B-cell CLL/lymphoma 11A (zinc finger protein) (BCL11A) - coding DNA reference sequence

(used for variant description)

(last modified July 28, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_022893.3 in the BCL11A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011968.1, covering BCL11A transcript NM_022893.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             ttttttttttttttttgcttaaaaaaaagccatgacggctctcccaca       c.-181

 .         .         .         .         .         .                g.5108
 attcatcttccctgcgccatctttgtattatttctaatttattttggatgtcaaaaggca       c.-121

 .         .         .         .         .         .                g.5168
 ctgatgaagatattttctctggagtctccttctttctaacccggctctcccgatgtgaac       c.-61

 .         .         .         .         .         .                g.5228
 cgagccgtcgtccgcccgccgccgccgccgccgccgccgccgcccgccccgcagcccacc       c.-1

          .         .         .         .         .      | 02  .    g.12203
 ATGTCTCGCCGCAAGCAAGGCAAACCCCAGCACTTAAGCAAACGGGAATTCTCGC | CCGAG    c.60
 M  S  R  R  K  Q  G  K  P  Q  H  L  S  K  R  E  F  S  P |   E      p.20

          .         .         .         .         .         .       g.12263
 CCTCTTGAAGCCATTCTTACAGATGATGAACCAGACCACGGCCCGTTGGGAGCTCCAGAA       c.120
 P  L  E  A  I  L  T  D  D  E  P  D  H  G  P  L  G  A  P  E         p.40

          .         .         .         .         .         .       g.12323
 GGGGATCATGACCTCCTCACCTGTGGGCAGTGCCAGATGAACTTCCCATTGGGGGACATT       c.180
 G  D  H  D  L  L  T  C  G  Q  C  Q  M  N  F  P  L  G  D  I         p.60

          .         .         .         .         .         .       g.12383
 CTTATTTTTATCGAGCACAAACGGAAACAATGCAATGGCAGCCTCTGCTTAGAAAAAGCT       c.240
 L  I  F  I  E  H  K  R  K  Q  C  N  G  S  L  C  L  E  K  A         p.80

          .         .         .         .         .         .       g.12443
 GTGGATAAGCCACCTTCCCCTTCACCAATCGAGATGAAAAAAGCATCCAATCCCGTGGAG       c.300
 V  D  K  P  P  S  P  S  P  I  E  M  K  K  A  S  N  P  V  E         p.100

          .         .         .         .         .         .       g.12503
 GTTGGCATCCAGGTCACGCCAGAGGATGACGATTGTTTATCAACGTCATCTAGAGGAATT       c.360
 V  G  I  Q  V  T  P  E  D  D  D  C  L  S  T  S  S  R  G  I         p.120

          .         .      | 03  .         .         .         .    g.89700
 TGCCCCAAACAGGAACACATAGCAG | ATAAACTTCTGCACTGGAGGGGCCTCTCCTCCCCT    c.420
 C  P  K  Q  E  H  I  A  D |   K  L  L  H  W  R  G  L  S  S  P      p.140

          .         .         .         .         .         .       g.89760
 CGTTCTGCACATGGAGCTCTAATCCCCACGCCTGGGATGAGTGCAGAATATGCCCCGCAG       c.480
 R  S  A  H  G  A  L  I  P  T  P  G  M  S  A  E  Y  A  P  Q         p.160

         | 04.         .         .         .         .         .    g.96127
 GGTATTT | GTAAAGATGAGCCCAGCAGCTACACATGTACAACTTGCAAACAGCCATTCACC    c.540
 G  I  C |   K  D  E  P  S  S  Y  T  C  T  T  C  K  Q  P  F  T      p.180

          .         .         .         .         .         .       g.96187
 AGTGCATGGTTTCTCTTGCAACACGCACAGAACACTCATGGATTAAGAATCTACTTAGAA       c.600
 S  A  W  F  L  L  Q  H  A  Q  N  T  H  G  L  R  I  Y  L  E         p.200

          .         .         .         .         .         .       g.96247
 AGCGAACACGGAAGTCCCCTGACCCCGCGGGTTGGTATCCCTTCAGGACTAGGTGCAGAA       c.660
 S  E  H  G  S  P  L  T  P  R  V  G  I  P  S  G  L  G  A  E         p.220

          .         .         .         .         .         .       g.96307
 TGTCCTTCCCAGCCACCTCTCCATGGGATTCATATTGCAGACAATAACCCCTTTAACCTG       c.720
 C  P  S  Q  P  P  L  H  G  I  H  I  A  D  N  N  P  F  N  L         p.240

