Bardet-Biedl syndrome 2 (BBS2) - coding DNA reference sequence

(used for variant description)

(last modified June 14, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_031885.3 in the BBS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009312.1, covering BBS2 transcript NM_031885.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5241
       cacagaaggcgccgaggctccaccgcgcagccgcaaaaagagcggacgggtctg       c.-181

 .         .         .         .         .         .                g.5301
 cgccgccgcaggaggagcaggcggtacctggacgggttcgtcccgggctgtttcgcgtcc       c.-121

 .         .         .         .         .         .                g.5361
 ggcctgaggcggctggggccgcgcaggtagtgtccctgcacttcttgcccgggcgcgtga       c.-61

 .         .         .         .         .         .                g.5421
 ggccagctccgctgcgcttgtctccagcttccagccctcctcccctaagccgccgccatc       c.-1

          .         .         .         .         .         .       g.5481
 ATGCTGCTGCCTGTGTTCACCCTGAAACTGCGCCACAAAATCAGCCCCCGAATGGTGGCC       c.60
 M  L  L  P  V  F  T  L  K  L  R  H  K  I  S  P  R  M  V  A         p.20

          .         .         .         .         .        | 02.    g.10606
 ATAGGGCGCTACGACGGGACTCACCCGTGCCTGGCGGCCGCCACCCAAACGGGCAAG | GTT    c.120
 I  G  R  Y  D  G  T  H  P  C  L  A  A  A  T  Q  T  G  K   | V      p.40

          .         .         .         .         .         .       g.10666
 TTTATTCATAATCCTCATACACGGAACCAGCATGTCAGTGCATCCAGGGTCTTCCAGAGC       c.180
 F  I  H  N  P  H  T  R  N  Q  H  V  S  A  S  R  V  F  Q  S         p.60

          .         .         .         .         .         .       g.10726
 CCCCTGGAATCTGATGTTTCTCTTCTCAACATTAACCAGGCAGTCAGCTGTCTGACTGCA       c.240
 P  L  E  S  D  V  S  L  L  N  I  N  Q  A  V  S  C  L  T  A         p.80

          .         .         .         .         .         .       g.10786
 GGCGTATTGAACCCTGAGCTTGGCTATGATGCCCTTTTAGTGGGGACACAGACTAATCTT       c.300
 G  V  L  N  P  E  L  G  Y  D  A  L  L  V  G  T  Q  T  N  L         p.100

          .         .         .         .      | 03  .         .    g.14014
 TTGGCTTATGATGTCTACAATAATTCGGATTTGTTCTACAGAGAG | GTAGCAGATGGGGCA    c.360
 L  A  Y  D  V  Y  N  N  S  D  L  F  Y  R  E   | V  A  D  G  A      p.120

          .         .         .         .         .         .       g.14074
 AATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGC       c.420
 N  A  I  V  L  G  T  L  G  D  I  S  S  P  L  A  I  I  G  G         p.140

          .         .         .         .         .  | 04      .    g.14371
 AATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTGATCTCTTTTGGACG | GTTACTGGA    c.480
 N  C  A  L  Q  G  F  N  H  E  G  S  D  L  F  W  T   | V  T  G      p.160

          .         .         .         .         .     | 05   .    g.15255
 GACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAG | CTTCTT    c.540
 D  N  V  N  S  L  A  L  C  D  F  D  G  D  G  K  K  E   | L  L      p.180

          .         .         .         .         .         .       g.15315
 GTTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATG       c.600
 V  G  S  E  D  F  D  I  R  V  F  K  E  D  E  I  V  A  E  M         p.200

          .   | 06     .         .         .         .         .    g.19107
 ACAGAAACAGAG | ATAGTCACCTCTCTTTGTCCCATGTATGGCAGTCGATTTGGTTATGCC    c.660
 T  E  T  E   | I  V  T  S  L  C  P  M  Y  G  S  R  F  G  Y  A      p.220

          .         .         .         .         .        | 07.    g.19250
 CTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAA | TCG    c.720
 L  S  N  G  T  V  G  V  Y  D  K  T  S  R  Y  W  R  I  K   | S      p.240

