bone morphogenetic protein 6 (BMP6) - coding DNA reference sequence

(used for variant description)

(last modified October 14, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001718.4 in the BMP6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering BMP6 transcript NM_001718.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   caactgggggcgccccggacgaccatgagagataaggactgagggccaggaaggggaa       c.-121

 .         .         .         .         .         .                g.5118
 gcgagcccgccgagaggtggcggggactgctcacgccaagggccacagcggccgcgctcc       c.-61

 .         .         .         .         .         .                g.5178
 ggcctcgctccgccgctccacgcctcgcgggatccgcgggggcagcccggccgggcgggg       c.-1

          .         .         .         .         .         .       g.5238
 ATGCCGGGGCTGGGGCGGAGGGCGCAGTGGCTGTGCTGGTGGTGGGGGCTGCTGTGCAGC       c.60
 M  P  G  L  G  R  R  A  Q  W  L  C  W  W  W  G  L  L  C  S         p.20

          .         .         .         .         .         .       g.5298
 TGCTGCGGGCCCCCGCCGCTGCGGCCGCCCTTGCCCGCTGCCGCGGCCGCCGCCGCCGGG       c.120
 C  C  G  P  P  P  L  R  P  P  L  P  A  A  A  A  A  A  A  G         p.40

          .         .         .         .         .         .       g.5358
 GGGCAGCTGCTGGGGGACGGCGGGAGCCCCGGCCGCACGGAGCAGCCGCCGCCGTCGCCG       c.180
 G  Q  L  L  G  D  G  G  S  P  G  R  T  E  Q  P  P  P  S  P         p.60

          .         .         .         .         .         .       g.5418
 CAGTCCTCCTCGGGCTTCCTGTACCGGCGGCTCAAGACGCAGGAGAAGCGGGAGATGCAG       c.240
 Q  S  S  S  G  F  L  Y  R  R  L  K  T  Q  E  K  R  E  M  Q         p.80

          .         .         .         .         .         .       g.5478
 AAGGAGATCTTGTCGGTGCTGGGGCTCCCGCACCGGCCCCGGCCCCTGCACGGCCTCCAA       c.300
 K  E  I  L  S  V  L  G  L  P  H  R  P  R  P  L  H  G  L  Q         p.100

          .         .         .         .         .         .       g.5538
 CAGCCGCAGCCCCCGGCGCTCCGGCAGCAGGAGGAGCAGCAGCAGCAGCAGCAGCTGCCT       c.360
 Q  P  Q  P  P  A  L  R  Q  Q  E  E  Q  Q  Q  Q  Q  Q  L  P         p.120

          .         .         .         .         .         .       g.5598
 CGCGGAGAGCCCCCTCCCGGGCGACTGAAGTCCGCGCCCCTCTTCATGCTGGATCTGTAC       c.420
 R  G  E  P  P  P  G  R  L  K  S  A  P  L  F  M  L  D  L  Y         p.140

          .         .         .         .         .         .       g.5658
 AACGCCCTGTCCGCCGACAACGACGAGGACGGGGCGTCGGAGGGGGAGAGGCAGCAGTCC       c.480
 N  A  L  S  A  D  N  D  E  D  G  A  S  E  G  E  R  Q  Q  S         p.160

          .         .         .         .         .         .       g.5718
 TGGCCCCACGAAGCAGCCAGCTCGTCCCAGCGTCGGCAGCCGCCCCCGGGCGCCGCGCAC       c.540
 W  P  H  E  A  A  S  S  S  Q  R  R  Q  P  P  P  G  A  A  H         p.180

          .         .         .         .         .         .       g.5778
 CCGCTCAACCGCAAGAGCCTTCTGGCCCCCGGATCTGGCAGCGGCGGCGCGTCCCCACTG       c.600
 P  L  N  R  K  S  L  L  A  P  G  S  G  S  G  G  A  S  P  L         p.200

          .         .         .         .         .         .       g.5838
 ACCAGCGCGCAGGACAGCGCCTTCCTCAACGACGCGGACATGGTCATGAGCTTTGTGAAC       c.660
 T  S  A  Q  D  S  A  F  L  N  D  A  D  M  V  M  S  F  V  N         p.220

      | 02   .         .         .         .         .         .    g.123418
 CTGG | TGGAGTACGACAAGGAGTTCTCCCCTCGTCAGCGACACCACAAAGAGTTCAAGTTC    c.720
 L  V |   E  Y  D  K  E  F  S  P  R  Q  R  H  H  K  E  F  K  F      p.240

