bicaudal D homolog 2 (Drosophila) (BICD2) - coding DNA reference sequence

(used for variant description)

(last modified December 22, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_001003800.1 in the BICD2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering BICD2 transcript NM_001003800.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    tgaggagggcccggcctgcgagagcctcagtgggagccggctcagccctcggccacc       c.-1

          .         .         .         .         .         .       g.5117
 ATGTCGGCGCCGTCGGAGGAGGAGGAGTACGCGCGGCTGGTGATGGAGGCGCAGCCGGAG       c.60
 M  S  A  P  S  E  E  E  E  Y  A  R  L  V  M  E  A  Q  P  E         p.20

          .         .         .         .         .         .       g.5177
 TGGCTGCGCGCCGAGGTGAAGCGGCTGTCCCACGAGCTGGCCGAGACCACGCGTGAGAAG       c.120
 W  L  R  A  E  V  K  R  L  S  H  E  L  A  E  T  T  R  E  K         p.40

          .         .         .         .         .         .       g.5237
 ATCCAGGCGGCCGAGTACGGGCTGGCGGTGCTCGAGGAGAAGCACCAGCTCAAGCTGCAG       c.180
 I  Q  A  A  E  Y  G  L  A  V  L  E  E  K  H  Q  L  K  L  Q         p.60

          .         .         .         .         .         .       g.5297
 TTCGAGGAGCTCGAGGTGGACTATGAGGCTATCCGCAGCGAGATGGAGCAGCTCAAGGAG       c.240
 F  E  E  L  E  V  D  Y  E  A  I  R  S  E  M  E  Q  L  K  E         p.80

  | 02       .         .         .         .         .         .    g.40625
  | GCCTTTGGACAAGCACACACAAACCACAAGAAGGTGGCTGCTGACGGAGAGAGCCGGGAG    c.300
  | A  F  G  Q  A  H  T  N  H  K  K  V  A  A  D  G  E  S  R  E      p.100

          .         .         .         .         .         .       g.40685
 GAGAGCCTGATCCAGGAGTCGGCCTCCAAGGAGCAGTACTACGTGCGGAAGGTGCTAGAG       c.360
 E  S  L  I  Q  E  S  A  S  K  E  Q  Y  Y  V  R  K  V  L  E         p.120

          .         .         .         .         .         .       g.40745
 CTGCAGACGGAGCTGAAGCAGTTGCGCAATGTCCTCACCAACACGCAGTCGGAGAATGAG       c.420
 L  Q  T  E  L  K  Q  L  R  N  V  L  T  N  T  Q  S  E  N  E         p.140

          .         .         .    | 03    .         .         .    g.47020
 CGCCTGGCCTCTGTGGCCCAGGAGCTGAAGGAG | ATCAACCAGAATGTGGAGATCCAGCGT    c.480
 R  L  A  S  V  A  Q  E  L  K  E   | I  N  Q  N  V  E  I  Q  R      p.160

          .         .         .         .         .         .       g.47080
 GGCCGCCTGCGGGATGACATCAAGGAGTACAAATTCCGGGAAGCTCGTCTGCTGCAGGAC       c.540
 G  R  L  R  D  D  I  K  E  Y  K  F  R  E  A  R  L  L  Q  D         p.180

          .         .         .         .         .         .       g.47140
 TACTCGGAACTGGAGGAGGAGAACATCAGCCTGCAGAAGCAAGTGTCTGTGCTCAGACAG       c.600
 Y  S  E  L  E  E  E  N  I  S  L  Q  K  Q  V  S  V  L  R  Q         p.200

        | 04 .         .         .         .         .         .    g.49100
 AACCAG | GTGGAGTTTGAGGGCCTCAAGCATGAGATCAAGCGTCTGGAGGAGGAGACCGAG    c.660
 N  Q   | V  E  F  E  G  L  K  H  E  I  K  R  L  E  E  E  T  E      p.220

