ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (ATP6V1B2) - coding DNA reference sequence

(used for variant description)

(last modified March 27, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_001693.3 in the ATP6V1B2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.10, covering ATP6V1B2 transcript NM_001693.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           gcctcccagcacgctggtcagctcctcttgctcg       c.-181

 .         .         .         .         .         .                g.5094
 caagcaggtctggccccagcggcgcgaagtcacgaggctgggggcggccggcggcgaagg       c.-121

 .         .         .         .         .         .                g.5154
 gggcggggcgaggccggggcgccgcagcgcgcataggcggagcctcgggccgcgggccgc       c.-61

 .         .         .         .         .         .                g.5214
 cttggtatatctgcgcgtgcgcggcgtcgctgctgggccagtcgggacagaggagacaag       c.-1

          .         .         .         .         .         .       g.5274
 ATGGCGCTGCGGGCGATGCGGGGGATTGTCAACGGGGCCGCACCCGAGCTACCCGTGCCC       c.60
 M  A  L  R  A  M  R  G  I  V  N  G  A  A  P  E  L  P  V  P         p.20

          .         .         .         .         .         .       g.5334
 ACCGGTGGGCCGGCGGTGGGAGCTCGGGAGCAGGCGCTGGCAGTCAGTCGGAACTACCTC       c.120
 T  G  G  P  A  V  G  A  R  E  Q  A  L  A  V  S  R  N  Y  L         p.40

          .       | 02 .         .         .         .         .    g.12335
 TCCCAGCCTCGCCTCA | CATACAAGACAGTATCTGGAGTCAATGGTCCACTAGTGATCTTA    c.180
 S  Q  P  R  L  T |   Y  K  T  V  S  G  V  N  G  P  L  V  I  L      p.60

          .   | 03     .         .         .         .         .    g.17288
 GATCATGTTAAG | TTTCCCAGGTATGCTGAAATTGTCCATTTGACCTTACCGGATGGCACA    c.240
 D  H  V  K   | F  P  R  Y  A  E  I  V  H  L  T  L  P  D  G  T      p.80

          .         .         .         .         .  | 04      .    g.18162
 AAGAGAAGTGGGCAAGTTCTGGAAGTTAGTGGTTCCAAGGCAGTAGTTCAG | GTATTTGAA    c.300
 K  R  S  G  Q  V  L  E  V  S  G  S  K  A  V  V  Q   | V  F  E      p.100

          .         .         .         .         .         .       g.18222
 GGGACTTCAGGTATAGATGCTAAGAAAACGTCCTGTGAGTTTACTGGGGATATTCTCCGA       c.360
 G  T  S  G  I  D  A  K  K  T  S  C  E  F  T  G  D  I  L  R         p.120

          .         .      | 05  .         .         .         .    g.18411
 ACACCGGTGTCTGAGGATATGCTTG | GTCGGGTATTCAATGGATCGGGAAAACCCATTGAC    c.420
 T  P  V  S  E  D  M  L  G |   R  V  F  N  G  S  G  K  P  I  D      p.140

          .         .         .         .    | 06    .         .    g.19001
 AGAGGTCCTGTTGTACTGGCCGAAGACTTCCTTGATATCATGG | GTCAGCCAATCAACCCT    c.480
 R  G  P  V  V  L  A  E  D  F  L  D  I  M  G |   Q  P  I  N  P      p.160

          .         .         .         .         .         .       g.19061
 CAATGTCGAATCTACCCAGAGGAAATGATTCAGACTGGCATTTCGGCCATCGATGGGATG       c.540
 Q  C  R  I  Y  P  E  E  M  I  Q  T  G  I  S  A  I  D  G  M         p.180

          .         .         .         .         .         .       g.19121
 AACAGTATTGCTAGGGGGCAGAAAATTCCTATCTTCTCTGCTGCTGGGCTACCACACAAT       c.600
 N  S  I  A  R  G  Q  K  I  P  I  F  S  A  A  G  L  P  H  N         p.200

     | 07    .         .         .         .         .         .    g.19516
 GAG | ATTGCAGCTCAGATCTGTCGCCAGGCTGGTTTGGTAAAGAAATCCAAAGATGTAGTA    c.660
 E   | I  A  A  Q  I  C  R  Q  A  G  L  V  K  K  S  K  D  V  V      p.220

