ATPase, aminophospholipid transporter, class I, type 8A, member 2 (ATP8A2) - coding DNA reference sequence

(used for variant description)

(last modified May 24, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_016529.4 in the ATP8A2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000013.10, covering ATP8A2 transcript NM_016529.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       acaggcgccggcggtccccgcc       c.-121

 .         .         .         .         .         .                g.5082
 agctagcagcccggcgaggcgctggcccacccatggtcctcgggcggcggcccctgcgcc       c.-61

 .         .         .         .         .         .                g.5142
 cagccctgcgcgtagcctccgtctctcgcccggggccgccgagcccccgacacgggcgag       c.-1

          .         .         .         .         .         .       g.5202
 ATGCTGAACGGCGCAGGCCTGGACAAAGCTCTTAAGATGTCCCTGCCGCGGAGGTCGAGG       c.60
 M  L  N  G  A  G  L  D  K  A  L  K  M  S  L  P  R  R  S  R         p.20

          .       | 02 .         .         .         .         .    g.101950
 ATCCGCTCGTCCGTGG | GACCTGTTCGTTCTTCTTTGGGCTATAAGAAGGCAGAGGATGAG    c.120
 I  R  S  S  V  G |   P  V  R  S  S  L  G  Y  K  K  A  E  D  E      p.40

          .         .         .         .         .         .       g.102010
 ATGTCCCGGGCCACGTCTGTTGGAGACCAGCTGGAGGCACCCGCCCGCACCATTTACCTC       c.180
 M  S  R  A  T  S  V  G  D  Q  L  E  A  P  A  R  T  I  Y  L         p.60

          .         .         .         .  | 03      .         .    g.162947
 AACCAACCGCATCTCAACAAATTCCGCGACAACCAGATCAG | TACGGCCAAGTACAGCGTG    c.240
 N  Q  P  H  L  N  K  F  R  D  N  Q  I  S  |  T  A  K  Y  S  V      p.80

          .         .         .         .         .         .       g.163007
 TTGACATTTCTACCTCGATTCTTGTATGAGCAGATTAGAAGAGCTGCTAATGCCTTCTTT       c.300
 L  T  F  L  P  R  F  L  Y  E  Q  I  R  R  A  A  N  A  F  F         p.100

          .         .  | 04      .         .         .         .    g.163530
 CTCTTCATTGCCTTATTACAG | CAAATTCCAGATGTATCTCCAACAGGAAGATATACCACC    c.360
 L  F  I  A  L  L  Q   | Q  I  P  D  V  S  P  T  G  R  Y  T  T      p.120

          .         .         .         .         .         .       g.163590
 CTGGTGCCATTGATCATTATTTTAACAATTGCAGGCATCAAAGAGATTGTAGAAGATTTT       c.420
 L  V  P  L  I  I  I  L  T  I  A  G  I  K  E  I  V  E  D  F         p.140

  | 05       .         .         .         .       | 06 .         . g.166216
  | AAGCGACACAAGGCAGACAATGCAGTTAACAAAAAGAAAACAATAG | TGTTAAGAAATGGT c.480
  | K  R  H  K  A  D  N  A  V  N  K  K  K  T  I  V |   L  R  N  G   p.160

          .         .        | 07.         .         .         .    g.170950
 ATGTGGCATACCATTATGTGGAAAGAG | GTGGCAGTGGGAGACATTGTGAAGGTCGTCAAT    c.540
 M  W  H  T  I  M  W  K  E   | V  A  V  G  D  I  V  K  V  V  N      p.180

          .         .         .         .  | 08      .         .    g.173267
 GGGCAGTATCTTCCAGCAGATGTGGTCCTGCTGTCATCCAG | TGAACCTCAGGCAATGTGT    c.600
 G  Q  Y  L  P  A  D  V  V  L  L  S  S  S  |  E  P  Q  A  M  C      p.200

          .         .         .         .         .  | 09      .    g.174857
 TATGTTGAAACAGCTAATCTGGATGGGGAGACGAACCTTAAAATACGTCAG | GGTTTGAGT    c.660
 Y  V  E  T  A  N  L  D  G  E  T  N  L  K  I  R  Q   | G  L  S      p.220

          .         .         .         .         .         .       g.174917
 CACACTGCTGACATGCAAACACGTGAAGTTCTGATGAAGTTATCTGGAACTATAGAGTGT       c.720
 H  T  A  D  M  Q  T  R  E  V  L  M  K  L  S  G  T  I  E  C         p.240