          .         .         .         .         .         .       g.123478
 AACTTATCCCAGATTCCTGAGGGTGAGGTGGTGACGGCTGCAGAATTCCGCATCTACAAG       c.780
 N  L  S  Q  I  P  E  G  E  V  V  T  A  A  E  F  R  I  Y  K         p.260

          .         .         .         .         .         .       g.123538
 GACTGTGTTATGGGGAGTTTTAAAAACCAAACTTTTCTTATCAGCATTTATCAAGTCTTA       c.840
 D  C  V  M  G  S  F  K  N  Q  T  F  L  I  S  I  Y  Q  V  L         p.280

          .        | 03.         .         .         .         .    g.139716
 CAGGAGCATCAGCACAG | AGACTCTGACCTGTTTTTGTTGGACACCCGTGTAGTATGGGCC    c.900
 Q  E  H  Q  H  R  |  D  S  D  L  F  L  L  D  T  R  V  V  W  A      p.300

          .         .         .         .         .         .       g.139776
 TCAGAAGAAGGCTGGCTGGAATTTGACATCACGGCCACTAGCAATCTGTGGGTTGTGACT       c.960
 S  E  E  G  W  L  E  F  D  I  T  A  T  S  N  L  W  V  V  T         p.320

          .         .         .         .       | 04 .         .    g.140537
 CCACAGCATAACATGGGGCTTCAGCTGAGCGTGGTGACAAGGGATG | GAGTCCACGTCCAC    c.1020
 P  Q  H  N  M  G  L  Q  L  S  V  V  T  R  D  G |   V  H  V  H      p.340

          .         .         .         .         .         .       g.140597
 CCCCGAGCCGCAGGCCTGGTGGGCAGAGACGGCCCTTACGACAAGCAGCCCTTCATGGTG       c.1080
 P  R  A  A  G  L  V  G  R  D  G  P  Y  D  K  Q  P  F  M  V         p.360

          .         .         .         .         .         .       g.140657
 GCTTTCTTCAAAGTGAGTGAGGTGCACGTGCGCACCACCAGGTCAGCCTCCAGCCGGCGC       c.1140
 A  F  F  K  V  S  E  V  H  V  R  T  T  R  S  A  S  S  R  R         p.380

          .         .         .         .         .         .       g.140717
 CGACAACAGAGTCGTAATCGCTCTACCCAGTCCCAGGACGTGGCGCGGGTCTCCAGTGCT       c.1200
 R  Q  Q  S  R  N  R  S  T  Q  S  Q  D  V  A  R  V  S  S  A         p.400

      | 05   .         .         .         .         .         .    g.157352
 TCAG | ATTACAACAGCAGTGAATTGAAAACAGCCTGCAGGAAGCATGAGCTGTATGTGAGT    c.1260
 S  D |   Y  N  S  S  E  L  K  T  A  C  R  K  H  E  L  Y  V  S      p.420

          .         .  | 06      .         .         .         .    g.158252
 TTCCAAGACCTGGGATGGCAG | GACTGGATCATTGCACCCAAGGGCTATGCTGCCAATTAC    c.1320
 F  Q  D  L  G  W  Q   | D  W  I  I  A  P  K  G  Y  A  A  N  Y      p.440

          .         .         .         .         .         .       g.158312
 TGTGATGGAGAATGCTCCTTCCCACTCAACGCACACATGAATGCAACCAACCACGCGATT       c.1380
 C  D  G  E  C  S  F  P  L  N  A  H  M  N  A  T  N  H  A  I         p.460

          .   | 07     .         .         .         .         .    g.158464
 GTGCAGACCTTG | GTTCACCTTATGAACCCCGAGTATGTCCCCAAACCGTGCTGTGCGCCA    c.1440
 V  Q  T  L   | V  H  L  M  N  P  E  Y  V  P  K  P  C  C  A  P      p.480

