Bardet-Biedl syndrome 7 (BBS7) - coding DNA reference sequence

(used for variant description)

(last modified November 11, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_176824.2 in the BBS7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009111.1, covering BBS7 transcript NM_176824.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         gacg       c.-181

 .         .         .         .         .         .                g.5064
 tcacgcaggacgccactgccctgtcgccccgcctgtgcagcccaggacctaggcgcggta       c.-121

 .         .         .         .         .         .                g.5124
 gctggggctggcttttgaggggcgcgggcagccttctgactgggtcggaggcctgcgggc       c.-61

 .         .         .         .         .         .                g.5184
 ccgaagcctctgtccctcctgttcttgtccggcgctgcttagcccctccgcgtagtcatc       c.-1

          .         .         .       | 02 .         .         .    g.7475
 ATGGATCTGATTTTAAACCGAATGGATTATCTGCAG | GTGGGAGTAACATCTCAGAAGACT    c.60
 M  D  L  I  L  N  R  M  D  Y  L  Q   | V  G  V  T  S  Q  K  T      p.20

          .         .         .         .   | 03     .         .    g.12236
 ATGAAGCTAATTCCTGCCTCAAGACACAGAGCTACACAAAAG | GTGGTTATTGGAGATCAT    c.120
 M  K  L  I  P  A  S  R  H  R  A  T  Q  K   | V  V  I  G  D  H      p.40

          .         .         .         .      | 04  .         .    g.13833
 GATGGGGTAGTTATGTGCTTTGGCATGAAGAAAGGAGAAGCAGCA | GCAGTGTTCAAGACT    c.180
 D  G  V  V  M  C  F  G  M  K  K  G  E  A  A   | A  V  F  K  T      p.60

          .         .         .         .         .         .       g.13893
 TTACCCGGGCCGAAGATTGCAAGGCTGGAACTGGGAGGGGTTATCAACACACCTCAGGAG       c.240
 L  P  G  P  K  I  A  R  L  E  L  G  G  V  I  N  T  P  Q  E         p.80

          .         .         .         .         .         .       g.13953
 AAAATTTTTATTGCTGCAGCATCTGAGATTAGAGGCTTCACAAAAAGAGGAAAACAGTTC       c.300
 K  I  F  I  A  A  A  S  E  I  R  G  F  T  K  R  G  K  Q  F         p.100

          .         .         .         .  | 05      .         .    g.16338
 CTCTCCTTTGAAACAAACCTCACTGAAAGCATTAAAGCTAT | GCACATATCTGGCTCAGAC    c.360
 L  S  F  E  T  N  L  T  E  S  I  K  A  M  |  H  I  S  G  S  D      p.120

          .         .         .         .         .         .       g.16398
 CTCTTTCTCAGTGCAAGTTACATCTATAACCATTATTGTGACTGCAAAGACCAACATTAT       c.420
 L  F  L  S  A  S  Y  I  Y  N  H  Y  C  D  C  K  D  Q  H  Y         p.140

          .         .         .         .         .         .       g.16458
 TACCTTTCTGGGGATAAAATCAATGATGTGATCTGCCTTCCAGTGGAAAGATTATCTCGT       c.480
 Y  L  S  G  D  K  I  N  D  V  I  C  L  P  V  E  R  L  S  R         p.160

          .         .         .         .         | 06         .    g.19948
 ATCACACCTGTATTGGCCTGCCAGGACAGAGTGCTCAGAGTTTTACAG | GGATCTGATGTG    c.540
 I  T  P  V  L  A  C  Q  D  R  V  L  R  V  L  Q   | G  S  D  V      p.180

          .         .         .         .         .         .       g.20008
 ATGTATGCAGTTGAAGTTCCTGGACCCCCTACTGTCTTAGCACTACACAATGGAAATGGC       c.600
 M  Y  A  V  E  V  P  G  P  P  T  V  L  A  L  H  N  G  N  G         p.200

   | 07      .         .         .         .         .         .    g.20736
 G | GTGACTCTGGAGAAGACCTTTTGTTTGGGACATCAGACGGAAAACTTGCGCTTATACAG    c.660
 G |   D  S  G  E  D  L  L  F  G  T  S  D  G  K  L  A  L  I  Q      p.220