          .         .         .         .         .          | 10    g.176221
 GAAGGGCCCAACCGCCACCTCTATGACTTCACTGGAAACTTGAACTTAGATGGGAAAAG | C    c.780
 E  G  P  N  R  H  L  Y  D  F  T  G  N  L  N  L  D  G  K  S  |      p.260

          .         .         .         .         .         .       g.176281
 CTTGTTGCCCTTGGGCCTGACCAGATCTTATTAAGAGGTACACAGCTTAGAAATACTCAG       c.840
 L  V  A  L  G  P  D  Q  I  L  L  R  G  T  Q  L  R  N  T  Q         p.280

          .         .         .         .         .  | 11      .    g.184276
 TGGGTCTTTGGCATAGTTGTTTATACTGGACACGACACCAAACTCATGCAG | AATTCAACC    c.900
 W  V  F  G  I  V  V  Y  T  G  H  D  T  K  L  M  Q   | N  S  T      p.300

          .         .         .         .         .         .       g.184336
 AAAGCGCCTCTCAAGAGATCAAATGTTGAGAAGGTGACTAACGTGCAGATCCTGGTGTTG       c.960
 K  A  P  L  K  R  S  N  V  E  K  V  T  N  V  Q  I  L  V  L         p.320

          .         .         .         .         .         .       g.184396
 TTTGGCATCCTCTTGGTCATGGCCTTGGTGAGCTCGGCGGGGGCCCTGTACTGGAACAGG       c.1020
 F  G  I  L  L  V  M  A  L  V  S  S  A  G  A  L  Y  W  N  R         p.340

          .         .         .        | 12.         .         .    g.186745
 TCTCATGGTGAAAAGAACTGGTACATCAAGAAGATGG | ACACCACCTCAGATAATTTTGGA    c.1080
 S  H  G  E  K  N  W  Y  I  K  K  M  D |   T  T  S  D  N  F  G      p.360

          .         .         .         .         .         .       g.186805
 TACAACCTACTGACGTTCATCATCTTATACAACAATCTTATTCCCATCAGTCTGTTGGTG       c.1140
 Y  N  L  L  T  F  I  I  L  Y  N  N  L  I  P  I  S  L  L  V         p.380

          .         .         .         .      | 13  .         .    g.187935
 ACTCTTGAGGTTGTGAAGTATACTCAAGCCCTTTTCATAAACTGG | GACACAGATATGTAT    c.1200
 T  L  E  V  V  K  Y  T  Q  A  L  F  I  N  W   | D  T  D  M  Y      p.400

          .         .         .         .         .         .       g.187995
 TATATAGGAAATGACACTCCTGCCATGGCCAGGACATCAAACCTTAATGAAGAGCTTGGG       c.1260
 Y  I  G  N  D  T  P  A  M  A  R  T  S  N  L  N  E  E  L  G         p.420

     | 14    .         .         .         .         .         .    g.191959
 CAG | GTGAAATATCTCTTTTCTGACAAGACTGGAACGCTTACATGCAATATCATGAACTTT    c.1320
 Q   | V  K  Y  L  F  S  D  K  T  G  T  L  T  C  N  I  M  N  F      p.440

          .         .         .   | 15     .         .         .    g.192678
 AAGAAGTGCAGCATTGCCGGAGTAACCTATGG | TCACTTCCCAGAATTGGCAAGAGAGCCG    c.1380
 K  K  C  S  I  A  G  V  T  Y  G  |  H  F  P  E  L  A  R  E  P      p.460

          .        | 16.         .         .         .         .    g.196928
 TCTTCAGATGACTTCTG | TCGGATGCCTCCTCCCTGTAGTGATTCCTGTGACTTTGATGAC    c.1440
 S  S  D  D  F  C  |  R  M  P  P  P  C  S  D  S  C  D  F  D  D      p.480

          .         .         .    | 17    .         .         .    g.203723
 CCCAGGCTGTTGAAGAACATTGAGGATCGCCAT | CCCACAGCCCCTTGCATTCAGGAGTTC    c.1500
 P  R  L  L  K  N  I  E  D  R  H   | P  T  A  P  C  I  Q  E  F      p.500

          .         .         .         .         .         .       g.203783
 CTCACCCTTCTGGCCGTGTGCCACACGGTTGTTCCTGAGAAGGATGGAGATAACATCATC       c.1560
 L  T  L  L  A  V  C  H  T  V  V  P  E  K  D  G  D  N  I  I         p.520

