtaaccttatctaagaacttgg       c.*300

          .         .         .         .         .         .       g.74045
 aagccgtcagccaagtcgccacatttctctgcaaaatgtcatagcttatataaatgtaca       c.*360

          .         .         .         .         .         .       g.74105
 gtattcaattgtaatgcatgccttcggttgtaagtagccagatccctctccagtgacatt       c.*420

          .         .         .         .         .         .       g.74165
 ggaacatgctactttttaattggccctgtacagtttgcttatttataaattcattaaaaa       c.*480

          .         .         .         .         .         .       g.74225
 cactacaggtgttgaatggttaaaatgtaggcctccagttcattttcagttattttctga       c.*540

          .         .         .         .         .         .       g.74285
 gtgtgcagacagctatttcgcactgtattaaatgtaacttatttaatgaaatcagaagca       c.*600

          .         .         .         .         .         .       g.74345
 gtagacagatgttggtgcaatacaaatattgtgatgcatttatcttaataaaatgctaaa       c.*660

          .         .         .         .         .         .       g.74405
 tgtcaatttatcactgcgcatgtttgactttagactgtaaatagagatcagtttgtttct       c.*720

          .         .         .         .         .         .       g.74465
 ttctgtgctggtaacaatgagcgtcgcacagacatggtttcaggtaaataaatctattct       c.*780

                                                                    g.74473
 atgataaa                                                           c.*788

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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