BRCA1-associated ATM activator 1 (BRAT1) - coding DNA reference sequence

(used for variant description)

(last modified July 25, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_152743.3 in the BRAT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032167.1, covering BRAT1 transcript NM_152743.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             accggatgctcggcatgaaccactaggcgcctggcgggggtgatctgt       c.-241

 .         .         .         .         .         .                g.5108
 cggagcgaccggcttggcgcctgcctgtccccagcccctctcagcttgaactccttcctt       c.-181

 .         .         .         .         .         .                g.5168
 caagtctgggccctcgaggcttccagagcggcctccaggggtgcagtctcagttccccac       c.-121

 .         .         .         .         .         .                g.5228
 gccagccgtctccgtcctccgcctcctccgggcctggcaggtggcactgtccggaggcgg       c.-61

 .         .         .         .         .    | 02    .             g.6327
 agccttgggcgaggggtggttgcggcggaggacgcaaccgagcg | ggcctgcggcctcacc    c.-1

          .         .         .         .         .         .       g.6387
 ATGGACCCAGAATGCGCCCAGCTGCTCCCGGCTCTCTGTGCTGTTCTGGTAGATCCCAGG       c.60
 M  D  P  E  C  A  Q  L  L  P  A  L  C  A  V  L  V  D  P  R         p.20

          .         .         .         .         .         .       g.6447
 CAGCCGGTGGCAGATGACACCTGTTTGGAGAAGCTCCTGGACTGGTTTAAAACGGTCACT       c.120
 Q  P  V  A  D  D  T  C  L  E  K  L  L  D  W  F  K  T  V  T         p.40

         | 03.         .         .         .         .         .    g.13333
 GAAGGAG | AGTCCAGTGTCGTGCTGCTGCAGGAGCACCCCTGCCTGGTGGAGCTGCTGTCC    c.180
 E  G  E |   S  S  V  V  L  L  Q  E  H  P  C  L  V  E  L  L  S      p.60

          .         .         .         .         .         .       g.13393
 CATGTGCTGAAAGTCCAGGACCTGAGTTCTGGGGTCCTCTCCTTCTCACTGCGCCTGGCA       c.240
 H  V  L  K  V  Q  D  L  S  S  G  V  L  S  F  S  L  R  L  A         p.80

          .         .         .         .   | 04     .         .    g.15720
 GGAACCTTCGCAGCCCAGGAAAACTGCTTCCAGTATCTTCAG | CAGGGGGAGTTACTACCA    c.300
 G  T  F  A  A  Q  E  N  C  F  Q  Y  L  Q   | Q  G  E  L  L  P      p.100

          .         .         .         .         .         .       g.15780
 GGGCTCTTTGGGGAGCCAGGACCCCTCGGCCGAGCAACCTGGGCCGTCCCCACCGTGCGC       c.360
 G  L  F  G  E  P  G  P  L  G  R  A  T  W  A  V  P  T  V  R         p.120

          .         .         .         .         .         .       g.15840
 AGCGGCTGGATCCAGGGCCTGCGCTCCCTGGCACAGCACCCCAGCGCCCTGCGCTTCCTG       c.420
 S  G  W  I  Q  G  L  R  S  L  A  Q  H  P  S  A  L  R  F  L         p.140

          . | 05       .         .         .         .         .    g.16846
 GCCGACCATG | GTGCGGTCGACACCATCTTCTCCCTGCAGGGAGACTCCAGCCTGTTTGTG    c.480
 A  D  H  G |   A  V  D  T  I  F  S  L  Q  G  D  S  S  L  F  V      p.160

          .         .         .         .         .         .       g.16906
 GCCTCGGCGGCCAGTCAGCTCCTGGTGCACGTCCTGGCTTTGTCCATGCGAGGTGGAGCC       c.540
 A  S  A  A  S  Q  L  L  V  H  V  L  A  L  S  M  R  G  G  A         p.180

          .         .         .         .         .         .       g.16966
 GAGGGGCAGCCCTGCCTGCCGGGGGGTGACTGGCCCGCGTGTGCCCAGAAGATCATGGAT       c.600
 E  G  Q  P  C  L  P  G  G  D  W  P  A  C  A  Q  K  I  M  D         p.200

          .         .         .         .         .         .       g.17026
 CACGTTGAAGAGTCCTTGTGCTCCGCGGCCACCCCCAAGGTCACTCAGGCCCTGAACGTC       c.660
 H  V  E  E  S  L  C  S  A  A  T  P  K  V  T  Q  A  L  N  V         p.220

          .         .         .         .         .         .       g.17086
 CTGACCACGACCTTCGGGCGCTGCCAGAGCCCCTGGACGGAAGCCCTGTGGGTGCGGCTG       c.720
 L  T  T  T  F  G  R  C  Q  S  P  W  T  E  A  L  W  V  R  L         p.240

          .         .         .         .         .         .       g.17146
 AGTCCCCGCGTGGCCTGTCTGCTGGAGAGAGACCCCATCCCCGCCGCACACTCGTTCGTG       c.780
 S  P  R  V  A  C  L  L  E  R  D  P  I  P  A  A  H  S  F  V         p.260

