Bardet-Biedl syndrome 5 (BBS5) - coding DNA reference sequence

(used for variant description)

(last modified November 11, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_152384.2 in the BBS5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011567.1, covering BBS5 transcript NM_152384.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   agagacgcagctaggcctgcacggctgtggagagatcctgccacgggccttgttcacc       c.-1

          .         .         .         .         .          | 02    g.7756
 ATGTCGGTGCTGGATGCGCTTTGGGAGGATCGGGATGTCCGTTTCGACCTGTCCGCGCA | G    c.60
 M  S  V  L  D  A  L  W  E  D  R  D  V  R  F  D  L  S  A  Q  |      p.20

          .         .         .         .         .         .       g.7816
 CAAATGAAAACAAGACCTGGAGAAGTCCTTATTGATTGTTTAGATTCCATTGAAGACACC       c.120
 Q  M  K  T  R  P  G  E  V  L  I  D  C  L  D  S  I  E  D  T         p.40

          .         .   | 03     .         .         .         .    g.12611
 AAAGGAAATAATGGAGATAGAG | GTAGACTCTTGGTAACAAATTTAAGAATTCTCTGGCAC    c.180
 K  G  N  N  G  D  R  G |   R  L  L  V  T  N  L  R  I  L  W  H      p.60

          .         .         | 04         .         .         .    g.13342
 TCTTTGGCATTATCAAGAGTCAATGTTT | CTGTCGGTTACAATTGCATATTGAATATTACA    c.240
 S  L  A  L  S  R  V  N  V  S |   V  G  Y  N  C  I  L  N  I  T      p.80

          .         | 05         .         .         .         .    g.13533
 ACAAGGACTGCTAACTCT | AAATTACGAGGCCAAACTGAAGCTCTCTATATACTAACAAAA    c.300
 T  R  T  A  N  S   | K  L  R  G  Q  T  E  A  L  Y  I  L  T  K      p.100

          .         .         .         .         .         .       g.13593
 TGTAACAGTACTCGTTTTGAATTTATATTTACAAATTTGGTTCCTGGAAGCCCTAGACTT       c.360
 C  N  S  T  R  F  E  F  I  F  T  N  L  V  P  G  S  P  R  L         p.120

          .         .       | 06 .         .         .         .    g.18412
 TTTACTTCTGTGATGGCAGTACACAG | AGCTTATGAAACTTCTAAAATGTATCGTGATTTT    c.420
 F  T  S  V  M  A  V  H  R  |  A  Y  E  T  S  K  M  Y  R  D  F      p.140

          .         .         .         .         .         .       g.18472
 AAATTAAGAAGTGCACTAATTCAGAACAAGCAACTAAGACTGTTGCCACAAGAACATGTA       c.480
 K  L  R  S  A  L  I  Q  N  K  Q  L  R  L  L  P  Q  E  H  V         p.160

          .         .         .         .   | 07     .         .    g.19263
 TATGATAAAATAAATGGAGTTTGGAATTTATCCAGTGATCAG | GGCAATTTAGGAACCTTT    c.540
 Y  D  K  I  N  G  V  W  N  L  S  S  D  Q   | G  N  L  G  T  F      p.180

          .         .         .         .         .         .       g.19323
 TTTATTACCAATGTGAGAATTGTGTGGCATGCAAATATGAATGATAGTTTTAATGTCAGT       c.600
 F  I  T  N  V  R  I  V  W  H  A  N  M  N  D  S  F  N  V  S         p.200

          .         | 08         .         .         .         .    g.23173
 ATACCATATCTGCAAATT | CGTTCAATAAAGATTAGAGATTCAAAATTTGGTTTAGCTCTT    c.660
 I  P  Y  L  Q  I   | R  S  I  K  I  R  D  S  K  F  G  L  A  L      p.220

          .         .  | 09      .         .         .         .    g.25029
 GTCATAGAAAGCTCTCAGCAG | AGTGGTGGATATGTTCTTGGCTTTAAAATAGATCCTGTG    c.720
 V  I  E  S  S  Q  Q   | S  G  G  Y  V  L  G  F  K  I  D  P  V      p.240

          .         .         .         .         .         .       g.25089
 GAAAAACTACAAGAATCAGTTAAGGAAATCAATTCACTTCACAAAGTCTATTCTGCCAGT       c.780
 E  K  L  Q  E  S  V  K  E  I  N  S  L  H  K  V  Y  S  A  S         p.260

          .         .         .       | 10 .         .         .    g.28623
 CCCATATTTGGAGTTGATTATGAGATGGAAGAAAAG | CCCCAGCCGCTCGAAGCTCTGACA    c.840
 P  I  F  G  V  D  Y  E  M  E  E  K   | P  Q  P  L  E  A  L  T      p.280

          .         .         .         .         .         .       g.28683
 GTCGAACAAATTCAAGATGATGTAGAAATAGACTCTGATGGTCACACGGATGCTTTTGTG       c.900
 V  E  Q  I  Q  D  D  V  E  I  D  S  D  G  H  T  D  A  F  V         p.300

  | 11       .         .     | 12   .         .         .         . g.30021
  | GCTTATTTTGCTGATGGCAATAAG | CAACAAGATCGTGAACCTGTATTTTCAGAAGAACTG c.960
  | A  Y  F  A  D  G  N  K   | Q  Q  D  R  E  P  V  F  S  E  E  L   p.320

          .         .         .         .         .         .       g.30081
 GGGCTTGCAATAGAGAAATTGAAGGATGGATTCACCCTACAGGGACTTTGGGAAGTAATG       c.1020
 G  L  A  I  E  K  L  K  D  G  F  T  L  Q  G  L  W  E  V  M         p.340

