ATPase, H+ transporting, lysosomal V0 subunit a4 (ATP6V0A4) - coding DNA reference sequence

(used for variant description)

(last modified December 18, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_020632.2 in the ATP6V0A4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008145.1, covering ATP6V0A4 transcript NM_020632.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  ataacgctacctgccgagcaagccgagtggagggaggcaaagg       c.-241

 .         .         .         .         .         .                g.5103
 ccaggctgaggatcagggtggcccgggtggcagcggggaggcgctgcatgctggaggctg       c.-181

 .         .         .         .         .         .                g.5163
 tgctgagtgcccggtgcaggtgagccggtcctgcggagttgtgccgagtgcctgctgcag       c.-121

  | 02        .         .         .         .         .             g.16996
  | tctcatttccagttcctccatgacgtggcaagtgaagacaggaatgaaaggaatgtaaag    c.-61

 .         .         .         .         .   | 03     .             g.31949
 cagcttttctctgaagagaagaagagagagagacacagccaag | accgaggctgggccaag    c.-1

          .         .         .         .         .         .       g.32009
 ATGGTGTCTGTGTTTCGAAGCGAGGAGATGTGTTTGTCACAACTGTTTCTCCAGGTGGAA       c.60
 M  V  S  V  F  R  S  E  E  M  C  L  S  Q  L  F  L  Q  V  E         p.20

          .         .         .         .         .        | 04.    g.33948
 GCTGCATATTGCTGTGTGGCTGAGCTCGGAGAGCTCGGATTGGTTCAGTTCAAAGAT | TTA    c.120
 A  A  Y  C  C  V  A  E  L  G  E  L  G  L  V  Q  F  K  D   | L      p.40

          .         .         .         .         .         .       g.34008
 AATATGAATGTGAACAGCTTTCAAAGGAAATTTGTGAATGAAGTCAGAAGGTGTGAATCA       c.180
 N  M  N  V  N  S  F  Q  R  K  F  V  N  E  V  R  R  C  E  S         p.60

          .       | 05 .         .         .         .         .    g.34366
 CTGGAGAGAATCCTCC | GTTTTCTGGAAGACGAGATGCAAAATGAGATTGTAGTTCAGTTG    c.240
 L  E  R  I  L  R |   F  L  E  D  E  M  Q  N  E  I  V  V  Q  L      p.80

          .         .         .         .         .  | 06      .    g.40180
 CTCGAGAAAAGCCCACTGACCCCGCTCCCACGGGAAATGATTACCCTGGAG | ACTGTTCTA    c.300
 L  E  K  S  P  L  T  P  L  P  R  E  M  I  T  L  E   | T  V  L      p.100

          .         .         .         .         .         .       g.40240
 GAAAAACTGGAAGGAGAGTTACAGGAAGCCAACCAGAACCAGCAGGCCTTGAAACAAAGC       c.360
 E  K  L  E  G  E  L  Q  E  A  N  Q  N  Q  Q  A  L  K  Q  S         p.120

          .         .         .         .         .        | 07.    g.40765
 TTCCTAGAACTGACAGAACTGAAATACCTCCTGAAGAAAACCCAAGACTTCTTTGAG | ACG    c.420
 F  L  E  L  T  E  L  K  Y  L  L  K  K  T  Q  D  F  F  E   | T      p.140

          .         .         .         .         .         .       g.40825
 GAAACCAATTTAGCTGATGATTTCTTTACTGAGGACACTTCTGGCCTCCTGGAGTTGAAA       c.480
 E  T  N  L  A  D  D  F  F  T  E  D  T  S  G  L  L  E  L  K         p.160

          .         .         .   | 08     .         .         .    g.43346
 GCAGTGCCTGCATATATGACCGGAAAGTTGGG | GTTCATAGCCGGTGTGATCAACAGGGAG    c.540
 A  V  P  A  Y  M  T  G  K  L  G  |  F  I  A  G  V  I  N  R  E      p.180

          .         .         .         .         .         .       g.43406
 AGGATGGCTTCCTTTGAGCGGTTACTGTGGCGAATCTGCCGAGGAAACGTGTACTTGAAG       c.600
 R  M  A  S  F  E  R  L  L  W  R  I  C  R  G  N  V  Y  L  K         p.200

          .         .         .          | 09        .         .    g.46677
 TTCAGTGAGATGGACGCCCCTCTGGAGGATCCTGTGACG | AAAGAAGAAATTCAGAAGAAC    c.660
 F  S  E  M  D  A  P  L  E  D  P  V  T   | K  E  E  I  Q  K  N      p.220

          .         .         .         .         .         .       g.46737
 ATATTCATCATATTTTACCAAGGAGAGCAGCTCAGGCAGAAAATCAAGAAGATCTGTGAT       c.720
 I  F  I  I  F  Y  Q  G  E  Q  L  R  Q  K  I  K  K  I  C  D         p.240

    | 10     .         .         .         .         .         .    g.47472
 GG | GTTTCGAGCCACTGTCTACCCTTGCCCAGAGCCTGCGGTGGAGCGCAGAGAGATGTTG    c.780
 G  |  F  R  A  T  V  Y  P  C  P  E  P  A  V  E  R  R  E  M  L      p.260

