ATPase, H+ transporting, lysosomal V0 subunit a1 (ATP6V0A1) - coding DNA reference sequence

(used for variant description)

(last modified May 18, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001130020.1 in the ATP6V0A1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_047037.1, covering ATP6V0A1 transcript NM_001130020.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              ggcggcgcaggggcggggctttacggacgcaagcacgtcgaagcgct       c.-121

 .         .         .         .         .         .                g.5107
 gctcctggagccgcggagggtgcgggtttggctgcggtggtttctgtggcggttgctgtg       c.-61

 .         .   | 02     .         .         .         .             g.7051
 gcggagtttggag | gttggagagaaatccaggtactcactagactggtaccttctgccacc    c.-1

          .         .         .         .         .         .       g.7111
 ATGGGGGAGCTTTTCCGGAGTGAAGAAATGACACTGGCCCAGCTTTTTCTACAGTCAGAG       c.60
 M  G  E  L  F  R  S  E  E  M  T  L  A  Q  L  F  L  Q  S  E         p.20

          .         .         .         .         .        | 03.    g.12588
 GCTGCTTATTGTTGTGTCAGTGAATTAGGAGAACTTGGAAAGGTTCAGTTTCGTGAC | TTA    c.120
 A  A  Y  C  C  V  S  E  L  G  E  L  G  K  V  Q  F  R  D   | L      p.40

          .         .         .         .         .         .       g.12648
 AATCCAGATGTGAATGTTTTCCAACGGAAATTTGTGAATGAAGTTAGAAGATGTGAAGAA       c.180
 N  P  D  V  N  V  F  Q  R  K  F  V  N  E  V  R  R  C  E  E         p.60

          .       | 04 .         .         .         .         .    g.14210
 ATGGATCGAAAGCTTC | GATTTGTTGAGAAAGAGATAAGAAAAGCTAACATTCCGATTATG    c.240
 M  D  R  K  L  R |   F  V  E  K  E  I  R  K  A  N  I  P  I  M      p.80

          .         .         .         .         .     | 05   .    g.16252
 GACACCGGTGAAAACCCAGAGGTTCCCTTCCCCCGGGACATGATTGACTTAGAG | GCCAAT    c.300
 D  T  G  E  N  P  E  V  P  F  P  R  D  M  I  D  L  E   | A  N      p.100

          .         .         .         .         .         .       g.16312
 TTTGAGAAGATTGAAAATGAACTGAAGGAAATCAACACAAACCAGGAAGCTCTGAAGAGA       c.360
 F  E  K  I  E  N  E  L  K  E  I  N  T  N  Q  E  A  L  K  R         p.120

          .         .         .         .         .         .       g.16372
 AACTTCCTGGAACTGACCGAATTAAAATTTATACTTCGCAAAACTCAGCAATTTTTTGAT       c.420
 N  F  L  E  L  T  E  L  K  F  I  L  R  K  T  Q  Q  F  F  D         p.140

     | 06    .         .         .         .         .         .    g.23852
 GAG | GCTGAATTGCATCATCAGCAGATGGCGGATCCAGACTTGTTGGAAGAGTCCTCATCC    c.480
 E   | A  E  L  H  H  Q  Q  M  A  D  P  D  L  L  E  E  S  S  S      p.160

          .         .         .         .        | 07.         .    g.24632
 CTCTTGGAGCCAAGTGAGATGGGAAGAGGCACTCCTTTAAGACTTGG | CTTCGTGGCTGGT    c.540
 L  L  E  P  S  E  M  G  R  G  T  P  L  R  L  G  |  F  V  A  G      p.180

          .         .         .         .         .         .       g.24692
 GTCATTAACCGGGAGCGCATCCCTACTTTTGAGCGCATGCTTTGGCGGGTATGCCGGGGA       c.600
 V  I  N  R  E  R  I  P  T  F  E  R  M  L  W  R  V  C  R  G         p.200

          .         .         .         .         .     | 08   .    g.26829
 AATGTGTTCCTGCGACAGGCTGAAATCGAGAACCCCCTGGAGGATCCTGTGACT | GGCGAC    c.660
 N  V  F  L  R  Q  A  E  I  E  N  P  L  E  D  P  V  T   | G  D      p.220

          .         .         .         .         .         .       g.26889
 TACGTGCACAAGTCTGTGTTTATCATTTTCTTCCAAGGCGATCAGCTGAAAAACAGAGTC       c.720
 Y  V  H  K  S  V  F  I  I  F  F  Q  G  D  Q  L  K  N  R  V         p.240

