Bardet-Biedl syndrome 1 (BBS1) - coding DNA reference sequence

(used for variant description)

(last modified April 23, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_024649.4 in the BBS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009093.1, covering BBS1 transcript NM_024649.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5012
                                                 acgcctgcgaag       c.-1

          .         .         .         .        | 02.         .    g.5378
 ATGGCCGCTGCGTCCTCATCGGATTCCGACGCCTGCGGAGCTGAGAG | CAATGAGGCCAAT    c.60
 M  A  A  A  S  S  S  D  S  D  A  C  G  A  E  S  |  N  E  A  N      p.20

          .         .         .         .         .         .       g.5438
 TCGAAGTGGTTGGATGCGCACTACGACCCAATGGCCAATATCCACACCTTTTCTGCCTGC       c.120
 S  K  W  L  D  A  H  Y  D  P  M  A  N  I  H  T  F  S  A  C         p.40

      | 03   .         .         .          | 04        .         . g.8779
 CTAG | CGCTGGCAGATTTACATGGGGATGGGGAATACAAG | CTGGTGGTAGGGGACCTTGGC c.180
 L  A |   L  A  D  L  H  G  D  G  E  Y  K   | L  V  V  G  D  L  G   p.60

          .         .         .         .         .         .       g.8839
 CCTGGTGGGCAGCAGCCCCGCCTGAAGGTGCTCAAAGGACCACTGGTGATGACCGAAAGC       c.240
 P  G  G  Q  Q  P  R  L  K  V  L  K  G  P  L  V  M  T  E  S         p.80

          .         .         .         .         .         .       g.8899
 CCGCTACCTGCTCTGCCAGCTGCTGCTGCCACCTTCCTCATGGAGCAACATGAGCCCCGG       c.300
 P  L  P  A  L  P  A  A  A  A  T  F  L  M  E  Q  H  E  P  R         p.100

          .         .         .         .         .         .       g.8959
 ACCCCAGCTCTGGCACTTGCTTCAGGCCCTTGTGTCTATGTGTATAAGAATCTCAGACCC       c.360
 T  P  A  L  A  L  A  S  G  P  C  V  Y  V  Y  K  N  L  R  P         p.120

          .         .         .         .         .         .       g.9019
 TACTTCAAGTTCAGCCTGCCCCAATTGCCTCCAAATCCTCTGGAACAAGACCTTTGGAAC       c.420
 Y  F  K  F  S  L  P  Q  L  P  P  N  P  L  E  Q  D  L  W  N         p.140

          .   | 05     .         .         .         .          | 06 g.10046
 CAGGCCAAAGAG | GACCGAATCGACCCCTTAACCCTGAAGGAGATGCTGGAGAGCATCCG | G c.480
 Q  A  K  E   | D  R  I  D  P  L  T  L  K  E  M  L  E  S  I  R  |   p.160

          .         .         .         | 07         .         .    g.10235
 GAGACGGCAGAGGAGCCTTTGTCCATCCAGTCACTCAG | GTTTCTGCAGCTGGAGCTAAGT    c.540
 E  T  A  E  E  P  L  S  I  Q  S  L  R  |  F  L  Q  L  E  L  S      p.180

          .         .         .         .         .  | 08      .    g.13978
 GAAATGGAGGCATTTGTAAACCAACACAAGTCCAACTCCATCAAGCGGCAG | ACAGTCATC    c.600
 E  M  E  A  F  V  N  Q  H  K  S  N  S  I  K  R  Q   | T  V  I      p.200

          .         .         .         .         .         .       g.14038
 ACCACCATGACCACCTTGAAGAAGAACCTGGCTGACGAGGATGCTGTGTCTTGCCTGGTG       c.660
 T  T  M  T  T  L  K  K  N  L  A  D  E  D  A  V  S  C  L  V         p.220

          .         .         .         .         .         .       g.14098
 CTGGGCACCGAGAACAAGGAGCTCCTGGTGCTTGACCCCGAGGCCTTCACCATTTTAGCC       c.720
 L  G  T  E  N  K  E  L  L  V  L  D  P  E  A  F  T  I  L  A         p.240

     | 09    .         .         .         .         .         .    g.15679
 AAG | ATGAGCCTTCCCAGCGTCCCCGTCTTCCTAGAGGTTTCTGGCCAGTTTGATGTTGAG    c.780
 K   | M  S  L  P  S  V  P  V  F  L  E  V  S  G  Q  F  D  V  E      p.260

          .         .         .         .         . | 10       .    g.17818
 TTCCGGCTTGCCGCGGCCTGCCGCAATGGAAACATCTATATTCTGAGAAG | AGACTCCAAG    c.840
 F  R  L  A  A  A  C  R  N  G  N  I  Y  I  L  R  R  |  D  S  K      p.280