          .         .         .         .         .         .       g.96367
 CTAAGAATACCAGGATCAGTATCGAGAGAGGCTTCCGGCCTGGCAGAAGGGCGCTTTCCA       c.780
 L  R  I  P  G  S  V  S  R  E  A  S  G  L  A  E  G  R  F  P         p.260

          .         .         .         .         .         .       g.96427
 CCCACTCCCCCCCTGTTTAGTCCACCACCGAGACATCACTTGGACCCCCACCGCATAGAG       c.840
 P  T  P  P  L  F  S  P  P  P  R  H  H  L  D  P  H  R  I  E         p.280

          .         .         .         .         .         .       g.96487
 CGCCTGGGGGCGGAAGAGATGGCCCTGGCCACCCATCACCCGAGTGCCTTTGACAGGGTG       c.900
 R  L  G  A  E  E  M  A  L  A  T  H  H  P  S  A  F  D  R  V         p.300

          .         .         .         .         .         .       g.96547
 CTGCGGTTGAATCCAATGGCTATGGAGCCTCCCGCCATGGATTTCTCTAGGAGACTTAGA       c.960
 L  R  L  N  P  M  A  M  E  P  P  A  M  D  F  S  R  R  L  R         p.320

          .         .         .         .         .         .       g.96607
 GAGCTGGCAGGGAACACGTCTAGCCCACCGCTGTCCCCAGGCCGGCCCAGCCCTATGCAA       c.1020
 E  L  A  G  N  T  S  S  P  P  L  S  P  G  R  P  S  P  M  Q         p.340

          .         .         .         .         .         .       g.96667
 AGGTTACTGCAACCATTCCAGCCAGGTAGCAAGCCGCCCTTCCTGGCGACGCCCCCCCTC       c.1080
 R  L  L  Q  P  F  Q  P  G  S  K  P  P  F  L  A  T  P  P  L         p.360

          .         .         .         .         .         .       g.96727
 CCTCCTCTGCAATCCGCCCCTCCTCCCTCCCAGCCCCCGGTCAAGTCCAAGTCATGCGAG       c.1140
 P  P  L  Q  S  A  P  P  P  S  Q  P  P  V  K  S  K  S  C  E         p.380

          .         .         .         .         .         .       g.96787
 TTCTGCGGCAAGACGTTCAAATTTCAGAGCAACCTGGTGGTGCACCGGCGCAGCCACACG       c.1200
 F  C  G  K  T  F  K  F  Q  S  N  L  V  V  H  R  R  S  H  T         p.400

          .         .         .         .         .         .       g.96847
 GGCGAGAAGCCCTACAAGTGCAACCTGTGCGACCACGCGTGCACCCAGGCCAGCAAGCTG       c.1260
 G  E  K  P  Y  K  C  N  L  C  D  H  A  C  T  Q  A  S  K  L         p.420

          .         .         .         .         .         .       g.96907
 AAGCGCCACATGAAGACGCACATGCACAAATCGTCCCCCATGACGGTCAAGTCCGACGAC       c.1320
 K  R  H  M  K  T  H  M  H  K  S  S  P  M  T  V  K  S  D  D         p.440

          .         .         .         .         .         .       g.96967
 GGTCTCTCCACCGCCAGCTCCCCGGAACCCGGCACCAGCGACTTGGTGGGCAGCGCCAGC       c.1380
 G  L  S  T  A  S  S  P  E  P  G  T  S  D  L  V  G  S  A  S         p.460

          .         .         .         .         .         .       g.97027
 AGCGCGCTCAAGTCCGTGGTGGCCAAGTTCAAGAGCGAGAACGACCCCAACCTGATCCCG       c.1440
 S  A  L  K  S  V  V  A  K  F  K  S  E  N  D  P  N  L  I  P         p.480

          .         .         .         .         .         .       g.97087
 GAGAACGGGGACGAGGAGGAAGAGGAGGACGACGAGGAAGAGGAAGAAGAGGAGGAAGAG       c.1500
 E  N  G  D  E  E  E  E  E  D  D  E  E  E  E  E  E  E  E  E         p.500

          .         .         .         .         .         .       g.97147
 GAGGAGGAGGAGCTGACGGAGAGCGAGAGGGTGGACTACGGCTTCGGGCTGAGCCTGGAG       c.1560
 E  E  E  E  L  T  E  S  E  R  V  D  Y  G  F  G  L  S  L  E         p.520

