Bardet-Biedl syndrome 9 (BBS9) - coding DNA reference sequence

(used for variant description)

(last modified January 8, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_198428.2 in the BBS9 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009306.1, covering BBS9 transcript NM_198428.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            agtggcgtccgttgtaagtgctatgacaacagg       c.-481

 .         .         .         .         .         .                g.5093
 gcgaagatggctcagagttaggctggagaggggaggtgtcccttccgctgcggccgtcgg       c.-421

 .         .         .         .         .         .                g.5153
 gtttctgctacatcccattcaccgcctcctccatcctttcctcctcggtgtgagcagcag       c.-361

 .         .         .         .         .         .                g.5213
 gacttgcatttgttctcgcctgcctagtgtcttccaagggatagatgccgtttcctctgc       c.-301

 .         .         .         .         .         .                g.5273
 tggtctctgggggtgacggggggcgcaggggagcttcttgggggaatcactccaactctg       c.-241

 .         .         .         .         .         .                g.5333
 tggagctggtggtgctgcctggtggggctctctctttgcccgggacgtggaacaactttc       c.-181

 .         .         .         .         .         .                g.5393
 agctggaggacgagagggaatagtgaagctaaaggttgcttttctctgcaccgtccgttc       c.-121

 .         .         .         .         .         .                g.5453
 ttgctccctctgctccatcactgggaccttgtcaggcgttcataaagcaaaatttgccga       c.-61

 .         .         .         .         .         | 02             g.21713
 acgagggttcgcagaaaggtggggcagagctcatctgacgtggcatcag | tgtgaaagaaa    c.-1

          .         .         .         .         .         .       g.21773
 ATGTCTTTATTTAAAGCCCGTGATTGGTGGTCTACTATTCTGGGAGATAAAGAAGAATTT       c.60
 M  S  L  F  K  A  R  D  W  W  S  T  I  L  G  D  K  E  E  F         p.20

          .         .         .         .         .   | 03     .    g.28169
 GATCAAGGCTGTTTGTGTCTGGCTAATGTTGACAATAGTGGAAATGGACAAG | ATAAAATA    c.120
 D  Q  G  C  L  C  L  A  N  V  D  N  S  G  N  G  Q  D |   K  I      p.40

          .         .         .         .         .         .       g.28229
 ATTGTGGGTAGCTTTATGGGATACCTAAGGATCTTTAGCCCCCATCCTGCAAAAACAGGA       c.180
 I  V  G  S  F  M  G  Y  L  R  I  F  S  P  H  P  A  K  T  G         p.60

          .         .         .         .         .         .       g.28289
 GATGGAGCTCAAGCCGAAGATTTGCTTCTAGAAGTGGATCTACGAGATCCAGTACTTCAA       c.240
 D  G  A  Q  A  E  D  L  L  L  E  V  D  L  R  D  P  V  L  Q         p.80

          .         .    | 04    .         .         .         .    g.31135
 GTGGAAGTAGGAAAGTTTGTTTC | AGGTACCGAAATGCTACATTTGGCTGTGTTACATTCT    c.300
 V  E  V  G  K  F  V  S  |  G  T  E  M  L  H  L  A  V  L  H  S      p.100

          .         .         | 05         .         .         .    g.52970
 AGAAAACTTTGTGTCTACTCTGTCTCAG | GAACCTTGGGTAATGTGGAACATGGGAACCAA    c.360
 R  K  L  C  V  Y  S  V  S  G |   T  L  G  N  V  E  H  G  N  Q      p.120

          .         .         .         .         .         .       g.53030
 TGTCAGATGAAATTGATGTATGAACATAATCTTCAGAGAACAGCCTGCAATATGACCTAT       c.420
 C  Q  M  K  L  M  Y  E  H  N  L  Q  R  T  A  C  N  M  T  Y         p.140

          .         .   | 06     .         .         .         .    g.132734
 GGATCATTTGGTGGTGTAAAAG | GTCGAGATTTAATTTGCATCCAGTCTATGGATGGGATG    c.480
 G  S  F  G  G  V  K  G |   R  D  L  I  C  I  Q  S  M  D  G  M      p.160

          .         .         .         .         .         .       g.132794
 CTGATGGTATTTGAGCAGGAGAGCTATGCTTTTGGAAGATTTCTCCCTGGCTTTCTTCTG       c.540
 L  M  V  F  E  Q  E  S  Y  A  F  G  R  F  L  P  G  F  L  L         p.180