          .         .         .         .         .         .       g.19310
 AAAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTG       c.780
 K  N  H  A  M  S  I  H  A  F  D  L  N  S  D  G  V  N  E  L         p.260

          .         .     | 08   .         .         .         .    g.22511
 ATAACTGGTTGGTCCAATGGGAAG | GTTGATGCTCGAAGTGACCGAACTGGGGAGGTCATC    c.840
 I  T  G  W  S  N  G  K   | V  D  A  R  S  D  R  T  G  E  V  I      p.280

          .         .         .         .         .         .       g.22571
 TTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGAT       c.900
 F  K  D  N  F  S  S  A  I  A  G  V  V  E  G  D  Y  R  M  D         p.300

          .         .         .         . | 09       .         .    g.22847
 GGCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAA | TCCGGGGCTACCTGCCTGGC    c.960
 G  H  I  Q  L  I  C  C  S  V  D  G  E  I |   R  G  Y  L  P  G      p.320

          .         .         .         .         .         .       g.22907
 ACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTGCAGAGCAGGACCTGATCCGAGAG       c.1020
 T  A  E  M  R  G  N  L  M  D  T  S  A  E  Q  D  L  I  R  E         p.340

          .         .         .         .         .         .       g.22967
 CTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAG       c.1080
 L  S  Q  K  K  Q  N  L  L  L  E  L  R  N  Y  E  E  N  A  K         p.360

  | 10       .         .         .         .         .         .    g.23846
  | GCTGAATTGGCCAGTCCACTGAACGAGGCTGATGGGCATCGGGGCATAATCCCAGCCAAT    c.1140
  | A  E  L  A  S  P  L  N  E  A  D  G  H  R  G  I  I  P  A  N      p.380

          .         .         .         .         .         .       g.23906
 ACCAGGCTCCACACCACGCTCTCAGTCAGCCTGGGGAATGAGACCCAAACTGCTCATACA       c.1200
 T  R  L  H  T  T  L  S  V  S  L  G  N  E  T  Q  T  A  H  T         p.400

          .         .      | 11  .         .         .         .    g.24293
 GAATTACGCATTTCCACTTCTAATG | ACACCATCATCCGAGCAGTATTGATTTTTGCAGAA    c.1260
 E  L  R  I  S  T  S  N  D |   T  I  I  R  A  V  L  I  F  A  E      p.420

          .         .         .         .         .         .       g.24353
 GGAATTTTTACAGGTGAAAGCCACGTGGTACATCCCAGCATTCACAACCTCTCCAGTTCC       c.1320
 G  I  F  T  G  E  S  H  V  V  H  P  S  I  H  N  L  S  S  S         p.440

          .         .         .         .         .         .       g.24413
 ATCTGCATCCCTATTGTGCCTCCCAAAGATGTCCCTGTGGATCTGCACTTGAAGGCATTC       c.1380
 I  C  I  P  I  V  P  P  K  D  V  P  V  D  L  H  L  K  A  F         p.460

          .        | 12.         .         .         .         .    g.25419
 GTGGGTTACAGAAGCAG | CACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGA    c.1440
 V  G  Y  R  S  S  |  T  Q  F  H  V  F  E  S  T  R  Q  L  P  R      p.480

          .         .         .         .         .         .       g.25479
 TTCTCCATGTATGCGCTGACCAGCCTGGACCCTGCCAGTGAGCCAATCAGTTATGTTAAC       c.1500
 F  S  M  Y  A  L  T  S  L  D  P  A  S  E  P  I  S  Y  V  N         p.500

          .         .        | 13.         .         .         .    g.26748
 TTTACCATTGCAGAACGGGCACAGAGG | GTTGTTGTATGGCTCGGTCAGAACTTTCTGTTA    c.1560
 F  T  I  A  E  R  A  Q  R   | V  V  V  W  L  G  Q  N  F  L  L      p.520