          .         .    | 06    .         .         .         .    g.17472
 GACCTGCTTCTCTGTGTGGCTCG | TTCTCCCGTGTTCAGTTCTTCCGACGGCAGCCTGTGG    c.840
 D  L  L  L  C  V  A  R  |  S  P  V  F  S  S  S  D  G  S  L  W      p.280

          .         .         .         .         .         .       g.17532
 GAGACAGTGGCGCGGGCTCTGAGCTGCCTGGGTCCCACCCACATGGGACCCCTGGCTTTG       c.900
 E  T  V  A  R  A  L  S  C  L  G  P  T  H  M  G  P  L  A  L         p.300

          .         .    | 07    .         .         .         .    g.18584
 GGGATCCTGAAGCTCGAGCACTG | TCCACAGGCACTGAGGACCCAGGCCTTCCAGGTCCTT    c.960
 G  I  L  K  L  E  H  C  |  P  Q  A  L  R  T  Q  A  F  Q  V  L      p.320

          .         .         .         .         .      | 08  .    g.18927
 CTCCAGCCCCTGGCCTGTGTCCTGAAGGCCACGGTTCAGGCCCCCGGACCCCCAG | GCTTG    c.1020
 L  Q  P  L  A  C  V  L  K  A  T  V  Q  A  P  G  P  P  G |   L      p.340

          .         .         .         .         .         .       g.18987
 CTGGACGGGACGGCAGACGATGCCACGACGGTGGACACACTCCTGGCCTCCAAGTCGTCC       c.1080
 L  D  G  T  A  D  D  A  T  T  V  D  T  L  L  A  S  K  S  S         p.360

          .         .         .         .         .     | 09   .    g.19280
 TGCGCCGGCCTCCTGTGCCGCACCCTGGCTCACCTGGAGGAGCTGCAGCCGCTG | CCCCAG    c.1140
 C  A  G  L  L  C  R  T  L  A  H  L  E  E  L  Q  P  L   | P  Q      p.380

          .         .         .         .         .         .       g.19340
 CGCCCTTCACCGTGGCCCCAGGCGTCTCTACTGGGGGCTACAGTGACTGTCCTGCGGCTC       c.1200
 R  P  S  P  W  P  Q  A  S  L  L  G  A  T  V  T  V  L  R  L         p.400

          .         .         .         .         .         .       g.19400
 TGTGACGGCTCGGCTGCCCCTGCCTCCAGTGTGGGGGGCCACCTCTGTGGGACCCTGGCG       c.1260
 C  D  G  S  A  A  P  A  S  S  V  G  G  H  L  C  G  T  L  A         p.420

          .         .         .         .         .         .       g.19460
 GGCTGCGTCCGGGTCCAGCGAGCAGCCCTCGACTTCCTGGGGACGCTGTCACAGGGGACA       c.1320
 G  C  V  R  V  Q  R  A  A  L  D  F  L  G  T  L  S  Q  G  T         p.440

   | 10      .         .         .         .         .         .    g.19765
 G | GCCCCCAGGAGCTGGTGACGCAGGCGCTTGCTGTCCTCCTGGAGTGCCTCGAGAGCCCC    c.1380
 G |   P  Q  E  L  V  T  Q  A  L  A  V  L  L  E  C  L  E  S  P      p.460

          .      | 11  .         .         .         .         .    g.20915
 GGCTCCAGCCCCACG | GTTCTGAAGAAGGCCTTCCAGGCCACGCTCAGGTGGCTCCTGAGC    c.1440
 G  S  S  P  T   | V  L  K  K  A  F  Q  A  T  L  R  W  L  L  S      p.480

          .         .         .         .         .         | 12    g.21118
 TCACCCAAGACCCCCGGCTGCTCTGATCTCGGCCCCCTCATCCCGCAGTTCCTCAGAG | AG    c.1500
 S  P  K  T  P  G  C  S  D  L  G  P  L  I  P  Q  F  L  R  E |       p.500

          .         .         .         .         .         .       g.21178
 CTGTTCCCTGTGCTGCAGAAACGCCTGTGCCACCCCTGCTGGGAGGTGAGGGACTCCGCC       c.1560
 L  F  P  V  L  Q  K  R  L  C  H  P  C  W  E  V  R  D  S  A         p.520

          .         .         .        | 13.         .         .    g.21430
 CTCGAGTTCCTGACCCAGCTGAGCAGGCACTGGGGAG | GACAGGCTGACTTCAGATGCGCA    c.1620
 L  E  F  L  T  Q  L  S  R  H  W  G  G |   Q  A  D  F  R  C  A      p.540

          .         .         .         .         .         .       g.21490
 CTCTTGGCTTCAGAGGTGCCTCAGCTGGCCCTGCAGCTCCTCCAGGACCCTGAGAGTTAT       c.1680
 L  L  A  S  E  V  P  Q  L  A  L  Q  L  L  Q  D  P  E  S  Y         p.560

