bone morphogenetic protein 8b (BMP8B) - coding DNA reference sequence

(used for variant description)

(last modified October 14, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001720.3 in the BMP8B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering BMP8B transcript NM_001720.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             actcgcgggaaccgca       c.-361

 .         .         .         .         .         .                g.5076
 ccaagcgggtggctgcaggagctcgcccatcgcccctgcgctgctcggaccgcggccaca       c.-301

 .         .         .         .         .         .                g.5136
 gccggactggcgggtacggcggcgacagacggattggccgagagtcccagtccgcagagt       c.-241

 .         .         .         .         .         .                g.5196
 agccccggcctcgaggcggtggcgtccgcgtcctctcgtccaggagccaggacaggtgtc       c.-181

 .         .         .         .         .         .                g.5256
 gcgcggcgggcgctccagggaccgcgctgaggccgcggtcgccgcccgtcccgccccgcc       c.-121

 .         .         .         .         .         .                g.5316
 ccgccgcccgccgcccgccgagcccagcctccttgccgtcggggcgtccccaggccctgg       c.-61

 .         .         .         .         .         .                g.5376
 gtcggccgcggagccgatgcgcgcccgctgagcgccccagctgagcgcccccggcctgcc       c.-1

          .         .         .         .         .         .       g.5436
 ATGACCGCGCTCCCCGGCCCGCTCTGGCTCCTGGGCCTGGCGCTATGCGCGCTGGGCGGG       c.60
 M  T  A  L  P  G  P  L  W  L  L  G  L  A  L  C  A  L  G  G         p.20

          .         .         .         .         .         .       g.5496
 GGCGGCCCCGGCCTGCGACCCCCGCCCGGCTGTCCCCAGCGACGTCTGGGCGCGCGCGAG       c.120
 G  G  P  G  L  R  P  P  P  G  C  P  Q  R  R  L  G  A  R  E         p.40

          .         .         .         .         .         .       g.5556
 CGCCGGGACGTGCAGCGCGAGATCCTGGCGGTGCTCGGGCTGCCTGGGCGGCCCCGGCCC       c.180
 R  R  D  V  Q  R  E  I  L  A  V  L  G  L  P  G  R  P  R  P         p.60

          .         .         .         .         .         .       g.5616
 CGCGCGCCACCCGCCGCCTCCCGGCTGCCCGCGTCCGCGCCGCTCTTCATGCTGGACCTG       c.240
 R  A  P  P  A  A  S  R  L  P  A  S  A  P  L  F  M  L  D  L         p.80

          .         .         .         .         .         .       g.5676
 TACCACGCCATGGCCGGCGACGACGACGAGGACGGCGCGCCCGCGGAGCGGCGCCTGGGC       c.300
 Y  H  A  M  A  G  D  D  D  E  D  G  A  P  A  E  R  R  L  G         p.100

          .         .         .     | 02   .         .         .    g.18849
 CGCGCCGACCTGGTCATGAGCTTCGTTAACATGG | TGGAGCGAGACCGTGCCCTGGGCCAC    c.360
 R  A  D  L  V  M  S  F  V  N  M  V |   E  R  D  R  A  L  G  H      p.120

          .         .         .         .         .         .       g.18909
 CAGGAGCCCCATTGGAAGGAGTTCCGCTTTGACCTGACCCAGATCCCGGCTGGGGAGGCG       c.420
 Q  E  P  H  W  K  E  F  R  F  D  L  T  Q  I  P  A  G  E  A         p.140

          .         .         .         .         .         .       g.18969
 GTCACAGCTGCGGAGTTCCGGATTTACAAGGTGCCCAGCATCCACCTGCTCAACAGGACC       c.480
 V  T  A  A  E  F  R  I  Y  K  V  P  S  I  H  L  L  N  R  T         p.160

          .         .         .         .     | 03   .         .    g.19421
 CTCCACGTCAGCATGTTCCAGGTGGTCCAGGAGCAGTCCAACAG | GGAGTCTGACTTGTTC    c.540
 L  H  V  S  M  F  Q  V  V  Q  E  Q  S  N  R  |  E  S  D  L  F      p.180

          .         .         .         .         .         .       g.19481
 TTTTTGGATCTTCAGACGCTCCGAGCTGGAGACGAGGGCTGGCTGGTGCTGGATGTCACA       c.600
 F  L  D  L  Q  T  L  R  A  G  D  E  G  W  L  V  L  D  V  T         p.200