          .         .         .       | 11 .         .         .    g.50383
 GAGAGCGTCAATGTGAGGCTGGAAGATTTAATCACC | GTCATAACACAAACAGAGTCTCAC    c.840
 E  S  V  N  V  R  L  E  D  L  I  T   | V  I  T  Q  T  E  S  H      p.280

          .         .         .         .         .         .       g.50443
 CGCCAGCGCCTGCTGCAGGAAGCCGCTGCCAACTGGCACTCCTGGCTCATCAAGGTGCAG       c.900
 R  Q  R  L  L  Q  E  A  A  A  N  W  H  S  W  L  I  K  V  Q         p.300

          .         .         .         .         .         .       g.50503
 AAGATGAAAGCTGTCTACCACATCCTGAACATGTGCAACATCGACGTCACCCAGCAGTGT       c.960
 K  M  K  A  V  Y  H  I  L  N  M  C  N  I  D  V  T  Q  Q  C         p.320

          .         .         .         .         .         .       g.50563
 GTCATCGCCGAGATCTGGTTCCCGGTGGCAGATGCCACACGTATCAAGAGGGCACTGGAG       c.1020
 V  I  A  E  I  W  F  P  V  A  D  A  T  R  I  K  R  A  L  E         p.340

           | 12        .         .         .         .         .    g.53930
 CAAGGCATG | GAACTAAGTGGCTCCTCCATGGCCCCCATCATGACCACAGTGCAATCTAAA    c.1080
 Q  G  M   | E  L  S  G  S  S  M  A  P  I  M  T  T  V  Q  S  K      p.360

          .         .         .         .         .         .       g.53990
 ACAGCCCCTCCCACATTTAACAGGACCAATAAATTCACAGCTGGCTTCCAGAATATTGTT       c.1140
 T  A  P  P  T  F  N  R  T  N  K  F  T  A  G  F  Q  N  I  V         p.380

          .         .         .         . | 13       .         .    g.55652
 GATGCCTATGGTGTCGGCAGCTACCGGGAGATAAACCCAG | CCCCCTACACCATCATCACT    c.1200
 D  A  Y  G  V  G  S  Y  R  E  I  N  P  A |   P  Y  T  I  I  T      p.400

          .         .         .         .         .         .       g.55712
 TTCCCCTTCCTGTTCGCTGTGATGTTTGGAGACTGTGGTCATGGAACCGTGATGCTCCTG       c.1260
 F  P  F  L  F  A  V  M  F  G  D  C  G  H  G  T  V  M  L  L         p.420

          .         .         .         .         .         .       g.55772
 GCTGCACTTTGGATGATTCTGAATGAGAGACGCTTGCTCTCCCAGAAGACAGACAATGAG       c.1320
 A  A  L  W  M  I  L  N  E  R  R  L  L  S  Q  K  T  D  N  E         p.440

  | 14       .         .         .         .         .         .    g.57976
  | ATTTGGAACACCTTCTTCCACGGGCGCTATCTGATCCTACTTATGGGCATCTTCTCCATC    c.1380
  | I  W  N  T  F  F  H  G  R  Y  L  I  L  L  M  G  I  F  S  I      p.460

          .         .         .         .         .         .       g.58036
 TACACGGGTTTGATCTACAATGACTGCTTCTCCAAGTCCTTGAACATCTTTGGCTCTTCT       c.1440
 Y  T  G  L  I  Y  N  D  C  F  S  K  S  L  N  I  F  G  S  S         p.480

          .         .         .         | 15         .         .    g.63585
 TGGAGTGTCCAACCCATGTTCAGAAACGGCACATGGAA | TACTCATGTAATGGAGGAAAGT    c.1500
 W  S  V  Q  P  M  F  R  N  G  T  W  N  |  T  H  V  M  E  E  S      p.500

          .         .         .         .         .         .       g.63645
 CTATATCTGCAGCTGGACCCAGCCATACCAGGAGTGTATTTTGGAAATCCATACCCGTTT       c.1560
 L  Y  L  Q  L  D  P  A  I  P  G  V  Y  F  G  N  P  Y  P  F         p.520

          .   | 16     .         .         .         .         .    g.68990
 GGGATTGATCCG | ATTTGGAACTTGGCTTCAAACAAACTCACATTTCTGAACTCGTATAAA    c.1620
 G  I  D  P   | I  W  N  L  A  S  N  K  L  T  F  L  N  S  Y  K      p.540

          .         .         .         .         .         .       g.69050
 ATGAAGATGTCGGTGATCCTGGGAATTGTCCAGATGGTTTTCGGTGTCATCCTCAGCCTT       c.1680
 M  K  M  S  V  I  L  G  I  V  Q  M  V  F  G  V  I  L  S  L         p.560

          .  | 17      .         .         .         .         .    g.70152
 TTCAATCACAT | ATACTTCAGAAGAACTCTCAACATCATTCTGCAATTTATCCCTGAGATG    c.1740
 F  N  H  I  |  Y  F  R  R  T  L  N  I  I  L  Q  F  I  P  E  M      p.580

