Bardet-Biedl syndrome 4 (BBS4) - coding DNA reference sequence

(used for variant description)

(last modified March 23, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_033028.4 in the BBS4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009416.2, covering BBS4 transcript NM_033028.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
            gtctgggaaaccgccgacttccggccgcgcagcggtgggctgagctaaa       c.-1

          .         .     | 02   .         .         .         .    g.14028
 ATGGCTGAGGAGAGAGTCGCGACG | AGAACTCAATTTCCTGTATCTACTGAGTCTCAAAAA    c.60
 M  A  E  E  R  V  A  T   | R  T  Q  F  P  V  S  T  E  S  Q  K      p.20

          .       | 03 .         .         .         .         .    g.28559
 CCCCGGCAGAAAAAAG | CTCCAGAGTTTCCTATTTTGGAGAAGCAGAACTGGTTGATTCAT    c.120
 P  R  Q  K  K  A |   P  E  F  P  I  L  E  K  Q  N  W  L  I  H      p.40

          .         .         .       | 04 .         .         .    g.31083
 CTTCATTATATCCGGAAAGATTATGAAGCCTGCAAG | GCTGTTATCAAAGAACAGCTTCAA    c.180
 L  H  Y  I  R  K  D  Y  E  A  C  K   | A  V  I  K  E  Q  L  Q      p.60

          .         .         .         . | 05       .         .    g.34126
 GAGACTCAGGGATTGTGTGAATATGCTATCTATGTCCAAG | CATTGATATTTCGCCTAGAA    c.240
 E  T  Q  G  L  C  E  Y  A  I  Y  V  Q  A |   L  I  F  R  L  E      p.80

          .         .         .         .         .         .       g.34186
 GGAAATATCCAAGAATCCCTAGAACTCTTCCAGACATGTGCAGTTCTTAGTCCTCAGAGT       c.300
 G  N  I  Q  E  S  L  E  L  F  Q  T  C  A  V  L  S  P  Q  S         p.100

          .         .         .   | 06     .         .         .    g.35621
 GCTGATAACCTCAAGCAGGTGGCCAGATCTTT | ATTTCTTTTGGGAAAACATAAAGCTGCC    c.360
 A  D  N  L  K  Q  V  A  R  S  L  |  F  L  L  G  K  H  K  A  A      p.120

          .         .         .         .      | 07  .         .    g.41624
 ATTGAAGTATATAATGAAGCAGCTAAACTCAACCAGAAAGATTGG | GAGATCAGCCATAAC    c.420
 I  E  V  Y  N  E  A  A  K  L  N  Q  K  D  W   | E  I  S  H  N      p.140

          .         .         .          | 08        .         .    g.43364
 CTAGGAGTTTGCTACATATACCTGAAGCAGTTCAACAAG | GCACAAGACCAGTTGCACAAT    c.480
 L  G  V  C  Y  I  Y  L  K  Q  F  N  K   | A  Q  D  Q  L  H  N      p.160

          .         .         .         .         .         .       g.43424
 GCCCTGAATCTTAATAGGCACGATCTGACTTATATAATGCTGGGGAAGATCCACTTGCTG       c.540
 A  L  N  L  N  R  H  D  L  T  Y  I  M  L  G  K  I  H  L  L         p.180

          .         .         .         .        | 09.         .    g.46768
 GAGGGAGACTTGGACAAGGCCATTGAAGTCTACAAGAAAGCAGTGGA | GTTCTCACCAGAA    c.600
 E  G  D  L  D  K  A  I  E  V  Y  K  K  A  V  E  |  F  S  P  E      p.200

          .         .         .         .   | 10     .         .    g.48449
 AATACAGAGCTTCTTACAACTTTAGGATTACTCTACTTACAG | CTCGGCATTTACCAGAAG    c.660
 N  T  E  L  L  T  T  L  G  L  L  Y  L  Q   | L  G  I  Y  Q  K      p.220

          .         .         .         .         .  | 11      .    g.50129
 GCATTTGAACATCTTGGCAATGCACTGACTTATGACCCTACCAACTACAAG | GCCATCTTG    c.720
 A  F  E  H  L  G  N  A  L  T  Y  D  P  T  N  Y  K   | A  I  L      p.240

          .         .         .         .         .         .       g.50189
 GCAGCAGGCAGCATGATGCAGACCCACGGGGACTTTGATGTTGCCCTCACCAAATACAGA       c.780
 A  A  G  S  M  M  Q  T  H  G  D  F  D  V  A  L  T  K  Y  R         p.260

          .         .         .         .         .         .       g.50249
 GTTGTGGCTTGTGCTGTTCCAGAAAGTCCTCCACTCTGGAATAACATTGGAATGTGTTTC       c.840
 V  V  A  C  A  V  P  E  S  P  P  L  W  N  N  I  G  M  C  F         p.280

          .         .     | 12   .         .         .         .    g.50406
 TTTGGCAAGAAGAAATATGTGGCG | GCCATCAGCTGCCTGAAACGAGCCAACTACTTGGCA    c.900
 F  G  K  K  K  Y  V  A   | A  I  S  C  L  K  R  A  N  Y  L  A      p.300

          .         .         .         .         .         .       g.50466
 CCCTTCGATTGGAAGATTCTGTATAATTTGGGCCTTGTCCATTTGACCATGCAGCAGTAT       c.960
 P  F  D  W  K  I  L  Y  N  L  G  L  V  H  L  T  M  Q  Q  Y         p.320

