BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) (BRF1) - coding DNA reference sequence

(used for variant description)

(last modified January 21, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001242786.1 in the BRF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029489.1, covering BRF1 transcript NM_001242786.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    aaatgagagacagcgccaaccaggtacccgcgaggacgaccccgccccgcaggacag       c.-361

 .         .         .         .         .         .                g.5117
 ggcatctccaccgcgcgctggacggaggatacaaccgagtcctgcgcgccccgtgcgccg       c.-301

 .         .         .         .         .         .                g.5177
 ggggtcgctcccaggccgaggtctgacagtgtcgccgaacgcgaaaggaagcgtgtggta       c.-241

 .         .         .         .         .         .                g.5237
 cccgagagaggaagcaccctcgtcaccccggccggcaccgcattgaggcaggtgtgcagg       c.-181

 .         .         | 02         .         .         .             g.34242
 tgcggttgcggcgagccag | gtgctggcaaaaccccgactctgggtggcggcttccacgtg    c.-121

 .         .         .         .          | 03        .             g.47703
 aatctggggaaggagtcgagagcgcagaccctgcagaatg | ggaggcgccacatccaccac    c.-61

 .         .         .         .         .         .                g.47763
 ctggggaaccagctgcagctgaaccagcactgcctggacaccgccttcaacttcttcaag       c.-1

          .         .         .         .         .         .       g.47823
 ATGGCCGTGAGCAGGCACCTGACCCGCGGCCGGAAGATGGCCCACGTGATTGCTGCCTGC       c.60
 M  A  V  S  R  H  L  T  R  G  R  K  M  A  H  V  I  A  A  C         p.20

          .         .         .     | 04   .         .         .    g.64054
 CTCTACCTGGTCTGCCGTACGGAGGGCACGCCGC | ACATGCTCCTGGACCTCAGCGACCTG    c.120
 L  Y  L  V  C  R  T  E  G  T  P  H |   M  L  L  D  L  S  D  L      p.40

        | 05 .         .         .         .         .         .    g.68052
 CTCCAG | GTGAATGTGTACGTGCTTGGAAAGACGTTTCTTCTCTTGGCAAGAGAGCTCTGC    c.180
 L  Q   | V  N  V  Y  V  L  G  K  T  F  L  L  L  A  R  E  L  C      p.60

          .          | 06        .         .         .         .    g.79204
 ATCAATGCGCCGGCCATAG | ACCCGTGCCTGTATATTCCACGCTTTGCGCACCTGCTGGAA    c.240
 I  N  A  P  A  I  D |   P  C  L  Y  I  P  R  F  A  H  L  L  E      p.80

          .         .         .         .         .         .       g.79264
 TTCGGGGAGAAGAACCACGAGGTGTCCATGACTGCCCTGAGGCTCCTACAGAGGATGAAG       c.300
 F  G  E  K  N  H  E  V  S  M  T  A  L  R  L  L  Q  R  M  K         p.100

          .         .         .         .          | 07        .    g.91675
 CGGGACTGGATGCACACAGGCCGGCGCCCCTCGGGCCTCTGCGGAGCAG | CGCTCCTGGTT    c.360
 R  D  W  M  H  T  G  R  R  P  S  G  L  C  G  A  A |   L  L  V      p.120

          .         .         .         .         .         .       g.91735
 GCAGCCAGAATGCATGACTTCAGGAGGACTGTGAAGGAGGTCATCAGTGTGGTCAAAGTG       c.420
 A  A  R  M  H  D  F  R  R  T  V  K  E  V  I  S  V  V  K  V         p.140

          .         .    | 08    .         .         .         .    g.93854
 TGTGAGTCCACGCTGCGGAAGAG | GCTCACGGAATTTGAAGACACCCCCACCAGTCAGTTG    c.480
 C  E  S  T  L  R  K  R  |  L  T  E  F  E  D  T  P  T  S  Q  L      p.160

          .         .         .         .         .         .       g.93914
 ACCATTGATGAGTTCATGAAGATCGACCTGGAGGAGGAGTGCGACCCCCCCTCGTACACA       c.540
 T  I  D  E  F  M  K  I  D  L  E  E  E  C  D  P  P  S  Y  T         p.180

          .         .         . | 09       .         .         .    g.94317
 GCTGGGCAGAGGAAGCTGCGGATGAAGCAG | CTTGAACAAGTCCTGTCAAAAAAACTGGAG    c.600
 A  G  Q  R  K  L  R  M  K  Q   | L  E  Q  V  L  S  K  K  L  E      p.200

          . | 10       .         .         .         .         .    g.94466
 GAGGTTGAAG | GTGAAATATCCAGTTACCAGGATGCAATTGAGATTGAACTAGAAAACAGC    c.660
 E  V  E  G |   E  I  S  S  Y  Q  D  A  I  E  I  E  L  E  N  S      p.220