          .         .         .         .         .         .       g.132854
 CCTGGTCCTCTTGCCTACAGTTCCCGTACAGATTCCTTCCTTACTGTCTCTTCCTGCCAA       c.600
 P  G  P  L  A  Y  S  S  R  T  D  S  F  L  T  V  S  S  C  Q         p.200

          .        | 07.         .         .         .         .    g.139793
 CAAGTGGAAAGTTATAA | GTACCAGGTACTTGCTTTTGCAACAGATGCAGATAAAAGGCAG    c.660
 Q  V  E  S  Y  K  |  Y  Q  V  L  A  F  A  T  D  A  D  K  R  Q      p.220

          .         .         .         .   | 08     .         .    g.148490
 GAGACTGAACAGCAAAAACTTGGTTCTGGAAAAAGACTAGTT | GTGGATTGGACTCTAAAT    c.720
 E  T  E  Q  Q  K  L  G  S  G  K  R  L  V   | V  D  W  T  L  N      p.240

          .         .         .         .         .         .       g.148550
 ATTGGAGAGCAAGCCCTTGACATATGTATTGTCTCTTTCAATCAGTCGGCATCCTCTGTT       c.780
 I  G  E  Q  A  L  D  I  C  I  V  S  F  N  Q  S  A  S  S  V         p.260

          .         .         .         .         .         .       g.148610
 TTTGTTCTTGGTGAGAGAAACTTTTTTTGCCTTAAGGATAATGGACAAATTCGATTCATG       c.840
 F  V  L  G  E  R  N  F  F  C  L  K  D  N  G  Q  I  R  F  M         p.280

          .         .         .         .       | 09 .         .    g.149301
 AAGAAGCTTGATTGGAGCCCAAGTTGTTTTCTGCCATATTGCTCAG | TTTCTGAAGGAACA    c.900
 K  K  L  D  W  S  P  S  C  F  L  P  Y  C  S  V |   S  E  G  T      p.300

          .         .         .         .         .         .       g.149361
 ATAAATACTTTGATTGGAAATCATAATAACATGCTGCATATTTATCAAGATGTGACACTG       c.960
 I  N  T  L  I  G  N  H  N  N  M  L  H  I  Y  Q  D  V  T  L         p.320

          .         .         .         .         .       | 10 .    g.211905
 AAGTGGGCCACCCAACTTCCCCACATTCCTGTAGCAGTAAGAGTGGGCTGTTTGCA | TGAT    c.1020
 K  W  A  T  Q  L  P  H  I  P  V  A  V  R  V  G  C  L  H  |  D      p.340

          .         .         .         .         .         .       g.211965
 TTAAAGGGAGTGATAGTCACTCTGAGTGATGATGGTCACTTGCAGTGTTCATACCTGGGG       c.1080
 L  K  G  V  I  V  T  L  S  D  D  G  H  L  Q  C  S  Y  L  G         p.360

          .         .         .         .         .         .       g.212025
 ACAGATCCTTCTCTGTTCCAAGCTCCAAACGTTCAATCTCGAGAACTAAACTATGATGAA       c.1140
 T  D  P  S  L  F  Q  A  P  N  V  Q  S  R  E  L  N  Y  D  E         p.380

          .         .         .         .         .         | 11    g.216359
 CTTGATGTAGAAATGAAAGAACTTCAGAAAATCATCAAAGATGTTAACAAATCACAAG | GT    c.1200
 L  D  V  E  M  K  E  L  Q  K  I  I  K  D  V  N  K  S  Q  G |       p.400

          .         .         .         .         .         .       g.216419
 GTTTGGCCCATGACTGAGAGAGAAGATGACTTGAACGTTTCTGTCGTGGTTTCTCCTAAC       c.1260
 V  W  P  M  T  E  R  E  D  D  L  N  V  S  V  V  V  S  P  N         p.420

          .      | 12  .         .         .         .         .    g.220086
 TTTGATTCAGTTTCT | CAAGCGACCGATGTTGAGGTGGGAACTGACCTTGTCCCTTCTGTC    c.1320
 F  D  S  V  S   | Q  A  T  D  V  E  V  G  T  D  L  V  P  S  V      p.440

           | 13        .         .         .         .         .    g.224579
 ACGGTGAAG | GTCACACTGCAGAACAGAGTGATATTGCAAAAAGCCAAATTATCAGTCTAC    c.1380
 T  V  K   | V  T  L  Q  N  R  V  I  L  Q  K  A  K  L  S  V  Y      p.460

