ATPase, H+ transporting, lysosomal accessory protein 1 (ATP6AP1) - coding DNA reference sequence

(used for variant description)

(last modified October 24, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001183.4 in the ATP6AP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_052807.1, covering ATP6AP1 transcript NM_001183.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            g       c.-61

 .         .         .         .         .         .                g.5061
 ggggcaacggtcacctgatctgcggctgtcgaggccgctgaggcagtggaggctgaggct       c.-1

          .         .         .         .         .         .       g.5121
 ATGATGGCGGCCATGGCGACGGCTCGAGTGCGGATGGGGCCGCGATGCGCCCAGGCGCTC       c.60
 M  M  A  A  M  A  T  A  R  V  R  M  G  P  R  C  A  Q  A  L         p.20

          .         .         .         .         .         .       g.5181
 TGGCGCATGCCGTGGCTGCCGGTGTTTTTGTCGTTGGCGGCGGCGGCGGCGGCGGCAGCG       c.120
 W  R  M  P  W  L  P  V  F  L  S  L  A  A  A  A  A  A  A  A         p.40

          .         .         .         .  | 02      .         .    g.5435
 GCGGAGCAGCAGGTCCCGCTGGTGCTGTGGTCGAGTGACCG | GGACTTGTGGGCTCCTGCG    c.180
 A  E  Q  Q  V  P  L  V  L  W  S  S  D  R  |  D  L  W  A  P  A      p.60

          .         .         .         .         .         .       g.5495
 GCCGACACTCATGAAGGCCACATCACCAGCGACTTGCAGCTCTCTACCTACTTAGATCCC       c.240
 A  D  T  H  E  G  H  I  T  S  D  L  Q  L  S  T  Y  L  D  P         p.80

          .         .         .         .         | 03         .    g.8210
 GCCCTGGAGCTGGGTCCCAGGAATGTGCTGCTGTTCCTGCAGGACAAG | CTGAGCATTGAG    c.300
 A  L  E  L  G  P  R  N  V  L  L  F  L  Q  D  K   | L  S  I  E      p.100

          .         .         .         .         .         .       g.8270
 GATTTCACAGCATATGGCGGTGTGTTTGGAAACAAGCAGGACAGCGCCTTTTCTAACCTA       c.360
 D  F  T  A  Y  G  G  V  F  G  N  K  Q  D  S  A  F  S  N  L         p.120

     | 04    .         .         .         .         .         .    g.8691
 GAG | AATGCCCTGGACCTGGCCCCCTCCTCACTGGTGCTTCCTGCCGTCGACTGGTATGCA    c.420
 E   | N  A  L  D  L  A  P  S  S  L  V  L  P  A  V  D  W  Y  A      p.140

          .         .         .         .         .         .       g.8751
 GTCAGCACTCTGACCACTTACCTGCAGGAGAAGCTCGGGGCCAGCCCCTTGCATGTGGAC       c.480
 V  S  T  L  T  T  Y  L  Q  E  K  L  G  A  S  P  L  H  V  D         p.160

          .         .         .         .         .         .       g.8811
 CTGGCCACCCTGCGGGAGCTGAAGCTCAATGCCAGCCTCCCTGCTCTGCTGCTCATTCGC       c.540
 L  A  T  L  R  E  L  K  L  N  A  S  L  P  A  L  L  L  I  R         p.180

          .        | 05.         .         .         .         | 06 g.10005
 CTGCCCTACACAGCCAG | CTCTGGTCTGATGGCACCCAGGGAAGTCCTCACAGGCAACG | AT c.600
 L  P  Y  T  A  S  |  S  G  L  M  A  P  R  E  V  L  T  G  N  D |    p.200

          .         .         .         .         .         .       g.10065
 GAGGTCATCGGGCAGGTCCTGAGCACACTCAAGTCCGAAGATGTCCCATACACAGCGGCC       c.660
 E  V  I  G  Q  V  L  S  T  L  K  S  E  D  V  P  Y  T  A  A         p.220

          .         .     | 07   .         .         .         .    g.10612
 CTCACAGCGGTCCGCCCTTCCAGG | GTGGCCCGTGATGTAGCCGTGGTGGCCGGAGGGCTA    c.720
 L  T  A  V  R  P  S  R   | V  A  R  D  V  A  V  V  A  G  G  L      p.240

          .         .         .         .         .         .       g.10672
 GGTCGCCAGCTGCTACAAAAACAGCCAGTATCACCTGTGATCCATCCTCCTGTGAGTTAC       c.780
 G  R  Q  L  L  Q  K  Q  P  V  S  P  V  I  H  P  P  V  S  Y         p.260

          .         .         .         .         .         .       g.10732
 AATGACACCGCTCCCCGGATCCTGTTCTGGGCCCAAAACTTCTCTGTGGCGTACAAGGAC       c.840
 N  D  T  A  P  R  I  L  F  W  A  Q  N  F  S  V  A  Y  K  D         p.280