          .         .         .         .      | 08  .         .    g.19924
 GACTACAGTGAGGAAAATTTTGCAATTGTATTTGCTGCTATGGGT | GTAAACATGGAAACT    c.720
 D  Y  S  E  E  N  F  A  I  V  F  A  A  M  G   | V  N  M  E  T      p.240

          .         .         .         .         .         .       g.19984
 GCCCGGTTCTTCAAATCTGACTTTGAAGAAAATGGCTCAATGGACAATGTCTGCCTCTTT       c.780
 A  R  F  F  K  S  D  F  E  E  N  G  S  M  D  N  V  C  L  F         p.260

          .         .    | 09    .         .         .         .    g.20626
 TTGAACTTGGCTAATGACCCAAC | CATTGAGCGAATTATCACTCCTCGCCTGGCTCTAACC    c.840
 L  N  L  A  N  D  P  T  |  I  E  R  I  I  T  P  R  L  A  L  T      p.280

          .         .         .         .         .         .       g.20686
 ACAGCTGAATTTCTGGCGTACCAATGTGAGAAACATGTATTGGTTATTCTAACAGACATG       c.900
 T  A  E  F  L  A  Y  Q  C  E  K  H  V  L  V  I  L  T  D  M         p.300

          .         .        | 10.         .         .         .    g.22658
 AGTTCTTATGCTGAAGCACTTCGAGAG | GTTTCAGCAGCCAGGGAAGAGGTACCTGGTCGA    c.960
 S  S  Y  A  E  A  L  R  E   | V  S  A  A  R  E  E  V  P  G  R      p.320

          .         .         .         .         .         .       g.22718
 CGAGGTTTTCCAGGTTACATGTATACAGATTTAGCCACGATATATGAACGCGCTGGGCGA       c.1020
 R  G  F  P  G  Y  M  Y  T  D  L  A  T  I  Y  E  R  A  G  R         p.340

          .         .         .         .         .         | 11    g.24222
 GTGGAAGGGAGAAACGGCTCGATTACTCAAATCCCTATTCTAACCATGCCTAATGATG | AT    c.1080
 V  E  G  R  N  G  S  I  T  Q  I  P  I  L  T  M  P  N  D  D |       p.360

          .         .         .         .         .         .       g.24282
 ATCACTCACCCCATCCCAGACTTGACTGGCTACATTACAGAGGGGCAGATCTATGTGGAC       c.1140
 I  T  H  P  I  P  D  L  T  G  Y  I  T  E  G  Q  I  Y  V  D         p.380

          .         .  | 12      .         .         .         .    g.25066
 AGACAGCTGCACAACAGACAG | ATTTATCCACCTATCAATGTGCTGCCCTCACTATCACGG    c.1200
 R  Q  L  H  N  R  Q   | I  Y  P  P  I  N  V  L  P  S  L  S  R      p.400

          .         .         .         .         .         .       g.25126
 TTAATGAAGTCTGCTATTGGAGAAGGGATGACCAGGAAGGATCATGCCGATGTATCTAAC       c.1260
 L  M  K  S  A  I  G  E  G  M  T  R  K  D  H  A  D  V  S  N         p.420

        | 13 .         .         .         .         .         .    g.26014
 CAGCTA | TATGCGTGCTATGCTATTGGAAAGGATGTGCAAGCCATGAAAGCTGTCGTTGGA    c.1320
 Q  L   | Y  A  C  Y  A  I  G  K  D  V  Q  A  M  K  A  V  V  G      p.440

          .         .         .         .         .         .       g.26074
 GAAGAAGCCCTTACCTCAGATGATCTTCTCTACTTGGAATTTCTGCAGAAGTTTGAGAGG       c.1380
 E  E  A  L  T  S  D  D  L  L  Y  L  E  F  L  Q  K  F  E  R         p.460

