arginine vasopressin receptor 2 (AVPR2) - coding DNA reference sequence

(used for variant description)

(last modified August 31, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000054.4 in the AVPR2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008687.1, covering AVPR2 transcript NM_000054.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.7555
                                                  cttgctcctca       c.-61

 .         .         .         .         .         .                g.7615
 ggcagaggctgagtccgcacatcacctccaggccctcagaacacctgccccagccccacc       c.-1

          .         .      | 02  .         .         .         .    g.8036
 ATGCTCATGGCGTCCACCACTTCCG | CTGTGCCTGGGCATCCCTCTCTGCCCAGCCTGCCC    c.60
 M  L  M  A  S  T  T  S  A |   V  P  G  H  P  S  L  P  S  L  P      p.20

          .         .         .         .         .         .       g.8096
 AGCAACAGCAGCCAGGAGAGGCCACTGGACACCCGGGACCCGCTGCTAGCCCGGGCGGAG       c.120
 S  N  S  S  Q  E  R  P  L  D  T  R  D  P  L  L  A  R  A  E         p.40

          .         .         .         .         .         .       g.8156
 CTGGCGCTGCTCTCCATAGTCTTTGTGGCTGTGGCCCTGAGCAATGGCCTGGTGCTGGCG       c.180
 L  A  L  L  S  I  V  F  V  A  V  A  L  S  N  G  L  V  L  A         p.60

          .         .         .         .         .         .       g.8216
 GCCCTAGCTCGGCGGGGCCGGCGGGGCCACTGGGCACCCATACACGTCTTCATTGGCCAC       c.240
 A  L  A  R  R  G  R  R  G  H  W  A  P  I  H  V  F  I  G  H         p.80

          .         .         .         .         .         .       g.8276
 TTGTGCCTGGCCGACCTGGCCGTGGCTCTGTTCCAAGTGCTGCCCCAGCTGGCCTGGAAG       c.300
 L  C  L  A  D  L  A  V  A  L  F  Q  V  L  P  Q  L  A  W  K         p.100

          .         .         .         .         .         .       g.8336
 GCCACCGACCGCTTCCGTGGGCCAGATGCCCTGTGTCGGGCCGTGAAGTATCTGCAGATG       c.360
 A  T  D  R  F  R  G  P  D  A  L  C  R  A  V  K  Y  L  Q  M         p.120

          .         .         .         .         .         .       g.8396
 GTGGGCATGTATGCCTCCTCCTACATGATCCTGGCCATGACGCTGGACCGCCACCGTGCC       c.420
 V  G  M  Y  A  S  S  Y  M  I  L  A  M  T  L  D  R  H  R  A         p.140

          .         .         .         .         .         .       g.8456
 ATCTGCCGTCCCATGCTGGCGTACCGCCATGGAAGTGGGGCTCACTGGAACCGGCCGGTG       c.480
 I  C  R  P  M  L  A  Y  R  H  G  S  G  A  H  W  N  R  P  V         p.160

          .         .         .         .         .         .       g.8516
 CTAGTGGCTTGGGCCTTCTCGCTCCTTCTCAGCCTGCCCCAGCTCTTCATCTTCGCCCAG       c.540
 L  V  A  W  A  F  S  L  L  L  S  L  P  Q  L  F  I  F  A  Q         p.180

          .         .         .         .         .         .       g.8576
 CGCAACGTGGAAGGTGGCAGCGGGGTCACTGACTGCTGGGCCTGCTTTGCGGAGCCCTGG       c.600
 R  N  V  E  G  G  S  G  V  T  D  C  W  A  C  F  A  E  P  W         p.200

          .         .         .         .         .         .       g.8636
 GGCCGTCGCACCTATGTCACCTGGATTGCCCTGATGGTGTTCGTGGCACCTACCCTGGGT       c.660
 G  R  R  T  Y  V  T  W  I  A  L  M  V  F  V  A  P  T  L  G         p.220

          .         .         .         .         .         .       g.8696
 ATCGCCGCCTGCCAGGTGCTCATCTTCCGGGAGATTCATGCCAGTCTGGTGCCAGGGCCA       c.720
 I  A  A  C  Q  V  L  I  F  R  E  I  H  A  S  L  V  P  G  P         p.240

          .         .         .         .         .         .       g.8756
 TCAGAGAGGCCTGGGGGGCGCCGCAGGGGACGCCGGACAGGCAGCCCCGGTGAGGGAGCC       c.780
 S  E  R  P  G  G  R  R  R  G  R  R  T  G  S  P  G  E  G  A         p.260

          .         .         .         .         .         .       g.8816
 CACGTGTCAGCAGCTGTGGCCAAGACTGTGAGGATGACGCTAGTGATTGTGGTCGTCTAT       c.840
 H  V  S  A  A  V  A  K  T  V  R  M  T  L  V  I  V  V  V  Y         p.280

          .         .         .         .         .         .       g.8876
 GTGCTGTGCTGGGCACCCTTCTTCCTGGTGCAGCTGTGGGCCGCGTGGGACCCGGAGGCA       c.900
 V  L  C  W  A  P  F  F  L  V  Q  L  W  A  A  W  D  P  E  A         p.300

          . | 03       .         .         .         .         .    g.9042
 CCTCTGGAAG | GGGCGCCCTTTGTGCTACTCATGTTGCTGGCCAGCCTCAACAGCTGCACC    c.960
 P  L  E  G |   A  P  F  V  L  L  M  L  L  A  S  L  N  S  C  T      p.320

          .         .         .         .         .         .       g.9102
 AACCCCTGGATCTATGCATCTTTCAGCAGCAGCGTGTCCTCAGAGCTGCGAAGCTTGCTC       c.1020
 N  P  W  I  Y  A  S  F  S  S  S  V  S  S  E  L  R  S  L  L         p.340

          .         .         .         .         .         .       g.9162
 TGCTGTGCCCGGGGACGCACCCCACCCAGCCTGGGTCCCCAAGATGAGTCCTGCACCACC       c.1080
 C  C  A  R  G  R  T  P  P  S  L  G  P  Q  D  E  S  C  T  T         p.360

          .         .         .                                     g.9198
 GCCAGCTCCTCCCTGGCCAAGGACACTTCATCGTGA                               c.1116
 A  S  S  S  L  A  K  D  T  S  S  X                                 p.371

          .         .         .         .         .         .       g.9258
 ggagctgttgggtgtcttgcctctagaggctttgagaagctcagctgccttcctggggct       c.*60

          .         .         .         .         .         .       g.9318
 ggtcctgggagccactgggagggggacccgtggagaattggccagagcctgtggccccga       c.*120

          .         .         .         .         .         .       g.9378
 ggctgggacactgtgtggccctggacaagccacagcccctgcctgggtctccacatcccc       c.*180

          .         .         .         .         .         .       g.9438
 agctgtatgaggagagcttcaggccccaggactgtgggggcccctcaggtcagctcactg       c.*240

          .         .         .         .         .         .       g.9498
 agctgggtgtaggaggggctgcagcagaggcctgaggagtggcaggaaagagggagcagg       c.*300

          .         .         .         .         .         .       g.9558
 tgcccccaggtgagacagcggtcccaggggcctgaaaaggaaggaccaggctggggccag       c.*360

          .         .         .         .         .         .       g.9618
 gggaccttcctgtctccgcctttctaatccctccctcctcattctctccctaataaaaat       c.*420

          .                                                         g.9636
 tggagctcattttccaca                                                 c.*438

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Arginine vasopressin receptor 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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