          .         .         .         .         .         .       g.70212
 ATTTTTATCCTGTGTCTGTTTGGATACCTGGTTTTCATGATCATTTTCAAATGGTGCTGC       c.1800
 I  F  I  L  C  L  F  G  Y  L  V  F  M  I  I  F  K  W  C  C         p.600

          .         .         .         .         .         .       g.70272
 TTTGACGTCCATGTATCTCAGCACGCCCCCAGCATCCTCATCCACTTCATCAACATGTTT       c.1860
 F  D  V  H  V  S  Q  H  A  P  S  I  L  I  H  F  I  N  M  F         p.620

          .         .         .         .         | 18         .    g.74346
 CTGTTTAACTACAGTGACTCTTCCAACGCACCCCTCTACAAACATCAG | CAAGAAGTCCAA    c.1920
 L  F  N  Y  S  D  S  S  N  A  P  L  Y  K  H  Q   | Q  E  V  Q      p.640

          .         .         .         .         .         .       g.74406
 AGTTTCTTTGTGGTTATGGCTTTGATTTCTGTGCCGTGGATGCTTCTGATTAAGCCGTTT       c.1980
 S  F  F  V  V  M  A  L  I  S  V  P  W  M  L  L  I  K  P  F         p.660

          .         .         . | 19       .         .         .    g.81201
 ATTCTTAGAGCCAGTCATCGGAAATCCCAG | CTGCAGGCATCCAGGATCCAAGAAGATGCC    c.2040
 I  L  R  A  S  H  R  K  S  Q   | L  Q  A  S  R  I  Q  E  D  A      p.680

          .         .         .         .         .         .       g.81261
 ACTGAGAACATTGAAGGTGATAGCTCCAGCCCTTCTAGCCGTTCTGGCCAGAGGACTTCT       c.2100
 T  E  N  I  E  G  D  S  S  S  P  S  S  R  S  G  Q  R  T  S         p.700

          .         .         .          | 20        .         .    g.87336
 GCAGATACCCACGGGGCTCTGGACGACCATGGAGAAGAG | TTCAACTTTGGAGACGTCTTT    c.2160
 A  D  T  H  G  A  L  D  D  H  G  E  E   | F  N  F  G  D  V  F      p.720

          .         .         .         .         .         .       g.87396
 GTCCACCAAGCCATCCACACCATCGAGTACTGCCTGGGCTGCATTTCAAACACAGCCTCC       c.2220
 V  H  Q  A  I  H  T  I  E  Y  C  L  G  C  I  S  N  T  A  S         p.740

          .         .         .        | 21.         .         .    g.93424
 TACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGCAC | AACTGTCTGAAGTGCTCTGGACT    c.2280
 Y  L  R  L  W  A  L  S  L  A  H  A  Q |   L  S  E  V  L  W  T      p.760

          .         .         .         .         .         .       g.93484
 ATGGTGATGAACAGCGGCCTTCAGACGCGAGGCTGGGGAGGAATCGTCGGGGTTTTTATT       c.2340
 M  V  M  N  S  G  L  Q  T  R  G  W  G  G  I  V  G  V  F  I         p.780

          .         .         .         .         .         .       g.93544
 ATTTTTGCCGTATTTGCTGTCCTGACAGTAGCCATCCTTCTGATCATGGAGGGCCTCTCT       c.2400
 I  F  A  V  F  A  V  L  T  V  A  I  L  L  I  M  E  G  L  S         p.800

          .         .          | 22        .         .         .    g.96510
 GCTTTCCTGCACGCCCTGCGACTGCACTG | GGTTGAGTTCCAGAACAAGTTCTATGTCGGG    c.2460
 A  F  L  H  A  L  R  L  H  W  |  V  E  F  Q  N  K  F  Y  V  G      p.820

          .         .         .         .         .         .       g.96570
 GATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAGCCGAGGAG       c.2520
 D  G  Y  K  F  S  P  F  S  F  K  H  I  L  D  G  T  A  E  E         p.840

                                                                    g.96573
 TAG                                                                c.2523
 X                                                                  p.840

          .         .         .         .         .         .       g.96633
 gctgagggctgcacctcccacggtggtcaccatgccaatgaaggaagttcagtcttgtct       c.*60

          .         .         .         .         .         .       g.96693
 ttgatatcagcccctgcaaggcgctcaatgggaaggttgttcttggctcacctgaagcat       c.*120

          .         .         .         .         .         .       g.96753
 gaaactgtgtattatttggacgtcagcctgtggatttgatacgacttaaccacgtcagag       c.*180

          .         .         .         .         .         .       g.96813
 gaaggactttggcaagtgatattgtcttcatgtggggtattaattctcaaataataaagt       c.*240

          .         .         .         .         .         .       g.96873
 aattgacaaatgaggggagaatgctaaacagatgtcttcttgcaatattttaaatattgt       c.*300

          .         .         .                                     g.96903
 atttgagaaaataaacatctgagtcattca                                     c.*330

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ATPase, H+ transporting, lysosomal V0 subunit a4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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