          .         .         .         .         .         .       g.49160
 TACCTCAACAGCCAGCTGGAGGATGCCATCCGCCTCAAGGAGATCTCAGAGCGGCAGCTG       c.720
 Y  L  N  S  Q  L  E  D  A  I  R  L  K  E  I  S  E  R  Q  L         p.240

          .         .         .         .         .         .       g.49220
 GAGGAGGCGCTGGAGACCCTGAAGACGGAGCGCGAACAGAAGAACAGCCTGCGCAAGGAG       c.780
 E  E  A  L  E  T  L  K  T  E  R  E  Q  K  N  S  L  R  K  E         p.260

          .         .         .         .         .         .       g.49280
 CTGTCACACTACATGAGCATCAATGACTCCTTCTACACCAGCCACCTGCATGTCTCGCTG       c.840
 L  S  H  Y  M  S  I  N  D  S  F  Y  T  S  H  L  H  V  S  L         p.280

          .         .         .         .         .         .       g.49340
 GATGGCCTCAAGTTCAGTGACGATGCTGCCGAGCCCAACAACGATGCCGAGGCCCTGGTC       c.900
 D  G  L  K  F  S  D  D  A  A  E  P  N  N  D  A  E  A  L  V         p.300

          .         .         .         .         .         .       g.49400
 AATGGCTTTGAGCACGGCGGCCTGGCCAAGCTGCCACTGGACAACAAGACCTCCACGCCC       c.960
 N  G  F  E  H  G  G  L  A  K  L  P  L  D  N  K  T  S  T  P         p.320

          .         .         .         .         .         .       g.49460
 AAGAAGGAGGGCCTCGCACCGCCCTCCCCCAGCCTCGTCTCCGACCTACTCAGTGAGCTC       c.1020
 K  K  E  G  L  A  P  P  S  P  S  L  V  S  D  L  L  S  E  L         p.340

          .         .         .         .   | 05     .         .    g.50237
 AACATCTCTGAGATCCAGAAGCTGAAGCAGCAGCTGATGCAG | ATGGAGCGGGAAAAGGCG    c.1080
 N  I  S  E  I  Q  K  L  K  Q  Q  L  M  Q   | M  E  R  E  K  A      p.360

          .         .         .         .         .         .       g.50297
 GGCCTGCTGGCAACGCTGCAGGACACACAGAAGCAGCTGGAGCACACGCGGGGCTCCCTG       c.1140
 G  L  L  A  T  L  Q  D  T  Q  K  Q  L  E  H  T  R  G  S  L         p.380

          .         .         .         .         .         .       g.50357
 TCAGAACAGCAGGAGAAGGTGACCCGCCTCACAGAGAATCTGAGTGCCCTGCGGCGCCTG       c.1200
 S  E  Q  Q  E  K  V  T  R  L  T  E  N  L  S  A  L  R  R  L         p.400

          .         .         .         .         .         .       g.50417
 CAGGCCAGCAAGGAGCGGCAGACAGCCCTGGACAACGAGAAGGACCGTGACAGCCATGAG       c.1260
 Q  A  S  K  E  R  Q  T  A  L  D  N  E  K  D  R  D  S  H  E         p.420

          .         .         .         .         .         .       g.50477
 GATGGGGACTACTACGAGGTGGACATCAACGGGCCTGAGATCTTGGCCTGCAAGTACCAT       c.1320
 D  G  D  Y  Y  E  V  D  I  N  G  P  E  I  L  A  C  K  Y  H         p.440

          .         .         .         .         .         .       g.50537
 GTGGCTGTGGCTGAGGCTGGCGAGCTCCGCGAGCAGCTCAAGGCACTGCGCAGCACGCAC       c.1380
 V  A  V  A  E  A  G  E  L  R  E  Q  L  K  A  L  R  S  T  H         p.460

          .         .         .         .         .         .       g.50597
 GAGGCTCGTGAGGCCCAGCACGCCGAGGAGAAGGGCCGCTATGAGGCTGAGGGCCAGGCA       c.1440
 E  A  R  E  A  Q  H  A  E  E  K  G  R  Y  E  A  E  G  Q  A         p.480