                                                                    g.30087
 AGTTGA                                                             c.1026
 S  X                                                               p.341

          .         .         .         .         .         .       g.30147
 ttgaccttgagttgagatggatttctattaaagatatctctagtttaaagatactagtca       c.*60

          .         .         .         .         .         .       g.30207
 cctgccataagtcatggaatagtttttatatttacagcttttatatttaaaacttgtaag       c.*120

          .         .         .         .         .         .       g.30267
 agtttttttaatgattgaggaaaaagtcatttagaaaacttcagttttcggccagcgcgt       c.*180

          .         .         .         .         .         .       g.30327
 cgagggaggggccagcgacacatggcctagtaaccgtccggccgcggcgctggcttaagc       c.*240

          .         .         .         .         .         .       g.30387
 catggctgagggtagctggattcctcaggcccgggcgctcctacagcagtgcctgcacgc       c.*300

          .         .         .         .         .         .       g.30447
 ccggctgcaaattcgcccagccaatggggacgttgcggcccagtgggtggaggtccaaag       c.*360

          .         .         .         .         .         .       g.30507
 aggactggtgatctacgtgtgctttttcaagggagctgataaagaacttcttcccaaaat       c.*420

          .         .         .         .         .         .       g.30567
 ggccgaagctggactgtactgctgccatctctggctcactgcaacctccctgcctgattc       c.*480

          .         .         .         .         .         .       g.30627
 tcctgcctcagcctgccgagtgcctgcgattacaggcgcgcgccgccacacctgactggt       c.*540

          .         .         .         .         .         .       g.30687
 tttcgtatttttttggtggagacggggtttcgctgtgttggccgggctggtctccagctc       c.*600

          .         .         .         .         .         .       g.30747
 ctaaccgcgagtgatccgccagcctcggcctcccgaggtgccgggattgcagacggagtc       c.*660

          .         .         .         .         .         .       g.30807
 tggttcacttagtgctcaatggtgcccaggctggagtgcagtggcgtgatctccgctcgc       c.*720

          .         .         .         .         .         .       g.30867
 tacaacctccacctcccagctgcctgccttggcctcccgaagtgccaagagtgcagcctc       c.*780

          .         .         .         .         .         .       g.30927
 tgcccggccgccaccccgtctgggaagtgaggagcgtctctgcctggctgcccattgtct       c.*840

          .         .         .         .         .         .       g.30987
 gggacgtgagcagcccctctgcctggctgcccagtctggaaagtgaggagcgtctctgcc       c.*900

          .         .         .         .         .         .       g.31047
 cggccgccatcccatctaggaagtgaggagcgcctcttcccacccgccatcccatctagg       c.*960

          .         .         .         .         .         .       g.31107
 aagtgaggagcttctctgcctggccgcccatcgtctgagatgtggggagcacctctgccc       c.*1020

          .         .         .         .         .         .       g.31167
 ggccgcgaccccatttgggaggtgaggagcaactctgcccagccgccccgtctgagaagt       c.*1080

          .         .         .         .         .         .       g.31227
 gaggagaccctccgcctggcaaccgccccgtctgataagtaaggagcccctctgcccagc       c.*1140

          .         .         .         .         .         .       g.31287
 agccgccccgtctgagaagtgaggagcccctctgcccagcagccaccctgtctgggaagt       c.*1200

          .         .         .         .         .         .       g.31347
 gaggagcgtctccgcccggcagccacccagtccgggagggaggtgggggggtcagtcccc       c.*1260

          .         .         .         .         .         .       g.31407
 cgtccggccagccgccccgtccgggaggtgaggggcgcctctgcccagctgcccctactg       c.*1320

          .         .         .         .         .         .       g.31467
 ggaagtgaggagcccctctgccccgccagccaccccgtccgggagggaggtgggggggtc       c.*1380

          .         .         .         .         .         .       g.31527
 agccccccgcccggccagccgccccgtccgggagggaggtgggggatcagccccccgccc       c.*1440

          .         .         .         .         .         .       g.31587
 ggctagccgccccgtccgggaggcgaggggcgcctctgcccggctgcccctactgggaag       c.*1500

          .         .         .         .         .         .       g.31647
 tgaggagcccctctgcccggccagccgccccgtccaggagggaggtgggggggtcagccc       c.*1560

          .         .         .         .         .         .       g.31707
 cccgcccggccagccgcccggtccgggagggaggtgggggggtcagccccccgcccggcc       c.*1620

          .         .         .         .         .         .       g.31767
 agccgccccgtccgggaggttaggggcgcctctgcccggccgcccctactgggaagtgag       c.*1680

          .         .         .         .         .         .       g.31827
 gagcccctctgcccggccaccaccccgtctgggaggtgtacccaacagctcattgagagc       c.*1740

          .         .         .         .         .         .       g.31887
 gggcgatgatgacagtggcggctttgtggagtggaggtggggggaaggtggggaaaagat       c.*1800

          .         .         .         .         .         .       g.31947
 tgagaaatcggatggttgccgtgtctgtgtagaaagaagtagacatgggagacttttcat       c.*1860

          .         .         .         .         .         .       g.32007
 tttgttctgtactaagaaaaattcttaccctaaaacttaaagtataataaaaaaaaaaaa       c.*1920

          .         .         .         .         .         .       g.32067
 acttcagttttctaaaaattatatttaaaattgtaatcaaaatgtacctagtttataaat       c.*1980

          .         .         .         .         .         .       g.32127
 gtttattttgtacttaatacctgtaaagtcttagttttcagacattaagtgactgtatca       c.*2040

          .         .         .                                     g.32160
 tgttcggtttaataaagaatttatgcagcacca                                  c.*2073

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bardet-Biedl syndrome 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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