          .         .         .         .         .         .       g.97207
 GCGGCGCGCCACCACGAGAACAGCTCGCGGGGCGCGGTCGTGGGCGTGGGCGACGAGAGC       c.1620
 A  A  R  H  H  E  N  S  S  R  G  A  V  V  G  V  G  D  E  S         p.540

          .         .         .         .         .         .       g.97267
 CGCGCCCTGCCCGACGTCATGCAGGGCATGGTGCTCAGCTCCATGCAGCACTTCAGCGAG       c.1680
 R  A  L  P  D  V  M  Q  G  M  V  L  S  S  M  Q  H  F  S  E         p.560

          .         .         .         .         .         .       g.97327
 GCCTTCCACCAGGTCCTGGGCGAGAAGCATAAGCGCGGCCACCTGGCCGAGGCCGAGGGC       c.1740
 A  F  H  Q  V  L  G  E  K  H  K  R  G  H  L  A  E  A  E  G         p.580

          .         .         .         .         .         .       g.97387
 CACAGGGACACTTGCGACGAAGACTCGGTGGCCGGCGAGTCGGACCGCATAGACGATGGC       c.1800
 H  R  D  T  C  D  E  D  S  V  A  G  E  S  D  R  I  D  D  G         p.600

          .         .         .         .         .         .       g.97447
 ACTGTTAATGGCCGCGGCTGCTCCCCGGGCGAGTCGGCCTCGGGGGGCCTGTCCAAAAAG       c.1860
 T  V  N  G  R  G  C  S  P  G  E  S  A  S  G  G  L  S  K  K         p.620

          .         .         .         .         .         .       g.97507
 CTGCTGCTGGGCAGCCCCAGCTCGCTGAGCCCCTTCTCTAAGCGCATCAAGCTCGAGAAG       c.1920
 L  L  L  G  S  P  S  S  L  S  P  F  S  K  R  I  K  L  E  K         p.640

          .         .         .         .         .         .       g.97567
 GAGTTCGACCTGCCCCCGGCCGCGATGCCCAACACGGAGAACGTGTACTCGCAGTGGCTC       c.1980
 E  F  D  L  P  P  A  A  M  P  N  T  E  N  V  Y  S  Q  W  L         p.660

          .         .         .         .         .         .       g.97627
 GCCGGCTACGCGGCCTCCAGGCAGCTCAAAGATCCCTTCCTTAGCTTCGGAGACTCCAGA       c.2040
 A  G  Y  A  A  S  R  Q  L  K  D  P  F  L  S  F  G  D  S  R         p.680

          .         .         .         .         .         .       g.97687
 CAATCGCCTTTTGCCTCCTCGTCGGAGCACTCCTCGGAGAACGGGAGTTTGCGCTTCTCC       c.2100
 Q  S  P  F  A  S  S  S  E  H  S  S  E  N  G  S  L  R  F  S         p.700

          .         .         .         .         .         .       g.97747
 ACACCGCCCGGGGAGCTGGACGGAGGGATCTCGGGGCGCAGCGGCACGGGAAGTGGAGGG       c.2160
 T  P  P  G  E  L  D  G  G  I  S  G  R  S  G  T  G  S  G  G         p.720

          .         .         .         .         .         .       g.97807
 AGCACGCCCCATATTAGTGGTCCGGGCCCGGGCAGGCCCAGCTCAAAAGAGGGCAGACGC       c.2220
 S  T  P  H  I  S  G  P  G  P  G  R  P  S  S  K  E  G  R  R         p.740

          .         .         .         .         .         .       g.97867
 AGCGACACTTGTGAGTACTGTGGGAAAGTCTTCAAGAACTGTAGCAATCTCACTGTCCAC       c.2280
 S  D  T  C  E  Y  C  G  K  V  F  K  N  C  S  N  L  T  V  H         p.760

          .         .         .         .         .         .       g.97927
 AGGAGAAGCCACACGGGCGAAAGGCCTTATAAATGCGAGCTGTGCAACTATGCCTGTGCC       c.2340
 R  R  S  H  T  G  E  R  P  Y  K  C  E  L  C  N  Y  A  C  A         p.780

          .         .         .         .         .         .       g.97987
 CAGAGTAGCAAGCTCACCAGGCACATGAAAACGCATGGCCAGGTGGGGAAGGACGTTTAC       c.2400
 Q  S  S  K  L  T  R  H  M  K  T  H  G  Q  V  G  K  D  V  Y         p.800