          .         .         .         .         .   | 14     .    g.226687
 GTGCAACCACCATTAGAATTGACTTGTGATCAGTTCACCTTTGAATTTATGA | CACCAGAT    c.1440
 V  Q  P  P  L  E  L  T  C  D  Q  F  T  F  E  F  M  T |   P  D      p.480

          .         .         .         .         .         .       g.226747
 TTGACTAGAACAGTAAGCTTTTCTGTTTATCTGAAAAGAAGTTATACACCATCAGAATTG       c.1500
 L  T  R  T  V  S  F  S  V  Y  L  K  R  S  Y  T  P  S  E  L         p.500

          .         .         .        | 15.         .   | 16     . g.233323
 GAAGGAAATGCTGTTGTTTCTTATTCCAGACCAACAG | ATCGAAATCCTGATG | GCATTCCG c.1560
 E  G  N  A  V  V  S  Y  S  R  P  T  D |   R  N  P  D  G |   I  P   p.520

          .         .         .         .         .         .       g.233383
 CGAGTTATCCAATGTAAATTTAGACTTCCCCTAAAGTTAATTTGCCTACCAGGTCAGCCT       c.1620
 R  V  I  Q  C  K  F  R  L  P  L  K  L  I  C  L  P  G  Q  P         p.540

          .         .         .         .         .         .       g.233443
 TCAAAAACTGCAAGCCACAAAATTACTATTGATACCAACAAATCTCCAGTCAGTCTTCTT       c.1680
 S  K  T  A  S  H  K  I  T  I  D  T  N  K  S  P  V  S  L  L         p.560

          .    | 17    .         .         .         .         .    g.243274
 AGTCTCTTCCCAG | GTTTTGCCAGTCAGTCAGATGATGATCAGGTGAATGTAATGGGTTTT    c.1740
 S  L  F  P  G |   F  A  S  Q  S  D  D  D  Q  V  N  V  M  G  F      p.580

          .         .         .         .          | 18        .    g.259137
 CACTTCTTAGGAGGTGCTCGAATTACTGTTCTTGCTTCCAAAACTTCTC | AACGATATCGC    c.1800
 H  F  L  G  G  A  R  I  T  V  L  A  S  K  T  S  Q |   R  Y  R      p.600

          .         .         .         .         .         .       g.259197
 ATTCAGAGTGAACAATTTGAAGATCTTTGGCTCATAACCAATGAGCTTATTCTTCGCCTT       c.1860
 I  Q  S  E  Q  F  E  D  L  W  L  I  T  N  E  L  I  L  R  L         p.620

          .         .         .         .         .         .       g.259257
 CAAGAATATTTTGAAAAACAGGGAGTCAAAGATTTTGCATGTTCTTTTTCGGGATCTATA       c.1920
 Q  E  Y  F  E  K  Q  G  V  K  D  F  A  C  S  F  S  G  S  I         p.640

          .         .         .         .   | 19     .         .    g.263470
 CCCCTTCAAGAATATTTTGAGTTGATTGATCATCATTTTGAG | CTACGGATAAATGGTGAA    c.1980
 P  L  Q  E  Y  F  E  L  I  D  H  H  F  E   | L  R  I  N  G  E      p.660

          .         .         .         .         .         .       g.263530
 AAATTAGAAGAACTCTTATCTGAGAGAGCTGTACAATTTCGGGCCATTCAACGCCGGCTA       c.2040
 K  L  E  E  L  L  S  E  R  A  V  Q  F  R  A  I  Q  R  R  L         p.680

          .         .         .         .         .         .       g.263590
 CTAGCAAGATTCAAAGATAAAACTCCTGCCCCTCTTCAACACCTGGACACCTTGTTAGAT       c.2100
 L  A  R  F  K  D  K  T  P  A  P  L  Q  H  L  D  T  L  L  D         p.700

          .      | 20  .         .         .         .         .    g.380968
 GGAACCTACAAGCAG | GTAATTGCTCTAGCAGATGCAGTGGAGGAAAACCAAGGCAATCTG    c.2160
 G  T  Y  K  Q   | V  I  A  L  A  D  A  V  E  E  N  Q  G  N  L      p.720

          .         .         .         .         .         .       g.381028
 TTCCAGTCATTCACCAGGCTGAAGAGTGCCACCCATTTGGTGATTCTGCTGATCGCGCTG       c.2220
 F  Q  S  F  T  R  L  K  S  A  T  H  L  V  I  L  L  I  A  L         p.740

          .         .         .         .         .         .       g.381088
 TGGCAGAAGCTTAGTGCTGACCAGGTTGCTATTCTGGAAGCGGCATTTCTGCCGCTACAA       c.2280
 W  Q  K  L  S  A  D  Q  V  A  I  L  E  A  A  F  L  P  L  Q         p.760