          .          | 18        .         .         .         .    g.204580
 TACCAGGCCTCTTCCCCAG | ATGAAGCTGCTTTGGTGAAAGGAGCTAAAAAGCTGGGCTTT    c.1620
 Y  Q  A  S  S  P  D |   E  A  A  L  V  K  G  A  K  K  L  G  F      p.540

          .         .         .         .   | 19     .         .    g.207755
 GTCTTCACAGCCAGAACACCATTCTCAGTCATCATAGAAGCG | ATGGGACAGGAACAAACA    c.1680
 V  F  T  A  R  T  P  F  S  V  I  I  E  A   | M  G  Q  E  Q  T      p.560

          .         .         .   | 20     .         .         .    g.210026
 TTCGGAATCCTTAATGTCCTGGAATTTTCTAG | TGACAGAAAAAGAATGTCTGTAATTGTT    c.1740
 F  G  I  L  N  V  L  E  F  S  S  |  D  R  K  R  M  S  V  I  V      p.580

          .         .         .         .   | 21     .         .    g.211762
 CGAACTCCTTCAGGACGACTTCGGCTTTACTGTAAAGGGGCT | GATAATGTGATTTTTGAG    c.1800
 R  T  P  S  G  R  L  R  L  Y  C  K  G  A   | D  N  V  I  F  E      p.600

          .         .         .         .         .         .       g.211822
 AGACTTTCAAAAGACTCAAAATATATGGAGGAAACATTATGCCATCTGGAATACTTTGCC       c.1860
 R  L  S  K  D  S  K  Y  M  E  E  T  L  C  H  L  E  Y  F  A         p.620

         | 22.         .         .         .         .         .    g.212790
 ACGGAAG | GCTTGCGGACTCTCTGTGTGGCTTATGCTGATCTCTCTGAGAATGAGTATGAG    c.1920
 T  E  G |   L  R  T  L  C  V  A  Y  A  D  L  S  E  N  E  Y  E      p.640

          .         .         .         .         .         .       g.212850
 GAGTGGCTGAAAGTCTATCAGGAAGCCAGCACCATATTGAAGGACAGAGCTCAACGGTTG       c.1980
 E  W  L  K  V  Y  Q  E  A  S  T  I  L  K  D  R  A  Q  R  L         p.660

          .         .        | 23.         .         .         .    g.214781
 GAAGAGTGTTACGAGATCATTGAGAAG | AATTTGCTGCTACTTGGAGCCACAGCCATAGAA    c.2040
 E  E  C  Y  E  I  I  E  K   | N  L  L  L  L  G  A  T  A  I  E      p.680

          .         .         .         .         .         .       g.214841
 GATCGCCTTCAAGCAGGAGTTCCAGAAACCATCGCAACACTGTTGAAGGCAGAAATTAAA       c.2100
 D  R  L  Q  A  G  V  P  E  T  I  A  T  L  L  K  A  E  I  K         p.700

          .         .         .         .       | 24 .         .    g.222578
 ATATGGGTGTTGACAGGAGACAAACAAGAAACTGCGATTAATATAG | GGTATTCCTGCCGA    c.2160
 I  W  V  L  T  G  D  K  Q  E  T  A  I  N  I  G |   Y  S  C  R      p.720

          .         .         .         .         .  | 25      .    g.332111
 TTGGTATCGCAGAATATGGCCCTTATCCTATTGAAGGAGGACTCTTTGGAT | GCCACAAGG    c.2220
 L  V  S  Q  N  M  A  L  I  L  L  K  E  D  S  L  D   | A  T  R      p.740

          .         .         .         .         .         .       g.332171
 GCAGCCATTACTCAGCACTGCACTGACCTTGGGAATTTGCTGGGCAAGGAAAATGACGTG       c.2280
 A  A  I  T  Q  H  C  T  D  L  G  N  L  L  G  K  E  N  D  V         p.760

          .         .         .         .         .         .       g.332231
 GCCCTGATCATCGATGGCCACACCCTGAAGTACGCGCTCTCCTTCGAAGTCCGGAGGAGT       c.2340
 A  L  I  I  D  G  H  T  L  K  Y  A  L  S  F  E  V  R  R  S         p.780

          .         .         .         .     | 26   .         .    g.401991
 TTCCTGGATTTGGCACTCTCGTGCAAAGCGGTCATATGCTGCAG | AGTGTCTCCTCTGCAG    c.2400
 F  L  D  L  A  L  S  C  K  A  V  I  C  C  R  |  V  S  P  L  Q      p.800