          .         .         .         .         .         .       g.50657
 CTCACGGAGAAGGTCTCCCTGCTAGAGAAGGCCAGCCGCCAGGACCGCGAGCTGCTGGCC       c.1500
 L  T  E  K  V  S  L  L  E  K  A  S  R  Q  D  R  E  L  L  A         p.500

          .         .         .         .         .         .       g.50717
 CGGCTGGAGAAGGAGCTAAAGAAGGTGAGCGACGTCGCCGGCGAGACACAGGGCAGCCTG       c.1560
 R  L  E  K  E  L  K  K  V  S  D  V  A  G  E  T  Q  G  S  L         p.520

          .         .         .         .         .         .       g.50777
 AGTGTGGCCCAGGATGAGCTGGTGACCTTCAGTGAGGAGCTGGCCAATCTCTACCACCAC       c.1620
 S  V  A  Q  D  E  L  V  T  F  S  E  E  L  A  N  L  Y  H  H         p.540

          .         .         .         .         .         .       g.50837
 GTGTGCATGTGCAACAATGAGACACCCAACCGTGTCATGCTGGACTACTACCGCGAGGGC       c.1680
 V  C  M  C  N  N  E  T  P  N  R  V  M  L  D  Y  Y  R  E  G         p.560

          .         .         .         .         .         .       g.50897
 CAGGGCGGGGCCGGCCGCACCAGTCCCGGGGGCCGCACCAGCCCCGAGGCGCGTGGCCGG       c.1740
 Q  G  G  A  G  R  T  S  P  G  G  R  T  S  P  E  A  R  G  R         p.580

          .         .         .         .         .         .       g.50957
 CGCTCACCCATCCTCCTACCCAAGGGGCTGCTGGCTCCTGAGGCGGGCCGAGCAGATGGT       c.1800
 R  S  P  I  L  L  P  K  G  L  L  A  P  E  A  G  R  A  D  G         p.600

          .         .         .         .         .         .       g.51017
 GGGACGGGGGACAGCAGCCCCTCGCCTGGCTCCTCACTGCCATCACCCCTGAGTGACCCA       c.1860
 G  T  G  D  S  S  P  S  P  G  S  S  L  P  S  P  L  S  D  P         p.620

          .         .         .         .         .         .       g.51077
 CGCCGGGAGCCCATGAACATCTACAACCTGATCGCTATCATCCGTGACCAGATCAAGCAC       c.1920
 R  R  E  P  M  N  I  Y  N  L  I  A  I  I  R  D  Q  I  K  H         p.640

          .         .         .         .         .         .       g.51137
 CTGCAGGCAGCCGTGGACCGCACCACGGAGCTGTCACGCCAGCGCATTGCCTCTCAGGAG       c.1980
 L  Q  A  A  V  D  R  T  T  E  L  S  R  Q  R  I  A  S  Q  E         p.660

          .         .         .         .         .         .       g.51197
 CTGGGCCCCGCCGTGGACAAGGACAAGGAAGCGCTTATGGAGGAGATCCTCAAGCTGAAG       c.2040
 L  G  P  A  V  D  K  D  K  E  A  L  M  E  E  I  L  K  L  K         p.680

          .         .         .         .         .         .       g.51257
 TCGCTGCTCAGCACCAAGCGGGAGCAGATCACCACGCTGCGCACTGTGCTCAAGGCCAAC       c.2100
 S  L  L  S  T  K  R  E  Q  I  T  T  L  R  T  V  L  K  A  N         p.700

        | 06 .         .         .         .         .         .    g.51907
 AAGCAG | ACGGCCGAGGTGGCCCTTGCCAACCTGAAGAGCAAGTATGAGAATGAGAAGGCC    c.2160
 K  Q   | T  A  E  V  A  L  A  N  L  K  S  K  Y  E  N  E  K  A      p.720

          .         .         .         .         .         .       g.51967
 ATGGTTACCGAGACCATGATGAAGCTGCGCAATGAGCTCAAGGCCCTCAAGGAGGACGCA       c.2220
 M  V  T  E  T  M  M  K  L  R  N  E  L  K  A  L  K  E  D  A         p.740