          .        | 09.         .         .         .         .    g.29237
 AAGAAAATCTGTGAAGG | GTTCCGAGCCTCACTCTATCCCTGTCCTGAGACACCACAGGAG    c.780
 K  K  I  C  E  G  |  F  R  A  S  L  Y  P  C  P  E  T  P  Q  E      p.260

          .         .         .         .         .  | 10      .    g.33320
 AGGAAGGAAATGGCTTCTGGAGTGAATACCAGGATTGATGATCTCCAAATG | GTTCTGAAT    c.840
 R  K  E  M  A  S  G  V  N  T  R  I  D  D  L  Q  M   | V  L  N      p.280

          .         .         .         .         .         .       g.33380
 CAAACGGAGGATCACCGCCAGAGGGTTCTGCAGGCAGCTGCTAAGAACATCCGTGTCTGG       c.900
 Q  T  E  D  H  R  Q  R  V  L  Q  A  A  A  K  N  I  R  V  W         p.300

          .         .         .         .         .         .       g.33440
 TTCATCAAAGTGCGGAAGATGAAGGCCATCTATCACACCCTGAACCTGTGCAACATAGAT       c.960
 F  I  K  V  R  K  M  K  A  I  Y  H  T  L  N  L  C  N  I  D         p.320

          .         .         .         .         .         .       g.33500
 GTGACTCAGAAATGCTTGATTGCAGAGGTCTGGTGCCCTGTCACCGACCTTGACTCCATC       c.1020
 V  T  Q  K  C  L  I  A  E  V  W  C  P  V  T  D  L  D  S  I         p.340

          .         .     | 11   .         .         .         .    g.36679
 CAGTTTGCACTCAGAAGGGGCACG | GAACACAGTGGTTCCACTGTACCTTCCATTTTGAAC    c.1080
 Q  F  A  L  R  R  G  T   | E  H  S  G  S  T  V  P  S  I  L  N      p.360

          .         .         .         .         .         .       g.36739
 AGGATGCAGACAAACCAGACTCCCCCAACCTATAACAAAACCAACAAGTTTACCTATGGC       c.1140
 R  M  Q  T  N  Q  T  P  P  T  Y  N  K  T  N  K  F  T  Y  G         p.380

          .         .         .         .         .      | 12  .    g.40495
 TTTCAGAACATAGTAGATGCTTATGGAATTGGAACTTACCGAGAGATAAATCCAG | CTCCG    c.1200
 F  Q  N  I  V  D  A  Y  G  I  G  T  Y  R  E  I  N  P  A |   P      p.400

          .         .         .         .         .         .       g.40555
 TATACTATTATCACGTTCCCTTTTCTATTTGCTGTGATGTTTGGAGACTTCGGTCATGGC       c.1260
 Y  T  I  I  T  F  P  F  L  F  A  V  M  F  G  D  F  G  H  G         p.420

          .         .         .         .         .         .       g.40615
 ATTTTAATGACCCTTTTTGCTGTGTGGATGGTACTGAGGGAGAGCCGGATCCTTTCCCAG       c.1320
 I  L  M  T  L  F  A  V  W  M  V  L  R  E  S  R  I  L  S  Q         p.440

          .      | 13  .         .         .         .         .    g.41235
 AAGAATGAGAATGAG | ATGTTTAGCACTGTGTTCAGTGGTCGATACATTATTTTATTGATG    c.1380
 K  N  E  N  E   | M  F  S  T  V  F  S  G  R  Y  I  I  L  L  M      p.460

          .         .         .         .         .         .       g.41295
 GGTGTGTTCTCCATGTACACTGGCCTCATCTACAATGATTGCTTTTCCAAGTCTCTTAAT       c.1440
 G  V  F  S  M  Y  T  G  L  I  Y  N  D  C  F  S  K  S  L  N         p.480

          .         .         .         .         . | 14       .    g.41792
 ATCTTTGGGTCATCCTGGAGTGTACGGCCGATGTTTACTTATAATTGGAC | TGAAGAGACG    c.1500
 I  F  G  S  S  W  S  V  R  P  M  F  T  Y  N  W  T  |  E  E  T      p.500

          .         .         .         .         .         .       g.41852
 CTTCGGGGGAACCCTGTTCTACAGCTGAACCCAGCCCTCCCTGGAGTGTTTGGTGGACCA       c.1560
 L  R  G  N  P  V  L  Q  L  N  P  A  L  P  G  V  F  G  G  P         p.520

