BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1) - coding DNA reference sequence

(used for variant description)

(last modified June 24, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_004656.2 in the BAP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031859.1, covering BAP1 transcript NM_004656.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5055
      gcccgttgtctgtgtgtgggactgaggggccccgggggcggtgggggctcccggt       c.-61

 .         .         .         .         .         .                g.5115
 gggggcagcggtggggagggagggcctggacatggcgctgaggggccgccccgcgggaag       c.-1

          .         .         .        | 02.         .         .    g.5273
 ATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAG | GCCTCTTCACCCTGCTCGTGGAA    c.60
 M  N  K  G  W  L  E  L  E  S  D  P  G |   L  F  T  L  L  V  E      p.20

         | 03.         .         .         .         .         .    g.5438
 GATTTCG | GTGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAG    c.120
 D  F  G |   V  K  G  V  Q  V  E  E  I  Y  D  L  Q  S  K  C  Q      p.40

    | 04     .         .         .         .         .         .    g.6445
 GG | CCCTGTATATGGATTTATCTTCCTGTTCAAATGGATCGAAGAGCGCCGGTCCCGGCGA    c.180
 G  |  P  V  Y  G  F  I  F  L  F  K  W  I  E  E  R  R  S  R  R      p.60

          .         .         .         .         .         .       g.6505
 AAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAATAACATG       c.240
 K  V  S  T  L  V  D  D  T  S  V  I  D  D  D  I  V  N  N  M         p.80

          .      | 05  .         .         .         .         .    g.6961
 TTCTTTGCCCACCAG | CTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTC    c.300
 F  F  A  H  Q   | L  I  P  N  S  C  A  T  H  A  L  L  S  V  L      p.100

          .         .         .         .         .         .       g.7021
 CTGAACTGCAGCAGCGTGGACCTGGGACCCACCCTGAGTCGCATGAAGGACTTCACCAAG       c.360
 L  N  C  S  S  V  D  L  G  P  T  L  S  R  M  K  D  F  T  K         p.120

          .      | 06  .         .         .         .         .    g.7578
 GGTTTCAGCCCTGAG | AGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCCAAGGCC    c.420
 G  F  S  P  E   | S  K  G  Y  A  I  G  N  A  P  E  L  A  K  A      p.140

          .        | 07.         .         .         .         .    g.7720
 CATAATAGCCATGCCAG | GCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGT    c.480
 H  N  S  H  A  R  |  P  E  P  R  H  L  P  E  K  Q  N  G  L  S      p.160

          .         .         .         .         .         .       g.7780
 GCAGTGCGGACCATGGAGGCGTTCCACTTTGTCAGCTATGTGCCTATCACAGGCCGGCTC       c.540
 A  V  R  T  M  E  A  F  H  F  V  S  Y  V  P  I  T  G  R  L         p.180

          .         .         .         . | 08       .         .    g.8106
 TTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATG | GGCCCTGGGGGGAGGACGAG    c.600
 F  E  L  D  G  L  K  V  Y  P  I  D  H  G |   P  W  G  E  D  E      p.200

          .         .         .         .         .          | 09    g.8618
 GAGTGGACAGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGG | G    c.660
 E  W  T  D  K  A  R  R  V  I  M  E  R  I  G  L  A  T  A  G  |      p.220

          .         .         .         .         .         .       g.8678
 GAGCCCTACCACGACATCCGCTTCAACCTGATGGCAGTGGTGCCCGACCGCAGGATCAAG       c.720
 E  P  Y  H  D  I  R  F  N  L  M  A  V  V  P  D  R  R  I  K         p.240

          .         .         .         .         .         .       g.8738
 TATGAGGCCAGGCTGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAG       c.780
 Y  E  A  R  L  H  V  L  K  V  N  R  Q  T  V  L  E  A  L  Q         p.260

     | 10    .         .         .         .         .         .    g.9138
 CAG | CTGATAAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCTCAAGAGTCACAG    c.840
 Q   | L  I  R  V  T  Q  P  E  L  I  Q  T  H  K  S  Q  E  S  Q      p.280

          .         .         .         .         .         .       g.9198
 CTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCCGCTGGTGCTGGAAGCAAACAGG       c.900
 L  P  E  E  S  K  S  A  S  N  K  S  P  L  V  L  E  A  N  R         p.300

          .         .         .  | 11      .         .         .    g.9728
 GCCCCTGCAGCCTCTGAGGGCAACCACACAG | ATGGTGCAGAGGAGGCGGCTGGTTCATGC    c.960
 A  P  A  A  S  E  G  N  H  T  D |   G  A  E  E  A  A  G  S  C      p.320