          .         .         .         .         .         .       g.98047
 AAATGTGAAATTTGTAAGATGCCTTTTAGCGTGTACAGTACCCTGGAGAAACACATGAAA       c.2460
 K  C  E  I  C  K  M  P  F  S  V  Y  S  T  L  E  K  H  M  K         p.820

          .         .         .         .                           g.98095
 AAATGGCACAGTGATCGAGTGTTGAATAATGATATAAAAACTGAATAG                   c.2508
 K  W  H  S  D  R  V  L  N  N  D  I  K  T  E  X                     p.835

          .         .         .         .         .         .       g.98155
 aggtatattaatacccctccctcactcccacctgacaccccctttttcaccactcccctt       c.*60

          .         .         .         .         .         .       g.98215
 ccccatcgccctccagccccactccctgtaggatttttttctagtcccatgtgatttaaa       c.*120

          .         .         .         .         .         .       g.98275
 caaacaaacaaacaaacagaagtaacgaagctaagaatatgagagtgcttgtcaccagca       c.*180

          .         .         .         .         .         .       g.98335
 cacctgttttttttctttttctttttcttttttctttttccttttttttttttttccttt       c.*240

          .         .         .         .         .         .       g.98395
 atgttctcaccgtttgaatgcatgatctgtatggggcaatactattgcattttacgcaaa       c.*300

          .         .         .         .         .         .       g.98455
 ctttgagcctttctcttgtgcaataatttacatgttgtgtatgtttttttttaaacttag       c.*360

          .         .         .         .         .         .       g.98515
 acagcatgtatggtatgttatggctattttaaattgtccctaattcgttgctgagcaaac       c.*420

          .         .         .         .         .         .       g.98575
 atgttgctgtttccagttccgttctgagagaaaaagagagagagagagaaaaagaccatg       c.*480

          .         .         .         .         .         .       g.98635
 ctgcatacattctgtaatacatatcatgtacagttttattttataacgtgaggaggaaaa       c.*540

          .         .         .         .         .         .       g.98695
 acagtctttggattaaccctctatagacagaatagatagcactgaaaaaaaatctctatg       c.*600

          .         .         .         .         .         .       g.98755
 agctaaatgtctgtctctaaagggttaaatgtatcaattggaaaggaagaaaaaaggcct       c.*660

          .         .         .         .         .         .       g.98815
 tgaattgacaaattaacagaaaaacagaacaagtttattctatcatttggttttaaaata       c.*720

          .         .         .         .         .         .       g.98875
 tgagtgccttggatctattaaaaccacatcgatggttctttctacttgttataaacttgt       c.*780

          .         .         .         .         .         .       g.98935
 agcttaattcagcattgggtgaggtaataaaccttaggaactagcatataattctatatt       c.*840

          .         .         .         .         .         .       g.98995
 gtatttctcacaacaatggctacctaaaaagatgacccattatgtcctagttaatcatca       c.*900

          .         .         .         .         .         .       g.99055
 tttttcctttagtttaattttataaacaaaactgattataccagtataaaagctactttg       c.*960

          .         .         .         .         .         .       g.99115
 ctcctggtgagagcttaaaagaaatgggctgttttgcccaaagttttattttttttaaac       c.*1020

          .         .         .         .         .         .       g.99175
 aatgattaaattgaatgtgtaatgtgcaaaagccctggaacgcaattaaatacactagta       c.*1080

          .         .         .         .         .         .       g.99235
 aggagttcattttatgaagatatttgctttaataatgtctttttaaaaatactggcacca       c.*1140

          .         .         .         .         .         .       g.99295
 aaagaaatagatccagatctacttggttgtcaagtggacaatcaaatgataaactttaag       c.*1200

          .         .         .         .         .         .       g.99355
 accttgtataccatattgaaaggaagaggctgacaataaggtttgacagaggggaacaga       c.*1260

          .         .         .         .         .         .       g.99415
 agaaaataatatgatttattagcacaacgtggtactatttgccatttaaaactagaacag       c.*1320

          .         .         .         .         .         .       g.99475
 gtatataagctaatattgatacaatgatgattaactatgaattcttaagacttgcattta       c.*1380

          .         .         .         .         .         .       g.99535
 aatgtgacattcttaaaaaaagaagagaaagaattttaagagtagcagtatatatgtctg       c.*1440

          .         .         .         .         .         .       g.99595
 tgctccctaaaagttgtacttcatttcttttccatacactgtgtgctatttgtgttaaca       c.*1500

          .         .         .         .         .         .       g.99655
 tggaagaggattcattgtttttatttttatttttttaattttttcttttttattaagcta       c.*1560