          .         .  | 15      .         .         .         .    g.45119
 TACCCTTTTGGCATTGATCCA | ATTTGGAACATTGCTACCAATAAACTGACGTTCTTGAAC    c.1620
 Y  P  F  G  I  D  P   | I  W  N  I  A  T  N  K  L  T  F  L  N      p.540

          .         .         .         .         .         .       g.45179
 TCCTTTAAGATGAAGATGTCTGTTATCCTTGGTATCATCCATATGCTGTTTGGAGTCAGC       c.1680
 S  F  K  M  K  M  S  V  I  L  G  I  I  H  M  L  F  G  V  S         p.560

          .         . | 16       .         .         .         .    g.46903
 CTGAGTCTGTTCAACCATAT | CTATTTCAAGAAGCCCCTGAATATCTACTTTGGATTTATT    c.1740
 L  S  L  F  N  H  I  |  Y  F  K  K  P  L  N  I  Y  F  G  F  I      p.580

          .         .         .         .         .         .       g.46963
 CCTGAAATAATCTTCATGACCTCTTTGTTTGGCTATTTGGTTATCCTTATTTTTTACAAG       c.1800
 P  E  I  I  F  M  T  S  L  F  G  Y  L  V  I  L  I  F  Y  K         p.600

          .         .         .         .         .         .       g.47023
 TGGACGGCCTATGATGCTCATACCTCTGAGAATGCACCAAGCCTTCTGATCCATTTCATA       c.1860
 W  T  A  Y  D  A  H  T  S  E  N  A  P  S  L  L  I  H  F  I         p.620

          .         .         .         .         .        | 17.    g.47356
 AACATGTTCCTCTTTTCCTACCCAGAGTCTGGTTATTCAATGTTGTATTCTGGACAG | AAA    c.1920
 N  M  F  L  F  S  Y  P  E  S  G  Y  S  M  L  Y  S  G  Q   | K      p.640

          .         .         .         .         .         .       g.47416
 GGAATTCAGTGTTTCCTGGTAGTGGTTGCACTACTGTGTGTACCTTGGATGCTGCTGTTT       c.1980
 G  I  Q  C  F  L  V  V  V  A  L  L  C  V  P  W  M  L  L  F         p.660

          .         .         .         .      | 18  .         .    g.53691
 AAACCATTGGTCCTTCGCCGTCAGTATTTGAGGAGAAAGCATTTG | GGAACTCTCAACTTT    c.2040
 K  P  L  V  L  R  R  Q  Y  L  R  R  K  H  L   | G  T  L  N  F      p.680

          .         .         .         .         .         .       g.53751
 GGTGGGATCAGGGTGGGCAACGGACCGACAGAGGAGGATGCTGAGATTATTCAGCATGAC       c.2100
 G  G  I  R  V  G  N  G  P  T  E  E  D  A  E  I  I  Q  H  D         p.700

          .         .         .    | 19    .         .         .    g.60044
 CAGCTCTCCACCCACTCAGAGGACGCAGACGAG | TTTGACTTTGGGGACACCATGGTCCAC    c.2160
 Q  L  S  T  H  S  E  D  A  D  E   | F  D  F  G  D  T  M  V  H      p.720

          .         .         .         .         .         .       g.60104
 CAGGCCATCCACACCATCGAGTACTGCCTGGGCTGCATCTCCAACACTGCCTCCTACTTG       c.2220
 Q  A  I  H  T  I  E  Y  C  L  G  C  I  S  N  T  A  S  Y  L         p.740

          .         .         .  | 20      .         .         .    g.60474
 CGGCTCTGGGCCCTCAGCCTCGCTCATGCGC | AGCTGTCTGAGGTGCTTTGGACCATGGTG    c.2280
 R  L  W  A  L  S  L  A  H  A  Q |   L  S  E  V  L  W  T  M  V      p.760

          .         .         .         .         .         .       g.60534
 ATCCACATCGGCCTGAGCGTGAAGAGCTTGGCGGGAGGTTTGGTGCTGTTCTTCTTCTTC       c.2340
 I  H  I  G  L  S  V  K  S  L  A  G  G  L  V  L  F  F  F  F         p.780

          .         .         .         .         .         .       g.60594
 ACTGCCTTTGCCACCCTGACCGTGGCCATCCTCCTGATCATGGAGGGCCTCTCGGCCTTT       c.2400
 T  A  F  A  T  L  T  V  A  I  L  L  I  M  E  G  L  S  A  F         p.800