          .         .         .         .         .         | 08    g.22413
 ATTACTACATCCAAACCAGTACGCAAGTGGGAAATTCAAAATGAGAAAAAGAGAGGAG | GT    c.720
 I  T  T  S  K  P  V  R  K  W  E  I  Q  N  E  K  K  R  G  G |       p.240

          .         .         .         .         .         .       g.22473
 ATTTTGTGTATTGACAGCTTTGACATTGTGGGTGATGGGGTTAAAGATTTACTTGTTGGG       c.780
 I  L  C  I  D  S  F  D  I  V  G  D  G  V  K  D  L  L  V  G         p.260

          .         .         .         .         .         .       g.22533
 AGAGATGACGGAATGGTGGAAGTGTATAGTTTTGATAATGCAAATGAACCTGTTCTACGA       c.840
 R  D  D  G  M  V  E  V  Y  S  F  D  N  A  N  E  P  V  L  R         p.280

           | 09        .         .         .         .         .    g.26620
 TTTGATCAG | ATGTTGTCTGAAAGCGTCACATCTATCCAGGGTGGTTGTGTAGGAAAAGAC    c.900
 F  D  Q   | M  L  S  E  S  V  T  S  I  Q  G  G  C  V  G  K  D      p.300

          .         .         .     | 10   .         .         .    g.28017
 AGCTATGATGAAATCGTGGTGTCCACATATTCAG | GCTGGGTTACAGGTCTGACAACAGAG    c.960
 S  Y  D  E  I  V  V  S  T  Y  S  G |   W  V  T  G  L  T  T  E      p.320

          .         .         .         .         .         .       g.28077
 CCCATTCATAAGGAAAGTGGACCAGGAGAAGAACTAAAAATTAATCAGGAGATGCAGAAT       c.1020
 P  I  H  K  E  S  G  P  G  E  E  L  K  I  N  Q  E  M  Q  N         p.340

          .        | 11.         .         .         .         .    g.29844
 AAAATTTCTTCCTTACG | GAATGAGTTGGAACATTTGCAGTATAAGGTATTGCAGGAAAGA    c.1080
 K  I  S  S  L  R  |  N  E  L  E  H  L  Q  Y  K  V  L  Q  E  R      p.360

          .         .         .         .         .         .       g.29904
 GAGAATTATCAACAGTCTTCTCAATCAAGCAAAGCAAAATCAGCAGTACCTTCCTTTGGT       c.1140
 E  N  Y  Q  Q  S  S  Q  S  S  K  A  K  S  A  V  P  S  F  G         p.380

          .         .         .         .         .         .       g.29964
 ATAAATGATAAATTTACACTAAATAAAGATGATGCCAGTTACAGCCTTATCTTAGAGGTA       c.1200
 I  N  D  K  F  T  L  N  K  D  D  A  S  Y  S  L  I  L  E  V         p.400

          .         .         . | 12       .         .         .    g.31526
 CAGACTGCAATAGATAATGTCTTAATACAG | AGTGATGTTCCAATAGATTTACTTGATGTG    c.1260
 Q  T  A  I  D  N  V  L  I  Q   | S  D  V  P  I  D  L  L  D  V      p.420

          .         .         .         .      | 13  .         .    g.35816
 GATAAAAATTCTGCTGTTGTTAGCTTTAGCAGCTGTGATTCTGAG | TCAAACGACAACTTC    c.1320
 D  K  N  S  A  V  V  S  F  S  S  C  D  S  E   | S  N  D  N  F      p.440

          .         .         .         .         .  | 14      .    g.40223
 CTTCTTGCCACTTATCGGTGCCAGGCAGATACTACAAGGCTGGAACTCAAG | ATTCGCTCA    c.1380
 L  L  A  T  Y  R  C  Q  A  D  T  T  R  L  E  L  K   | I  R  S      p.460