          .         .         .         .         .         .       g.10792
 CAGTGGGAGGACCTGACTCCCCTCACCTTTGGGGTGCAGGAACTCAACCTGACTGGCTCC       c.900
 Q  W  E  D  L  T  P  L  T  F  G  V  Q  E  L  N  L  T  G  S         p.300

          .         .    | 08    .         .         .         .    g.11544
 TTCTGGAATGACTCCTTTGCCAG | GCTCTCACTGACCTATGAACGACTCTTTGGTACCACA    c.960
 F  W  N  D  S  F  A  R  |  L  S  L  T  Y  E  R  L  F  G  T  T      p.320

          .  | 09      .         .         .         .         .    g.11691
 GTGACATTCAA | GTTCATTCTGGCCAACCGCCTCTACCCAGTGTCTGCCCGGCACTGGTTT    c.1020
 V  T  F  K  |  F  I  L  A  N  R  L  Y  P  V  S  A  R  H  W  F      p.340

          .         .         .         .         .         .       g.11751
 ACCATGGAGCGCCTCGAAGTCCACAGCAATGGCTCCGTCGCCTACTTCAATGCTTCCCAG       c.1080
 T  M  E  R  L  E  V  H  S  N  G  S  V  A  Y  F  N  A  S  Q         p.360

          .         .         .         .         .         .       g.11811
 GTCACAGGGCCCAGCATCTACTCCTTCCACTGCGAGTATGTCAGCAGCCTGAGCAAGAAG       c.1140
 V  T  G  P  S  I  Y  S  F  H  C  E  Y  V  S  S  L  S  K  K         p.380

          .         .         .         .         .         .       g.11871
 GGTAGTCTCCTCGTGGCCCGCACGCAGCCCTCTCCCTGGCAGATGATGCTTCAGGACTTC       c.1200
 G  S  L  L  V  A  R  T  Q  P  S  P  W  Q  M  M  L  Q  D  F         p.400

     | 10    .         .         .         .         .         .    g.12107
 CAG | ATCCAGGCTTTCAACGTAATGGGGGAGCAGTTCTCCTACGCCAGCGACTGTGCCAGC    c.1260
 Q   | I  Q  A  F  N  V  M  G  E  Q  F  S  Y  A  S  D  C  A  S      p.420

          .         .         .         .         .         .       g.12167
 TTCTTCTCCCCCGGCATCTGGATGGGGCTGCTCACCTCCCTGTTCATGCTCTTCATCTTC       c.1320
 F  F  S  P  G  I  W  M  G  L  L  T  S  L  F  M  L  F  I  F         p.440

          .         .         .         .         .         .       g.12227
 ACCTATGGCCTGCACATGATCCTCAGCCTCAAGACCATGGATCGCTTTGATGACCACAAG       c.1380
 T  Y  G  L  H  M  I  L  S  L  K  T  M  D  R  F  D  D  H  K         p.460

          .         .         .                                     g.12260
 GGCCCCACTATTTCTTTGACCCAGATTGTGTGA                                  c.1413
 G  P  T  I  S  L  T  Q  I  V  X                                    p.470

          .         .         .         .         .         .       g.12320
 ccctgtgccagtgggggggttgagggtgggacggtgtccgtgttgttgctttcccaccct       c.*60

          .         .         .         .         .         .       g.12380
 gcagcgcactggactgaagagcttccctcttcctactgcagcatgaactgcaagctcccc       c.*120

          .         .         .         .         .         .       g.12440
 tcagcccatcttgctccctcttcagcccgctgaggagctttcttgggctgcccccatctc       c.*180

          .         .         .         .         .         .       g.12500
 tcccaacaaggtgtacatattctgcgtagatgctagaccaaccagcttcccagggttcgt       c.*240

          .         .         .         .         .         .       g.12560
 cgctgtgaggcgtaagggacatgaattctagggtctcctttctccttatttattcttgtg       c.*300

          .         .         .         .         .         .       g.12620
 gctacatcatccctggctgtggatagtgcttttgtgtagcaaatgctccctccttaaggt       c.*360

          .         .         .         .         .         .       g.12680
 tatagggctccctgagtttgggagtgtggaagtactacttaactgtctgtcctgcttggc       c.*420

          .         .         .         .         .         .       g.12740
 tgtcgttatcgttttctggtgatgttgtgctaacaataagaagtacacgggtttatttct       c.*480

          .         .         .         .         .         .       g.12800
 gtggcctgagaaggaagggacctccacgacaggtgggctgggtgcgatcgccggctgttt       c.*540

          .         .         .         .         .         .       g.12860
 ggcatgttcccaccgggagtgccgggcaggagcatggggtgcttggttgtttccttccta       c.*600

          .         .                                               g.12885
 ataaaataaacgcgggtcgccatgc                                          c.*625

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ATPase, H+ transporting, lysosomal accessory protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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