          .         .         .         .         .         .       g.26808
 CCAGAAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAAT       c.1620
 P  E  D  T  H  I  Q  N  A  P  F  Q  V  C  F  T  S  L  R  N         p.540

          .         .         .          | 14        .         .    g.27424
 GGCGGCCACCTGCATATAAAAATAAAACTTAGTGGAGAG | ATCACTATAAATACTGATGAT    c.1680
 G  G  H  L  H  I  K  I  K  L  S  G  E   | I  T  I  N  T  D  D      p.560

          .         .         .         .         .         .       g.27484
 ATTGATTTGGCTGGTGATATCATCCAGTCAATGGCATCATTTTTTGCTATTGAAGACCTT       c.1740
 I  D  L  A  G  D  I  I  Q  S  M  A  S  F  F  A  I  E  D  L         p.580

          .         .         .         .         .        | 15.    g.28207
 CAAGTAGAAGCGGATTTTCCTGTCTATTTTGAGGAATTACGAAAGGTGCTAGTTAAG | GTG    c.1800
 Q  V  E  A  D  F  P  V  Y  F  E  E  L  R  K  V  L  V  K   | V      p.600

          .         .         .         .         .         .       g.28267
 GATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATATGGCTGATCATTCTAATTTG       c.1860
 D  E  Y  H  S  V  H  Q  K  L  S  A  D  M  A  D  H  S  N  L         p.620

          .         .         .         .         . | 16       .    g.39555
 ATCCGAAGTTTGCTGGTCGGAGCTGAGGATGCTCGTCTGATGAGGGACAT | GAAAACAATG    c.1920
 I  R  S  L  L  V  G  A  E  D  A  R  L  M  R  D  M  |  K  T  M      p.640

          .         .         .         .         .         .       g.39615
 AAGAGTCGTTATATGGAACTCTATGACCTTAATAGAGACTTGCTAAATGGATATAAAATT       c.1980
 K  S  R  Y  M  E  L  Y  D  L  N  R  D  L  L  N  G  Y  K  I         p.660

          .         .         .         .         .         .       g.39675
 CGCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGCAGTAAATCAAGCAATTCAA       c.2040
 R  C  N  N  H  T  E  L  L  G  N  L  K  A  V  N  Q  A  I  Q         p.680

          .          | 17        .         .         .         .    g.40457
 AGAGCAGGTCGTCTGCGGG | TTGGAAAACCAAAGAACCAGGTGATCACTGCTTGTCGGGAT    c.2100
 R  A  G  R  L  R  V |   G  K  P  K  N  Q  V  I  T  A  C  R  D      p.700

          .         .         .         .         .         .       g.40517
 GCAATTCGAAGCAATAACATCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCTTCT       c.2160
 A  I  R  S  N  N  I  N  T  L  F  K  I  M  R  V  G  T  A  S         p.720

                                                                    g.40523
 TCCTAG                                                             c.2166
 S  X                                                               p.721

          .         .         .         .         .         .       g.40583
 gtgaggaaaatacaggtcatgaagttcctggcaaagattttctgttaaaaacctatgctg       c.*60

          .         .         .         .         .         .       g.40643
 gtttgctttggatcacaccctggtgaaccccgggtgctaagaatgaaaataaccttggtg       c.*120

          .         .         .         .         .         .       g.40703
 agttgtacaaattaaagacaaagaactacatgtgaagatagacttgctttctatttttaa       c.*180

          .         .         .         .         .         .       g.40763
 atcagtagtagtactgttgctgaataatactaggtttttatggaataggatgaatgcttt       c.*240

          .         .         .         .         .         .       g.40823
 tgaagtattagggcttcagagtccaattttgcttatttatggtatataaatacatatttt       c.*300

          .         .         .         .         .         .       g.40883
 tttcttgaaattgcaattgagtttgtacttttcaaatagattatctactttttcattaaa       c.*360

          .         .         .         .         .                 g.40937
 atgtaaagatgttaaactttgtgttgattgattataaaatcaccaccaaatcag             c.*414

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bardet-Biedl syndrome 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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