aurora kinase C (AURKC) - coding DNA reference sequence

(used for variant description)

(last modified November 5, 2020)

This file was created to facilitate the description of sequence variants on transcript NM_001015878.1 in the AURKC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012134.1, covering AURKC transcript NM_001015878.1.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.5060
                                                    ccacggctg       c.-181

 .         .         .         .         .         .                g.5120
 ctcacgacgccgcggatcccgaagcctgtgtagcagtgagacatcagtgaggctgcagga       c.-121

 .         .         .         .         .         .                g.5180
 cgagcaggattggaagcgccccggccagaaagtgaccccccacccctttcaggaccctgt       c.-61

 .         .         .         .         .         .                g.5240
 gaacgggaacagccatccagagggttcaggaaggcgtccgcgccctcacctcttctcccc       c.-1

          .         .         .         .         .         | 02    g.5735
 ATGAGCTCCCCCAGAGCTGTGGTGCAGCTGGGCAAAGCTCAACCTGCAGGCGAAGAGT | TG    c.60
 M  S  S  P  R  A  V  V  Q  L  G  K  A  Q  P  A  G  E  E  L |       p.20

          .         .         .         .     | 03   .         .    g.6040
 GCTACAGCAAACCAAACAGCCCAGCAGCCCAGCAGCCCAGCCAT | GCGGCGCCTCACAGTC    c.120
 A  T  A  N  Q  T  A  Q  Q  P  S  S  P  A  M  |  R  R  L  T  V      p.40

          .         .         .         .         .         .       g.6100
 GATGACTTTGAAATCGGGCGTCCCCTGGGCAAGGGGAAATTTGGGAATGTGTACCTGGCT       c.180
 D  D  F  E  I  G  R  P  L  G  K  G  K  F  G  N  V  Y  L  A         p.60

          .         .         .         .         .         .       g.6160
 CGGCTCAAGGAAAGCCATTTCATTGTGGCCCTGAAGGTTCTCTTCAAGTCGCAGATAGAG       c.240
 R  L  K  E  S  H  F  I  V  A  L  K  V  L  F  K  S  Q  I  E         p.80

          .         .         .         .         .       | 04 .    g.6537
 AAGGAAGGACTGGAGCACCAGCTGCGCCGGGAAATTGAGATCCAGGCTCATCTACA | ACAC    c.300
 K  E  G  L  E  H  Q  L  R  R  E  I  E  I  Q  A  H  L  Q  |  H      p.100

          .         .         .         .         .         .       g.6597
 CCCAATATCCTGCGCCTGTATAACTATTTCCATGATGCACGCCGGGTGTACCTGATTCTG       c.360
 P  N  I  L  R  L  Y  N  Y  F  H  D  A  R  R  V  Y  L  I  L         p.120

          .         .         .         .         .         .       g.6657
 GAATATGCTCCAAGGGGTGAGCTCTACAAGGAGCTGCAGAAAAGCGAGAAATTAGATGAA       c.420
 E  Y  A  P  R  G  E  L  Y  K  E  L  Q  K  S  E  K  L  D  E         p.140

          .      | 05  .         .         .         .         .    g.7496
 CAGCGCACAGCCACG | ATAATAGAGGAGTTGGCAGATGCCCTGACCTACTGCCATGACAAG    c.480
 Q  R  T  A  T   | I  I  E  E  L  A  D  A  L  T  Y  C  H  D  K      p.160

          .         .         .         .         .         .       g.7556
 AAAGTGATTCACAGAGATATTAAGCCAGAGAACCTGCTGCTGGGGTTCAGGGGTGAGGTG       c.540
 K  V  I  H  R  D  I  K  P  E  N  L  L  L  G  F  R  G  E  V         p.180

          .         .         .         .     | 06   .         .    g.8891
 AAGATTGCAGATTTTGGCTGGTCTGTGCACACCCCCTCCCTGAG | GAGGAAGACAATGTGT    c.600
 K  I  A  D  F  G  W  S  V  H  T  P  S  L  R  |  R  K  T  M  C      p.200

          .         .         .         .         .         .       g.8951
 GGGACACTGGACTACTTGCCGCCAGAAATGATTGAGGGGAGAACATATGATGAAAAGGTG       c.660
 G  T  L  D  Y  L  P  P  E  M  I  E  G  R  T  Y  D  E  K  V         p.220

          .         .         .         .         .         .       g.9011
 GATTTGTGGTGCATTGGAGTGCTCTGCTATGAGCTGCTGGTGGGATATCCACCCTTTGAG       c.720
 D  L  W  C  I  G  V  L  C  Y  E  L  L  V  G  Y  P  P  F  E         p.240

          .         .         .          | 07        .         .    g.9259
 AGCGCCTCCCACAGTGAGACTTACAGACGCATCCTCAAG | GTAGATGTGAGGTTTCCACTA    c.780
 S  A  S  H  S  E  T  Y  R  R  I  L  K   | V  D  V  R  F  P  L      p.260

          .         .         .         .         .         .       g.9319
 TCAATGCCTCTGGGGGCCCGGGACTTGATTTCCAGGCTTCTCAGATACCAGCCCTTGGAG       c.840
 S  M  P  L  G  A  R  D  L  I  S  R  L  L  R  Y  Q  P  L  E         p.280

          .         .         .         .         .         .       g.9379
 AGACTGCCCCTGGCCCAGATCCTGAAGCACCCCTGGGTTCAGGCCCACTCCCGAAGGGTG       c.900
 R  L  P  L  A  Q  I  L  K  H  P  W  V  Q  A  H  S  R  R  V         p.300

          .         .         .                                     g.9409
 CTGCCTCCCTGTGCTCAGATGGCTTCCTGA                                     c.930
 L  P  P  C  A  Q  M  A  S  X                                       p.309

          .         .         .         .         .         .       g.9469
 gccctgtctgcctctgttccctttgtgtgtgttcagggagctctcctggctctgccacct       c.*60

          .         .         .         .         .         .       g.9529
 catttgtctttatttttttctcttttaagatgtaagatgctaattaataaaagctgaatc       c.*120

          .                                                         g.9540
 atttcatacca                                                        c.*131

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Aurora kinase C protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.