          .         .         .         .         .         .       g.402051
 AAGTCTGAGATAGTGGATGTGGTGAAGAAGCGGGTGAAGGCCATCACCCTCGCCATCGGA       c.2460
 K  S  E  I  V  D  V  V  K  K  R  V  K  A  I  T  L  A  I  G         p.820

          .         .         .         .         .         .       g.402111
 GACGGCGCCAACGATGTCGGGATGATCCAGACAGCCCACGTGGGTGTGGGAATCAGTGGG       c.2520
 D  G  A  N  D  V  G  M  I  Q  T  A  H  V  G  V  G  I  S  G         p.840

          .         .         .         .         | 27         .    g.407790
 AATGAAGGCATGCAGGCCACCAACAACTCGGATTACGCCATCGCACAG | TTTTCCTACTTA    c.2580
 N  E  G  M  Q  A  T  N  N  S  D  Y  A  I  A  Q   | F  S  Y  L      p.860

          .         .         .         .         .         .       g.407850
 GAGAAGCTTCTGTTGGTTCATGGAGCCTGGAGCTACAACCGGGTGACCAAGTGCATCTTG       c.2640
 E  K  L  L  L  V  H  G  A  W  S  Y  N  R  V  T  K  C  I  L         p.880

          .         .         .          | 28        .         .    g.461068
 TACTGCTTCTATAAGAACGTGGTCCTGTATATTATTGAG | CTTTGGTTCGCCTTTGTTAAT    c.2700
 Y  C  F  Y  K  N  V  V  L  Y  I  I  E   | L  W  F  A  F  V  N      p.900

          .         .         .         .         .     | 29   .    g.470098
 GGATTTTCTGGGCAGATTTTATTTGAACGTTGGTGCATCGGCCTGTACAATGTG | ATTTTC    c.2760
 G  F  S  G  Q  I  L  F  E  R  W  C  I  G  L  Y  N  V   | I  F      p.920

          .         .         .         .         .         .       g.470158
 ACCGCTTTGCCGCCCTTCACTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATG       c.2820
 T  A  L  P  P  F  T  L  G  I  F  E  R  S  C  T  Q  E  S  M         p.940

          .         .         .         .         .        | 30.    g.472478
 CTCAGGTTTCCCCAGCTCTACAAAATCACCCAGAATGGCGAAGGCTTCAACACAAAG | GTT    c.2880
 L  R  F  P  Q  L  Y  K  I  T  Q  N  G  E  G  F  N  T  K   | V      p.960

          .         .         .         .         .         .       g.472538
 TTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTCATCCTCTTCTGGTTTCCCATG       c.2940
 F  W  G  H  C  I  N  A  L  V  H  S  L  I  L  F  W  F  P  M         p.980

          .       | 31 .         .         .         .         .    g.493168
 AAAGCTCTGGAGCATG | ATACTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTT    c.3000
 K  A  L  E  H  D |   T  V  L  T  S  G  H  A  T  D  Y  L  F  V      p.1000

          .         | 32         .         .         .         .    g.493775
 GGAAATATTGTTTACACA | TATGTTGTTGTTACTGTTTGTCTGAAAGCTGGTTTGGAGACC    c.3060
 G  N  I  V  Y  T   | Y  V  V  V  T  V  C  L  K  A  G  L  E  T      p.1020

          .      | 33  .         .         .         .         .    g.495275
 ACAGCTTGGACTAAA | TTCAGTCATCTGGCTGTCTGGGGAAGCATGCTGACCTGGCTGGTG    c.3120
 T  A  W  T  K   | F  S  H  L  A  V  W  G  S  M  L  T  W  L  V      p.1040

          .         .         .         .         .         .       g.495335
 TTTTTTGGCATCTACTCGACCATCTGGCCCACCATTCCCATTGCTCCAGATATGAGAGGA       c.3180
 F  F  G  I  Y  S  T  I  W  P  T  I  P  I  A  P  D  M  R  G         p.1060

     | 34    .         .         .         .         .         .    g.594561
 CAG | GCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACT    c.3240
 Q   | A  T  M  V  L  S  S  A  H  F  W  L  G  L  F  L  V  P  T      p.1080

          .         .         .   | 35     .         .         .    g.601532
 GCCTGTTTGATTGAAGATGTGGCATGGAGAGC | AGCCAAGCACACCTGCAAAAAGACATTG    c.3300
 A  C  L  I  E  D  V  A  W  R  A  |  A  K  H  T  C  K  K  T  L      p.1100

