Bardet-Biedl syndrome 12 (BBS12) - coding DNA reference sequence

(used for variant description)

(last modified January 31, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001178007.1 in the BBS12 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021203.1, covering BBS12 transcript NM_001178007.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5021
                                        gtctcttagcaactaagcccc       c.-361

 .         .         .         .         .         .                g.5081
 cggctcctccagaagcccctcttcgcacatgcgcaaactgcggacggggaactgggctcc       c.-301

 .         .         .         .         .         .                g.5141
 ctagccctggcgtttttggtgttgctgtcccagccagaatcgcgtctggccggtgggaag       c.-241

 .         .         .         .         .  | 02      .             g.6220
 ccgggaactccagccccctgtaggagaggagaaaggagcgag | gcaggagaggaaaacaag    c.-181

 .         .         .         .         .         .                g.6280
 tgcaaagtgcattcttgaagcactctgtcaaatcacttttcatgcttcattgagtagaaa       c.-121

 .         .         .         .         .         .                g.6340
 catggcacattttccaaagccatcagcctgtcttgttcatattatatcccagacagacac       c.-61

 .         .         .         .         .          | 03            g.14191
 gcaagtattgtaatcattgataaaaatctcattaggcttctggaaaatag | atcatgatac    c.-1

          .         .         .         .         .         .       g.14251
 ATGGTGATGGCTTGCAGAGTCGTAAACAAAAGAAGACACATGGGACTTCAACAACTTTCA       c.60
 M  V  M  A  C  R  V  V  N  K  R  R  H  M  G  L  Q  Q  L  S         p.20

          .         .         .         .         .         .       g.14311
 TCATTCGCGGAAACAGGAAGAACTTTCCTAGGCCCACTAAAATCATCCAAATTTATTATA       c.120
 S  F  A  E  T  G  R  T  F  L  G  P  L  K  S  S  K  F  I  I         p.40

          .         .         .         .         .         .       g.14371
 GATGAAGAATGTCATGAAAGTGTATTAATCAGTTCAACAGTAAGGCTTCTTGAAAGTTTG       c.180
 D  E  E  C  H  E  S  V  L  I  S  S  T  V  R  L  L  E  S  L         p.60

          .         .         .         .         .         .       g.14431
 GATTTAACCAGTGCAGTGGGACAACTTCTCAATGAAGCAGTTCAAGCACAAAACAACACA       c.240
 D  L  T  S  A  V  G  Q  L  L  N  E  A  V  Q  A  Q  N  N  T         p.80

          .         .         .         .         .         .       g.14491
 TATAGAACTGGAATCAGTACTCTTTTGTTTCTTGTTGGTGCTTGGAGCAGTGCAGTTGAA       c.300
 Y  R  T  G  I  S  T  L  L  F  L  V  G  A  W  S  S  A  V  E         p.100

          .         .         .         .         .         .       g.14551
 GAATGTCTTCATCTTGGTGTCCCCATTTCCATAATAGTATCAGTAATGTCAGAAGGCTTA       c.360
 E  C  L  H  L  G  V  P  I  S  I  I  V  S  V  M  S  E  G  L         p.120

          .         .         .         .         .         .       g.14611
 AACTTTTGTAGTGAAGAGGTAGTTTCTCTTCATGTACCTGTTCACAATATATTTGACTGT       c.420
 N  F  C  S  E  E  V  V  S  L  H  V  P  V  H  N  I  F  D  C         p.140

          .         .         .         .         .         .       g.14671
 ATGGACAGCACAAAAACATTTTCTCAACTTGAAACATTTAGTGTAAGTTTGTGTCCTTTT       c.480
 M  D  S  T  K  T  F  S  Q  L  E  T  F  S  V  S  L  C  P  F         p.160

          .         .         .         .         .         .       g.14731
 CTACAGGTCCCTTCAGATACTGATTTGATAGAGGAATTGCATGGTCTCAAAGATGTTGCC       c.540
 L  Q  V  P  S  D  T  D  L  I  E  E  L  H  G  L  K  D  V  A         p.180

          .         .         .         .         .         .       g.14791
 TCTCAAACACTGACCATTTCCAACCTTTCTGGGAGACCTCTTAAATCATATGAATTATTT       c.600
 S  Q  T  L  T  I  S  N  L  S  G  R  P  L  K  S  Y  E  L  F         p.200

          .         .         .         .         .         .       g.14851
 AAACCTCAGACAAAGGTTGAAGCAGATAACAACACATCACGAACTCTGAAAAACAGCCTG       c.660
 K  P  Q  T  K  V  E  A  D  N  N  T  S  R  T  L  K  N  S  L         p.220

          .         .         .         .         .         .       g.14911
 CTTGCAGATACCTGCTGCAGACAGTCAATACTAATCCACAGTAGGCATTTTAATAGGACA       c.720
 L  A  D  T  C  C  R  Q  S  I  L  I  H  S  R  H  F  N  R  T         p.240