          .         .         .         | 07         .         .    g.54360
 GCCACCTTCTCCTCGCTGCGTGCTATGTTTGCCACCAG | GTGTGACGAGTACATTACACAG    c.2280
 A  T  F  S  S  L  R  A  M  F  A  T  R  |  C  D  E  Y  I  T  Q      p.760

          .         .         .         .         .         .       g.54420
 CTGGATGAGATGCAGCGGCAGCTGGCGGCTGCTGAGGACGAGAAGAAGACGCTGAACTCG       c.2340
 L  D  E  M  Q  R  Q  L  A  A  A  E  D  E  K  K  T  L  N  S         p.780

          .         .         .         .         .         .       g.54480
 CTGCTGCGCATGGCCATCCAGCAGAAGCTGGCGCTGACCCAGCGGCTGGAGCTGCTCGAG       c.2400
 L  L  R  M  A  I  Q  Q  K  L  A  L  T  Q  R  L  E  L  L  E         p.800

          .         .         .         .         .         .       g.54540
 CTGGACCATGAGCAGACCCGGCGTGGCCGTGCCAAAGCCGCCCCGAAGACCAAGCCAGCC       c.2460
 L  D  H  E  Q  T  R  R  G  R  A  K  A  A  P  K  T  K  P  A         p.820

          .         .         .         .         .         .       g.54600
 ACACCGAGCGTAAGTCACACCTGTGCCTGTGCCAGCGACAGGGCCGAGGGCACCGGGCTG       c.2520
 T  P  S  V  S  H  T  C  A  C  A  S  D  R  A  E  G  T  G  L         p.840

          .         .         .         .                           g.54648
 GCCAACCAGGTGTTCTGCAGCGAGAAGCACAGCATTTACTGTGATTAG                   c.2568
 A  N  Q  V  F  C  S  E  K  H  S  I  Y  C  D  X                     p.855

          .         .         .         .         .         .       g.54708
 gggctgtggggcgccgcacgctgcagctaacatctgcttcacctcaactaacccagcagc       c.*60

          .         .         .         .         .         .       g.54768
 agcgggacggcggtgctaggtcaatcttaacgtgactaatgcacagagggtaggagtcta       c.*120

          .         .         .         .         .         .       g.54828
 gccgaggcgccatggggcgttgcatcagcaggacacttgtgagagctttgtgtcgcttct       c.*180

          .         .         .         .         .         .       g.54888
 cactcctcaaagccccctcaggagcacccagtcctcagctgctctcttaggtgggggtca       c.*240

          .         .         .         .         .         .       g.54948
 gaggtggggatagagctgcacattcttgcagcagatgtgtgatgaaagcatcttctaagc       c.*300

          .         .         .         .         .         .       g.55008
 cctgcgcacccgtggggaaacccaagggaggagtcctggtcctgctccctcagcacccaa       c.*360

          .         .         .         .         .         .       g.55068
 aaggggcagaacctgagttgagacttgcatgttcctcgcatgtgtctaatgtcagcacta       c.*420

          .         .         .         .         .         .       g.55128
 gaaagcagttttaggaggttccagcctgcagcataggtacgacctcagaggatggctttg       c.*480

          .         .         .         .         .         .       g.55188
 cacttggcatagtttcatggaaaggagtacgttgtagtttatgcagtatctgactgcaaa       c.*540

          .         .         .         .         .         .       g.55248
 tcatattcaggaaagaagtgcagaatttcttccccaagcccagagaagagcagccctgag       c.*600

          .         .         .         .         .         .       g.55308
 cccctgtattctgctggccagacacacatggcacagacacagctgaccataacccaggaa       c.*660

          .         .         .         .         .         .       g.55368
 tccagagctcggtttctcatttctgagatcaggatgcttgtatagtggcctgtgaggtga       c.*720

          .         .         .         .         .         .       g.55428
 cagattggcagggcccaaggccccaggttttcatttttcatgagaaaagctttccaagtg       c.*780