          .         .         .         .         .         .       g.9788
 GCACAAGCCCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTGAAGCCTCCAGGC       c.1020
 A  Q  A  P  S  H  S  P  P  N  K  P  K  L  V  V  K  P  P  G         p.340

          .         .         .         .         .         .       g.9848
 AGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCATTGTCCAGCGGCTGCCGGCCTTT       c.1080
 S  S  L  N  G  V  H  P  N  P  T  P  I  V  Q  R  L  P  A  F         p.360

          .         .         .       | 12 .         .         .    g.10431
 CTAGACAATCACAATTATGCCAAGTCCCCCATGCAG | GAGGAAGAAGACCTGGCGGCAGGT    c.1140
 L  D  N  H  N  Y  A  K  S  P  M  Q   | E  E  E  D  L  A  A  G      p.380

          .         .         .         .         .         .       g.10491
 GTGGGCCGCAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGATGATGAGGATGAC       c.1200
 V  G  R  S  R  V  P  V  R  P  P  Q  Q  Y  S  D  D  E  D  D         p.400

          .         .         .         .         . | 13       .    g.11109
 TATGAGGATGACGAGGAGGATGACGTGCAGAACACCAACTCTGCCCTTAG | GTATAAGGGG    c.1260
 Y  E  D  D  E  E  D  D  V  Q  N  T  N  S  A  L  R  |  Y  K  G      p.420

          .         .         .         .         .         .       g.11169
 AAGGGAACAGGGAAGCCAGGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTG       c.1320
 K  G  T  G  K  P  G  A  L  S  G  S  A  D  G  Q  L  S  V  L         p.440

          .         .         .         .         .         .       g.11229
 CAGCCCAACACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAGAAGGACCTCTCA       c.1380
 Q  P  N  T  I  N  V  L  A  E  K  L  K  E  S  Q  K  D  L  S         p.460

          .         .         .         .         .         .       g.11289
 ATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAGTCCGGCTGTGGCAGTGCCCACA       c.1440
 I  P  L  S  I  K  T  S  S  G  A  G  S  P  A  V  A  V  P  T         p.480

          .         .         .         .         .         .       g.11349
 CACTCGCAGCCCTCACCCACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGC       c.1500
 H  S  Q  P  S  P  T  P  S  N  E  S  T  D  T  A  S  E  I  G         p.500

          .         .         .         .         .         .       g.11409
 AGTGCTTTCAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCGACGCGGCCCTCC       c.1560
 S  A  F  N  S  P  L  R  S  P  I  R  S  A  N  P  T  R  P  S         p.520

          .         .         .         .         .         .       g.11469
 AGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGGAGAGGATGACAGCCTGCTGCGT       c.1620
 S  P  V  T  S  H  I  S  K  V  L  F  G  E  D  D  S  L  L  R         p.540

          .         .         .         .         .         .       g.11529
 GTTGACTGCATACGCTACAACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGC       c.1680
 V  D  C  I  R  Y  N  R  A  V  R  D  L  G  P  V  I  S  T  G         p.560

          .         .         .         .          | 14        .    g.11706
 CTGCTGCACCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACAG | AGGGTGGGAAG    c.1740
 L  L  H  L  A  E  D  G  V  L  S  P  L  A  L  T  E |   G  G  K      p.580

          .         .         .         .         .         .       g.11766
 GGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCAGGGGTCCAGCAGCCCAGTGGAG       c.1800
 G  S  S  P  S  I  R  P  I  Q  G  S  Q  G  S  S  S  P  V  E         p.600

          .         .         .         .         .         .       g.11826
 AAGGAGGTCGTGGAAGCCACGGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAG       c.1860
 K  E  V  V  E  A  T  D  S  R  E  K  T  G  M  V  R  P  G  E         p.620

          .         .         . | 15       .         .         .    g.12152
 CCCTTGAGTGGGGAGAAATACTCACCCAAG | GAGCTGCTGGCACTGCTGAAGTGTGTGGAG    c.1920
 P  L  S  G  E  K  Y  S  P  K   | E  L  L  A  L  L  K  C  V  E      p.640

          .         .         .         .         .         .       g.12212
 GCTGAGATTGCAAACTATGAGGCGTGCCTCAAGGAGGAGGTAGAGAAGAGGAAGAAGTTC       c.1980
 A  E  I  A  N  Y  E  A  C  L  K  E  E  V  E  K  R  K  K  F         p.660

     | 16    .         .         .         .         .         .    g.12376
 AAG | ATTGATGACCAGAGAAGGACCCACAACTACGATGAGTTCATCTGCACCTTTATCTCC    c.2040
 K   | I  D  D  Q  R  R  T  H  N  Y  D  E  F  I  C  T  F  I  S      p.680