          .       | 14 .         .         .         .         .    g.28114
 AACTTCATTGCTCAGG | GTCCTTACGAAAATCGCACTGTCTTTGAGACTTTGGACATTGGC    c.1440
 N  F  I  A  Q  G |   P  Y  E  N  R  T  V  F  E  T  L  D  I  G      p.480

          .         .         .         .         .         .       g.28174
 TGGCAGCTACTCCGAATCTTCCCCAAAGAAATGCTGAAGAGAATCCCTCAGAGCACCCTC       c.1500
 W  Q  L  L  R  I  F  P  K  E  M  L  K  R  I  P  Q  S  T  L         p.500

          .         .         .                                     g.28210
 AGCGAATTTTACCCTCGAGACTCTGCAAAGCATTAG                               c.1536
 S  E  F  Y  P  R  D  S  A  K  H  X                                 p.511

          .         .         .         .         .         .       g.28270
 ctgctgcttctgcattgctccgcgctcttgtgaaatactggttctgttttctttattcct       c.*60

          .         .         .         .         .         .       g.28330
 tttgcactctcggttcccacctttgtgttggagtttaccatgttaccctgtaattaaaaa       c.*120

          .         .         .         .         .         .       g.28390
 caaagaataggtaacatattgtgccagtgttgcaacgttttaaactgctaacagacctta       c.*180

          .         .         .         .         .         .       g.28450
 aaatatccccctacctgggtcctcagtgctatgtttaaagtgctgcagggatggagtggc       c.*240

          .         .         .         .         .         .       g.28510
 gttttcttattgctgtatgtattgtacatagtggagtagttagttacctgataacagtct       c.*300

          .         .         .         .         .         .       g.28570
 tgttatttgggtctcttagaccttacctctcaactccctcaagagtaccagtctctgaag       c.*360

          .         .         .         .         .         .       g.28630
 ttataatgctttggtctctacattaggggcaagatccagtctgagagaagtctcctttga       c.*420

          .         .         .         .         .         .       g.28690
 gaagggccaagaggctctttcctgagtgtttgctttcggtttgttggtatgcctgtattg       c.*480

          .         .         .         .         .         .       g.28750
 ctgggctgtgctgctgctcgaagcagatggttttgactgtctttttgctctttcctatat       c.*540

          .         .         .         .         .         .       g.28810
 aatgaatagatgagtgaaaggagttttctttttctctttagtacttacgtattgggattc       c.*600

          .         .         .         .         .         .       g.28870
 ctgtgtcttacagctctccctctccaaataatacacagaatcctgcaactttttgcacag       c.*660

          .         .         .         .         .         .       g.28930
 ctggtatctgtctggtagcagtgagaccccttgtcttggtgatccttactgggtttccaa       c.*720

          .         .         .         .         .         .       g.28990
 gcagaggagtcacatgattacaattgccagtagagttgttgtttggggtacaagatgaga       c.*780

          .         .         .         .         .         .       g.29050
 agaaagaaaaacctacagcctttctacattctgacatgctaacagtggtttaagtttcta       c.*840

          .         .         .         .         .         .       g.29110
 aagtgtttaccagatgctgaaggcaaggggagggagcagaagcacttatgtttacggata       c.*900

          .         .         .         .         .         .       g.29170
 ttttaaactctgttagagagcagcctttgaaaatccccaatttggttctgctttttgacc       c.*960

          .         .         .         .         .         .       g.29230
 tctctctaccttttcagggtaatctttgtggcacaaacgatagcatttccaagctttaga       c.*1020

          .         .         .         .         .         .       g.29290
 gttttctgaattcctgcgccttcctgacgtgagccctgagcgatcttctatgcagttctg       c.*1080

          .         .         .         .         .         .       g.29350
 ccatgcgtcctgttggtctctctgtgttctttgttacttgggtgcaatagcaacttccct       c.*1140

          .         .         .         .         .         .       g.29410
 accccgtgcattccatctttcatgttgtgtaaagttcttcacttttttctctgagggctg       c.*1200

          .         .         .         .         .         .       g.29470
 ggggttgggggagtcagcatgattatattttaatgtagaaaatgtgacatctggatataa       c.*1260

          .         .         .                                     g.29504
 aatgaaaataaatgttaaattaaatggaccttaa                                 c.*1294

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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