          .         .         .         .         .         .       g.19541
 GCAGCCAGTGACTGCTGGTTGCTGAAGCGTCACAAGGACCTGGGACTCCGCCTCTATGTG       c.660
 A  A  S  D  C  W  L  L  K  R  H  K  D  L  G  L  R  L  Y  V         p.220

          .    | 04    .         .         .         .         .    g.29091
 GAGACTGAGGACG | GGCACAGCGTGGATCCTGGCCTGGCCGGCCTGCTGGGTCAACGGGCC    c.720
 E  T  E  D  G |   H  S  V  D  P  G  L  A  G  L  L  G  Q  R  A      p.240

          .         .         .         .         .         .       g.29151
 CCACGCTCCCAACAGCCTTTCGTGGTCACTTTCTTCAGGGCCAGTCCGAGTCCCATCCGC       c.780
 P  R  S  Q  Q  P  F  V  V  T  F  F  R  A  S  P  S  P  I  R         p.260

          .         .         .         .         .         .       g.29211
 ACCCCTCGGGCAGTGAGGCCACTGAGGAGGAGGCAGCCGAAGAAAAGCAACGAGCTGCCG       c.840
 T  P  R  A  V  R  P  L  R  R  R  Q  P  K  K  S  N  E  L  P         p.280

          .         .         | 05         .         .         .    g.30102
 CAGGCCAACCGACTCCCAGGGATCTTTG | ATGACGTCCACGGCTCCCACGGCCGGCAGGTC    c.900
 Q  A  N  R  L  P  G  I  F  D |   D  V  H  G  S  H  G  R  Q  V      p.300

          .         .         .         .         | 06         .    g.30671
 TGCCGTCGGCACGAGCTCTACGTCAGCTTCCAGGACCTCGGCTGGCTG | GACTGGGTCATC    c.960
 C  R  R  H  E  L  Y  V  S  F  Q  D  L  G  W  L   | D  W  V  I      p.320

          .         .         .         .         .         .       g.30731
 GCTCCCCAAGGCTACTCGGCCTATTACTGTGAGGGGGAGTGCTCCTTCCCACTGGACTCC       c.1020
 A  P  Q  G  Y  S  A  Y  Y  C  E  G  E  C  S  F  P  L  D  S         p.340

          .         .         .          | 07        .         .    g.33314
 TGCATGAATGCCACCAACCACGCCATCCTGCAGTCCCTG | GTGCACCTGATGATGCCAGAC    c.1080
 C  M  N  A  T  N  H  A  I  L  Q  S  L   | V  H  L  M  M  P  D      p.360

          .         .         .         .         .         .       g.33374
 GCAGTCCCCAAGGCGTGCTGTGCACCCACCAAGCTGAGCGCCACCTCTGTGCTCTACTAT       c.1140
 A  V  P  K  A  C  C  A  P  T  K  L  S  A  T  S  V  L  Y  Y         p.380

          .         .         .         .         .         .       g.33434
 GACAGCAGCAACAATGTCATCCTGCGCAAGCACCGCAACATGGTGGTCAAGGCCTGCGGC       c.1200
 D  S  S  N  N  V  I  L  R  K  H  R  N  M  V  V  K  A  C  G         p.400

                                                                    g.33443
 TGCCACTGA                                                          c.1209
 C  H  X                                                            p.402

          .         .         .         .         .         .       g.33503
 gtccacccgcccggcccagctgcagccacccttctcatctggatcgggcccctcagaagc       c.*60

          .         .         .         .         .         .       g.33563
 aggaaaccctcaaacccagccagaccccaggccggggcattgccagggaggaccctcaca       c.*120

          .         .         .         .         .         .       g.33623
 accacgtacatgaccctttctccttcatgccaggctcctatgctccccttgccctgccag       c.*180

          .         .         .         .         .         .       g.33683
 gcatttgtgtgactgtcctgtttccagcccaggtggtctcaatcatcaggcagtgttcta       c.*240

          .         .         .         .         .         .       g.33743
 cccaaatgcaaacgcctctcccggaggcatgtcctggctggttctttggggttggcacag       c.*300

          .         .         .         .         .         .       g.33803
 aagtcctgtctgaggtcctatccatgccccttactggctcaggtcgtgagatagatgtgg       c.*360

          .         .         .         .         .         .       g.33863
 aatgacctgagaggcacctggagcccactgttggccaccttgagctcttcaccatccatc       c.*420

          .         .         .         .         .         .       g.33923
 acagggtgtggtgtgtgtagtcagggtctggttggctccccattgcctgcccgaggtgca       c.*480

          .         .         .         .         .         .       g.33983
 aggtggggtataaaactggataacccctgaagtattgtatattcatggatctgaagcact       c.*540