          .         .         .         .         .         .       g.14971
 GATAATACTGAAGGGGTAAGCAAACCAGATGGATTTCAAGAACATGTTACAGCTACTCAC       c.780
 D  N  T  E  G  V  S  K  P  D  G  F  Q  E  H  V  T  A  T  H         p.260

          .         .         .         .         .         .       g.15031
 AAAACTTACAGATGTAATGATTTGGTAGAGTTGGCAGTAGGCTTGAGTCATGGAGATCAC       c.840
 K  T  Y  R  C  N  D  L  V  E  L  A  V  G  L  S  H  G  D  H         p.280

          .         .         .         .         .         .       g.15091
 AGCAGCATGAAGTTAGTAGAAGAAGCAGTACAGCTGCAATATCAGAATGCTTGTGTGCAA       c.900
 S  S  M  K  L  V  E  E  A  V  Q  L  Q  Y  Q  N  A  C  V  Q         p.300

          .         .         .         .         .         .       g.15151
 CAAGGCAACTGTACAAAACCATTTATGTTTGACATTTCAAGAATTTTCACTTGCTGTCTA       c.960
 Q  G  N  C  T  K  P  F  M  F  D  I  S  R  I  F  T  C  C  L         p.320

          .         .         .         .         .         .       g.15211
 CCAGGCTTACCTGAAACTTCTTCTTGTGTTTGTCCAGGATATATCACTGTTGTGTCAGTA       c.1020
 P  G  L  P  E  T  S  S  C  V  C  P  G  Y  I  T  V  V  S  V         p.340

          .         .         .         .         .         .       g.15271
 TCTAATAATCCTGTGATCAAGGAATTGCAGAATCAGCCTGTGCGAATAGTTCTCATTGAG       c.1080
 S  N  N  P  V  I  K  E  L  Q  N  Q  P  V  R  I  V  L  I  E         p.360

          .         .         .         .         .         .       g.15331
 GGTGACCTCACAGAGAATTACCGCCACCTGGGATTTAATAAGTCTGCAAATATTAAAACA       c.1140
 G  D  L  T  E  N  Y  R  H  L  G  F  N  K  S  A  N  I  K  T         p.380

          .         .         .         .         .         .       g.15391
 GTATTAGATAGCATGCGGCTTCAAGAAGACAGCTCAGAAGAACTGTGGGCAAATCACGTG       c.1200
 V  L  D  S  M  R  L  Q  E  D  S  S  E  E  L  W  A  N  H  V         p.400

          .         .         .         .         .         .       g.15451
 TTACAGGTGTTAATCCAGTTCAAGGTGAACCTTGTCCTGGTACAAGGAAATGTGTCCGAA       c.1260
 L  Q  V  L  I  Q  F  K  V  N  L  V  L  V  Q  G  N  V  S  E         p.420

          .         .         .         .         .         .       g.15511
 CGCTTAATTGAAAAATGTATAAACAGTAAGCGGTTGGTAATCGGCTCAGTGAATGGCAGT       c.1320
 R  L  I  E  K  C  I  N  S  K  R  L  V  I  G  S  V  N  G  S         p.440

          .         .         .         .         .         .       g.15571
 GTGATGCAGGCTTTTGCAGAGGCTGCAGGAGCAGTACAGGTGGCCTACATTACACAAGTG       c.1380
 V  M  Q  A  F  A  E  A  A  G  A  V  Q  V  A  Y  I  T  Q  V         p.460

          .         .         .         .         .         .       g.15631
 AATGAAGATTGTGTGGGCGACGGGGTCTGCGTGACCTTCTGGAGAAGCAGCCCTTTGGAT       c.1440
 N  E  D  C  V  G  D  G  V  C  V  T  F  W  R  S  S  P  L  D         p.480

          .         .         .         .         .         .       g.15691
 GTTGTAGATAGGAACAACAGAATCGCAATCTTATTAAAAACAGAAGGAATTAATTTGGTT       c.1500
 V  V  D  R  N  N  R  I  A  I  L  L  K  T  E  G  I  N  L  V         p.500

          .         .         .         .         .         .       g.15751
 ACGGCCGTGCTCACTAACCCAGTTACTGCACAGATGCAAATCAAAGAAGATAGGTTCTGG       c.1560
 T  A  V  L  T  N  P  V  T  A  Q  M  Q  I  K  E  D  R  F  W         p.520

          .         .         .         .         .         .       g.15811
 ACATGTGCCTATCGTTTGTATTATGCTCTAAAAGAGGAAAAGGTCTTCCTTGGAGGTGGT       c.1620
 T  C  A  Y  R  L  Y  Y  A  L  K  E  E  K  V  F  L  G  G  G         p.540

          .         .         .         .         .         .       g.15871
 GCAGTTGAATTTTTGTGTCTTAGCTGTCTTCATATTCTTGCAGAGCAATCTCTGAAAAAA       c.1680
 A  V  E  F  L  C  L  S  C  L  H  I  L  A  E  Q  S  L  K  K         p.560