          .         .         .         .    | 11    .         .    g.98680
 CGGCCAAAGGCCAAGGGGGGCCTGGCCAGCCTGGCAAAAGATG | GCTCCACCGAGGACACC    c.720
 R  P  K  A  K  G  G  L  A  S  L  A  K  D  G |   S  T  E  D  T      p.240

          .         .         .         .         .         .       g.98740
 GCGTCCAGCTTGTGTGGCGAGGAGGACACAGAGGACGAGGAGCTGGAAGCCGCGGCCAGC       c.780
 A  S  S  L  C  G  E  E  D  T  E  D  E  E  L  E  A  A  A  S         p.260

          .         .         .         .         .         .       g.98800
 CACCTGAACAAAGACTTATACCGGGAGCTCCTTGGTGGTGCCCCCGGCAGCTCGGAAGCA       c.840
 H  L  N  K  D  L  Y  R  E  L  L  G  G  A  P  G  S  S  E  A         p.280

          .         .         .         .         .         .       g.98860
 GCAGGAAGCCCCGAGTGGGGCGGCAGACCTCCGGCCCTGGGGTCCCTGCTGGACCCCCTC       c.900
 A  G  S  P  E  W  G  G  R  P  P  A  L  G  S  L  L  D  P  L         p.300

          .         .         .         .         .         .       g.98920
 CCCACTGCAGCCAGCCTGGGCATCTCAGACTCCATCCGCGAATGCATCTCCTCTCAGAGC       c.960
 P  T  A  A  S  L  G  I  S  D  S  I  R  E  C  I  S  S  Q  S         p.320

          . | 12       .         .         .         .         .    g.100497
 AGCGACCCCA | AAGATGCTTCAGGAGACGGTGAGCTGGACCTCAGTGGCATTGATGACCTG    c.1020
 S  D  P  K |   D  A  S  G  D  G  E  L  D  L  S  G  I  D  D  L      p.340

          .   | 13     .         .         .         .         .    g.101327
 GAGATTGACAGG | CGCGACCTTAGCATGCCCCGGTGTGCGAAGGCTAAAAGCCAGCCCCAC    c.1080
 E  I  D  R   | R  D  L  S  M  P  R  C  A  K  A  K  S  Q  P  H      p.360

          .         .         .         .         .         .       g.101387
 TTCCCTGTGCTCGCCCAGTACATCCTGAATGAGTCGGAAGCCCGCGTGAAGGCCGAGCTG       c.1140
 F  P  V  L  A  Q  Y  I  L  N  E  S  E  A  R  V  K  A  E  L         p.380

          .         .         .         . | 14       .         .    g.101544
 TGGATGAGGGAGAACGCCGAGTACCTGCGGGAACAGAGGG | AAAAAGAAGCAAGAATAGCG    c.1200
 W  M  R  E  N  A  E  Y  L  R  E  Q  R  E |   K  E  A  R  I  A      p.400

          .         .         .       | 15 .         .         .    g.102801
 AAAGAGAAGGAGCTCGGCATCTACAAGGAACACAAG | CCCAAGAAGTCTTGCAAGCGACGG    c.1260
 K  E  K  E  L  G  I  Y  K  E  H  K   | P  K  K  S  C  K  R  R      p.420

          .         .         .         .         .         .       g.102861
 GAGCCAATTCAGGCCAGTACCGCCAGGGAGGCCATCGAGAAGATGCTGGAGCAGAAGAAG       c.1320
 E  P  I  Q  A  S  T  A  R  E  A  I  E  K  M  L  E  Q  K  K         p.440

          .         .         .         .         .         .       g.102921
 ATCTCCAGCAAGATCAATTATAGCGTGCTCCGGGGCCTCAGCAGCGCCGGCGGGGGCAGT       c.1380
 I  S  S  K  I  N  Y  S  V  L  R  G  L  S  S  A  G  G  G  S         p.460

          .         .         .         .         .         .       g.102981
 CCGCACAGGGAGGATGCACAGCCCGAGCATAGCGCCAGTGCCAGGAAGCTGTCACGAAGG       c.1440
 P  H  R  E  D  A  Q  P  E  H  S  A  S  A  R  K  L  S  R  R         p.480

          .         .         .         .         .    | 16    .    g.108420
 AGGACGCCGGCCAGCAGAAGTGGGGCTGACCCTGTGACCAGTGTGGGGAAAAG | GTTGAGG    c.1500
 R  T  P  A  S  R  S  G  A  D  P  V  T  S  V  G  K  R  |  L  R      p.500