          .         | 21         .         .         .         .    g.409456
 GAAGACACTCAAGAATTG | GGCTGGGAAGAAACGGTGGATGCCGCCATTTCCCACCTGTTG    c.2340
 E  D  T  Q  E  L   | G  W  E  E  T  V  D  A  A  I  S  H  L  L      p.780

          .         .         .         .         .         .       g.409516
 AAGACTTGCCTGTCGAAGAGTTCTAAGGAGCAGGCTTTGAACCTCAACAGCCAGCTGAAC       c.2400
 K  T  C  L  S  K  S  S  K  E  Q  A  L  N  L  N  S  Q  L  N         p.800

          .         .         .         .         .         .       g.409576
 ATACCCAAAGACACAAGCCAACTGAAGAAACATATCACCTTGCTCTGCGATAGATTATCC       c.2460
 I  P  K  D  T  S  Q  L  K  K  H  I  T  L  L  C  D  R  L  S         p.820

          .         .         .         .         .         .       g.409636
 AAAGGTGGCCGTCTCTGCCTAAGTACCGATGCAGCAGCCCCACAGACCATGGTCATGCCA       c.2520
 K  G  G  R  L  C  L  S  T  D  A  A  A  P  Q  T  M  V  M  P         p.840

   | 22      .         .         .         .         .         .    g.480384
 G | GTGGTTGTACTACAATCCCAGAGTCAGACCTAGAAGAAAGATCAGTAGAACAAGACTCT    c.2580
 G |   G  C  T  T  I  P  E  S  D  L  E  E  R  S  V  E  Q  D  S      p.860

          .         .         .         .         .   | 23     .    g.480663
 ACAGAACTGTTTACCAACCACAGACATCTCACTGCAGAGACACCCAGGCCTG | AAGTTTCA    c.2640
 T  E  L  F  T  N  H  R  H  L  T  A  E  T  P  R  P  E |   V  S      p.880

          .         .                                               g.480687
 CCCCTCCAAGGAGTCTCGGAATAA                                           c.2664
 P  L  Q  G  V  S  E  X                                             p.887

          .         .         .         .         .         .       g.480747
 ttcaagtagagttgtttggttgagaggaacatccccatctcaaggccgaacctgtgtgaa       c.*60

          .         .         .         .         .         .       g.480807
 cctcatgccaagcacagatatagggctggcgcaggtgcttcctaaagctcaccttcctgg       c.*120

          .         .         .         .         .         .       g.480867
 agatgacatgcatagaaagaggggttgggactttttacttcactaggagaacttgtaaca       c.*180

          .         .         .         .         .         .       g.480927
 ccatggggaagtcagctgaaacttgtcttgttttgccaggaaaggaagtagttgcctttg       c.*240

          .         .         .         .         .         .       g.480987
 gtcatccatctgctaatagtcacagaatacagtgaaatgacatagttttgggttagattt       c.*300

          .         .         .         .         .         .       g.481047
 tataatgcaaagattcagatccaaaataatttcataccccattttttcacagaattctta       c.*360

          .         .         .         .         .         .       g.481107
 tatagtaaatgtatcaagtttaataaagcatctcattgtcaaataatatcttggatttta       c.*420

          .         .         .         .         .         .       g.481167
 tttataattagagggatttatgagtgattgctctacattatttcttcaaaggaaaggaaa       c.*480

          .         .         .         .         .         .       g.481227
 ggaattgaagactttgctactctctggtaagacttgaatgtgattattttataaataaaa       c.*540

          .         .         .         .         .         .       g.481287
 gaaccactatgaaactttcatgtgatttgttctattaagctaaacgtggaagaagggaag       c.*600

          .         .         .         .         .         .       g.481347
 ttttctagtattgtatgaaaatgtttaaatattttcaaggaagctagtacattaacatcc       c.*660

          .         .         .         .         .         .       g.481407
 ccttttcattaccccattgggtggcaccttttaaaaatccaggttattaaaggattcaca       c.*720

          .         .         .         .         .         .       g.481467
 ctttattacagttaaaatttaaggtttttatgtgtaagaagtgaaagaaactttgctaat       c.*780

          .         .         .         .         .         .       g.481527
 ttcaagttcgaattacagttgtgagattgatttatttaaataaaaatatgcctttgccag       c.*840

                                                                    g.481529
 tt                                                                 c.*842

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bardet-Biedl syndrome 9 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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