          .         .         .         .         .         .       g.21550
 GTCCGAGCGAGTGCAGTGACCGCCATGGGGCAGCTGTCCAGCCAGGGCCTGCACGCCCCC       c.1740
 V  R  A  S  A  V  T  A  M  G  Q  L  S  S  Q  G  L  H  A  P         p.580

          .         .         . | 14       .         .         .    g.22024
 ACCAGCCCTGAGCATGCAGAGGCCCGGCAG | AGCCTGTTCCTGGAGCTCCTGCACATCCTC    c.1800
 T  S  P  E  H  A  E  A  R  Q   | S  L  F  L  E  L  L  H  I  L      p.600

          .         .         .         .         .         .       g.22084
 TCCGTAGACTCGGAGGGCTTCCCACGGCGGGCGGTCATGCAAGTCTTCACTGAGTGGCTG       c.1860
 S  V  D  S  E  G  F  P  R  R  A  V  M  Q  V  F  T  E  W  L         p.620

          .         .         .         .         .         .       g.22144
 CGGGACGGCCACGCCGACGCGGCCCAGGACACGGAGCAGTTCGTGGCCACTGTGCTGCAG       c.1920
 R  D  G  H  A  D  A  A  Q  D  T  E  Q  F  V  A  T  V  L  Q         p.640

          .         .         .         .         .         .       g.22204
 GCGGCGAGCCGAGACCTGGACTGGGAGGTCCGCGCCCAGGGCCTGGAGCTGGCCCTCGTG       c.1980
 A  A  S  R  D  L  D  W  E  V  R  A  Q  G  L  E  L  A  L  V         p.660

          .         .         .         .         .         .       g.22264
 TTCCTGGGCCAGACTTTGGGGCCGCCGCGTACCCACTGCCCCTATGCCGTGGCCCTACCC       c.2040
 F  L  G  Q  T  L  G  P  P  R  T  H  C  P  Y  A  V  A  L  P         p.680

          .         .         .         .         .         .       g.22324
 GAGGTGGCCCCAGCCCAGCCACTCACCGAGGCACTGAGGGCTCTCTGCCACGTGGGGCTC       c.2100
 E  V  A  P  A  Q  P  L  T  E  A  L  R  A  L  C  H  V  G  L         p.700

          .         .         .         .         .         .       g.22384
 TTTGACTTCGCCTTTTGTGCCTTGTTTGACTGCGACCGCCCTGTGGCGCAGAAGTCTTGT       c.2160
 F  D  F  A  F  C  A  L  F  D  C  D  R  P  V  A  Q  K  S  C         p.720

          .         .         .         .         .         .       g.22444
 GACCTCCTTCTCTTCCTGAGGGACAAGATTGCTTCCTACAGCAGCCTGCGGGAGGCCAGG       c.2220
 D  L  L  L  F  L  R  D  K  I  A  S  Y  S  S  L  R  E  A  R         p.740

          .         .         .         .         .         .       g.22504
 GGCAGCCCCAACACTGCCTCCGCAGAGGCCACCCTGCCGAGGTGGCGGGCGGGTGAGCAG       c.2280
 G  S  P  N  T  A  S  A  E  A  T  L  P  R  W  R  A  G  E  Q         p.760

          .         .         .         .         .         .       g.22564
 GCCCAGCCCCCAGGGGACCAGGAGCCTGAGGCTGTGCTGGCCATGCTCAGGTCCCTAGAC       c.2340
 A  Q  P  P  G  D  Q  E  P  E  A  V  L  A  M  L  R  S  L  D         p.780

          .         .         .         .         .         .       g.22624
 CTGGAGGGCCTGCGGAGCACGCTGGCCGAGAGCAGCGACCACGTGGAAAAGAGTCCCCAG       c.2400
 L  E  G  L  R  S  T  L  A  E  S  S  D  H  V  E  K  S  P  Q         p.800

          .         .         .         .         .         .       g.22684
 TCCCTCCTGCAGGACATGCTGGCCACGGGAGGCTTCCTGCAGGGGGACGAGGCCGACTGC       c.2460
 S  L  L  Q  D  M  L  A  T  G  G  F  L  Q  G  D  E  A  D  C         p.820

                                                                    g.22690
 TACTGA                                                             c.2466
 Y  X                                                               p.821

          .         .         .         .         .         .       g.22750
 gcagaaccagagtctgccactggggctcaggaccaagggaggcagcaccatgtccttctg       c.*60

          .         .         .         .         .         .       g.22810
 tgggacactgccagccccagggctccagcccagcccggtggatcctctggggaagccagg       c.*120

          .         .         .         .         .         .       g.22870
 accaggagagaagcaaggtcaagaaatcccacagtttgatgtattaaagaaatgacttat       c.*180

          .         .         .         .         .         .       g.22930
 ttctactcaaaataaatggcattgaagtctttctttaaccctttttgagttaatttaata       c.*240

          .                                                         g.22949
 ataatgatctgagacaagg                                                c.*259

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The BRCA1-associated ATM activator 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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