          .         .         .         .         .         .       g.34043
 gatccactggtcacaggtagacatgtggagtcaactcaagaaaaagctgagtgaacagca       c.*600

          .         .         .         .         .         .       g.34103
 tgatttagggctaaagccaatggcatttatcttcccttgtcttcctgctttgcatttgcc       c.*660

          .         .         .         .         .         .       g.34163
 tctgccatctaggaaagacatgtaagagcatggacattttactttggagaaacagaaaaa       c.*720

          .         .         .         .         .         .       g.34223
 tcttggggcttccaattgacccatctatctgccaccatgttgccccaccaggagctcagc       c.*780

          .         .         .         .         .         .       g.34283
 tctgtggagttttccctttgctgagcaagcatgtggttgcattgggtggcccaggatgac       c.*840

          .         .         .         .         .         .       g.34343
 aatgcacagcacagatgccatcatttccctttcccctctgaatggcagacatcagtaatc       c.*900

          .         .         .         .         .         .       g.34403
 aatctggaatgtttttcttccaaatctgagtggaattttcaaatgatcagcacagccact       c.*960

          .         .         .         .         .         .       g.34463
 gccaacagatatgatgtaaagtgaaacctggttgccatcttctgccatgctgaggagcag       c.*1020

          .         .         .         .         .         .       g.34523
 tccatccctgcccgagcatgtatcggcaacatgggcagcctgtgaccgggtctggggcga       c.*1080

          .         .         .         .         .         .       g.34583
 ggccaggggccatcaaaaacaggctgatcaccaaagtcagtgtcaccctggatgcccagc       c.*1140

          .         .         .         .         .         .       g.34643
 agccctgtcctgtgtcttgggcctgtgagtcaaagaaaaggtccttttcagggagtgaca       c.*1200

          .         .         .         .         .         .       g.34703
 agtagtaattaggctgagttgggtggagaggtttgtctcagcctctgctgttctcggaaa       c.*1260

          .         .         .         .         .         .       g.34763
 ctgctgttctccttggagcagccactgggagttggagtgtttatttgatttctgacttgc       c.*1320

          .         .         .         .         .         .       g.34823
 taagcctgtaatttacctgctggaatagacagagtccagctgcccaaaccgtgtcattaa       c.*1380

          .         .         .         .         .         .       g.34883
 aagcagatcctgcgcccgccccatccacaggcacagcccggcagagtggttccacctccc       c.*1440

          .         .         .         .         .         .       g.34943
 catgggcccaaggatgcgcctctctggagttcacgtgctgcacccccagggaggggcctg       c.*1500

          .         .         .         .         .         .       g.35003
 gggaaagctggtccagcagcaggggtggaggctggggccacactgcgggacagcagcccc       c.*1560

          .         .         .         .         .         .       g.35063
 tccacctggaccagggagggcctccatgtgcaagcgcagaggaagagaccctcccatgta       c.*1620

          .         .         .         .         .         .       g.35123
 cgcaaagggcagccccaggctgtctggaagttggagaattccctatcagcacagggatct       c.*1680

          .         .         .         .         .         .       g.35183
 cagctctggcctggaggtgaagagacctgccttgtaggtggcttccttatctgcgcctcc       c.*1740

          .         .         .         .         .         .       g.35243
 attttctatctgcactttttgatctccaaacaaccttcagccaaagaatctgtctaccaa       c.*1800

          .         .         .         .         .         .       g.35303
 ctcctcatagtgagccagaagcagcctcataaccctgaatgtggggctctggtggctgtc       c.*1860

          .         .         .         .         .         .       g.35363
 acgaagcagagttggcacataacatggaacctggccaggcatggtggctcacacctataa       c.*1920

          .         .         .         .         .         .       g.35423
 ccccagcactttgggaggccaaggcaggcagatcacctgaagtcaggagttcaagaccat       c.*1980

          .         .         .         .         .         .       g.35483
 cctggccaacacagtgaaaccccatctgtactaaaaatacaagattacctgggcatggtg       c.*2040

          .         .         .         .         .         .       g.35543
 gtgcatgcctataatcccagctactcaggaggctgaggcagaattgcttgaacctgggag       c.*2100

          .         .         .         .         .         .       g.35603
 gtggaggttgcagtgagcagagatcacaacattgcacttcagcctggtgacatgagcaaa       c.*2160

          .         .                                               g.35631
 actgttgtctcaacaaaatgaaattatg                                       c.*2188

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bone morphogenetic protein 8b protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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