          .         .    | 21    .         .         .         .    g.67220
 CTCCACGCACTGCGCTTACACTG | GGTTGAGTTCCAGAATAAATTCTACAGCGGGACCGGT    c.2460
 L  H  A  L  R  L  H  W  |  V  E  F  Q  N  K  F  Y  S  G  T  G      p.820

          .         .         .         .         .                 g.67277
 TTCAAGTTCTTACCCTTCTCCTTCGAGCATATTCGGGAAGGGAAGTTTGAAGAGTGA          c.2517
 F  K  F  L  P  F  S  F  E  H  I  R  E  G  K  F  E  E  X            p.838

          .         .         .         .         .         .       g.67337
 gtccctgtgagggccgtgtgccccatgctaccctccccgcctccctccacagtgatcagc       c.*60

          .         .         .         .         .         .       g.67397
 tgtgcctctctgcctgttggttgtgatctgtgggcaccagctcattcgtgtcaccctgtc       c.*120

          .         .         .         .         .         .       g.67457
 tgtgagtcatttagatagaatagtcctccttgggtctcccaccacccctagctttgtgtg       c.*180

          .         .         .         .         .         .       g.67517
 tagtgtagtgattttctggctgtcactcatactcactgggcaccagccttgccctcttag       c.*240

          .         .         .         .         .         .       g.67577
 cctccatccatccagacagcccttcccacctcctggtggtgagccagtctgcattcccac       c.*300

          .         .         .         .         .         .       g.67637
 gccatcccaaagccctttcatcttccccgtgcattgtagatggaaggagcacccatgcca       c.*360

          .         .         .         .         .         .       g.67697
 ttcacatctagactttgagttccctgcatctgccaccgtagtttctagcaggagtagtgg       c.*420

          .         .         .         .         .         .       g.67757
 ggggagtaatacagattcttccctagaaggggacactggtaacatgtcccactcttggat       c.*480

          .         .         .         .         .         .       g.67817
 tagcaggggtgggtccaggaagatgatatttgcgtcttttgcccacccccctggcattca       c.*540

          .         .         .         .         .         .       g.67877
 gctggacccaactaggccatcatgagtggcttctccctgtcatccccaggggtcatagga       c.*600

          .         .         .         .         .         .       g.67937
 tatctacaccgcctttctgaccccaccctgcactcccatcctttcctctctccccgttca       c.*660

          .         .         .         .         .         .       g.67997
 tgccctgcactacatagcacagccgggatgcttggaacagaggccttggctgctccgcag       c.*720

          .         .         .         .         .         .       g.68057
 tgcacagggcttccctctctcggggttggcttcttcccaggccttgcatgggccctgccc       c.*780

          .         .         .         .         .         .       g.68117
 acaagcacaccctcaggccgagggtgcagactgatgctcttccctgatggagaccctgag       c.*840

          .         .         .         .         .         .       g.68177
 atcttccccacccccaatcatgatgtcttcagtgtgggactggggtcctcttggttctgc       c.*900

          .         .         .         .         .         .       g.68237
 ctgcagcctgcctggctccgcccctagtgccccctcctcaccacactggccccaggtctc       c.*960

          .         .         .         .         .         .       g.68297
 aggaggggtgtcctgggcagggaaggtcagtgtcactgatggtttgctgtttggaagcca       c.*1020

          .         .         .         .         .         .       g.68357
 ttggcagggctgccgtgcatgtggctgtgagggctgcacagtcctgccaaggggcttcct       c.*1080

          .         .         .         .         .         .       g.68417
 ccttgtcaccccgaaccttgtaatcgtgtgctggcgtggcagccctggctaagttaatcc       c.*1140

          .         .         .         .         .         .       g.68477
 ccaccgctttcagtggtagaaagaattccctgagtgggccaggctggtgccctcctccta       c.*1200

          .         .         .         .         .         .       g.68537
 ccctggcttttctgagtgagctgcctggagccctcatcccctctcccaggctgggctggc       c.*1260

          .         .         .         .         .         .       g.68597
 cctgggcggggccactgtgtgctggcccactgtgacctgacccgaccttgtgcagccccc       c.*1320

          .         .         .         .         .         .       g.68657
 ctgccctggtgtcctgggttttcgtgatgatctttgctctgtttccagtggggtttgaag       c.*1380

          .         .         .         .         .         .       g.68717
 cagagttcagggaaccctgcccaaggtcctcctgttcagacattcctatgttgaataaag       c.*1440

          .                                                         g.68736
 tatgtttgacttccccgga                                                c.*1459

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ATPase, H+ transporting, lysosomal V0 subunit a1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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