          .         .         .         .         .         .       g.601592
 CTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGG       c.3360
 L  E  E  V  Q  E  L  E  T  K  S  R  V  L  G  K  A  V  L  R         p.1120

          .        | 36.         .         .         .         .    g.645503
 GATAGCAATGGAAAGAG | GCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAG    c.3420
 D  S  N  G  K  R  |  L  N  E  R  D  R  L  I  K  R  L  G  R  K      p.1140

          .         .         .         .          | 37        .    g.652828
 ACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGC | ATGGGTATGCT    c.3480
 T  P  P  T  L  F  R  G  S  S  L  Q  Q  G  V  P  H |   G  Y  A      p.1160

          .         .         .         .         .         .       g.652888
 TTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACC       c.3540
 F  S  Q  E  E  H  G  A  V  S  Q  E  E  V  I  R  A  Y  D  T         p.1180

          .         .                                               g.652915
 ACCAAAAAGAAATCCAGGAAGAAATAA                                        c.3567
 T  K  K  K  S  R  K  K  X                                          p.1188

          .         .         .         .         .         .       g.652975
 gacatgaattttcctgactgatcttaggaaagagattcagtttgttgcacccagtgttaa       c.*60

          .         .         .         .         .         .       g.653035
 cacatctttgtcagagaagactggcgtcagcagccaaaacaccaggaaacacatttctgt       c.*120

          .         .         .         .         .         .       g.653095
 ggccttagccaagcagtttgttagttacatattccctcgcaaacctggagtgcagaccac       c.*180

          .         .         .         .         .         .       g.653155
 aggggaagctatctttgccctcccaactcgtctgcagtgcttagcctaacttttgtttat       c.*240

          .         .         .         .         .         .       g.653215
 gtcgttatgaagcattcaactgtgctctgtgaggtgtgaaattaaaaacattatgtttca       c.*300

          .         .         .         .         .         .       g.653275
 ccaatatttaaacatcagtactagttgtcctgggagaaagggaaaggagttttatgttgc       c.*360

          .         .         .         .         .         .       g.653335
 gtgagaggcccatcctgtgtaattggagcagggcacacttgcttcctgttgagttaactc       c.*420

          .         .         .         .         .         .       g.653395
 agaggttaagtccaacgggccacatgcagacttcactgtaggcaggttgctctcctgctt       c.*480

          .         .         .         .         .         .       g.653455
 tgattcctgttttgtgtgtaaaattggcataaacttcttgattgcagtgaaatcacaaaa       c.*540

          .         .         .         .         .         .       g.653515
 ttctctatcggggtggtcaacctgagaacatttatttgaacctcttagccacatttccag       c.*600

          .         .         .         .         .         .       g.653575
 cagggcaaaccaactgatgccctggaagagtcttccgcaccctctccaggtgcactcggc       c.*660

          .         .         .         .         .         .       g.653635
 ccagtcctgccgccgtgtccaggcgcccctcacccccacacctgctgcatggctggccac       c.*720

          .         .         .         .         .         .       g.653695
 accactcagtgcatggcggccgatgggcagccaacccaaacccgcgcctttccttgttcc       c.*780

          .         .         .         .         .         .       g.653755
 actgcagactcagatacagatgcgaaaaattccttcttccaccgcccttctcgttctgta       c.*840

          .         .         .         .         .         .       g.653815
 aagaaagaaaagaaacatagcctttctgcatatattctaaacgtctctctgcctctgtct       c.*900

          .         .         .         .         .         .       g.653875
 gacatggggccaccccacaggtcagagtggtggtagaaccccttcaggactcccagccgt       c.*960

          .         .         .         .         .         .       g.653935
 ggtcaggctctgaatactcccttcccaacatccagactgctgggcctttggcatccactt       c.*1020

          .         .         .         .         .         .       g.653995
 acattagaacccacgtttgtttcagagcacattttggactttcactgttgggaaatgaat       c.*1080

          .         .         .         .         .         .       g.654055
 gaatttataacatgcctgcacagcgaaggaacacacctgtcgctcttagctctagagtca       c.*1140

          .         .         .         .         .         .       g.654115
 gaggatgagtaaacccagatgcaagagtataggacattgagtggggagaacaagacgacc       c.*1200

          .         .         .         .         .         .       g.654175
 acagaagtcctcagaaggagaaggaaggacacggagacactgagaggaggacacagagga       c.*1260

          .         .         .                                     g.654212
 atcgccaccagatctttgcagtagaaactctgaaata                              c.*1297

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ATPase, aminophospholipid transporter, class I, type 8A, member 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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