          .         .         .         .         .         .       g.158524
 ACTAAGCTAAATGCCATCTCGGTTCTTTACTTTGATGACAACTCCAATGTCATTCTGAAA       c.1500
 T  K  L  N  A  I  S  V  L  Y  F  D  D  N  S  N  V  I  L  K         p.500

          .         .         .         .                           g.158566
 AAATACAGGAATATGGTTGTAAGAGCTTGTGGATGCCACTAA                         c.1542
 K  Y  R  N  M  V  V  R  A  C  G  C  H  X                           p.513

          .         .         .         .         .         .       g.158626
 ctcgaaaccagatgctggggacacacattctgccttggattcctagattacatctgcctt       c.*60

          .         .         .         .         .         .       g.158686
 aaaaaaacacggaagcacagttggaggtgggacgatgagactttgaaactatctcatgcc       c.*120

          .         .         .         .         .         .       g.158746
 agtgccttattacccaggaagattttaaaggacctcattaataatttgctcacttggtaa       c.*180

          .         .         .         .         .         .       g.158806
 atgacgtgagtagttgttggtctgtagcaagctgagtttggatgtctgtagcataaggtc       c.*240

          .         .         .         .         .         .       g.158866
 tggtaactgcagaaacataaccgtgaagctcttcctaccctcctcccccaaaaacccacc       c.*300

          .         .         .         .         .         .       g.158926
 aaaattagttttagctgtagatcaagctatttggggtgtttgttagtaaatagggaaaat       c.*360

          .         .         .         .         .         .       g.158986
 aatctcaaaggagttaaatgtattcttggctaaaggatcagctggttcagtactgtctat       c.*420

          .         .         .         .         .         .       g.159046
 caaaggtagattttacagagaacagaaatcggggaagtggggggaacgcctctgttcagt       c.*480

          .         .         .         .         .         .       g.159106
 tcattcccagaagtccacaggacgcacagcccaggccacagccagggctccacggggcgc       c.*540

          .         .         .         .         .         .       g.159166
 ccttgtctcagtcattgctgttgtatgttcgtgctggagttttgttggtgtgaaaataca       c.*600

          .         .         .         .         .         .       g.159226
 cttatttcagccaaaacataccatttctacacctcaatcctccatttgctgtactctttg       c.*660

          .         .         .         .         .         .       g.159286
 ctagtaccaaaagtagactgattacactgaggtgaggctacaaggggtgtgtaaccgtgt       c.*720

          .         .         .         .         .         .       g.159346
 aacacgtgaaggcaatgctcacctcttctttaccagaacggttctttgaccagcacatta       c.*780

          .         .         .         .         .         .       g.159406
 acttctggactgccggctctagtaccttttcagtaaagtggttctctgcctttttactat       c.*840

          .         .         .         .         .         .       g.159466
 acagcataccacgccacagggttagaaccaacgaagaaaataaaatgagggtgcccagct       c.*900

          .         .         .         .         .         .       g.159526
 tataagaatggtgttagggggatgagcatgctgtttatgaacggaaatcatgatttccct       c.*960

          .         .         .         .         .         .       g.159586
 tgtagaaagtgaggctcagattaaattttagaatattttctaaatgtctttttcacaatc       c.*1020

          .         .         .         .         .         .       g.159646
 atgtactgggaaggcaatttcatactaaactgattaaataatacatttataatctacaac       c.*1080

          .         .         .         .         .         .       g.159706
 tgtttgcacttacagctttttttgtaaatataaactataatttattgtctattttatatc       c.*1140

          .         .         .         .         .         .       g.159766
 tgttttgctgtaacattgaaggaaagaccagacttttaaaaaaaaagagtttatttagaa       c.*1200

          .         .         .         .         .         .       g.159826
 agtatcatagtgtaaacaaacaaattgtaccactttgattttcttggaatacaagactcg       c.*1260

          .         .         .         .         .         .       g.159886
 tgatgcaaagctgaagttgtgtgtacaagactcttgacagttgtgcttctctaggaggtt       c.*1320

          .         .         .         .         .         .       g.159946
 gggtttttttaaaaaaagaattatctgtgaaccatacgtgattaataaagatttccttta       c.*1380

                                                                    g.159951
 aggca                                                              c.*1385

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bone morphogenetic protein 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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