          .         .         .         .      | 17  .         .    g.109299
 CCTCTGGTGTCTACGCAGCCAGCAAAGAAGGTGGCCACGGGAGAG | GCTTTGCTCCCAAGC    c.1560
 P  L  V  S  T  Q  P  A  K  K  V  A  T  G  E   | A  L  L  P  S      p.520

          .         .         .         .         .         .       g.109359
 TCTCCCACCCTCGGAGCTGAGCCTGCCAGGCCCCAGGCGGTGCTGGTGGAGAGCGGGCCC       c.1620
 S  P  T  L  G  A  E  P  A  R  P  Q  A  V  L  V  E  S  G  P         p.540

          .         .         .         .         .         .       g.109419
 GTGTCATACCACGCCGACGAGGAGGCTGACGAGGAGGAGCCTGACGAGGAGGACGGGGAG       c.1680
 V  S  Y  H  A  D  E  E  A  D  E  E  E  P  D  E  E  D  G  E         p.560

          .         .         .        | 18.         .         .    g.110012
 CCCTGCGTCAGTGCCCTGCAGATGATGGGCAGCAACG | ACTATGGCTGTGATGGCGATGAG    c.1740
 P  C  V  S  A  L  Q  M  M  G  S  N  D |   Y  G  C  D  G  D  E      p.580

          .                                                         g.110027
 GACGACGGCTACTGA                                                    c.1755
 D  D  G  Y  X                                                      p.584

          .         .         .         .         .         .       g.110087
 agtgtggcctccaggcaggtgatgtcctggcagggggcctcgcgggtctcctcagcatca       c.*60

          .         .         .         .         .         .       g.110147
 gacgggcttccaggaccgcagcaggcaggccccagcgccgagactcctggtgacaggtgg       c.*120

          .         .         .         .         .         .       g.110207
 cacctgtcccacagccctcgtcccatgtggaacttaccattgggattgtgtttctattca       c.*180

          .         .         .         .         .         .       g.110267
 gcaagggaaaccggaccaagcgtctgcatgtgtgtgatcagatgtgggccgggtgtgtgc       c.*240

          .         .         .         .         .         .       g.110327
 agggctgggtcccgctgcctgccgtcgactcatccaaggaccctccaaggctggcagtgt       c.*300

          .         .         .         .         .         .       g.110387
 ggtgttgctactattaaggaaacaggcttggggcagccccactgctggtccaagtgtgtg       c.*360

          .         .         .         .         .         .       g.110447
 gagggctgagtgtgctggccctgtgactcaggaccagctctggagtctccagcccaccct       c.*420

          .         .         .         .         .         .       g.110507
 ccgcaccgtcccctcctgagcagcactcggcgccagcagcctctgccagagtggaagcca       c.*480

          .         .         .         .         .         .       g.110567
 gagccctgcaggtgtccggcgcagccgtgggagctgaggatctggcacttgagaggcagc       c.*540

          .         .         .         .         .         .       g.110627
 agctccttgaaggtcctctgcctccagctgtggccctgcatccagatacctgcctcgtcc       c.*600

          .         .         .         .         .         .       g.110687
 gaggcagacacccccacccctgcctcctccagacccccctccccgctgcctgcaccgcct       c.*660

          .         .         .         .         .         .       g.110747
 ggagcagcatgggggtcagacccctgctccagggccacttgagttgtgggcccaggagcc       c.*720

          .         .         .         .         .         .       g.110807
 ctgcggctgccggcaggtgaactgagtgcccgacagctgagaccggcgcccacccgtcct       c.*780

          .         .         .         .         .         .       g.110867
 gagcatagctctgtaggcagtgcgggcatagcctgcatagtgtcctggcgctgggagttc       c.*840

          .         .         .         .         .         .       g.110927
 cccgtggacagagccagagggcagtggcgctccctgtcagagctggatcaggccccccat       c.*900

          .         .         .         .         .         .       g.110987
 cgaggagggagggcagacggaggcccgagagcctccccaggcctcttcgtgggaaggccc       c.*960

          .         .         .         .         .         .       g.111047
 cagtaccactcgtaggaggtctcagctctggcatggctgccccggatgtggccgaggggg       c.*1020

          .         .         .         .         .         .       g.111107
 cttcaccctgtgtccttaggagggggtggccttgaggcagagccgtgcctcactgacccc       c.*1080

          .         .         .         .         .         .       g.111167
 caggggcctcatcctccccatggaatgggctgtatgtcctgccccaacttggcccgcagc       c.*1140

          .         .         .         .         .         .       g.111227
 aggccagacccccctacccccgcccagagctcagtagccagcctgggtcctgccagggct       c.*1200

          .         .         .         .         .         .       g.111287
 tctcgagggcttgggggaagaatagatttagtaaagcaggaagatctgttgttacttaac       c.*1260

                                                                    g.111292
 agaaa                                                              c.*1265

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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