BCS1-like (S. cerevisiae) (BCS1L) - coding DNA reference sequence

(used for variant description)

(last modified August 30, 2012)


This file was created to facilitate the description of sequence variants on transcript NM_004328.4 in the BCS1L gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering BCS1L transcript NM_004328.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5046
               gaaaggacccggggcggggccgaacgcagcttccccaaggtgcagg       c.-301

 .         .         .         .         .  | 02      .             g.5399
 cgcggtgaaaccatcgagacggagggccagagagtcacggcg | gatcttattgtctacgat    c.-241

 .         .         .         .         .         .                g.5459
 gtgacgatccgtggagaaagtagcagatgggcagattttcatttggggagaatgagggag       c.-181

 .         .         .         .         .         .                g.5519
 aaaagaacgggcattccgagccaagagcactgcatgagcaaggagttgggaggttgctta       c.-121

 .         .         .         .         .         .                g.5579
 cttgttgaacatatttgttgcgtatttgcatatttgctaaacaggtagtgttaggagcta       c.-61

 .         . | 03       .         .         .         .             g.6332
 atccatgaaag | gttttcgtaacaccccagggcctgtaaggtttggtgtttccctttcaag    c.-1

          .         .         .         .         .         .       g.6392
 ATGCCACTTTCAGACTTTATTCTGGCTCTGAAGGACAATCCCTACTTTGGGGCTGGATTT       c.60
 M  P  L  S  D  F  I  L  A  L  K  D  N  P  Y  F  G  A  G  F         p.20

          .         .         .         .         .         .       g.6452
 GGGCTGGTGGGTGTGGGCACAGCCCTGGCCCTGGCCCGGAAGGGTGTCCAACTGGGCCTG       c.120
 G  L  V  G  V  G  T  A  L  A  L  A  R  K  G  V  Q  L  G  L         p.40

          .         .         .         .         .         .       g.6512
 GTGGCATTCCGGCGCCATTACATGATCACACTGGAAGTCCCTGCTCGAGACAGGAGCTAT       c.180
 V  A  F  R  R  H  Y  M  I  T  L  E  V  P  A  R  D  R  S  Y         p.60

          .         .         .         .         .         .       g.6572
 GCCTGGTTGCTTAGCTGGCTCACCCGCCACAGTACCCGTACTCAGCACCTCAGTGTCGAG       c.240
 A  W  L  L  S  W  L  T  R  H  S  T  R  T  Q  H  L  S  V  E         p.80

          .         .         .         .         .         .       g.6632
 ACTTCGTACCTTCAGCATGAGAGTGGCCGCATTTCCACTAAGTTTGAATTTGTCCCCAGC       c.300
 T  S  Y  L  Q  H  E  S  G  R  I  S  T  K  F  E  F  V  P  S         p.100

          .         . | 04       .         .         .         .    g.6790
 CCTGGAAACCATTTTATCTG | GTATCGGGGGAAATGGATTCGGGTAGAACGAAGTCGAGAG    c.360
 P  G  N  H  F  I  W  |  Y  R  G  K  W  I  R  V  E  R  S  R  E      p.120

          .         .         .         .         .         .       g.6850
 ATGCAGATGATAGACTTGCAGACGGGGACTCCTTGGGAATCTGTCACCTTCACGGCCCTG       c.420
 M  Q  M  I  D  L  Q  T  G  T  P  W  E  S  V  T  F  T  A  L         p.140

          .         .         .         . | 05       .         .    g.7123
 GGCACTGACCGAAAGGTTTTCTTCAACATCCTGGAGGAAG | CTCGAGAGCTAGCCTTGCAG    c.480
 G  T  D  R  K  V  F  F  N  I  L  E  E  A |   R  E  L  A  L  Q      p.160

          .         .         .         .         .         .       g.7183
 CAGGAGGAAGGGAAGACCGTGATGTACACAGCTGTGGGCTCTGAATGGCGTCCCTTTGGC       c.540
 Q  E  E  G  K  T  V  M  Y  T  A  V  G  S  E  W  R  P  F  G         p.180