          .         .         .         .         .         .       g.99715
 gcatctgccccagttggtgttcaaatagcacttgactctgcctgtgatatctgtatcttt       c.*1620

          .         .         .         .         .         .       g.99775
 tctctaatcagagatacagaggttgagtataaaataaacctgctcagataggacaattaa       c.*1680

          .         .         .         .         .         .       g.99835
 gtgcactgtacaattttcccagtttacaggtctatacttaagggaaaagttgcaagaatg       c.*1740

          .         .         .         .         .         .       g.99895
 ctgaaaaaaaattgaacacaatctcattgaggagcattttttaaaaactaaaaaaaaaaa       c.*1800

          .         .         .         .         .         .       g.99955
 aactttgccagccatttacttgactattgagcttacttacttggacgcaacattgcaagc       c.*1860

          .         .         .         .         .         .       g.100015
 gctgtgaatggaaacagaatacacttaacatagaaatgaatgattgctttcgcttctaca       c.*1920

          .         .         .         .         .         .       g.100075
 gtgcaaggatttttttgtacaaaacttttttaaatataaatgttaagaaaaatttttttt       c.*1980

          .         .         .         .         .         .       g.100135
 aaaaaacacttcattatgtttaggggggaactgcattttagggttccattgtcttggtgg       c.*2040

          .         .         .         .         .         .       g.100195
 tgttacaagacttgttatccatttaaaaatggtagtggaaattctatgccttggatacac       c.*2100

          .         .         .         .         .         .       g.100255
 accgctcttcaggttgtaaaaaaaaaaaacatacattggggaaaggtttaagattatata       c.*2160

          .         .         .         .         .         .       g.100315
 gtacttaaatataggaaaatgcacactcatgttgattcctatgctaaaatacatttatgg       c.*2220

          .         .         .         .         .         .       g.100375
 tcttttttctgtatttctagaatggtatttgaattaaatgttcatctagtgttaggcact       c.*2280

          .         .         .         .         .         .       g.100435
 atagtatttatattgaagcttgtatttttaactgttgcttgttctcttaaaaggtatcaa       c.*2340

          .         .         .         .         .         .       g.100495
 tgtaccttttttggtagtggaaaaaaaaaagacaggctgccacagtatatttttttaatt       c.*2400

          .         .         .         .         .         .       g.100555
 tggcaggataatatagtgcaaattatttgtatgcttcaaaaaaaaaaaaaagagagaaac       c.*2460

          .         .         .         .         .         .       g.100615
 aaaaaagtgtgacattacagatgagaagccatataatggcggtttgggggagcctgctag       c.*2520

          .         .         .         .         .         .       g.100675
 aatgtcacatggatggctgtcataggggttgtacatatccttttttgttcctttttcctg       c.*2580

          .         .         .         .         .         .       g.100735
 ctgccatactgtatgcagtactgcaagctaataacgttggtttgttatgtagtgtgcttt       c.*2640

          .         .         .         .         .         .       g.100795
 ttgtccctttccttctatcaccctacattccagcatcttaccttcatatgcagtaaaaga       c.*2700

          .         .         .         .         .         .       g.100855
 aagaaagaaaaaaaaaggaaaaaaaaaaaaaaaccaatgttttgcagtttttttcattgc       c.*2760

          .         .         .         .         .         .       g.100915
 caaaaactaaatggtgctttatatttagattggaaagaatttcatatgcaaagcatatta       c.*2820

          .         .         .         .         .         .       g.100975
 aagagaaagcccgctttagtcaatacttttttgtaaatggcaatgcagaatattttgtta       c.*2880

          .         .         .         .         .         .       g.101035
 ttggccttttctattcctgtaatgaaagctgtttgtcgtaacttgaaattttatctttta       c.*2940

          .         .         .         .         .         .       g.101095
 ctatgggagtcactatttattattgcttatgtgccctgttcaaaacagaggcacttaatt       c.*3000

          .         .         .         .         .         .       g.101155
 tgatcttttatttttctttgtttttatttttttttttatttagatgaccaaaggtcatta       c.*3060

          .         .         .         .         .         .       g.101215
 caacctggctttttattgtatttgtttctggtctttgttaagttctattggaaaaaccac       c.*3120

          .         .         .         .         .         .       g.101275
 tgtctgtgtttttttggcagttgtctgcattaacctgttcatacacccattttgtccctt       c.*3180

          .         .         .                                     g.101305
 tattgaaaaaataaaaaaaattaaagtaca                                     c.*3210

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The B-cell CLL/lymphoma 11A (zinc finger protein) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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