          .         .         .         .         .         .       g.40283
 ATTGAAGGCCAGTATGGCACACTACAAGCATATGTGACTCCAAGAATTCAACCCAAAACC       c.1440
 I  E  G  Q  Y  G  T  L  Q  A  Y  V  T  P  R  I  Q  P  K  T         p.480

          .         .         .         .         .         .       g.40343
 TGTCAGGTCCGCCAGTACCACATCAAACCTCTTTCACTCCATCAAAGAACTCACTTTATT       c.1500
 C  Q  V  R  Q  Y  H  I  K  P  L  S  L  H  Q  R  T  H  F  I         p.500

          .  | 15      .         .         .         .         .    g.42151
 GATCATGACAG | ACCCATGAATACACTGACCCTAACAGGCCAGTTCAGTTTTGCTGAAGTT    c.1560
 D  H  D  R  |  P  M  N  T  L  T  L  T  G  Q  F  S  F  A  E  V      p.520

          .         .         .         .         .         .       g.42211
 CACTCCTGGGTGGTTTTTTGTCTGCCTGAAGTTCCAGAAAAACCTCCAGCAGGAGAATGT       c.1620
 H  S  W  V  V  F  C  L  P  E  V  P  E  K  P  P  A  G  E  C         p.540

          .         .         .         .         .       | 16 .    g.46773
 GTGACATTTTACTTTCAGAACACCTTTCTAGATACACAACTTGAAAGTACCTACAG | AAAA    c.1680
 V  T  F  Y  F  Q  N  T  F  L  D  T  Q  L  E  S  T  Y  R  |  K      p.560

          .         .         .         .         .         .       g.46833
 GGAGAGGGAGTTTTTAAATCTGACAACATTTCTACTATCTCCATCCTAAAAGATGTGCTT       c.1740
 G  E  G  V  F  K  S  D  N  I  S  T  I  S  I  L  K  D  V  L         p.580

          .         .         .         .       | 17 .         .    g.47006
 TCTAAAGAAGCTACAAAAAGGAAAATTAACCTCAACATATCATACG | AGATAAATGAAGTA    c.1800
 S  K  E  A  T  K  R  K  I  N  L  N  I  S  Y  E |   I  N  E  V      p.600

          .         .         .         .         .         .       g.47066
 TCAGTCAAACACACTTTAAAGCTAATCCACCCAAAGCTGGAGTACCAGTTGCTTTTGGCT       c.1860
 S  V  K  H  T  L  K  L  I  H  P  K  L  E  Y  Q  L  L  L  A         p.620

          .         .         . | 18       .         .         .    g.47258
 AAGAAAGTGCAGTTAATTGATGCTTTAAAA | GAATTACAGATTCATGAGGGAAATACGAAC    c.1920
 K  K  V  Q  L  I  D  A  L  K   | E  L  Q  I  H  E  G  N  T  N      p.640

          .         .         .         .         .         .       g.47318
 TTTCTGATACCAGAATATCACTGTATTCTAGAAGAGGCAGATCACCTACAGGAAGAATAC       c.1980
 F  L  I  P  E  Y  H  C  I  L  E  E  A  D  H  L  Q  E  E  Y         p.660

          .         .         .     | 19   .         .         .    g.49530
 AAAAAGCAACCTGCACATCTTGAAAGACTCTATG | GCATGATCACTGATCTTTTCATAGAT    c.2040
 K  K  Q  P  A  H  L  E  R  L  Y  G |   M  I  T  D  L  F  I  D      p.680

          .         .         .         .         .         .       g.49590
 AAATTTAAGTTTAAAGGCACCAATGTAAAAACTAAAGTACCCCTTCTATTGGAAATTCTG       c.2100
 K  F  K  F  K  G  T  N  V  K  T  K  V  P  L  L  L  E  I  L         p.700

          .         .         .         .                           g.49638
 GACAGTTATGACCAAAATGCATTGATTTCATTCTTCGATGCAGCATGA                   c.2148
 D  S  Y  D  Q  N  A  L  I  S  F  F  D  A  A  X                     p.715