          .         .         .         .         .         .       g.7243
 TATCCACGCCGCCGGCGACCACTGAATTCTGTGGTTCTACAACAGGGTCTGGCTGACCGA       c.600
 Y  P  R  R  R  R  P  L  N  S  V  V  L  Q  Q  G  L  A  D  R         p.200

          .         .         .         .         .      | 06  .    g.7546
 ATTGTCAGAGACGTCCAGGAATTCATCGATAACCCCAAGTGGTACACTGACAGAG | GCATT    c.660
 I  V  R  D  V  Q  E  F  I  D  N  P  K  W  Y  T  D  R  G |   I      p.220

          .         .         .         .         .          | 07    g.7855
 CCTTACAGACGTGGCTACCTGCTTTATGGGCCCCCTGGTTGCGGAAAGAGCAGTTTTAT | C    c.720
 P  Y  R  R  G  Y  L  L  Y  G  P  P  G  C  G  K  S  S  F  I  |      p.240

          .         .         .         .         .         .       g.7915
 ACAGCCCTGGCTGGGGAACTGGAGCACAGCATCTGCCTGCTGAGCCTCACGGACTCCAGC       c.780
 T  A  L  A  G  E  L  E  H  S  I  C  L  L  S  L  T  D  S  S         p.260

          .         .         .         .         .         .       g.7975
 CTCTCTGATGACCGACTCAACCACCTGCTGAGCGTGGCCCCGCAGCAGAGCCTGGTACTC       c.840
 L  S  D  D  R  L  N  H  L  L  S  V  A  P  Q  Q  S  L  V  L         p.280

          .         .         .         .          | 08        .    g.8238
 CTGGAGGATGTGGATGCTGCTTTTCTCAGTCGAGACTTGGCTGTGGAGA | ACCCAGTAAAG    c.900
 L  E  D  V  D  A  A  F  L  S  R  D  L  A  V  E  N |   P  V  K      p.300

          .         .         .         .         .         .       g.8298
 TACCAAGGCCTAGGTCGCCTCACCTTCAGTGGACTGCTCAATGCCTTGGATGGTGTGGCT       c.960
 Y  Q  G  L  G  R  L  T  F  S  G  L  L  N  A  L  D  G  V  A         p.320

          .         .         .         .        | 09.         .    g.8491
 TCCACCGAGGCCCGCATCGTGTTCATGACCACCAACCACGTTGACAG | GCTGGACCCTGCC    c.1020
 S  T  E  A  R  I  V  F  M  T  T  N  H  V  D  R  |  L  D  P  A      p.340

          .         .         .         .         .         .       g.8551
 CTGATACGCCCGGGGCGAGTGGACCTGAAGGAGTACGTGGGCTACTGCTCACACTGGCAG       c.1080
 L  I  R  P  G  R  V  D  L  K  E  Y  V  G  Y  C  S  H  W  Q         p.360

          .         .         .         .         .         .       g.8611
 CTGACCCAGATGTTCCAGAGGTTCTATCCAGGGCAGGCACCTTCCTTAGCTGAGAACTTT       c.1140
 L  T  Q  M  F  Q  R  F  Y  P  G  Q  A  P  S  L  A  E  N  F         p.380

          .         .         .         .         .         .       g.8671
 GCAGAACATGTCCTTCGAGCTACAAACCAGATCAGTCCTGCCCAGGTGCAGGGCTACTTC       c.1200
 A  E  H  V  L  R  A  T  N  Q  I  S  P  A  Q  V  Q  G  Y  F         p.400

          .         .         .         .         .         .       g.8731
 ATGCTGTATAAAAATGACCCTGTAGGGGCAATTCACAATGCTGAGTCTCTGAGGAGGTGA       c.1260
 M  L  Y  K  N  D  P  V  G  A  I  H  N  A  E  S  L  R  R  X         p.419

          .         .         .         .         .                 g.8788
 tcaggctgggctcagctcagctctcctcctctagctcaataaacatctgccacacta          c.*57

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The BCS1-like (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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