axin 1 (AXIN1) - coding DNA reference sequence

(used for variant description)

(last modified December 10, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_003502.3 in the AXIN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012267.1, covering AXIN1 transcript NM_003502.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.4817
                                tctggctcgggctctggctcgggaggcga       c.-361

 .         .         .         .         .         .                g.4877
 tcgtggccgctgccgccgccagagccggccggagtcggcccggagccgcgtccacgcgga       c.-301

 .         .         .         .         .         .                g.4937
 gcgggcgggtgggagctggcggctgggcccctgcggcgcccccgcggcctgccccgcgtc       c.-241

 .         .         .         .         .         .                g.4997
 cgcctccgggccgccgagccgcagccgccgagatgggggccgccccgggccgcgcccccg       c.-181

 .         .         .         .         .         .                g.5057
 ccgggtcccgcccgccgcgctgccgctgagcgcatgggcccggaccgcgccgcgccgctc       c.-121

 .         .         .         .         | 02         .             g.10379
 cgggagccgggcccggggtcccgccaccaccgcgcgcgg | gacagattgattcactttgga    c.-61

 .         .         .         .         .         .                g.10439
 gctgtaagtactgatgtattagggtgcagcgctcattgttccttgacgcagagtcccaaa       c.-1

          .         .         .         .         .         .       g.10499
 ATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCT       c.60
 M  N  I  Q  E  Q  G  F  P  L  D  L  G  A  S  F  T  E  D  A         p.20

          .         .         .         .         .         .       g.10559
 CCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCC       c.120
 P  R  P  P  V  P  G  E  E  G  E  L  V  S  T  D  P  R  P  A         p.40

          .         .         .         .         .         .       g.10619
 AGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACT       c.180
 S  Y  S  F  C  S  G  K  G  V  G  I  K  G  E  T  S  T  A  T         p.60

          .         .         .         .         .         .       g.10679
 CCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCA       c.240
 P  R  R  S  D  L  D  L  G  Y  E  P  E  G  S  A  S  P  T  P         p.80

          .         .         .         .         .         .       g.10739
 CCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGC       c.300
 P  Y  L  K  W  A  E  S  L  H  S  L  L  D  D  Q  D  G  I  S         p.100

          .         .         .         .         .         .       g.10799
 CTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCC       c.360
 L  F  R  T  F  L  K  Q  E  G  C  A  D  L  L  D  F  W  F  A         p.120

          .         .         .         .         .         .       g.10859
 TGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTG       c.420
 C  T  G  F  R  K  L  E  P  C  D  S  N  E  E  K  R  L  K  L         p.140

          .         .         .         .         .         .       g.10919
 GCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACC       c.480
 A  R  A  I  Y  R  K  Y  I  L  D  N  N  G  I  V  S  R  Q  T         p.160

          .         .         .         .         .         .       g.10979
 AAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCC       c.540
 K  P  A  T  K  S  F  I  K  G  C  I  M  K  Q  L  I  D  P  A         p.180

          .         .         .         .         .         .       g.11039
 ATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCC       c.600
 M  F  D  Q  A  Q  T  E  I  Q  A  T  M  E  E  N  T  Y  P  S         p.200

          .         .         .         .         .         .       g.11099
 TTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTC       c.660
 F  L  K  S  D  I  Y  L  E  Y  T  R  T  G  S  E  S  P  K  V         p.220

          .         .         .         .         .         .       g.11159
 TGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACC       c.720
 C  S  D  Q  S  S  G  S  G  T  G  K  G  I  S  G  Y  L  P  T         p.240

          .         .         .         .         .         .       g.11219
 TTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGAC       c.780
 L  N  E  D  E  E  W  K  C  D  Q  D  M  D  E  D  D  G  R  D         p.260

          .         .         .         .         .         .       g.11279
 GCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTC       c.840
 A  A  P  P  G  R  L  P  Q  K  L  L  L  E  T  A  A  P  R  V         p.280

          .         .         .         | 03         .         .    g.42803
 TCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAG | GTATGGATCCTGGCGGGAGCCA    c.900
 S  S  S  R  R  Y  S  E  G  R  E  F  R  |  Y  G  S  W  R  E  P      p.300

          .         .         .         .         .         .       g.42863
 GTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGAC       c.960
 V  N  P  Y  Y  V  N  A  G  Y  A  L  A  P  A  T  S  A  N  D         p.320

          .         .         .         .         .          | 04    g.47396
 AGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGT | G    c.1020
 S  E  Q  Q  S  L  S  S  D  A  D  T  L  S  L  T  D  S  S  V  |      p.340

          .         .         .         .         .         .       g.47456
 GATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTG       c.1080
 D  G  I  P  P  Y  R  I  R  K  Q  H  R  R  E  M  Q  E  S  V         p.360