          .         .         .         .         .         .       g.49698
 catacaaataaggtaaagtcccaaagaagtggtctgtttaaatgaaaaatgttaaaagag       c.*60

          .         .         .         .         .         .       g.49758
 aattagaagttaactgtgtatgtactttaatttcaaatgcttttttatatctaaaaatat       c.*120

          .         .         .         .         .         .       g.49818
 ttgagatataatggctttttaaagtaatgcttctatttcttttgacaaattgaactttct       c.*180

          .         .         .         .         .         .       g.49878
 aaaactaaaagagtctttttatttttaaaacacaagtagaatgatttaaataggatttta       c.*240

          .         .         .         .         .         .       g.49938
 atgaatttttggcaagtggctgttttaatttttaaattgagaagtaatatgtggaaaatt       c.*300

          .         .         .         .         .         .       g.49998
 aaaatatattcaaatgtattacaaggtacataaacacataaacatgtagaccgctttata       c.*360

          .         .         .         .         .         .       g.50058
 ggcttcaaaatgtatttttatatattaccttatttgatcttcacaactgttgtaaaattt       c.*420

          .         .         .         .         .         .       g.50118
 gtcaaatcatataagaaaactgattctcagtgaaattttgtgattaagaggacatgctaa       c.*480

          .         .         .         .         .         .       g.50178
 tattttgtaaagctgggaccagaacccaagtactggtacttgctttgtgtcctggttact       c.*540

          .         .         .         .         .         .       g.50238
 atgtatgttgccagctagtggaaataacctaccaattgttttttctaggagataggattg       c.*600

          .         .         .         .         .         .       g.50298
 atttgcaactgatattccttttgcttggtagtgttttatgactctgctgcagtttgtgga       c.*660

          .         .         .         .         .         .       g.50358
 aatgctggacttggctcagtgctataaattgtagccaggaaataagaagagcttacacag       c.*720

          .         .         .         .         .         .       g.50418
 agtcgggggatcttaattagacatgctgtaaccagtggagctattcagcgtgcttcaagt       c.*780

          .         .         .         .         .         .       g.50478
 gaagagtgcagaaatagtgatgccatcttagattttcctacactagtatcttctagatct       c.*840

          .         .         .         .         .         .       g.50538
 ctttttatcatatatgacattaaggctacagaagttttgtgcattaatcttaattcatat       c.*900

          .         .         .         .         .         .       g.50598
 ttattaatttcaagggaatattgaaaggttttaaaatggcatacagataatggaaaataa       c.*960

          .         .         .         .         .         .       g.50658
 gctttatgtttcaagaagggcagactcacgaattttttagaaaacagtgcttcttaatga       c.*1020

          .         .         .         .         .         .       g.50718
 tatgctattatacttattagttatgtgcaagctttgtatattcttatatttatatataaa       c.*1080

          .         .         .         .         .         .       g.50778
 tataaaaatttgttaaaggcacgtatagttaagagagttttattttaataaggtcatatt       c.*1140

          .         .         .         .         .         .       g.50838
 gtttttactatgtttaaaaaactttacttctgaaaggaacataattatatctaggtcact       c.*1200

          .         .         .         .         .         .       g.50898
 agaacgtcattgtgttttttgttggttgccacagcttggggaaaaatagaaaaaaattaa       c.*1260

          .         .         .         .         .         .       g.50958
 tgactgtatttgaatattttgtaatgcactgctatttattatatatatcaacagtagttc       c.*1320

          .         .         .         .         .         .       g.51018
 aaggtgccatcttaaattaattgcatcttcattaggaaaaataaaaagcataaaacacaa       c.*1380

          .         .         .         .         .         .       g.51078
 tttctggttactatgaataaacgcctaaatgttaagatgacattacagtcttgacacttg       c.*1440

          .         .         .         .         .         .       g.51138
 agtactgtattactatgtgagctccgtgttaaataatttatgcacattatttaatcctaa       c.*1500

          .         .         .                                     g.51169
 caaccatatgactgtagttattagtccctat                                    c.*1531

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bardet-Biedl syndrome 7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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