          .         .         .         .         .         .       g.15931
 GAAAACCATGCCTGCTCAGGGTGGCTGCATAATACTTCCTCTTGGCTGGCTTCATCTCTG       c.1740
 E  N  H  A  C  S  G  W  L  H  N  T  S  S  W  L  A  S  S  L         p.580

          .         .         .         .         .         .       g.15991
 GCAATATACAGACCAACTGTGCTTAAATTCCTGGCAAATGGATGGCAGAAATACCTTTCA       c.1800
 A  I  Y  R  P  T  V  L  K  F  L  A  N  G  W  Q  K  Y  L  S         p.600

          .         .         .         .         .         .       g.16051
 ACTCTCCTATATAACACTGCCAATTACTCATCAGAATTTGAAGCCAGCACATACATTCAA       c.1860
 T  L  L  Y  N  T  A  N  Y  S  S  E  F  E  A  S  T  Y  I  Q         p.620

          .         .         .         .         .         .       g.16111
 CATCATCTGCAAAATGCCACAGACTCTGGCTCTCCTTCATCTTACATCTTGAATGAATAT       c.1920
 H  H  L  Q  N  A  T  D  S  G  S  P  S  S  Y  I  L  N  E  Y         p.640

          .         .         .         .         .         .       g.16171
 AGTAAACTAAATAGTAGAATTTTTAATTCAGACATTTCAAATAAACTGGAGCAGATTCCG       c.1980
 S  K  L  N  S  R  I  F  N  S  D  I  S  N  K  L  E  Q  I  P         p.660

          .         .         .         .         .         .       g.16231
 AGAGTTTATGACGTTGTTACACCAAAGATTGAGGCGTGGCGCCGAGCATTGGATTTAGTA       c.2040
 R  V  Y  D  V  V  T  P  K  I  E  A  W  R  R  A  L  D  L  V         p.680

          .         .         .         .         .         .       g.16291
 TTGTTAGTACTTCAGACAGACAGTGAAATAATTACTGGACATGGACACACACAGATAAAT       c.2100
 L  L  V  L  Q  T  D  S  E  I  I  T  G  H  G  H  T  Q  I  N         p.700

          .         .         .                                     g.16324
 TCACAGGAATTAACGGGCTTTCTATTTTTGTAG                                  c.2133
 S  Q  E  L  T  G  F  L  F  L  X                                    p.710

          .         .         .         .         .         .       g.16384
 tgttactggctaagtctttggaaaataatttttcataatatgtcatgctaataataaata       c.*60

          .         .         .         .         .         .       g.16444
 tattgatagccaagtcatggtgcctaaaatgccagctattgccaagaagaaaatagttga       c.*120

          .         .         .         .         .         .       g.16504
 tgtctgtcaataactgtgcatggtctgagattttaccctacttataagctaacaagttag       c.*180

          .         .         .         .         .         .       g.16564
 cctgttactgtttcgtgggatgctacagaatgcataagacacctgggtcagaaacaaagg       c.*240

          .         .         .         .         .         .       g.16624
 acttatcgctcacagcaaaagctgtagccagagcttcatgttggttttattcagttcctc       c.*300

          .         .         .         .         .         .       g.16684
 atttttctagttcccacaggaggaacacaaagggcccatgatgaaagcctgcacacagtg       c.*360

          .         .         .         .         .         .       g.16744
 ggttatgttgtaagcttgggttattaactgcttttatagtaagcaaaaaaatcctggtct       c.*420

          .         .         .         .         .         .       g.16804
 ttgtccaaagggagttattaccccatacttgaagatagcttagtgtaaacacaagcctag       c.*480

          .         .         .         .         .         .       g.16864
 gacatggactaggtaaagacaaagtccttgcattcttgacatacccagtaagtatgcagg       c.*540

          .         .         .         .         .         .       g.16924
 gacactcagagcccatagtggatagtctcttccaacagtctgctcctcagcctgagatgt       c.*600

          .         .         .         .         .         .       g.16984
 tcttggccaaacttgaattttcacatgagtatgccactctatcagctactctgattaacc       c.*660

          .         .         .         .         .         .       g.17044
 tgacagtcgggttgtttagtcagtaccaaatttgttcatttggtctcatatagcaattaa       c.*720

          .         .         .         .         .         .       g.17104
 tgcaggctattatcagacacagcagcaggatgaagccaacctgcagtattaacctcagtc       c.*780

          .         .         .         .         .         .       g.17164
 ctgtcccccaaggtcttgactcaatcaactctaagttccaagggaggaccaataggtctt       c.*840

          .         .         .         .         .         .       g.17224
 tttattaggcagccagaatgtagtgaaggacaatttattatactttatgacccaataaag       c.*900

          .                                                         g.17242
 ggagctttgactgacgta                                                 c.*918

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bardet-Biedl syndrome 12 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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