          .         .         .       | 05 .         .         .    g.53047
 CAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCC | CGCACGTACCGGGTGCCGAAGGAG    c.1140
 Q  V  N  G  R  V  P  L  P  H  I  P   | R  T  Y  R  V  P  K  E      p.380

          .         .         .         .         .         .       g.53107
 GTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAG       c.1200
 V  R  V  E  P  Q  K  F  A  E  E  L  I  H  R  L  E  A  V  Q         p.400

          .         .         .         .         .     | 06   .    g.59219
 CGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATG | GAGGAG    c.1260
 R  T  R  E  A  E  E  K  L  E  E  R  L  K  R  V  R  M   | E  E      p.420

          .         .         .         .         .         .       g.59279
 GAAGGTGAGGACGGCGATCCATCGTCAGGGCCCCCAGGGCCGTGTCACAAGCTGCCTCCC       c.1320
 E  G  E  D  G  D  P  S  S  G  P  P  G  P  C  H  K  L  P  P         p.440

          .         .         .         .         .         .       g.59339
 GCCCCCGCTTGGCACCACTTCCCGCCCCGCTGTGTGGACATGGGCTGTGCCGGGCTCCGG       c.1380
 A  P  A  W  H  H  F  P  P  R  C  V  D  M  G  C  A  G  L  R         p.460

          .         .         .         .         .         .       g.59399
 GATGCACACGAGGAGAACCCTGAGAGCATCCTGGACGAGCACGTACAGCGTGTGCTGAGG       c.1440
 D  A  H  E  E  N  P  E  S  I  L  D  E  H  V  Q  R  V  L  R         p.480

          .         .         .         .         .         .       g.59459
 ACACCTGGCCGCCAGTCGCCTGGGCCTGGCCATCGCTCCCCGGACAGTGGGCACGTGGCC       c.1500
 T  P  G  R  Q  S  P  G  P  G  H  R  S  P  D  S  G  H  V  A         p.500

          .         .         .         .         .         .       g.59519
 AAGATGCCAGTGGCACTGGGGGGTGCCGCCTCGGGGCACGGGAAGCACGTACCCAAGTCA       c.1560
 K  M  P  V  A  L  G  G  A  A  S  G  H  G  K  H  V  P  K  S         p.520

          .         .         .         .         .         .       g.59579
 GGGGCGAAGCTGGACGCGGCCGGCCTGCACCACCACCGACACGTCCACCACCACGTCCAC       c.1620
 G  A  K  L  D  A  A  G  L  H  H  H  R  H  V  H  H  H  V  H         p.540

          .         .         .         .         .         .       g.59639
 CACAGCACAGCCCGGCCCAAGGAGCAGGTGGAGGCCGAGGCCACCCGCAGGGCCCAGAGC       c.1680
 H  S  T  A  R  P  K  E  Q  V  E  A  E  A  T  R  R  A  Q  S         p.560

          .         .         .         .         .         .       g.59699
 AGCTTCGCCTGGGGCCTGGAACCACACAGCCATGGGGCAAGGTCCCGAGGCTACTCAGAG       c.1740
 S  F  A  W  G  L  E  P  H  S  H  G  A  R  S  R  G  Y  S  E         p.580

          .         .         .         .     | 07   .         .    g.60254
 AGTGTTGGCGCTGCCCCCAACGCCAGTGATGGCCTCGCCCACAG | TGGGAAGGTGGGCGTG    c.1800
 S  V  G  A  A  P  N  A  S  D  G  L  A  H  S  |  G  K  V  G  V      p.600

          .         .         .         .         .         .       g.60314
 GCGTGCAAAAGAAATGCCAAGAAGGCTGAGTCGGGGAAGAGCGCCAGCACCGAGGTGCCA       c.1860
 A  C  K  R  N  A  K  K  A  E  S  G  K  S  A  S  T  E  V  P         p.620

          .         .         .         .         .         .       g.60374
 GGTGCCTCGGAGGATGCGGAGAAGAACCAGAAAATCATGCAGTGGATCATTGAGGGGGAA       c.1920
 G  A  S  E  D  A  E  K  N  Q  K  I  M  Q  W  I  I  E  G  E         p.640

          .         .         .      | 08  .         .         .    g.63771
 AAGGAGATCAGCAGGCACCGCAGGACCGGCCACGG | GTCTTCGGGGACGAGGAAGCCACAG    c.1980
 K  E  I  S  R  H  R  R  T  G  H  G  |  S  S  G  T  R  K  P  Q      p.660

          .         .         .         .         .         .       g.63831
 CCCCATGAGAACTCCAGACCCTTGTCCCTTGAGCACCCCTGGGCCGGCCCTCAGCTCCGG       c.2040
 P  H  E  N  S  R  P  L  S  L  E  H  P  W  A  G  P  Q  L  R         p.680