          .         .         .         .         .         .       g.17878
 CACCCCAAGTACTGCATCGAGCTGAGCGCCCAGCCTGTGGGACTTATCCGGGTACACAAG       c.900
 H  P  K  Y  C  I  E  L  S  A  Q  P  V  G  L  I  R  V  H  K         p.300

          .         .         .         .         .  | 11      .    g.18085
 GTCCTAGTGGTGGGCAGCACCCAAGACAGCCTGCATGGCTTCACCCACAAG | GGGAAGAAG    c.960
 V  L  V  V  G  S  T  Q  D  S  L  H  G  F  T  H  K   | G  K  K      p.320

          .         .         .         .         .         .       g.18145
 CTGTGGACAGTGCAGATGCCCGCAGCCATCCTGACCATGAACCTCCTGGAGCAGCATTCC       c.1020
 L  W  T  V  Q  M  P  A  A  I  L  T  M  N  L  L  E  Q  H  S         p.340

          .         .         .         .         .         .       g.18205
 CGGGGCCTGCAGGCCGTCATGGCTGGGCTGGCCAATGGAGAGGTCCGCATTTATCGTGAC       c.1080
 R  G  L  Q  A  V  M  A  G  L  A  N  G  E  V  R  I  Y  R  D         p.360

          .         .         . | 12       .         .         .    g.20505
 AAGGCCCTGCTCAATGTCATCCACACCCCG | GATGCAGTGACCAGCCTTTGCTTTGGCCGG    c.1140
 K  A  L  L  N  V  I  H  T  P   | D  A  V  T  S  L  C  F  G  R      p.380

          .         .         .         . | 13       .         .    g.21021
 TACGGGCGGGAGGACAACACCCTCATCATGACCACTCGAG | GTGGTGGCCTGATCATCAAG    c.1200
 Y  G  R  E  D  N  T  L  I  M  T  T  R  G |   G  G  L  I  I  K      p.400

          .         .         .         .         .         .       g.21081
 ATCCTGAAGCGTACAGCAGTGTTTGTAGAGGGAGGAAGTGAGGTGGGTCCCCCACCAGCC       c.1260
 I  L  K  R  T  A  V  F  V  E  G  G  S  E  V  G  P  P  P  A         p.420

          .         .         .         .         .         .       g.21141
 CAGGCCATGAAACTCAATGTGCCCCGAAAGACCCGGCTTTACGTGGATCAGACACTGCGA       c.1320
 Q  A  M  K  L  N  V  P  R  K  T  R  L  Y  V  D  Q  T  L  R         p.440

          .          | 14        .         .         .         .    g.24212
 GAGCGGGAGGCTGGCACCG | CCATGCACCGGGCCTTCCAGACAGACCTATACCTGCTGCGC    c.1380
 E  R  E  A  G  T  A |   M  H  R  A  F  Q  T  D  L  Y  L  L  R      p.460

          .         .         .         .         .         .       g.24272
 CTACGTGCTGCCCGCGCCTACCTGCAGGCCCTCGAGTCCAGCCTGAGCCCCCTGTCCACG       c.1440
 L  R  A  A  R  A  Y  L  Q  A  L  E  S  S  L  S  P  L  S  T         p.480

          .         .         .    | 15    .         .         .    g.25273
 ACAGCCCGAGAGCCACTCAAGCTGCACGCCGTG | GTTCAGGGCCTTGGCCCCACCTTTAAG    c.1500
 T  A  R  E  P  L  K  L  H  A  V   | V  Q  G  L  G  P  T  F  K      p.500

          .         .         .         .         .         .       g.25333
 CTCACACTTCACCTGCAGAACACCTCAACAACCCGTCCTGTCCTGGGGCTGCTGGTCTGC       c.1560
 L  T  L  H  L  Q  N  T  S  T  T  R  P  V  L  G  L  L  V  C         p.520

          .         .         .         .         | 16         .    g.26020
 TTCCTGTACAACGAGGCGCTCTATTCCCTGCCCCGGGCCTTCTTCAAG | GTACCCTTGCTG    c.1620
 F  L  Y  N  E  A  L  Y  S  L  P  R  A  F  F  K   | V  P  L  L      p.540

          .         .         .         .         .         .       g.26080
 GTGCCAGGGCTCAACTACCCCCTGGAGACCTTTGTGGAGAGTCTCAGTAACAAGGGCATC       c.1680
 V  P  G  L  N  Y  P  L  E  T  F  V  E  S  L  S  N  K  G  I         p.560