          .         .         .         .         .         .       g.55488
 cctggccagaccttggtccttagtgcagagcccgtccttttgtacttggggtgaccccag       c.*840

          .         .         .         .         .         .       g.55548
 cagccaattatccggccttccatagggggttcagtcccaaagacatggggctttgaaaac       c.*900

          .         .         .         .         .         .       g.55608
 cctagcctgaagtctgagccaccaagggcttggctgggttggacacccacaggtgtatcc       c.*960

          .         .         .         .         .         .       g.55668
 agagcccagcccggtgctgggaaagctttgcatagggccagggccacttgtcaggattca       c.*1020

          .         .         .         .         .         .       g.55728
 caggtaggagatgtttaggtctctttatttagtgcaatctgggggatggcaacagagaaa       c.*1080

          .         .         .         .         .         .       g.55788
 gaggaaaggtagctgtagggttctcccatttccagaggctccatccacacctgccttccc       c.*1140

          .         .         .         .         .         .       g.55848
 acattctgagcagaacttttctcagtacttttttcccgatcaccctgtgggaccagctgg       c.*1200

          .         .         .         .         .         .       g.55908
 acctgaggctgcagtcttctctcctgcaggctgcttgccttgtctctcatgcggaagagg       c.*1260

          .         .         .         .         .         .       g.55968
 cattcgagttacctggtgagagaccgtgttgccccctcccacagctctctgccctgcgcg       c.*1320

          .         .         .         .         .         .       g.56028
 ttcttccctttggtgccgagtatgtttcggtcccctccagactccaggacacgcccatgt       c.*1380

          .         .         .         .         .         .       g.56088
 atgtcccctgcgtgttcatcctgggcccagatccccctgccccagcaagactcgcagtgg       c.*1440

          .         .         .         .         .         .       g.56148
 gatggctgctggcatgcccaccctgcatgcgctttgccctctccttgcaagcctggcaca       c.*1500

          .         .         .         .         .         .       g.56208
 tagcttctctccatactcctaagggactttgcagacacccaagccactgggacccctgct       c.*1560

          .         .         .         .         .         .       g.56268
 aacacatgcaggtcttctcttctgccaactaacgtgctcgcgccctcccagcacgtggag       c.*1620

          .         .         .         .         .         .       g.56328
 agcttcaattgtcagataaacaggaagcgacagatgaccgctttctaacgctctcttttc       c.*1680

          .         .         .         .         .         .       g.56388
 tcccgttttcagctgtagagtagctgccaggaggacttggccacccggccctgtcacact       c.*1740

          .         .         .         .         .         .       g.56448
 gcagccccttccccttccctctcgtggcccacaaggaggaaggaagggcaacctaaaagc       c.*1800

          .         .         .         .         .         .       g.56508
 ccacttagaaactttttggatatgccactgcaattcttttcaaaatagcattccccaggt       c.*1860

          .         .         .         .         .         .       g.56568
 ttttaatgggaggaaaaaaagctttaatgttgagcatgctgcgagctgctgcgtggaaag       c.*1920

          .         .         .         .         .         .       g.56628
 gcctctgtatgggccgaagacccttcttccctggctgccaggctcgccaggagcccactg       c.*1980

          .         .         .         .         .         .       g.56688
 gaaacgcccaccacgggggctccttgttacacatgttctttttttatccgatcaacctgt       c.*2040

          .         .         .         .         .         .       g.56748
 gcacttttgatattttgatattatatttgcttccttaattcctcgcgtagagacggtctc       c.*2100

          .         .         .         .         .         .       g.56808
 aggtgccgtggtctatgctcgtggtcctgtagctgtccgcctcagctcccaccgtgtttg       c.*2160

          .         .         .         .         .         .       g.56868
 tctggtgtcagcacgaggcagagctgtgtgctccatagcgtgtagctttagactcggaga       c.*2220

          .         .         .         .         .         .       g.56928
 tgagtgctttgacccagcgaggagctcagctaagtgtatccacgctgtggttcagcagcc       c.*2280

          .         .         .         .         .         .       g.56988
 tttagatcatacggcattgtggttcatgtttgaaattacagattttaaatgccatgttca       c.*2340