          .         .         .         .         .         .       g.63891
 ACCTCCGTGCAGCCCTCCCACCTCTTCATCCAAGACCCCACCATGCCACCCCACCCAGCT       c.2100
 T  S  V  Q  P  S  H  L  F  I  Q  D  P  T  M  P  P  H  P  A         p.700

          .         .         .         .         .         .       g.63951
 CCCAACCCCCTAACCCAGCTGGAGGAGGCGCGCCGACGTCTGGAGGAGGAAGAAAAGAGA       c.2160
 P  N  P  L  T  Q  L  E  E  A  R  R  R  L  E  E  E  E  K  R         p.720

          .         .       | 09 .         .         .         .    g.66201
 GCCAGCCGAGCACCCTCCAAGCAGAG | GTATGTGCAGGAGGTTATGCGGCGGGGACGCGCC    c.2220
 A  S  R  A  P  S  K  Q  R  |  Y  V  Q  E  V  M  R  R  G  R  A      p.740

          .         .         .         .         .         .       g.66261
 TGCGTCAGGCCAGCGTGCGCGCCGGTGCTGCACGTGGTACCAGCCGTGTCGGACATGGAG       c.2280
 C  V  R  P  A  C  A  P  V  L  H  V  V  P  A  V  S  D  M  E         p.760

          .     | 10   .         .         .         .         .    g.67903
 CTCTCCGAGACAGA | GACAAGATCGCAGAGGAAGGTGGGCGGCGGGAGTGCCCAGCCGTGT    c.2340
 L  S  E  T  E  |  T  R  S  Q  R  K  V  G  G  G  S  A  Q  P  C      p.780

          .         .         .         .         .         .       g.67963
 GACAGCATCGTTGTGGCGTACTACTTCTGCGGGGAACCCATCCCCTACCGCACCCTGGTG       c.2400
 D  S  I  V  V  A  Y  Y  F  C  G  E  P  I  P  Y  R  T  L  V         p.800

          .         .         .         .         .         .       g.68023
 AGGGGCCGCGCTGTCACCCTGGGCCAGTTCAAGGAGCTGCTGACCAAAAAGGGCAGCTAC       c.2460
 R  G  R  A  V  T  L  G  Q  F  K  E  L  L  T  K  K  G  S  Y         p.820

    | 11     .         .         .         .         .         .    g.69274
 AG | ATACTACTTCAAGAAAGTGAGCGACGAGTTTGACTGTGGGGTGGTGTTTGAGGAGGTT    c.2520
 R  |  Y  Y  F  K  K  V  S  D  E  F  D  C  G  V  V  F  E  E  V      p.840

          .         .         .         .         .         .       g.69334
 CGAGAGGACGAGGCCGTCCTGCCCGTCTTTGAGGAGAAGATCATCGGCAAAGTGGAGAAG       c.2580
 R  E  D  E  A  V  L  P  V  F  E  E  K  I  I  G  K  V  E  K         p.860

                                                                    g.69343
 GTGGACTGA                                                          c.2589
 V  D  X                                                            p.862

          .         .         .         .         .         .       g.69403
 taggctggtgggctggccgctgtgccaggcgaggcccttggcgggcacgggtgtcacggc       c.*60

          .         .         .         .         .         .       g.69463
 caggcagatgacctcgtactcaggagcccgatggggaacagtgttgggtgtaccacccat       c.*120

          .         .         .         .         .         .       g.69523
 ccctgtggtctacccgtgtctagaggcaggtagggggtccctccaagtggtccacaagct       c.*180

          .         .         .         .         .         .       g.69583
 tctgtcctgcccccaaggaggcagcctggaccactcctcatagcaatacttggagggccc       c.*240

          .         .         .         .         .         .       g.69643
 agcccaagtgaggcagccgaggtccctgctgccagcttcaggtgacccccccccatcccc       c.*300

          .         .         .         .         .         .       g.69703
 cggcacctcccttgggcacgtgtgctgggatctactttccctctgggatttgcccacgta       c.*360

          .         .         .         .         .         .       g.69763
 cccaggtctgggtggggcccaggcccggatgcagaggcctgcagggcctctgtcaattgt       c.*420

          .         .         .         .         .         .       g.69823
 acgcgccaccgagtgccttcaacacagcttgtctcttgcctgccactgtgtgaatcggcg       c.*480

          .         .         .         .         .         .       g.69883
 acggagcactgcacctgcctccagccgccggctgtgcagtcctgggtcctcctttctgag       c.*540

          .         .         .         .         .         .       g.69943
 ggcccgtgtaaatatgtacatttctcaggctaggccagcaggggctgcccgagtctgttt       c.*600

          .         .         .         .         .         .       g.70003
 ttcatgcgatgacacttgtacaattaattatcttttcaaaggtacttggataataatgaa       c.*660

          .         .                                               g.70025
 ataaaactgtttttgaacctgc                                             c.*682

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Axin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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