          .      | 17  .         .         .         .         .    g.26348
 TCAGACATCATCAAG | GTGCTGGTGCTTCGAGAAGGCCAAAGTGCACCCCTGCTGAGTGCC    c.1740
 S  D  I  I  K   | V  L  V  L  R  E  G  Q  S  A  P  L  L  S  A      p.580

          .         .         .         .                           g.26390
 CACGTCAACATGCCTGGGAGCGAGGGGCTGGCGGCCGCCTGA                         c.1782
 H  V  N  M  P  G  S  E  G  L  A  A  A  X                           p.593

          .         .         .         .         .         .       g.26450
 gacctgagctgctgtgaaagcccctgcacaatcagccagggagaactgggcgggtttagt       c.*60

          .         .         .         .         .         .       g.26510
 ggccccaggcccactcctcatgcagcagtgtgctggggcgacagctcgtctcccctctct       c.*120

          .         .         .         .         .         .       g.26570
 taagcacccgcttcctcaccacccccactgttgggcctatagtagcaggttagtgagtac       c.*180

          .         .         .         .         .         .       g.26630
 ctagggcggctcaactcctcccacagcaccaacccagcatggtcccactgaagtcctact       c.*240

          .         .         .         .         .         .       g.26690
 acgccctcccctccccagccttttccagaaaccatactgggctcagatcagagctccgaa       c.*300

          .         .         .         .         .         .       g.26750
 gcggtcaaagtgagctgagcaggacaggcccagcctttctccactgccacgtccctcatg       c.*360

          .         .         .         .         .         .       g.26810
 cacatcactcatctcctgctgcaggccaaggccaaaattgggctagtcctggccagggaa       c.*420

          .         .         .         .         .         .       g.26870
 atcagaagctcttcttgggtgagattgagcctcctgttgctccctggagttccggaggct       c.*480

          .         .         .         .         .         .       g.26930
 gggctgcagcccactcagcttgcgggcaaaatacgtgctctcctctctccttgtcagctg       c.*540

          .         .         .         .         .         .       g.26990
 agcaaacccagggaatagccctcctctccccaggaaacttctctgaaatcttagacttag       c.*600

          .         .         .         .         .         .       g.27050
 ccagtcttaggcctacgatgccacacaaaggttgttcagggagaagggggtgcaggaggc       c.*660

          .         .         .         .         .         .       g.27110
 agagggtgccccgcagggagctggtggctccagccccactagagctcctaaagatcacac       c.*720

          .         .         .         .         .         .       g.27170
 agcagctgctcctgacagggatgctcatgcccagaaagcaagcccaggagaggaaggcag       c.*780

          .         .         .         .         .         .       g.27230
 agtgtgacagagcagagccagggccaggcgcaccaggagaggcgtttctggggctccaga       c.*840

          .         .         .         .         .         .       g.27290
 gaagtgccacgggaggcagaagtccagaactgcccatatagatgcccttctacatcctgg       c.*900

          .         .         .         .         .         .       g.27350
 agcccaaatcagtcatgtgggtgggaagttcccagggcagtggtcacatcgtgagaatta       c.*960

          .         .         .         .         .         .       g.27410
 gcaggaaaggcggggcctttcttgtcatagctatttctgaggatgaaatgggagacatat       c.*1020

          .         .         .         .         .         .       g.27470
 gcccagcacctgatgtaagtttatataatgtaatattatgtacctaccactaagaaatac       c.*1080

          .         .         .         .         .         .       g.27530
 atgaaccgtgccatgaggacagtaagtgttcataaagcaacatgaagcaagaaacagtgc       c.*1140

          .         .         .         .         .         .       g.27590
 agggtgcccagtgcacacactagagagaaattgtgaacattaaggacaaggagaattggt       c.*1200

          .         .         .         .         .         .       g.27650
 gtctttctaaaacatacttatttaaaaacacatacccacttactaatgtggaattacaca       c.*1260

          .         .         .         .         .         .       g.27710
 gtttgtaacaagaaaacagtctctcccattctctagtactgctcccctacccagcagtca       c.*1320

          .         .         .         .         .         .       g.27770
 cttccagttcattcagctatttttaaaatgtgcttatatgactcttgcttgatatatcaa       c.*1380

          .         .         .         .         .         .       g.27830
 tcttagacattacctgttgactccctgttgtcatacatgaggctttagctctcttttgtc       c.*1440

          .         .         .         .         .         .       g.27890
 agcaaccctcccccatccctagttattaggttaaaaaatactcagattactatttctatt       c.*1500

          .         .         .         .         .         .       g.27950
 actatgtgaaagttaactgcggagccaagagttggactataattaaattaccttccttgt       c.*1560

          .                                                         g.27966
 actttctttttaatgg                                                   c.*1576

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bardet-Biedl syndrome 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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