          .         .         .         .         .         .       g.57048
 ttaagaaatccagggtattcagattctggggtttttcatattgtattattattattctta       c.*2400

          .         .         .         .         .         .       g.57108
 ggaatagttcaatgtaacaagaagaaaacttgacctttgctctggttaaaacagtaatag       c.*2460

          .         .         .         .         .         .       g.57168
 gcacttgaaaaaaaaagataaattattgaatgagtagtattacctacaaattccagaatt       c.*2520

          .         .         .         .         .         .       g.57228
 ttctgggttttaggacgttgtgaagcatgactgattaacagaattttatacaactgtacc       c.*2580

          .         .         .         .         .         .       g.57288
 aataaaattccaaattggaattgttttgttactctggttgttgtgccaaattgtggtaca       c.*2640

          .         .         .         .         .         .       g.57348
 cttagaaaattctacagtcgtcgatttttagggtgttctctttcaacacctttttgttag       c.*2700

          .         .         .         .         .         .       g.57408
 taatcattgccagtagtgccttcatcagttaagggaggtgtcccagcacagatcattctc       c.*2760

          .         .         .         .         .         .       g.57468
 aaaagcgagcagggaagagctagtgggcatgctgaaggccagcgtggacagcaggtgagg       c.*2820

          .         .         .         .         .         .       g.57528
 caggtgctcctcacacccagacctgggcatcttcattgagggaaagaaaacagtcattgt       c.*2880

          .         .         .         .         .         .       g.57588
 gcaaaattctgttagtcagtgattctttacttgcaaattcaggggcttagaaaatgaaag       c.*2940

          .         .         .         .         .         .       g.57648
 caaacacaaaaccttgagtgtgctttgggaaccaaatggaccttctgggacaagctgagc       c.*3000

          .         .         .         .         .         .       g.57708
 aagctgtatgaacgccacgtttgtgaagagctgagggtatcaggagggccgacgctgtgt       c.*3060

          .         .         .         .         .         .       g.57768
 tggcatgcgcagtaggggatgagggttagccatagtattctttgcaaatgtgaaagcgag       c.*3120

          .         .         .         .         .         .       g.57828
 acattatatcttctcttgcttggtgtaactaatcactgttaatttcaggaaacagaactc       c.*3180

          .         .         .         .         .         .       g.57888
 attaaaactccttagcaaaccaggtctacatcctgttttgtttgctgagtgaggttagtg       c.*3240

          .         .         .         .         .         .       g.57948
 ggagtggtcaaattggtactcttggaggaagaaaaactgtccttccttctccaaaaaagg       c.*3300

          .         .         .         .         .         .       g.58008
 aaaaattataataatataaatgacaaaaataaaagaattctgtttcctggaataagcatt       c.*3360

          .         .         .         .         .         .       g.58068
 tcttattcctagttgtagggactcctatttttaccttccgttacagtgttgattcataag       c.*3420

          .         .         .         .         .         .       g.58128
 aaatattgttacatttgagataacttcatctgtatggggtatttatttgcaatgatgtct       c.*3480

          .         .         .         .         .         .       g.58188
 gagtactgtattttttctgtgcattaccttagtgtcagaatgttggtctttattttaaag       c.*3540

          .         .         .         .         .         .       g.58248
 tcatatgcatgttctcctgccaaggaacctttacacagacccaaacaaaaaaataataat       c.*3600

          .         .         .         .         .         .       g.58308
 caaatgccttcaatttctgagaaaatgaggcagagcatggaaaaggaataggaaggagaa       c.*3660

          .         .         .         .         .         .       g.58368
 attaattgagattttcaggacacagacatatgatgtgaatgcctacaaagccagtgcgca       c.*3720

          .         .         .         .         .         .       g.58428
 taggaacagtgggcctgggtaaagagtcacattggtaggaccaataaagaataataaaaa       c.*3780

          .                                                         g.58439
 gacaaagcaca                                                        c.*3791

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bicaudal D homolog 2 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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