          .       | 17 .         .         .         .         .    g.12616
 ATGCTGGCTCAGGAAG | GCATGCTGGCCAACCTAGTGGAGCAGAACATCTCCGTGCGGCGG    c.2100
 M  L  A  Q  E  G |   M  L  A  N  L  V  E  Q  N  I  S  V  R  R      p.700

          .         .         .         .         .         .       g.12676
 CGCCAAGGGGTCAGCATCGGCCGGCTCCACAAGCAGCGGAAGCCTGACCGGCGGAAACGC       c.2160
 R  Q  G  V  S  I  G  R  L  H  K  Q  R  K  P  D  R  R  K  R         p.720

          .         .         .                                     g.12706
 TCTCGCCCCTACAAGGCCAAGCGCCAGTGA                                     c.2190
 S  R  P  Y  K  A  K  R  Q  X                                       p.729

          .         .         .         .         .         .       g.12766
 ggactgctggccctgactctgcagcccactcttgccgtgtggccctcaccagggtccttc       c.*60

          .         .         .         .         .         .       g.12826
 cctgccccacttccccttttcccagtattactgaatagtcccagctggagagtccaggcc       c.*120

          .         .         .         .         .         .       g.12886
 ctgggaatgggaggaaccaggccacattccttccatcgtgccctgaggcctgacacggca       c.*180

          .         .         .         .         .         .       g.12946
 gatcagccccatagtgctcaggaggcagcatctggagttggggcacagcgaggtactgca       c.*240

          .         .         .         .         .         .       g.13006
 gcttcctccacagccggctgtggagcagcaggacctggcccttctgcctgggcagcagaa       c.*300

          .         .         .         .         .         .       g.13066
 tatatattttacctatcagagacatctatttttctgggctccaacccaacatgccaccat       c.*360

          .         .         .         .         .         .       g.13126
 gttgacataagttcctacctgactatgctttctctcctaggagctgtcctggtgggccca       c.*420

          .         .         .         .         .         .       g.13186
 ggtccttgtatcatgccacggtcccaactacagggtcctagctgggggcctgggtgggcc       c.*480

          .         .         .         .         .         .       g.13246
 ctgggctctgggccctgctgctctagccccagccaccagcctgtccctgttgtaaggaag       c.*540

          .         .         .         .         .         .       g.13306
 ccaggtcttctctcttcattcctcttaggagagtgccaaactcagggacccagcactggg       c.*600

          .         .         .         .         .         .       g.13366
 ctgggttgggagtagggtgtcccagtggggttggggtgagcaggctgctgggatcccatg       c.*660

          .         .         .         .         .         .       g.13426
 gcctgagcagagcatgtgggaactgttcagtggcctgtgaactgtcttccttgttctagc       c.*720

          .         .         .         .         .         .       g.13486
 caggctgttcaagactgctctccatagcaaggttctagggctcttcgccttcagtgttgt       c.*780

          .         .         .         .         .         .       g.13546
 ggccctagctatgggcctaaattgggctctaggtctctgtccctggcgcttgaggctcag       c.*840

          .         .         .         .         .         .       g.13606
 aagagcctctgtccagcccctcagtattaccatgtctccctctcaggggtagcagagaca       c.*900

          .         .         .         .         .         .       g.13666
 gggttgcttataggaagctggcaccactcagctcttcctgctactccagtttcctcagcc       c.*960

          .         .         .         .         .         .       g.13726
 tctgcaaggcactcagggtgggggacagcaggatcaagacaacccgttggagcccctgtg       c.*1020

          .         .         .         .         .         .       g.13786
 ttccagaggacctgatgccaaggggtaatgggcccagcagtgcctctggagcccaggccc       c.*1080

          .         .         .         .         .         .       g.13846
 caacacagccccatggcctctgccagatggctttgaaaaaggtgatccaagcaggcccct       c.*1140

          .         .         .         .         .         .       g.13906
 ttatctgtacatagtgactgagtggggggtgctggcaagtgtggcagctgcctctgggct       c.*1200

          .         .         .         .         .         .       g.13966
 gagcacagcttgacccctctagcccctgtaaatactggatcaatgaatgaataaaactct       c.*1260

          .         .                                               g.13986
 cctaagaatctcctgagaaa                                               c.*1280

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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