          .         .         .         .         .         .       g.50526
 GCATCAGCTTTTCATTTTCTCAGTGCGGCCATCAACTTCCAGCCAAAGATGGGGGAGCTC       c.1020
 A  S  A  F  H  F  L  S  A  A  I  N  F  Q  P  K  M  G  E  L         p.340

          .       | 13 .         .         .         .         .    g.53972
 TACATGCTCTTGGCAG | TGGCTCTGACCAATCTGGAAGATATAGAAAATGCCAAGAGAGCC    c.1080
 Y  M  L  L  A  V |   A  L  T  N  L  E  D  I  E  N  A  K  R  A      p.360

          .         .       | 14 .         .         .         .    g.54674
 TACGCAGAAGCAGTCCACCTGGATAA | GTGTAACCCTTTAGTAAACCTGAACTATGCTGTG    c.1140
 Y  A  E  A  V  H  L  D  K  |  C  N  P  L  V  N  L  N  Y  A  V      p.380

          .         .         .         .         .         .       g.54734
 CTGCTGTACAACCAGGGCGAGAAGAAGAACGCCCTGGCCCAATATCAGGAGATGGAGAAG       c.1200
 L  L  Y  N  Q  G  E  K  K  N  A  L  A  Q  Y  Q  E  M  E  K         p.400

          .         .         .         .         | 15         .    g.55589
 AAAGTCAGCCTACTCAAGGACAATAGCTCTCTGGAATTTGACTCTGAG | ATGGTGGAGATG    c.1260
 K  V  S  L  L  K  D  N  S  S  L  E  F  D  S  E   | M  V  E  M      p.420

          .         .         .         .         .         .       g.55649
 GCTCAGAAGTTGGGAGCTGCTCTCCAGGTTGGGGAGGCACTGGTCTGGACCAAACCAGTT       c.1320
 A  Q  K  L  G  A  A  L  Q  V  G  E  A  L  V  W  T  K  P  V         p.440

          .         .         .         .         .         .       g.55709
 AAAGATCCCAAATCAAAGCACCAGACCACTTCAACCAGCAAACCTGCCAGTTTCCAGCAG       c.1380
 K  D  P  K  S  K  H  Q  T  T  S  T  S  K  P  A  S  F  Q  Q         p.460

          .         .         .         .         .         .       g.55769
 CCTCTGGGCTCTAATCAAGCTCTAGGACAGGCAATGTCTTCAGCAGCTGCATACAGGACG       c.1440
 P  L  G  S  N  Q  A  L  G  Q  A  M  S  S  A  A  A  Y  R  T         p.480

          . | 16       .         .         .         .         .    g.56343
 CTCCCCTCAG | GTGCTGGAGGAACATCCCAGTTCACAAAGCCCCCATCTCTTCCTCTGGAG    c.1500
 L  P  S  G |   A  G  G  T  S  Q  F  T  K  P  P  S  L  P  L  E      p.500

          .         .         .         .         .         .       g.56403
 CCAGAGCCTGCGGTGGAATCAAGTCCAACTGAAACATCAGAACAAATAAGAGAGAAATAA       c.1560
 P  E  P  A  V  E  S  S  P  T  E  T  S  E  Q  I  R  E  K  X         p.519

          .         .         .         .         .         .       g.56463
 gaatagaatgaatgaccccaaaatagggttttcttgggcgaggatgtgctggattaggaa       c.*60

          .         .         .         .         .         .       g.56523
 aggtgacatgacacaggcagagcagagtggcacccaccacagaatacagtgtgtgttatt       c.*120

          .         .         .         .         .         .       g.56583
 acgaggagccagcagttgagcctaaggtccttctacctacctggtattggcatttgaggt       c.*180

          .         .         .         .         .         .       g.56643
 cggaaaccctctactgccccataagccaggaaaagtgaaaagagaacacagttcctttaa       c.*240

          .         .         .         .         .         .       g.56703
 gaactggcagcaaggcttgaggccttatgtatgtagctgagtcagcaaggtacatgatgc       c.*300

          .         .         .         .         .         .       g.56763
 tgtctgctttcaaaaggacttttctctcctagctgactgactccttccttagttcaagga       c.*360

          .         .         .         .         .         .       g.56823
 acagctgagacagacctctgctgagtagctctgtgatgacaaagccttggtttaactgag       c.*420

          .         .         .         .         .         .       g.56883
 gtgatcctcaggttgtgaggtttattagtccccaaggcaaacacaaatattagattaata       c.*480

          .         .         .         .         .         .       g.56943
 atccaactttaatagtatacatttaaaagaaaaaaaacaaaagccctggaagttgaggcc       c.*540

          .         .         .         .         .         .       g.57003
 aagcctgctgagtattgcagctgcatttgcccaaagggaatccagaacaagtccctccct       c.*600

          .         .         .         .         .         .       g.57063
 gtattttgttcttgagaggggtcagtctagaagctagatcctatcaggatgaggagcagc       c.*660

          .         .         .         .         .         .       g.57123
 agcccagggcttgtctggatcagcaccaacgattttaaagaaaaaaggaagagtttctta       c.*720

          .         .         .         .         .         .       g.57183
 gatgagtaattgttattgaagatagtcagtgataaccactgaccagatgctatcaataca       c.*780

          .         .         .         .         .         .       g.57243
 ctatgtgtcctttttagaataaagattacatatcatcattcctttggggaaaattgttat       c.*840

          .         .         .         .                           g.57292
 tcaggtataaaaacaagagatcataataaaaacctaaaagaacctatga                  c.*889

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bardet-Biedl syndrome 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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